Artur Zimmermann

Summary

Affiliation: University of Bern
Country: Switzerland

Publications

  1. pmc HGF/c-Met related activation of β-catenin in hepatoblastoma
    Rachel Purcell
    Children s Cancer Research Group, University of Otago, Christchurch, Christchurch, New Zealand
    J Exp Clin Cancer Res 30:96. 2011
  2. pmc The diagnostic value of liver biopsy
    C Spycher
    Department of Clinical Pharmacology, University of Berne, Switzerland
    BMC Gastroenterol 1:12. 2001
  3. ncbi request reprint Primary perivascular epithelioid cell tumor of the liver not related to hepatic ligaments: hepatic PEComa as an emerging entity
    A Zimmermann
    Institute of Pathology of the University Berne, Switzerland
    Histol Histopathol 23:1185-93. 2008
  4. ncbi request reprint The emerging family of hepatoblastoma tumours: from ontogenesis to oncogenesis
    Arthur Zimmermann
    SIOPEL Liver Tumour Study Group, Institute of Pathology of the University, Berne, Switzerland
    Eur J Cancer 41:1503-14. 2005
  5. ncbi request reprint Regulation of liver regeneration
    Arthur Zimmermann
    Institute of Pathology of the University, Murtenstrasse 31, CH 3010 Berne, Switzerland
    Nephrol Dial Transplant 19:iv6-10. 2004
  6. ncbi request reprint Myofibroblasts in the cirrhotic rat liver reflect hepatic remodeling and correlate with fibrosis and sinusoidal capillarization
    A Zimmermann
    Department of Pathology, University of Berne, Switzerland
    J Hepatol 30:646-52. 1999
  7. ncbi request reprint Hepatocellular carcinoma with an unusual medullary-like histology and signs of regression ("medullary-like hepatocellular carcinoma")
    A Zimmermann
    Institute of Pathology, University of Berne, Switzerland
    Dig Liver Dis 34:748-53. 2002
  8. ncbi request reprint Pediatric liver tumors and hepatic ontogenesis: common and distinctive pathways
    Arthur Zimmermann
    Institute of Pathology of the University, Berne, Switzerland
    Med Pediatr Oncol 39:492-503. 2002
  9. ncbi request reprint Hepatoblastoma with cholangioblastic features ('cholangioblastic hepatoblastoma') and other liver tumors with bimodal differentiation in young patients
    Arthur Zimmermann
    Institute of Pathology of the University, Berne, Switzerland
    Med Pediatr Oncol 39:487-91. 2002
  10. ncbi request reprint Liver regeneration: the emergence of new pathways
    Artur Zimmermann
    Institute of Pathology of the University, Bern, Switzerland
    Med Sci Monit 8:RA53-63. 2002

Collaborators

  • G Perilongo
  • H Friess
  • Guido Seitz
  • B Gornicka
  • Thomas Giese
  • Klaus Lieb
  • Jean Francois Dufour
  • Andrea De Gottardi
  • Zulal Ulger
  • I Zlobec
  • Haruki Senoo
  • M Korc
  • G P Risbridger
  • Markus W Buchler
  • Jorg Kleeff
  • Eva Karamitopoulou
  • Antony M Wheatley
  • Michael N Tawadrous
  • Shailesh Shrikhande
  • Rachel Purcell
  • Ayako Mabuchi
  • Rudolf Maibach
  • Lukas Krahenbuhl
  • Corinne Lang
  • Maretta De Ioris
  • Thomas Schaffner
  • Thomas Brunner
  • Stefan Wildi
  • Haithem Chtioui
  • Yesim Aydinok
  • Florian Bihl
  • Monika Ledermann
  • Meike Korner
  • Jurg Reichen
  • Markus Borner
  • Abraham Koshy
  • Mark Hartel
  • Cheuk Kwan Sun
  • Fabio F di Mola
  • Elspeth J Gold
  • Markus Schafer
  • Xing yi Zhang
  • Stephan Krahenbuhl
  • Andrzej Prokurat
  • Beat M Künzli
  • Alexander Koliopanos
  • C Spycher
  • Michael Sullivan
  • Margaret Childs
  • Carina Miles
  • Clinton Turner
  • Ioannis Diamantis
  • Jon Pritchard
  • Luigi Tornillo
  • Penelope Brock
  • Laurence Brugieres
  • Joszef Zsiros
  • Piotr Czaudzerna
  • Jean Keeling
  • Liz Shafford
  • Lukas Cioccari
  • Luigi Terracciano
  • Vincenza Carafa
  • Deniz Nart
  • Claudio Vallan
  • Lalage Wakefield
  • Erwin P Bottinger
  • Luca Cioccari
  • Aysen Terzi
  • Nurten Cetiner
  • Julia Mayerle
  • Chantal Manz
  • Gareth Ellis
  • David Semela
  • Sabine Jakob
  • Arne Scholz
  • Klaus A Neftel
  • Bertram Wiedenmann
  • Jean Claude Reubi
  • Andreas Cerny
  • Gregory M Hayes
  • Ruth Rehmann
  • Urban Emmenegger
  • Laurence J Miller
  • Sidney G Shaw
  • Hans Saegesser
  • Philip W Sheard
  • Paolo Innocenti
  • Beth L Mallard
  • Andrea Gardini

Detail Information

Publications37

  1. pmc HGF/c-Met related activation of β-catenin in hepatoblastoma
    Rachel Purcell
    Children s Cancer Research Group, University of Otago, Christchurch, Christchurch, New Zealand
    J Exp Clin Cancer Res 30:96. 2011
    ..In this study we have investigated alternative activation of beta-catenin by HGF/c-Met signaling in a large cohort of 98 HB patients enrolled in the SIOPEL-3 clinical trial...
  2. pmc The diagnostic value of liver biopsy
    C Spycher
    Department of Clinical Pharmacology, University of Berne, Switzerland
    BMC Gastroenterol 1:12. 2001
    ..The aim was to review the liver biopsies for 5 years after introduction of testing for hepatitis C, in order to evaluate what diagnostic insights - if any - remain after serologic testing...
  3. ncbi request reprint Primary perivascular epithelioid cell tumor of the liver not related to hepatic ligaments: hepatic PEComa as an emerging entity
    A Zimmermann
    Institute of Pathology of the University Berne, Switzerland
    Histol Histopathol 23:1185-93. 2008
    ....
  4. ncbi request reprint The emerging family of hepatoblastoma tumours: from ontogenesis to oncogenesis
    Arthur Zimmermann
    SIOPEL Liver Tumour Study Group, Institute of Pathology of the University, Berne, Switzerland
    Eur J Cancer 41:1503-14. 2005
    ..In this review, novel findings relating to these issues are discussed...
  5. ncbi request reprint Regulation of liver regeneration
    Arthur Zimmermann
    Institute of Pathology of the University, Murtenstrasse 31, CH 3010 Berne, Switzerland
    Nephrol Dial Transplant 19:iv6-10. 2004
    ..Hepatocyte regeneration proceeds along a sequence of distinctive phases and results in a precise reconstitution of the lost tissue mass. The molecular mechanisms regulating liver regeneration have recently been elucidated...
  6. ncbi request reprint Myofibroblasts in the cirrhotic rat liver reflect hepatic remodeling and correlate with fibrosis and sinusoidal capillarization
    A Zimmermann
    Department of Pathology, University of Berne, Switzerland
    J Hepatol 30:646-52. 1999
    ..Myofibroblasts are essential in fibrogenesis during development of cirrhosis. In the present study we stereologically quantitated MFB's and correlated them with fibrosis and sinusoidal capillarization...
  7. ncbi request reprint Hepatocellular carcinoma with an unusual medullary-like histology and signs of regression ("medullary-like hepatocellular carcinoma")
    A Zimmermann
    Institute of Pathology, University of Berne, Switzerland
    Dig Liver Dis 34:748-53. 2002
    ..Medullary-like hepatocellular carcinoma is a lesion which mimics several features known for other medullary carcinomas, including a marked immune response which may be responsible for partial regression of this tumour...
  8. ncbi request reprint Pediatric liver tumors and hepatic ontogenesis: common and distinctive pathways
    Arthur Zimmermann
    Institute of Pathology of the University, Berne, Switzerland
    Med Pediatr Oncol 39:492-503. 2002
    ..Some key steps of hepatogenesis and the regulatory factors involved may, in the future, deliver an armamentarium to search for novel molecular mechanisms involved in tumorigenic pathways...
  9. ncbi request reprint Hepatoblastoma with cholangioblastic features ('cholangioblastic hepatoblastoma') and other liver tumors with bimodal differentiation in young patients
    Arthur Zimmermann
    Institute of Pathology of the University, Berne, Switzerland
    Med Pediatr Oncol 39:487-91. 2002
    ..A possible pathogenetic pathway is suggested, i.e., uni- or bipotential neoplastic progenitors switch into either of the two lineages...
  10. ncbi request reprint Liver regeneration: the emergence of new pathways
    Artur Zimmermann
    Institute of Pathology of the University, Bern, Switzerland
    Med Sci Monit 8:RA53-63. 2002
    ..In contrast to hepatocytes, less is known for the the regenerative replacement of bile ducts, blood vessels and hepatic stellate cells...
  11. ncbi request reprint Adult-type hepatocellular carcinoma in the center of a fibrolamellar hepatocellular carcinoma
    Guido Seitz
    Department of Visceral and Transplantation Surgery and the Institute of Pathology, University of Berne, Berne, Switzerland
    Hum Pathol 33:765-9. 2002
    ....
  12. ncbi request reprint Randomized placebo-controlled trial of ursodeoxycholic acid with vitamin e in nonalcoholic steatohepatitis
    Jean Francois Dufour
    Institute of Clinical Pharmacology, University of Bern, Bern, and Department of Gastroenterology, University Hospital of Lausanne, Switzerland
    Clin Gastroenterol Hepatol 4:1537-43. 2006
    ..UDCA and vitamin E have been considered separately as therapeutic options and have not been shown to be effective. This study tested their combination...
  13. ncbi request reprint Secretin receptors in the human liver: expression in biliary tract and cholangiocarcinoma, but not in hepatocytes or hepatocellular carcinoma
    Meike Korner
    Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Bern, Murtenstrasse 31, P O Box 62, CH 3010 Bern, Switzerland
    J Hepatol 45:825-35. 2006
    ..The secretin receptor expression was investigated in the human liver because the liver is a physiological secretin target and because novel diagnostic and treatment modalities are needed for liver cancer...
  14. ncbi request reprint Endothelial nitric oxide synthase is not essential for the development of fibrosis and portal hypertension in bile duct ligated mice
    Abraham Koshy
    Institute for Clinical Pharmacology, University of Bern, Murtenstrasse 35, 3010 Bern, Switzerland
    Liver Int 25:1044-52. 2005
    ..It is postulated that nitric oxide (NO) is responsible for the hyperdynamic circulation of portal hypertension. Therefore, we investigated induction of fibrosis and hyperdynamic circulation in endothelial NO synthase knock-out (KO) mice...
  15. ncbi request reprint Desmoplastic reaction influences pancreatic cancer growth behavior
    Mark Hartel
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
    World J Surg 28:818-25. 2004
    ..Because patients with high CTGF mRNA expression levels have a better prognosis, our findings indicate that the desmoplastic reaction provides a growth disadvantage for pancreatic cancer cells...
  16. ncbi request reprint Role of hepatic stellate cell/hepatocyte interaction and activation of hepatic stellate cells in the early phase of liver regeneration in the rat
    Ayako Mabuchi
    Department of Physiology, Otago School of Medical Sciences, University of Otago, P O Box 913, Dunedin, New Zealand
    J Hepatol 40:910-6. 2004
    ..Hepatic stellate cells (HSCs) are known to play a role in hepatic regeneration. We investigated hepatocyte/HSC interaction and HSC activation at various times after 70% partial hepatectomy (PHx) in the rat...
  17. ncbi request reprint Transitional liver cell tumors (TLCT) in older children and adolescents: a novel group of aggressive hepatic tumors expressing beta-catenin
    Andrzej Prokurat
    The Children s Memorial Health Institute, Warsaw, Poland
    Med Pediatr Oncol 39:510-8. 2002
    ..We encountered on seven malignant hepatocellular tumors developing in older children and adolescents...
  18. ncbi request reprint Reduced hepatic glycogen stores in patients with liver cirrhosis
    Lukas Krahenbuhl
    Department of Visceral and Transplantation Surgery, University of Berne, Switzerland
    Liver Int 23:101-9. 2003
    ..Patients with alcoholic liver cirrhosis have reduced hepatic glycogen stores but the mechanisms leading to this finding are not clear...
  19. pmc Suppression of transforming growth factor beta signalling aborts caerulein induced pancreatitis and eliminates restricted stimulation at high caerulein concentrations
    Stefan Wildi
    Department of Medicine and Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire, USA
    Gut 56:685-92. 2007
    ....
  20. ncbi request reprint Expression and activity of the cytochrome P450 2E1 in patients with nonalcoholic steatosis and steatohepatitis
    Haithem Chtioui
    Institute of Clinical Pharmacology, University of Bern, Bern, Switzerland
    Liver Int 27:764-71. 2007
    ..The pathogenesis of NASH implicates the overexpression of cytochrome P450 2E1 (CYP2E1). We investigated whether the noninvasive determination of CYP2E1 activity could replace a liver biopsy in order to differentiate NASH from NAFL...
  21. ncbi request reprint Active caspase 3 and DNA fragmentation as markers for apoptotic cell death in primary and metastatic liver tumours
    Eva Karamitopoulou
    Institute of Pathology, Flow Cytometry Facility, Department of Clinical Research, University of Bern, Switzerland
    Pathology 39:558-64. 2007
    ..The aim of this study was to compare the immunohistochemical detection of active caspase 3 and single-stranded DNA in primary and metastatic liver tumours as markers of apoptotic cell death...
  22. ncbi request reprint A randomized controlled 1-year study of daily deferiprone plus twice weekly desferrioxamine compared with daily deferiprone monotherapy in patients with thalassemia major
    Yesim Aydinok
    Ege University, Faculty of Medicine, Department of Pediatric Hematology 35100 Bornova, Izmir, Turkey
    Haematologica 92:1599-606. 2007
    ..The aim of this prospective, randomized, 1-year study was to compare the efficacy and safety of oral deferiprone (DFP) with those of combinations of parenteral desferrioxamine (DFO) with oral DFP...
  23. doi request reprint Hepatoblastoma with a low serum alpha-fetoprotein level at diagnosis: the SIOPEL group experience
    Maretta De Ioris
    Department of Paediatric Oncology, Institut Gustave Roussy, 39, rue Camille Desmoulins, 94805 Villejuif, France
    Eur J Cancer 44:545-50. 2008
    ..To investigate the characteristics of patients with hepatoblastoma and low serum alpha-fetoprotein (AFP) at diagnosis...
  24. ncbi request reprint Hepatic and skeletal muscle glycogen metabolism in rats with short-term cholestasis
    Corinne Lang
    Department of Clinical Pharmacology, Inselspital, University of Berne, Berne, Switzerland
    J Hepatol 36:22-9. 2002
    ..To study the effect of short-term cholestasis on glycogen metabolism...
  25. doi request reprint Clinical significance of cell cycle- and apoptosis-related markers in biliary tract cancer: a tissue microarray-based approach revealing a distinctive immunophenotype for intrahepatic and extrahepatic cholangiocarcinomas
    Eva Karamitopoulou
    Institutes of Pathology, University of Basel, Basel, Switzerland Second Department of Pathology, University of Athens, Haidari, Athens, Greece
    Am J Clin Pathol 130:780-6. 2008
    ..Moreover, p16 was identified as an important prognostic marker in cholangiocarcinomas...
  26. ncbi request reprint Down-regulation of DOC-2 in colorectal cancer points to its role as a tumor suppressor in this malignancy
    Jorg Kleeff
    Department of General Surgery, University of Heidelberg, Germany
    Dis Colon Rectum 45:1242-8. 2002
    ..In these tumors it negatively influences mitogenic signal transduction of growth factors and blocks ras activity. In the present study we sought to determine the role of DOC-2 in colorectal cancer...
  27. ncbi request reprint Macrophage activating syndrome is associated with lobular hepatitis and severe bile duct injury with cholestasis
    Florian Bihl
    Department of Internal Medicine, Ospedale Civico, 6900 Lugano, Switzerland, and Women s College Health Sciences Centre, Toronto, Ont, Canada
    J Hepatol 44:1208-12. 2006
    ..This communication suggests that a macrophage, T- and NK-cell network is operational in the pathogenesis of the cholangiocyte, hepatocyte and sinus endothelial cell damage in MAS...
  28. ncbi request reprint Effects of immunosuppressant FTY720 on renal and hepatic hemodynamics in the rat
    Michael N Tawadrous
    Microcirculation Research Laboratory, Department of Physiology, University of Otago
    Transplantation 74:602-10. 2002
    ..However, the effects of FTY720 on renal or hepatic hemodynamics are unknown. The aim of this study was to establish the hemodynamic and renal actions of FTY720 at therapeutically relevant dosages...
  29. ncbi request reprint The metabolic and microcirculatory impact of orthotopic liver transplantation on the obese Zucker rat
    Cheuk Kwan Sun
    Microcirculatory Research Laboratory, Department of Physiology, School of Medical Sciences, University of Otago, Dunedin, New Zealand
    Transplantation 75:761-9. 2003
    ....
  30. ncbi request reprint Management of hepatobiliary cystadenocarcinoma
    Shailesh Shrikhande
    Shrikhande Clinic, Mumbai, India
    Dig Surg 20:60-3. 2003
    ..The patient remains asymptomatic at 2 years following surgery. The importance of differentiating these rare tumors from hepatic hydatid cysts, especially in areas where the disease is endemic, is highlighted in this case report...
  31. ncbi request reprint Neurokinin-1 receptor expression and its potential effects on tumor growth in human pancreatic cancer
    Helmut Friess
    Department of General Surgery, University of Heidelberg, Germany
    Lab Invest 83:731-42. 2003
    ..These findings illustrate that the NK-1R pathway is activated in human pancreatic cancer and has the potential to contribute to cancer cell growth, thus suggesting the existence of a neuro-cancer cell interaction in vivo...
  32. ncbi request reprint Connective tissue growth factor gene expression alters tumor progression in esophageal cancer
    Alexander Koliopanos
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, CH 3010 Bern, Switzerland
    World J Surg 26:420-7. 2002
    ....
  33. ncbi request reprint Myoid hamartoma of the liver--a novel variant of hamartoma developing in the hilar region and imitating a malignant liver tumor
    Barbara Gornicka
    Department of Pathology, Medical University of Warsaw, uk Pawińskiego 7, 02 106 Warsaw, Poland
    Med Sci Monit 10:CS23-6. 2004
    ..We report here an unusual variant of hepatic mesenchymal hamartoma exhibiting a marked myoid differentiation and clinically imitating hilar malignancy...
  34. ncbi request reprint Bile duct infarction following intraarterial hepatic chemotherapy mimicking multiple liver metastasis: report of a case and review of the literature
    Shailesh Shrikhande
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland
    Dig Dis Sci 47:338-44. 2002
  35. ncbi request reprint Persistence of impaired hepatic microcirculation after nonarterialized liver transplantation in the rat
    Michael N Tawadrous
    Microcirculation Research Laboratory, Department of Physiology, University of Otago, Dunedin, New Zealand
    Microcirculation 9:363-75. 2002
    ..The present study sought to establish whether NOLT represents a reasonable model for the study of the hepatic microcirculation beyond the immediate reperfusion phase...
  36. ncbi request reprint Influences of the lysosomal associated membrane proteins (Lamp-1, Lamp-2) and Mac-2 binding protein (Mac-2-BP) on the prognosis of pancreatic carcinoma
    Beat M Künzli
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Bern, Switzerland
    Cancer 94:228-39. 2002
    ..The authors studied the expression of Lamp-1, Lamp-2, and Mac-2-BP in pancreatic carcinoma and evaluated their influence on patient prognosis...
  37. ncbi request reprint Changes in activin and activin receptor subunit expression in rat liver during the development of CCl4-induced cirrhosis
    Elspeth J Gold
    Department of Anatomy and Structural Biology and Centre for Gene Research, University of Otago, Otago School of Medical Sciences, P O Box 913, Dunedin, New Zealand
    Mol Cell Endocrinol 201:143-53. 2003
    ..We conclude that the increased activin subunit expression is associated with apoptosis, rather than hepatic fibrosis and nodule formation...