Bernard L Nahlen

Summary

Affiliation: World Health Organization
Country: Switzerland

Publications

  1. ncbi Insecticide-treated bed nets
    Bernard L Nahlen
    Roll Back Malaria, World Health Organization, Geneva, Switzerland
    Am J Trop Med Hyg 68:1-2. 2003
  2. pmc Lives saved by Global Fund-supported HIV/AIDS, tuberculosis and malaria programs: estimation approach and results between 2003 and end-2007
    Ryuichi Komatsu
    The Global Fund to Fight AIDS, Tuberculosis and Malaria, Chemin Blandonnet 8, 1214 Vernier, Geneva, Switzerland
    BMC Infect Dis 10:109. 2010
  3. pmc Malaria attributable to the HIV-1 epidemic, sub-Saharan Africa
    Eline L Korenromp
    World Health Organization, Geneva, Switzerland
    Emerg Infect Dis 11:1410-9. 2005
  4. ncbi Building to collective impact: the Global Fund support for measuring reduction in the burden of malaria
    Bernard L Nahlen
    Global Fund to Fight AIDS, Tuberculosis and Malaria, Chemin de Blandonnet, 1214 Vernier, Geneva, Switzerland
    Am J Trop Med Hyg 77:321-7. 2007
  5. ncbi Malaria risk: estimating clinical episodes of malaria
    Bernard L Nahlen
    World Health Organization, Roll Back Malaria Department, 1211 Geneva, Switzerland
    Nature 437:E3; discussion E4-5. 2005
  6. ncbi Effects of permethrin-treated bed nets on immunity to malaria in western Kenya I. Antibody responses in pregnant women and cord blood in an area of intense malaria transmission
    Simon K Kariuki
    Centre for Vector Biology and Control Research, Kenya Medical Research Institute, Kisumu, Kenya
    Am J Trop Med Hyg 68:61-7. 2003
  7. ncbi Reduction of malaria during pregnancy by permethrin-treated bed nets in an area of intense perennial malaria transmission in western Kenya
    Feiko O Ter Kuile
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:50-60. 2003
  8. ncbi Impact of permethrin-treated bed nets on entomologic indices in an area of intense year-round malaria transmission
    John E Gimnig
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:16-22. 2003
  9. ncbi Estimating the number of insecticide-treated nets required by African households to reach continent-wide malaria coverage targets
    John M Miller
    PATH Malaria Control and Evaluation Partnership in Africa MACEPA, National Malaria Control Centre, Lusaka, Zambia
    JAMA 297:2241-50. 2007
  10. pmc The burden of malaria mortality among African children in the year 2000
    Alexander K Rowe
    Malaria Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341 3724, USA
    Int J Epidemiol 35:691-704. 2006

Collaborators

Detail Information

Publications44

  1. ncbi Insecticide-treated bed nets
    Bernard L Nahlen
    Roll Back Malaria, World Health Organization, Geneva, Switzerland
    Am J Trop Med Hyg 68:1-2. 2003
  2. pmc Lives saved by Global Fund-supported HIV/AIDS, tuberculosis and malaria programs: estimation approach and results between 2003 and end-2007
    Ryuichi Komatsu
    The Global Fund to Fight AIDS, Tuberculosis and Malaria, Chemin Blandonnet 8, 1214 Vernier, Geneva, Switzerland
    BMC Infect Dis 10:109. 2010
    ..This paper presents and discusses a methodology for estimating the lives saved through selected service deliveries reported to the Global Fund...
  3. pmc Malaria attributable to the HIV-1 epidemic, sub-Saharan Africa
    Eline L Korenromp
    World Health Organization, Geneva, Switzerland
    Emerg Infect Dis 11:1410-9. 2005
    ..These effects were due to high HIV-1 prevalence in rural areas and the locally unstable nature of malaria transmission that results in a high proportion of adult cases...
  4. ncbi Building to collective impact: the Global Fund support for measuring reduction in the burden of malaria
    Bernard L Nahlen
    Global Fund to Fight AIDS, Tuberculosis and Malaria, Chemin de Blandonnet, 1214 Vernier, Geneva, Switzerland
    Am J Trop Med Hyg 77:321-7. 2007
    ..To sustain the scale-up in funding to support malaria interventions, countries must ensure that resources are used now to show robust, systematic, and regular measurement of impact on the burden of malaria...
  5. ncbi Malaria risk: estimating clinical episodes of malaria
    Bernard L Nahlen
    World Health Organization, Roll Back Malaria Department, 1211 Geneva, Switzerland
    Nature 437:E3; discussion E4-5. 2005
    ..2). Both groups agree that the burden of malaria disease outside Africa, especially in South Asia, is greater than was estimated in the 1990s...
  6. ncbi Effects of permethrin-treated bed nets on immunity to malaria in western Kenya I. Antibody responses in pregnant women and cord blood in an area of intense malaria transmission
    Simon K Kariuki
    Centre for Vector Biology and Control Research, Kenya Medical Research Institute, Kisumu, Kenya
    Am J Trop Med Hyg 68:61-7. 2003
    ..In contrast, ITN use was found to be associated with increased antibody responses to CSP in pregnant women, but had no effect on antibody levels to CSP in cord blood...
  7. ncbi Reduction of malaria during pregnancy by permethrin-treated bed nets in an area of intense perennial malaria transmission in western Kenya
    Feiko O Ter Kuile
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:50-60. 2003
    ..No beneficial impact was observed in gravidae five or higher. In areas of intense perennial malaria transmission, permethrin-treated bed nets reduce the adverse effect of malaria during the first four pregnancies...
  8. ncbi Impact of permethrin-treated bed nets on entomologic indices in an area of intense year-round malaria transmission
    John E Gimnig
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:16-22. 2003
    ..These results indicate that ITNs are optimally effective if used every night and if permethrin is reapplied at least biannually...
  9. ncbi Estimating the number of insecticide-treated nets required by African households to reach continent-wide malaria coverage targets
    John M Miller
    PATH Malaria Control and Evaluation Partnership in Africa MACEPA, National Malaria Control Centre, Lusaka, Zambia
    JAMA 297:2241-50. 2007
    ..African countries are scaling up malaria interventions, especially insecticide-treated nets (ITNs), for which ambitious coverage targets have been set...
  10. pmc The burden of malaria mortality among African children in the year 2000
    Alexander K Rowe
    Malaria Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341 3724, USA
    Int J Epidemiol 35:691-704. 2006
    ..Our objective was to estimate the number of deaths directly attributable to malaria among children <5 years old in sub-Saharan Africa for the year 2000...
  11. ncbi The household-level economics of using permethrin-treated bed nets to prevent malaria in children less than five years of age
    Martin I Meltzer
    Office of Surveillance, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 68:149-60. 2003
    ..50 U.S. dollars; P = 0.002), leaving little opportunity for household-level, ITN-induced direct savings. The widespread adoption of the ITNs will therefore probably require a subsidy...
  12. ncbi The cost-effectiveness of permethrin-treated bed nets in an area of intense malaria transmission in western Kenya
    Virginia Wiseman
    Health Economics and Financing Programme and Gates Malaria Partnership, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Trop Med Hyg 68:161-7. 2003
    ..S. dollars and 38 U.S. dollars, respectively. This study provides further evidence that ITNs are a highly cost-effective use of scarce health care resources...
  13. ncbi Implications of the western Kenya permethrin-treated bed net study for policy, program implementation, and future research
    William A Hawley
    Centre for Vector Biology and Control Research, Kenya Medical Research Institute, Kisumu, Kenya
    Am J Trop Med Hyg 68:168-73. 2003
    ..Research should continue to improve the intervention tools (the net, the insecticide, and methods for durable treatment and re-treatment) and their deployment...
  14. ncbi Burden of malaria during pregnancy in areas of stable and unstable transmission in Ethiopia during a nonepidemic year
    Robert D Newman
    Malaria Epidemiology, National Center for Infectious Diseases, and Epidemic Intelligence Service, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Infect Dis 187:1765-72. 2003
    ....
  15. ncbi Association of interferon-gamma responses to pre-erythrocytic stage vaccine candidate antigens of Plasmodium falciparum in young Kenyan children with improved hemoglobin levels: XV. Asembo Bay Cohort Project
    John M O Ong'echa
    Centre for Vector Biology and Control Research, Kenya Medical Research Institute, Kisumu, Kenya
    Am J Trop Med Hyg 68:590-7. 2003
    ..We propose that IFN-gamma production could be used as a potential marker of protective immunity against malaria associated anemia in young children living in malaria holoendemic areas...
  16. ncbi Implementation of intermittent preventive treatment with sulphadoxine-pyrimethamine for control of malaria in pregnancy in Kisumu, western Kenya
    Anna M van Eijk
    Kenya Medical Research Institute, Centre for Vector Biology and Control Research, Kisumu, Kenya
    Trop Med Int Health 9:630-7. 2004
    ..We evaluated the coverage and determinants of receipt of IPT after its introduction in the Provincial Hospital in Kisumu, western Kenya...
  17. ncbi Sustainability of reductions in malaria transmission and infant mortality in western Kenya with use of insecticide-treated bednets: 4 to 6 years of follow-up
    Kim A Lindblade
    Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    JAMA 291:2571-80. 2004
    ..Previous investigators have suggested that bednet use might paradoxically increase mortality in older children through delayed acquisition of immunity to malaria...
  18. pmc Placental malaria diminishes development of antibody responses to Plasmodium falciparum epitopes in infants residing in an area of western Kenya where P. falciparum is endemic
    Phillip Cullison Bonner
    Malaria Branch, Division of Parasitic Diseases, NCID, Centers for Disease Control and Prevention, U S Department of Health and Human Services, Atlanta, GA, USA
    Clin Diagn Lab Immunol 12:375-9. 2005
    ..0035). These findings suggest that PM can negatively influence the development of immune responses to malaria in infants...
  19. pmc Immunohistological characterization of macrophage migration inhibitory factor expression in Plasmodium falciparum-infected placentas
    Sujittra Chaisavaneeyakorn
    Centers for Disease Control and Prevention, 4770 Buford Highway, Mail Stop F 12, Chamblee, GA 30341, USA
    Infect Immun 73:3287-93. 2005
    ..These findings suggest that placental malaria modulates MIF expression in different placental compartments...
  20. ncbi Viewpoint: evaluating the impact of malaria control efforts on mortality in sub-Saharan Africa
    Alexander K Rowe
    Malaria Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention CDC, Atlanta, GA, USA
    Trop Med Int Health 12:1524-39. 2007
    ....
  21. ncbi Effect of sustained insecticide-treated bed net use on all-cause child mortality in an area of intense perennial malaria transmission in western Kenya
    Thomas P Eisele
    Department of International Heath and Development, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana 70112, USA
    Am J Trop Med Hyg 73:149-56. 2005
    ..9%), after controlling for seasonality (AHR = 1.03, P = 0.834). We find no evidence that sustained ITN use increased the risk of mortality in older children in this area of intense perennial malaria transmission...
  22. pmc Subclinical Plasmodium falciparum infection and HIV-1 viral load
    Kimberly C Brouwer
    Emerg Infect Dis 13:351-3. 2007
  23. ncbi Malaria and nutritional status among pre-school children: results from cross-sectional surveys in western Kenya
    Jennifer F Friedman
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 73:698-704. 2005
    ....
  24. ncbi Perceptions of bed nets and malaria prevention before and after a randomized controlled trial of permethrin-treated bed nets in western Kenya
    Jane A Alaii
    Centre for Vector Biology and Control Research, Kenya Medical Research Institute, Kisumu, Kenya
    Am J Trop Med Hyg 68:142-8. 2003
    ..036 (control) for re-treating a bed net. This study suggests that, despite two years of experience of use, bed nets and insecticides would not be purchased as a household priority in this impoverished rural community...
  25. ncbi Factors affecting use of permethrin-treated bed nets during a randomized controlled trial in western Kenya
    Jane A Alaii
    Centre for Vector Biology and Control Research, Kenya Medical Research Institute, Kisumu, Kenya
    Am J Trop Med Hyg 68:137-41. 2003
    ..Challenges faced by health education programs to maximize adherence with ITN use are discussed...
  26. ncbi Polymorphism in the gene encoding the Pfs48/45 antigen of Plasmodium falciparum. XI. Asembo Bay Cohort Project
    Ananias A Escalante
    Instituto Venezolano de Investigaciones Cientificas, Apartado 21827, 1020 A, Caracas, Venezuela
    Mol Biochem Parasitol 119:17-22. 2002
    ..No alleles could be linked to a specific geographic region. The results of this study suggest that this gametocyte antigen, like other asexual blood stage antigens, is under selection pressure...
  27. ncbi The efficacy of permethrin-treated bed nets on child mortality and morbidity in western Kenya II. Study design and methods
    Penelope A Phillips-Howard
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:10-5. 2003
    ..Methodologic difficulties encountered in such large-scale field trials are discussed...
  28. ncbi The efficacy of permethrin-treated bed nets on child mortality and morbidity in western Kenya I. Development of infrastructure and description of study site
    Penelope A Phillips-Howard
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:3-9. 2003
    ..We outline the development of the human and physical infrastructure required to conduct this trial and discuss some of the difficulties encountered and lessons learned in conducting it...
  29. ncbi HIV increases the risk of malaria in women of all gravidities in Kisumu, Kenya
    Anna M van Eijk
    Kenya Medical Research Institute, Center for Vector Biology and Control Research, Kisumu, Kenya
    AIDS 17:595-603. 2003
    ..To study the importance of HIV infection for malaria in pregnancy in Kisumu, Kenya...
  30. ncbi The effect of dual infection with HIV and malaria on pregnancy outcome in western Kenya
    John G Ayisi
    Centre for Vector Biology and Control Research, Kenya Medical Research Institute, Kisumu, Kenya
    AIDS 17:585-94. 2003
    ..To determine the effect of dual infection with HIV and malaria on birth outcomes and maternal anaemia among women delivering at a large public hospital in Kisumu, western Kenya...
  31. ncbi Treatment history and treatment dose are important determinants of sulfadoxine-pyrimethamine efficacy in children with uncomplicated malaria in Western Kenya
    Dianne J Terlouw
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Infect Dis 187:467-76. 2003
    ..Many age-based dose recommendations need urgent revision, because SP is increasingly used as first-line treatment in sub-Saharan Africa...
  32. ncbi Increased efficacy of sulfadoxine-pyrimethamine in the treatment of uncomplicated falciparum malaria among children with sickle cell trait in Western Kenya
    Dianne J Terlouw
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 186:1661-8. 2002
    ..02) or in parasitologic treatment failure on day 7 (RR, 0.51; 95% CI, 0.36-0.71; P<.0001). These results suggest that the HbAS phenotype should be included among factors that determine sulfadoxine-pyrimethamine treatment outcome...
  33. ncbi A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children
    Maurine R Hobbs
    Department of Internal Medicine, University of Utah and VA Medical Centers, Salt Lake City, UT, USA
    Lancet 360:1468-75. 2002
    ..We postulated that NOS2 promoter polymorphisms would affect resistance to severe malaria...
  34. ncbi Efficacy of permethrin-treated bed nets in the prevention of mortality in young children in an area of high perennial malaria transmission in western Kenya
    Penelope A Phillips-Howard
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:23-9. 2003
    ..ITNs prevent approximately one in four infant deaths in areas of intense perennial malaria transmission, but their efficacy is compromised if re-treatment is delayed beyond six months...
  35. ncbi Impact of permethrin-treated bed nets on the incidence of sick child visits to peripheral health facilities
    Penelope A Phillips-Howard
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:38-43. 2003
    ..Routine statistics from these facilities provided useful information on trends in malaria incidence, but underestimated the burden of severe anemia...
  36. ncbi Community reactions to the introduction of permethrin-treated bed nets for malaria control during a randomized controlled trial in western Kenya
    Jane A Alaii
    Center for Vector Biology and Control Research, Kenya Medical Research Institute, Kisumu, Kenya
    Am J Trop Med Hyg 68:128-36. 2003
    ..Attempts were made to allay fears by improved communication on these subjects and modification of the study design...
  37. ncbi Community-wide effects of permethrin-treated bed nets on child mortality and malaria morbidity in western Kenya
    William A Hawley
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:121-7. 2003
    ..The strength of the community effect depended upon the proportion of nearby compounds with treated nets. To maximize their public health impact, high coverage with treated nets is essential...
  38. ncbi Effect of permethrin-treated bed nets on the spatial distribution of malaria vectors in western Kenya
    John E Gimnig
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:115-20. 2003
    ....
  39. ncbi Effects of permethrin-treated bed nets on immunity to malaria in western Kenya II. Antibody responses in young children in an area of intense malaria transmission
    Simon K Kariuki
    Centre for Vector Biology and Control Research, Kenya Medical Research Institute, Kisumu, Kenya
    Am J Trop Med Hyg 68:108-14. 2003
    ....
  40. ncbi Impact of permethrin-treated bed nets on malaria and all-cause morbidity in young children in an area of intense perennial malaria transmission in western Kenya: cross-sectional survey
    Feiko O Ter Kuile
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:100-7. 2003
    ..The ITNs substantially reduced malaria-associated morbidity and improved weight gain in young children in this area of intense perennial malaria transmission...
  41. ncbi Permethrin-treated bed nets in the prevention of malaria and anemia in adolescent schoolgirls in western Kenya
    Tjalling Leenstra
    Department of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Am J Trop Med Hyg 68:86-93. 2003
    ..ITNs approximately halved the prevalence of mild anemia in young, school-attending, non-pregnant, adolescent girls, but had no impact in older girls or on other malaria-associated morbidity or nutritional status...
  42. ncbi Impact of permethrin-treated bed nets on growth, nutritional status, and body composition of primary school children in western Kenya
    Jennifer F Friedman
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:78-85. 2003
    ..2%; P = 0.04). This may be consequent to reduced exposure to malaria with subsequent reduced elaboration of pro-inflammatory cytokines known to promote muscle wasting...
  43. ncbi Impact of permethrin-treated bed nets on malaria, anemia, and growth in infants in an area of intense perennial malaria transmission in western Kenya
    Feiko O Ter Kuile
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:68-77. 2003
    ..Reduced malaria exposure during infancy did not result, with continued ITN use, in increased malaria morbidity in one-year-old children...
  44. ncbi Immunity to placental malaria. III. Impairment of interleukin(IL)-12, not IL-18, and interferon-inducible protein-10 responses in the placental intervillous blood of human immunodeficiency virus/malaria-coinfected women
    Sujittra Chaisavaneeyakorn
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 185:127-31. 2002
    ....