Wen Harn Pan

Summary

Affiliation: Academia Sinica
Country: Taiwan

Publications

  1. ncbi request reprint Hyperuricemia and metabolic syndrome in Taiwanese children
    Meei Shyuan Lee
    School of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC
    Asia Pac J Clin Nutr 16:594-600. 2007
  2. pmc A neural network model for constructing endophenotypes of common complex diseases: an application to male young-onset hypertension microarray data
    Ke Shiuan Lynn
    Institute of Information Sciences, Academia Sinica, Taipei, Taiwan
    Bioinformatics 25:981-8. 2009
  3. pmc Construction of gene clusters resembling genetic causal mechanisms for common complex disease with an application to young-onset hypertension
    Ke Shiuan Lynn
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    BMC Genomics 14:497. 2013
  4. pmc Genome-wide gene-based association study
    Hsin Chou Yang
    Institute of Statistical Science, Academia Sinica, Number 128, Section 2, Academia Road, Nankang, Taipei 115, Taiwan, Republic of China
    BMC Proc 3:S135. 2009
  5. pmc HypertenGene: extracting key hypertension genes from biomedical literature with position and automatically-generated template features
    Richard Tzong Han Tsai
    Department of Computer Science and Engineering, Yuan Ze University, Chung Li, Taiwan, Republic of China
    BMC Bioinformatics 10:S9. 2009
  6. ncbi request reprint Elderly Nutrition and Health Survey in Taiwan (1999-2000): research design, methodology and content
    Wen Harn Pan
    Institute of Biomedical Sciences, Academia Sinica, 128 Sec 2, Academia Rd, Nankang, Taipei 11529, and National Taiwan University Hospital, Bei Hu Branch, Taiwan
    Asia Pac J Clin Nutr 14:203-10. 2005
  7. ncbi request reprint How to define obesity? Evidence-based multiple action points for public awareness, screening, and treatment: an extension of Asian-Pacific recommendations
    Wen Harn Pan
    Division of Epidemiology and Genetics, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Asia Pac J Clin Nutr 17:370-4. 2008
  8. ncbi request reprint Gender-specific roles and needs in food-health security
    Wen Harn Pan
    Division of Epidemiology and Genetics, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Asia Pac J Clin Nutr 18:642-6. 2009
  9. ncbi request reprint The double malnutritional burden and regional disparities in Taiwan elementary school children: survey database and reference values
    Wen Harn Pan
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, ROC
    Asia Pac J Clin Nutr 16:478-506. 2007
  10. ncbi request reprint Diet and health trends in Taiwan: comparison of two nutrition and health surveys from 1993-1996 and 2005-2008
    Wen Harn Pan
    Nutrition Medicine Research Program, Division of Health Sciences Research and Preventive Medicine, Institute of Population Health Sciences, National Health Research Institute, 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan
    Asia Pac J Clin Nutr 20:238-50. 2011

Detail Information

Publications99

  1. ncbi request reprint Hyperuricemia and metabolic syndrome in Taiwanese children
    Meei Shyuan Lee
    School of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC
    Asia Pac J Clin Nutr 16:594-600. 2007
    ..Not only abdominal fatness, but also uric acid status, or both together may be of interest to public health workers and clinicians in regard to the transitional health problem of MS...
  2. pmc A neural network model for constructing endophenotypes of common complex diseases: an application to male young-onset hypertension microarray data
    Ke Shiuan Lynn
    Institute of Information Sciences, Academia Sinica, Taipei, Taiwan
    Bioinformatics 25:981-8. 2009
    ..Thus, a neural network model was adopted to simulate the gene-endophenotype-disease relationship in which endophenotypes were represented by hidden nodes...
  3. pmc Construction of gene clusters resembling genetic causal mechanisms for common complex disease with an application to young-onset hypertension
    Ke Shiuan Lynn
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    BMC Genomics 14:497. 2013
    ..In the present work, we developed a three-stage algorithm to construct gene clusters resembling Rothman's causal model for a complex disease, starting from finding influential gene pairs followed by grouping homogeneous pairs...
  4. pmc Genome-wide gene-based association study
    Hsin Chou Yang
    Institute of Statistical Science, Academia Sinica, Number 128, Section 2, Academia Road, Nankang, Taipei 115, Taiwan, Republic of China
    BMC Proc 3:S135. 2009
    ..Moreover, previously reported genes including PTPN22, C5, and IL2RB were confirmed; novel genes including HLA-DRA, BTNL2, C6orf10, NOTCH4, TAP2, and TNXB were identified by our analysis...
  5. pmc HypertenGene: extracting key hypertension genes from biomedical literature with position and automatically-generated template features
    Richard Tzong Han Tsai
    Department of Computer Science and Engineering, Yuan Ze University, Chung Li, Taiwan, Republic of China
    BMC Bioinformatics 10:S9. 2009
    ..Three major tasks are involved in the construction of this system: (1) gene and hypertension named entity recognition, (2) section categorization, and (3) gene-hypertension relation extraction...
  6. ncbi request reprint Elderly Nutrition and Health Survey in Taiwan (1999-2000): research design, methodology and content
    Wen Harn Pan
    Institute of Biomedical Sciences, Academia Sinica, 128 Sec 2, Academia Rd, Nankang, Taipei 11529, and National Taiwan University Hospital, Bei Hu Branch, Taiwan
    Asia Pac J Clin Nutr 14:203-10. 2005
    ..Furthermore, this information could be used in the development of public health nutrition policy aimed at improving the nutrition and health of the elderly in Taiwan...
  7. ncbi request reprint How to define obesity? Evidence-based multiple action points for public awareness, screening, and treatment: an extension of Asian-Pacific recommendations
    Wen Harn Pan
    Division of Epidemiology and Genetics, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Asia Pac J Clin Nutr 17:370-4. 2008
    ....
  8. ncbi request reprint Gender-specific roles and needs in food-health security
    Wen Harn Pan
    Division of Epidemiology and Genetics, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Asia Pac J Clin Nutr 18:642-6. 2009
    ..Risky health-related behaviours, including poor food choices, are more often practiced by men and warrant more public health attention...
  9. ncbi request reprint The double malnutritional burden and regional disparities in Taiwan elementary school children: survey database and reference values
    Wen Harn Pan
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, ROC
    Asia Pac J Clin Nutr 16:478-506. 2007
    ..For international comparison, these reference data are tabulated in this report and the survey data are made available in the data archive system maintained by the Center for Survey Research, Academia Sinica...
  10. ncbi request reprint Diet and health trends in Taiwan: comparison of two nutrition and health surveys from 1993-1996 and 2005-2008
    Wen Harn Pan
    Nutrition Medicine Research Program, Division of Health Sciences Research and Preventive Medicine, Institute of Population Health Sciences, National Health Research Institute, 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan
    Asia Pac J Clin Nutr 20:238-50. 2011
    ..Intake of dairy products remains low, and continues to be an important dietary issue in Taiwan...
  11. ncbi request reprint Reference spirometric values in healthy Chinese neversmokers in two townships of Taiwan
    W H Pan
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, ROC
    Chin J Physiol 40:165-74. 1997
    ..Age and height specific percentile values of FVC and FEV1 and the age-specific percentile value of FEV1% are provided for adult men and women in this community study...
  12. ncbi request reprint Body mass index and obesity-related metabolic disorders in Taiwanese and US whites and blacks: implications for definitions of overweight and obesity for Asians
    Wen Harn Pan
    Division of Epidemiology and Public Health, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Am J Clin Nutr 79:31-9. 2004
    ..Recommendations based on scanty data have been made to lower the body mass index (BMI; in kg/m(2)) cutoff for obesity in Asians...
  13. ncbi request reprint Using endophenotypes for pathway clusters to map complex disease genes
    Wen Harn Pan
    Institute of Biomedical Sciences, Academia Sinica, No 128 Section 2 Academia Road, Taipei, Taiwan 11529
    Genet Epidemiol 30:143-54. 2006
    ..Concerted efforts are required to carry out large-scale prospective studies that are integrated at the levels of phenotype characterization, high throughput experimental techniques, data analyses, and beyond...
  14. ncbi request reprint Linkage analysis with candidate genes: the Taiwan young-onset hypertension genetic study
    W H Pan
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Hum Genet 107:210-5. 2000
    ..0785) for the positive signal. Comprehensive genotyping with further markers in these regions is underway to confirm whether these genes are linked to young-onset hypertension...
  15. ncbi request reprint Epidemiology of metabolic syndrome in Asia
    Wen Harn Pan
    Institute of Biomedical Sciences, Academia Sinica, 128 Sec 2, Academia Rd, Nankang, Taipei 11529, Taiwan
    Asia Pac J Clin Nutr 17:37-42. 2008
    ..Macronutrient composition and the quality of the diet are associated with the risk of metabolic syndrome. More research is needed to relate diet and metabolic syndrome in Asians...
  16. ncbi request reprint Undiagnosed diabetes mellitus in Taiwanese subjects with impaired fasting glycemia: impact of female sex, central obesity, and short stature
    W H Pan
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, ROC
    Chin J Physiol 44:44-51. 2001
    ..To study the extent and determinants of undiagnosed diabetes mellitus (DM) in Taiwanese subjects with impaired fasting glycemia (IFG) defined by the newly proposed WHO criteria...
  17. ncbi request reprint Prevalence, awareness, treatment and control of hypertension in Taiwan: results of Nutrition and Health Survey in Taiwan (NAHSIT) 1993-1996
    W H Pan
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    J Hum Hypertens 15:793-8. 2001
    ..People in metropolitan areas had the highest rates of awareness, treatment, control, and compliance to medication...
  18. ncbi request reprint Prevalence and awareness of diabetes and mean fasting glucose by age, sex, and region: results from the Nutrition and Health Survey in Taiwan, 1993-1996
    W H Pan
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, ROC
    Diabet Med 20:182-5. 2003
    ..The objective of this study was to evaluate the prevalence and awareness of diabetes mellitus (DM) in Taiwan...
  19. doi request reprint Obesity pandemic, correlated factors and guidelines to define, screen and manage obesity in Taiwan
    W H Pan
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Obes Rev 9:22-31. 2008
    ..More research is needed to find effective determinants and public health measures for obesity, and concerted efforts are required to combat this rising health problem...
  20. ncbi request reprint Lipoprotein lipase gene is linked and associated with hypertension in Taiwan young-onset hypertension genetic study
    Pei Chen
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    J Biomed Sci 12:651-8. 2005
    ..02). We conclude that LPL variants may play a causal role in the development of hypertension in Taiwan Han Chinese. The moderate association with SNP haplotype suggests that other regulatory LPL variant may exist...
  21. ncbi request reprint Association of B vitamins status and homocysteine levels in elderly Taiwanese
    Kuan Ju Chen
    Institute of Microbiology and Biochemistry, National Taiwan University, Taipei, Taiwan
    Asia Pac J Clin Nutr 14:250-5. 2005
    ....
  22. ncbi request reprint Obesity in the elderly and its relationship with cardiovascular risk factors in Taiwan
    Kuo Chin Huang
    Department of Family Medicine, National Taiwan University Hospital, N141, Institute of Biomedical Sciences, Academia Sinica, 128 Academy Road, Section 2, Taipei, 11529 Taiwan
    Obes Res 13:170-8. 2005
    ..In this study, we examined the prevalence of obesity and relationship between various anthropometric indices (AI) and cardiovascular disease (CVD) risk factors in the elderly...
  23. pmc Fine-mapping angiotensin-converting enzyme gene: separate QTLs identified for hypertension and for ACE activity
    Chia Min Chung
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    PLoS ONE 8:e56119. 2013
    ..These two major QTLs of ACE activity and the moderate effect variant upstream of ACE promoter for young-onset hypertension were replicated by another independent association study with 842 subjects...
  24. ncbi request reprint A comparison of major histocompatibility complex SNPs in Han Chinese residing in Taiwan and Caucasians
    Hsin Chou Yang
    Academia Sinica, Institute of Biomedical Sciences, 128 Academia Road, Section 2 Nankang, Taipei 115, Taiwan, ROC
    J Biomed Sci 13:489-98. 2006
    ..These results are useful for understanding our genetic background and designing future disease gene mapping studies...
  25. ncbi request reprint Trends in nutrient and dietary intake among adults and the elderly: from NAHSIT 1993-1996 to 2005-2008
    Shin Jiuan Wu
    Division of Preventive Medicine and Health Services Research, Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan, ROC
    Asia Pac J Clin Nutr 20:251-65. 2011
    ....
  26. pmc Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes in Han Chinese with a genome-wide gene-based association study
    Hsin Chou Yang
    Institute of Statistical Science, Academia Sinica, Taipei, Taiwan
    PLoS ONE 7:e32907. 2012
    ..Identification of these genes enriches the collection of hypertension susceptibility genes, thereby shedding light on the etiology of hypertension in Han Chinese populations...
  27. pmc A genome-wide association study reveals a quantitative trait locus of adiponectin on CDH13 that predicts cardiometabolic outcomes
    Chia Min Chung
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Diabetes 60:2417-23. 2011
    ..Therefore, we aimed not only to identify genetic variants modulating plasma adiponectin levels but also to investigate whether these variants are associated with adiponectin-related metabolic traits and cardiovascular diseases...
  28. ncbi request reprint Genome-wide scan for quantitative ACE activity in Taiwan young-onset hypertension study
    Ruey Yun Wang
    Graduate Institute of Life Science, National Defense Medical Center, Taipei, Taiwan, ROC
    Hum Hered 65:85-90. 2008
    ..The purpose of this study was to map quantitative trait loci (QTL) for serum ACE activity, a heritable endophenotype of cardiovascular diseases (estimated heritability = 0.58)...
  29. pmc Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan
    Hsin Chou Yang
    Institute of Statistical Science, Academia Sinica, Taipei, Taiwan
    PLoS ONE 4:e5459. 2009
    ..IMPG1 encodes interphotoreceptor matrix proteoglycan 1 which has cation binding capacity. The genes are novel hypertension targets identified in this first genome-wide hypertension association study of the Han Chinese population...
  30. doi request reprint Genetic variation in C-reactive protein in ethnic Chinese population in Taiwan
    Chin Chou Huang
    Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan
    Eur J Clin Invest 43:449-56. 2013
    ..This study aimed to assess the potential genetic determinants for serum hs-CRP levels in a cohort with well-controlled nondiabetic hypertension...
  31. ncbi request reprint Association between dietary folate-rich food intake and folate status of elderly Taiwanese
    Kuan Ju Chen
    Institute of Microbiology and Biochemistry, National Taiwan University, Taipei, Taiwan
    Asia Pac J Clin Nutr 14:244-9. 2005
    ..A lower intake of fruit appeared to be responsible for the higher prevalence of marginal folate deficiency among females over the age of 80 years...
  32. ncbi request reprint Nutrition and Health Survey of Taiwan Elementary School Children 2001-2002: research design, methods and scope
    Su Hao Tu
    Center for Survey Research, Research Center for Humanities and Social Sciences, Academia Sinica, Nankang, Taipei, Taiwan, ROC
    Asia Pac J Clin Nutr 16:507-17. 2007
    ..The results of this survey will increase our understanding on the nutrition and health status of schoolchildren and can be used to shape public health policy in Taiwan...
  33. ncbi request reprint Trends in hyperuricemia and gout prevalence: Nutrition and Health Survey in Taiwan from 1993-1996 to 2005-2008
    Shao Yuan Chuang
    Institute of Biomedical Science, Academia Sinica, 128 Sec 2, Academia Rd, Nankang, Taipei 115 Taiwan, ROC
    Asia Pac J Clin Nutr 20:301-8. 2011
    ..Changes in dietary patterns may in part explain the decrease in uric acid levels between the two national surveys...
  34. ncbi request reprint Trends in folate status in the Taiwanese population aged 19 years and older from the Nutrition and Health Survey in Taiwan 1993-1996 to 2005-2008
    Kuan Ju Chen
    Department of Hospitality Management, Chung Hwa University of Medical Technology, no 89, Wen Hwa 1st ST, Jen Te Hsiang, Tainan 717, Taiwan, ROC
    Asia Pac J Clin Nutr 20:275-82. 2011
    ..This study suggests that folate status in Taiwan has not improved during the past fifteen years, and has worsened in the young population...
  35. ncbi request reprint Dietary supplements usage among elderly Taiwanese during 2005-2008
    Shih Ying Chen
    Department of Applied Life Science and Health, Chia Nan University of Pharmacy and Science, 60 Erh Jen Road, Section 1, 71710, Jen Te, Tainan, Taiwan, ROC
    Asia Pac J Clin Nutr 20:327-36. 2011
    ..Note that mean intakes of vitamins A, C, E, B-1, B-2, B-6, B-12, biotin, niacin, and pantothenic acid from supplements over-exceeded DRIs in Taiwan...
  36. ncbi request reprint Clinical characteristics of young-onset hypertension-implications for different genders
    Jaw Wen Chen
    Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Cardiovascular Research Center, 201 Shih Pai Road, Section 2, Taipei 11217, Taiwan, ROC
    Int J Cardiol 96:65-71. 2004
    ..Hypertension may develop early, before the age of 40 years, in both genders, so-called young-onset hypertension. The clinical characteristics of young-onset hypertension have not been well defined...
  37. ncbi request reprint Plasma retinol and a-tocopherol status of the Taiwanese elderly population
    Wei yi Cheng
    Institute of Microbiology and Biochemistry, National Taiwan University, Taipei, Taiwan
    Asia Pac J Clin Nutr 14:256-62. 2005
    ..In conclusion, the plasma vitamin A and vitamin E status in the Taiwanese elderly are comparable to those reported for adults of developed Western societies...
  38. ncbi request reprint High prevalence of hyperuricemia in elderly Taiwanese
    Meei Shyuan Lee
    School of Public Health, National Defense Medical Center, and Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Asia Pac J Clin Nutr 14:285-92. 2005
    ..Gene-environmental interaction may play a key role since great geographical variation exists within various Han Chinese groups in Taiwan and between Han Chinese and Taiwanese indigenes...
  39. ncbi request reprint Vitamin E status and its dietary determinants in Taiwanese--results of the Nutrition and Health Survey in Taiwan 1993-1996
    Mei Jyh Kang
    N141 Institute of Biomedical Sciences, Academia Sinica, 128 Academy Rd Sec 2, Taipei, 11529, Taiwan
    Eur J Nutr 43:86-92. 2004
    ..A large proportion of Taiwanese are considered to have inadequate vitamin E intake according to Taiwanese RDA...
  40. ncbi request reprint Influence of metabolic syndrome and general obesity on the risk of ischemic stroke
    Hsin Jen Chen
    Institute of Biomedical Sciences, Academia Sinica, Taiwan
    Stroke 37:1060-4. 2006
    ..In addition, because abdominal obesity is the measure of obesity used in the guideline to define MS, we also investigated whether general obesity (GOB) should be considered in the definition of MS...
  41. ncbi request reprint Dietary nutrient intake and major food sources: the Nutrition and Health Survey of Taiwan Elementary School Children 2001-2002
    Shin Jiuan Wu
    Department of Food and Nutrition, Chung Hwa University of Medical Technology, Tainan, Taiwan, ROC
    Asia Pac J Clin Nutr 16:518-33. 2007
    ....
  42. ncbi request reprint Design and sample characteristics of the 2005-2008 Nutrition and Health Survey in Taiwan
    Su Hao Tu
    Research Center for Humanities and Social Sciences, Academia Sinica, 128 Sec 2 Nankang, Taipei, 11529, Taiwan
    Asia Pac J Clin Nutr 20:225-37. 2011
    ..The results of this survey will be of benefit to researchers, policy makers and the public to understand and improve the nutrition and health status of pre-school children and adults in Taiwan...
  43. ncbi request reprint Risk of asthma associated with energy-dense but nutrient-poor dietary pattern in Taiwanese children
    Shu Chen Lee
    Departmen tof Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei, Taiwan, ROC
    Asia Pac J Clin Nutr 21:73-81. 2012
    ..82 [1.07-3.11] for Q4/Q1; p-for-trend=0.049). Our results suggest that a diet with a high intake of fat and simple sugars and low intake of fruit, vegetables and rice is associated with an increased risk of asthma in Taiwanese children...
  44. doi request reprint Co-occurrence of anemia, marginal vitamin B6, and folate status and depressive symptoms in older adults
    Wen Harn Pan
    Nutrition Medicine Research Program, Division of Preventive Medicine and Health Services Research, Institute of Population Health Sciences, National Health Research Institutes, Maoli County 35053, Taiwan
    J Geriatr Psychiatry Neurol 25:170-8. 2012
    ..Examining status of these nutrients is worthy of consideration for older adults with depressed symptoms...
  45. doi request reprint A two-stage matched case-control study on multiple hypertensive candidate genes in Han Chinese
    Tai Yue Kuo
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Am J Hypertens 25:804-11. 2012
    ..It is a major risk factor leading to stroke, cardiovascular disease, and end-stage renal disease. In each year, more than 13.5 million deaths are due to hypertension-related diseases worldwide...
  46. ncbi request reprint Time trend of obesity, the metabolic syndrome and related dietary pattern in Taiwan: from NAHSIT 1993-1996 to NAHSIT 2005-2008
    Chih Jung Yeh
    Division of Health Sciences Research and Preventive Medicine, Institute of Population Health Sciences, National Health Research Institute, 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan
    Asia Pac J Clin Nutr 20:292-300. 2011
    ..No apparent increase in intake of certain healthy foods including lean meat, milk, dark-green vegetables, and fruit in the last 12 years, challenges future strategies to promote health...
  47. doi request reprint A genome-wide survey of copy number variations in Han Chinese residing in Taiwan
    Chien Hsing Lin
    Institute of Biomedical Sciences, Academia Sinica, 128, Academia Road, Section 2 Nankang, Taipei 115, Taiwan
    Genomics 94:241-6. 2009
    ..The comprehensive knowledge of CNVs in the human genome is very important and useful in further genetic studies...
  48. doi request reprint Is ischemic stroke risk related to folate status or other nutrients correlated with folate intake?
    Lu Chen Weng
    Institute of Biomedical Sciences, Academia Sinica, National Taiwan University, Taipei, Taiwan
    Stroke 39:3152-8. 2008
    ..However, it is uncertain whether folate is causally associated with risk of ischemic stroke (IS). We aimed to examine the association between IS incidence and folate intake, biochemical folate status, and folate associated nutrients...
  49. doi request reprint Analysis of family- and population-based samples using multiple linkage disequilibrium mapping
    Yen Feng Chiu
    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Taiwan, ROC
    Ann Hum Genet 77:251-67. 2013
    ..The computing program for analysis using the separate and hybrid data sets is freely available on the author's website...
  50. ncbi request reprint Validation of a simplified food frequency questionnaire as used in the Nutrition and Health Survey in Taiwan (NAHSIT) for the elderly
    Yi Chen Huang
    School of Public Health, National Defense Medical Center, 161 Minchuan East Road, Sec 6, Taipei, Taiwan 114, ROC
    Asia Pac J Clin Nutr 20:134-40. 2011
    ..205 for men; 0.494, 0.475 and -0.174 for women; fish and fruit followed in overall validity. The SFFQ measured the food patterns of elderly NAHSIT elders with validity high for dairy and good for fish, and fruit intakes in both genders...
  51. pmc Adiponectin gene polymorphism is selectively associated with the concomitant presence of metabolic syndrome and essential hypertension
    Hsin Bang Leu
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan, ROC
    PLoS ONE 6:e19999. 2011
    ..Although the adiponectin (ADIPOQ) gene has been reported to be involved in MetS, its association with HTN remained undetermined. This study aimed to investigate the association of ADIPOQ gene with the phenotypes of HTN and MetS...
  52. ncbi request reprint Association between unhealthful eating patterns and unfavorable overall school performance in children
    Ming Ling Fu
    Department of Food Nutrition, Chung Hwa University of Medical Technology, Tainan, Taiwan, ROC
    J Am Diet Assoc 107:1935-43. 2007
    ..A potential relationship between eating patterns and unfavorable overall school performance is supported by a positive relationship between frequency of food intake and food preferences in our study...
  53. ncbi request reprint Evaluation of folate status by serum and erythrocyte folate levels and dietary folate intake in Taiwanese schoolchildren
    Kuan Ju Chen
    Department of Hospitality Management, Chung Hwa University of Medical Technology, Jen Te Hsiang, Tainan, Taiwan, ROC
    Asia Pac J Clin Nutr 16:572-8. 2007
    ..This study shows that the folate status of Taiwanese schoolchildren is currently inadequate and strategies are needed for improvement...
  54. ncbi request reprint Nutrition knowledge, attitude, and behavior of Taiwanese elementary school children
    Wei Lin
    Department of Food, Health and Nutrition Science, Chinese Culture University, Yang Ming Shan, Taipei, Taiwan, ROC
    Asia Pac J Clin Nutr 16:534-46. 2007
    ..Future nutrition education for school children should not only include food serving requirements of food groups, but also apply appropriate theories to improve the motivation for healthy eating...
  55. ncbi request reprint Prevalence of dyslipidemia and mean blood lipid values in Taiwan: results from the Nutrition and Health Survey in Taiwan (NAHSIT, 1993-1996)
    Hsing Yi Chang
    Institute of Biomedical Sciences, Academia Sinica Nan Kong, Taipei, Taiwan, Republic of China
    Chin J Physiol 45:187-97. 2002
    ..Average alcohol intakes per day were related to HDL-C positively, but LDL-C negatively in men and women. The regional differences in blood lipid profiles in Taiwan are consistent with the dietary and life-style variations island-wide...
  56. ncbi request reprint The relationship between snack intake and its availability of 4th-6th graders in Taiwan
    Chi Ming Hang
    Program of Nutritional Science and Education, Department of Human Development and Family Studies, National Taiwan Normal University, Taipei, Taiwan, ROC
    Asia Pac J Clin Nutr 16:547-53. 2007
    ..In addition to that, the role modeling of parents as eating healthy snacks instead of unhealthy snacks themselves may help children to develop similar behaviors...
  57. doi request reprint Reduced medication use and improved pulmonary function with supplements containing vegetable and fruit concentrate, fish oil and probiotics in asthmatic school children: a randomised controlled trial
    Shu Chen Lee
    Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei, Taiwan, ROC
    Br J Nutr 110:145-55. 2013
    ..FVFP supplements reduced medication use and improved pulmonary function in asthmatic children. The present study supports an adjuvant intervention with a combination of fruit, vegetable, fish and probiotic foods...
  58. doi request reprint Common carotid end-diastolic velocity and intima-media thickness jointly predict ischemic stroke in Taiwan
    Shao Yuan Chuang
    Institute of Biomedical Sciences, Academica Sinica, Taipei 11529, Taiwan
    Stroke 42:1338-44. 2011
    ..Therefore, we investigated the relationship between both EDV and IMT and incident ischemic stroke in an Asian population...
  59. ncbi request reprint Use of supplements by Taiwanese adults aged 19-44 during 2005-2008
    Jia Rong Lin
    Department of Early Childhood Education and Nursery, Chia Nan University of Pharmacy and Science, 60 Erh Jen Road, Sec I, Jen Te, 71710, Tainan, Taiwan, ROC
    Asia Pac J Clin Nutr 20:319-26. 2011
    ..Men were more likely than women to take excess iron. Women were more likely than men to take excess vitamin C and niacin. Our study results may be used by government agencies to develop policies regarding supplement use in Taiwan...
  60. doi request reprint Association of circadian genes with diurnal blood pressure changes and non-dipper essential hypertension: a genetic association with young-onset hypertension
    Hsin Bang Leu
    1 Institute of Clinical Medicine and Cardiovascular Research Center, National Yang Ming University, Taipei, Taiwan 2 Heath Care and Management Center, Taipei Veterans General Hospital, Taipei, Taiwan 3 Divison of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Hypertens Res 38:155-62. 2015
    ..Genetic variants in circadian genes were associated with the diurnal phenotype of hypertension, suggesting a genetic association with diurnal BP changes in essential hypertension...
  61. ncbi request reprint Predictability and implications of anthropometric indices for metabolic abnormalities in children: nutrition and health survey in Taiwan elementary children, 2001-2002
    Shao Yuan Chuang
    Institute of Biomedical Sciences, Academica Sinica, Taipei 11529, Taiwan
    Asia Pac J Clin Nutr 18:272-9. 2009
    ....
  62. doi request reprint Lipoprotein lipase variants associated with an endophenotype of hypertension: hypertension combined with elevated triglycerides
    Pei Chen
    Institute of Biomedical Sciences, Academia Sinica, Nankang, Taipei, Taiwan, R O C
    Hum Mutat 30:49-55. 2009
    ..In conclusion, this study strongly suggests that two LPL intronic variants may be associated with development of the hypertension endophenotype with elevated TG...
  63. doi request reprint The effects of physical activity, body mass index (BMI) and waist circumference (WC) on glucose intolerance in older people: a nationwide study from Taiwan
    Chia Lin Li
    Department of Health Care Management, Chang Gung University, 259 Wen Hwa First Road, Kwei Shan, Tao Yuan 333, Taiwan, ROC
    Arch Gerontol Geriatr 52:54-9. 2011
    ..Our findings highlight that older women with low physical activity or high WC, and older men with high BMI or WC are important target populations for interventions to prevent glucose intolerance...
  64. ncbi request reprint Prevalence of overweight and obesity and its associated factors: findings from National Nutrition and Health Survey in Taiwan, 1993-1996
    Yi Chin Lin
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Prev Med 37:233-41. 2003
    ..To report the overall and regional prevalence of obesity/overweight in Taiwan and to study its associated risk factors...
  65. ncbi request reprint Prevalence of functional gastrointestinal disorders in Taiwan: questionnaire-based survey for adults based on the Rome III criteria
    Fang Yuan Chang
    Children s Medical Center, Taipei Veterans General Hospital, Taipei, 11217 Taiwan, ROC
    Asia Pac J Clin Nutr 21:594-600. 2012
    ..Subjects who met the Rome III criteria for FGID in Taiwan were younger, had less vegetables and fruits intake, higher BSRS scores and were of greater female predominance...
  66. ncbi request reprint Dietary supplement usage among elementary school children in Taiwan: their school performance and emotional status
    Shih Ying Chen
    Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Jen Te Hsiang, Tainan Hsien, Taiwan, ROC
    Asia Pac J Clin Nutr 16:554-63. 2007
    ..Higher parental education level and household monthly income were associated with higher intakes. Supplement users were more competent at school; however, the frequency and number of supplement types were not related to competence...
  67. ncbi request reprint The U-shaped relationship between BMI and all-cause mortality contrasts with a progressive increase in medical expenditure: a prospective cohort study
    Wen Harn Pan
    Division of Preventive Medicine and Health Services Research, Institute of Population Health Sciences, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan
    Asia Pac J Clin Nutr 21:577-87. 2012
    ..Our findings suggest that current recommendations to maintain BMI at the lower end of the desirable range remain tenable for the apparently healthy general public...
  68. doi request reprint Gender differences in trends in diabetes prevalence from 1993 to 2008 in Taiwan
    Hsing Yi Chang
    Center for Health Policy Research and Development, Institute of Population Health, National Health Research Institutes, Zhunan Town, Maoli County, Taiwan
    Diabetes Res Clin Pract 90:358-64. 2010
    ..52, and 1.93 (all with p < 0.05). We recommend the development of innovative health promotion programs targeting not only the general population, but also high risk groups such as men, to further reduce diabetes...
  69. pmc SAQC: SNP array quality control
    Hsin Chou Yang
    Institute of Statistical Science, Academia Sinica, Taipei, Taiwan
    BMC Bioinformatics 12:100. 2011
    ..Data quality of SNP arrays plays a key role in the accuracy and precision of downstream data analyses. However, good indices for assessing data quality of SNP arrays have not yet been developed...
  70. ncbi request reprint Comparison of electrocardiographic findings and associated risk factors between Taiwan Chinese and US White adults
    Chih Cheng Wu
    Department of Medicine, Hsinchu General Hospital and School of Medicine, Yang Ming University, Taipei, Taiwan
    Int J Cardiol 128:224-31. 2008
    ..Electrocardiographic (ECG) findings are known to differ by race, however, systematic comparisons of findings between eastern and western countries are rare...
  71. ncbi request reprint Thiamin and riboflavin status of Taiwanese elementary schoolchildren
    Ning Sing Shaw
    Department of Biochemical Science and Technology, Institute of Microbiology and Biochemistry, National Taiwan University, Taipei, Taiwan, ROC
    Asia Pac J Clin Nutr 16:564-71. 2007
    ..5% and 3.5% for boys and 35.9% and 4.5% for girls. The marginal and deficient riboflavin statuses of Taiwanese schoolchildren were associated with a low frequency of dairy food consumption and an elevated risk of anemia...
  72. ncbi request reprint Reproducibility and validity of a Chinese food frequency questionnaire used in Taiwan
    Meei Shyuan Lee
    School of Public Health, National Defense Medical Center, 161 Sec 6, MinChuan East Road, Taipei 114, Taiwan, ROC
    Asia Pac J Clin Nutr 15:161-9. 2006
    ..These data indicate that this FFQ for Chinese-speaking people in Taiwan is reproducible and provides a useful measure of intake for many nutrients over a six-month period...
  73. ncbi request reprint A Food in Health Security (FIHS) platform in the Asia-Pacific Region: the way forward
    Mark L Wahlqvist
    Division of Health Policy Research and Development, Institute of Population Health Sciences, National Health Research Institutes, No 35, Keyan Road, Zhunan, Taiwan
    Asia Pac J Clin Nutr 18:688-702. 2009
    ....
  74. pmc Shorter GT repeat polymorphism in the heme oxygenase-1 gene promoter has protective effect on ischemic stroke in dyslipidemia patients
    Chyi Huey Bai
    Institutes of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    J Biomed Sci 17:12. 2010
    ..We aimed to examine whether the length of (GT)(n) repeats in HO-1 gene promoter is associated with ischemic stroke in people with CAD risk factors, especially low level of HDL...
  75. doi request reprint Prediction equations and point system derived from large-scale health check-up data for estimating diabetic risk in the Chinese population of Taiwan
    Shao Yuan Chuang
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Diabetes Res Clin Pract 92:128-36. 2011
    ..To develop tools for predicting diabetes development in middle-aged Chinese adults living in Taiwan...
  76. ncbi request reprint The opportunities and challenges of evidence-based nutrition (EBN) in the Asia Pacific region: clinical practice and policy-setting
    Mark L Wahlqvist
    Nutrition Consortium, Center for Health Policy Research Development, National Health Research Institutes, No 35, Keyan Road, Zhunan, Taiwan
    Asia Pac J Clin Nutr 17:2-7. 2008
    ..They found that clinical practice guidelines and proposals for health and nutrition policies required greater emphasis and expertise in EBN...
  77. ncbi request reprint Probable blind spot in the International Diabetes Federation definition of metabolic syndrome
    Hsin Jen Chen
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Obesity (Silver Spring) 15:1096-100. 2007
    ..We set out to compare the cardiovascular profiles of patients cross-defined by these two definitions to shed light on the differential meanings of the two...
  78. ncbi request reprint Practice to introduce complementary foods to infants in Taiwan--changes from 1997 to 2008
    Jia Rong Lin
    Department of Nutritional Science, Fu Jen Catholic University, No 510, ZhongZheng Rd, Xinzhuang District, New Taipei City 24205, Taiwan, ROC
    Asia Pac J Clin Nutr 20:337-45. 2011
    ..The government should not only promote breastfeeding, but also reevaluate current evidence-based recommendation on complementary food introduction time...
  79. doi request reprint Hyperuricemia and increased risk of ischemic heart disease in a large Chinese cohort
    Shao Yuan Chuang
    Institute of Population Health Sciences, National Health Research Institutes, Miaoli Country, Taiwan
    Int J Cardiol 154:316-21. 2012
    ..We investigated whether such a relation exists for ethnic Chinese with low CVD risk...
  80. doi request reprint Genetic variation in renin predicts the effects of thiazide diuretics
    Chin Chou Huang
    Department of Medical Research and Education Division of Cardiology, Department of Medicine, Taipei, Taiwan
    Eur J Clin Invest 41:828-35. 2011
    ..This study aimed to address the potential effects of genetic variations of RAAS on the response to initial treatment of hydrochlorothiazide (HCTZ)...
  81. doi request reprint Genetic variants of connexin37 are associated with carotid intima-medial thickness and future onset of ischemic stroke
    Hsin Bang Leu
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan, Republic of China
    Atherosclerosis 214:101-6. 2011
    ..This study aimed to investigate the impacts of genetic variants on IMT and future development of ischemic stroke in a cohort, followed by an independent replication study...
  82. doi request reprint Fibrinogen independently predicts the development of ischemic stroke in a Taiwanese population: CVDFACTS study
    Shao Yuan Chuang
    Institute of Biomedical Sciences, Academica Sinica, Taipei, Taiwan
    Stroke 40:1578-84. 2009
    ..Therefore, we aimed to investigate the temporal relationship between fibrinogen levels (plus several related parameters) and IS in a community-based study in Taiwan...
  83. ncbi request reprint Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients
    Ying Hwa Chen
    Institute of Clinical Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan, Republic of China
    Hum Genet 111:1-8. 2002
    ..Type 2 diabetics carrying longer (GT) (n) repeats might have higher oxidative stress and increased susceptibility to the development of CAD...
  84. pmc Incorporating covariates into multipoint association mapping in the case-parent design
    Yen Feng Chiu
    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan, ROC
    Hum Hered 69:229-41. 2010
    ..To improve the efficiency of disease locus localization in association mapping using case-parent designs and to assess or account for the main covariate effects and gene-covariate interaction effects, while localizing the disease locus...
  85. pmc A new analysis tool for individual-level allele frequency for genomic studies
    Hsin Chou Yang
    Institute of Statistical Science, Academia Sinica, Taipei 115, Taiwan
    BMC Genomics 11:415. 2010
    ..Estimation of allele frequency using genotypes is convenient but may lose data information and be sensitive to genotyping errors...
  86. doi request reprint Serum uric acid level as an independent risk factor for all-cause, cardiovascular, and ischemic stroke mortality: a Chinese cohort study
    Jiunn Horng Chen
    China Medical University Hospital, Taichung, and National Taiwan University, Taipei, Taiwan
    Arthritis Rheum 61:225-32. 2009
    ..This study assessed the temporal association between serum uric acid level, hyperuricemia, and cardiovascular mortality...
  87. doi request reprint Applying polynomial standard curve method to correct bias encountered in estimating allele frequencies using DNA pooling strategy
    Hsin Hung Chen
    Institute of Biomedical Sciences, Academia Sinica, Taiwan, ROC
    Genomics 92:429-35. 2008
    ..We demonstrated that applying PSCM in the SNaPshottrade mark platform is suitable for multiple-SNP association study using pooling strategy, due to its cost effectiveness and estimation accuracy...
  88. ncbi request reprint Quantitative vibration perception thresholds in normal and diabetic chinese: influence of age, height and body mass index
    Chii Min Hwu
    Section of General Medicine, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Neuroepidemiology 21:271-8. 2002
    ..Age significantly contributed to the variance of VPT in both DM and non-DM subjects. Height was positively associated with VPT in men, so was BMI in non-DM subjects with much smaller magnitudes of effect than for age...
  89. ncbi request reprint A modified locally weighted method for developing reference standards for height, weight, and body mass index of boys and girls aged 4 to 18 in Taiwan
    Jim Yih Chen
    Institute of Biomedical Science, Academia Sinica, Nan Kang, Taipei, Taiwan
    Hum Biol 75:749-70. 2003
    ..Genetic makeup and dietary patterns may contribute to these phenomena...
  90. ncbi request reprint Effect of potassium-enriched salt on cardiovascular mortality and medical expenses of elderly men
    Hsing Yi Chang
    Institute of Biomedical Sciences, Academia Sinica, Nan Kang, Taipei, Taiwan, ROC
    Am J Clin Nutr 83:1289-96. 2006
    ..The beneficial effects of potassium-enriched salt on blood pressure have been reported in a few short-term trials. The long-term effects of potassium-enriched salt on cardiovascular mortality have not been carefully studied...
  91. ncbi request reprint High titer of anticardiolipin antibody is associated with first-ever ischemic stroke in Taiwan
    Li Ming Lien
    Department of Neurology, Shin Kong WHS Memorial Hospital, Taipei, Taiwan
    Cerebrovasc Dis 22:225-30. 2006
    ..The aim of this study, therefore, was to determine whether aCL is an independent risk factor for ischemic stroke in Taiwanese patients over the age of 40 years...
  92. doi request reprint Evidence for improved control of hypertension in Taiwan: 1993-2002
    Ta Chen Su
    Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taiwan
    J Hypertens 26:600-6. 2008
    ....
  93. pmc Outbreak of beriberi among illegal mainland Chinese immigrants at a detention center in Taiwan
    Kow Tong Chen
    Field Epidemiology Training Program, Center for Disease Control, Department of Health, Taiwan, Republic of China
    Public Health Rep 118:59-64. 2003
    ..The authors describe an outbreak of beriberi in a detention center in Taiwan and examine risk factors for illness...
  94. ncbi request reprint Bone health status of the elderly in Taiwan by quantitative ultrasound
    Yi Chin Lin
    Institute of Nutritional Science, Chung Shan Medical University, Taichung, Taiwan
    Asia Pac J Clin Nutr 14:270-7. 2005
    ..The effects of dietary calcium intake may be influenced by the intake of other nutrients such as sodium and protein...
  95. pmc TPMD: a database and resources of microsatellite marker genotyped in Taiwanese populations
    Ya Hui Chang
    Division of Molecular and Genomic Medicine, National Health Research Institutes, Taipei 115, Taiwan
    Nucleic Acids Res 33:D174-7. 2005
    ....
  96. ncbi request reprint Intake levels and major food sources of energy and nutrients in the Taiwanese elderly
    Shin Jiuan Wu
    Department of Food and Nutrition, Chung Hwa College of Medical Technology, Tainan, Taiwan
    Asia Pac J Clin Nutr 14:211-20. 2005
    ..Suitable strategies are also needed to improve the calcium status of Taiwanese elderly, particularly as a high proportion of them are either lactose intolerant or dislike dairy products...
  97. ncbi request reprint Prevalence of diabetes mellitus and population attributable fractions for coronary heart disease and stroke mortality in the WHO South-East Asia and Western Pacific regions
    Crystal Man Ying Lee
    The George Institute for International Health, PO Box M 201, Missenden Road, Sydney, NSW 2050, Australia
    Asia Pac J Clin Nutr 16:187-92. 2007
    ..Accurate estimates of the prevalence of diabetes are of great importance and standard methods are needed for periodic surveillance across the Asia-Pacific region and elsewhere...
  98. ncbi request reprint Han Chinese cell and genome bank in Taiwan: purpose, design and ethical considerations
    Wen Harn Pan
    Hum Hered 61:27-30. 2006
  99. ncbi request reprint Ala55Val polymorphism on UCP2 gene predicts greater weight loss in morbidly obese patients undergoing gastric banding
    Hsin Hung Chen
    Institute of Microbiology and Biochemistry, College of Life Science, National Taiwan University, ROC
    Obes Surg 17:926-33. 2007
    ..Variability in weight loss has been observed from morbidly obese patients receiving bariatric operations. Genetic effects may play a crucial role in this variability...