Claes B Wollheim

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues
    Peter A Antinozzi
    Division of Clinical Biochemistry and Experimental Diabetology, Department of Internal Medicine, University Medical Center, CH 1211 Geneva 4, Switzerland
    J Biol Chem 277:11746-55. 2002
  2. ncbi Synaptotagmin V and IX isoforms control Ca2+ -dependent insulin exocytosis
    Mariella Iezzi
    Division of Clinical Biochemistry, Department of Internal Medicine, University Medical Center, 1211 Geneva 4, Switzerland
    J Cell Sci 117:3119-27. 2004
  3. ncbi Beta-cell mitochondria and insulin secretion: messenger role of nucleotides and metabolites
    Claes B Wollheim
    Division of Clinical Biochemistry, Department of Internal Medicine, University Medical Center, Geneva, Switzerland
    Diabetes 51:S37-42. 2002
  4. pmc Modulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stress
    Domitille Schvartz
    Biomedical Proteomics Research Group, Department of Human Protein Sciences, University Medical Center, Geneva 1211, Switzerland
    Mol Cell Proteomics 11:244-54. 2012
  5. ncbi Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells
    Hisamitsu Ishihara
    Division of Clinical Biochemistry, Department of Internal Medicine, University Medical Center, 1211 Geneva 4, Switzerland
    Nat Cell Biol 5:330-5. 2003
  6. ncbi Does chasing selected 'Fox' to the nucleus prevent diabetes?
    Haiyan Wang
    Department of Cell Physiology and Metabolism, University Medical Center, CH 1211 Geneva 4, Switzerland
    Trends Mol Med 11:262-5. 2005
  7. doi Mitochondrial matrix calcium is an activating signal for hormone secretion
    Andreas Wiederkehr
    Department of Cell Physiology and Metabolism, University of Geneva, University Medical Center, Switzerland
    Cell Metab 13:601-11. 2011
  8. ncbi Synaptotagmin VII splice variants alpha, beta, and delta are expressed in pancreatic beta-cells and regulate insulin exocytosis
    Benoit R Gauthier
    Department of Cell Physiology and Metabolism, University Medical Center, 1211 Geneva 4, Switzerland
    FASEB J 22:194-206. 2008
  9. ncbi The transcription factor SREBP-1c is instrumental in the development of beta-cell dysfunction
    Haiyan Wang
    Department of Internal Medicine, University Medical Centre, Geneva 4 CH 1211, Switzerland
    J Biol Chem 278:16622-9. 2003
  10. pmc Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice
    Fabrizio Thorel
    Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Diabetes 60:2872-82. 2011

Detail Information

Publications57

  1. ncbi Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues
    Peter A Antinozzi
    Division of Clinical Biochemistry and Experimental Diabetology, Department of Internal Medicine, University Medical Center, CH 1211 Geneva 4, Switzerland
    J Biol Chem 277:11746-55. 2002
    ..Based on these findings, we propose that fuel-stimulated secretion is in fact limited by the inherent thermodynamic constraints of proton gradient formation...
  2. ncbi Synaptotagmin V and IX isoforms control Ca2+ -dependent insulin exocytosis
    Mariella Iezzi
    Division of Clinical Biochemistry, Department of Internal Medicine, University Medical Center, 1211 Geneva 4, Switzerland
    J Cell Sci 117:3119-27. 2004
    ..Remarkably, hormone release in response to glucose was selectively and strongly reduced, indicating that Syt V and Syt IX are directly involved in the Ca2+ -dependent stimulation of exocytosis...
  3. ncbi Beta-cell mitochondria and insulin secretion: messenger role of nucleotides and metabolites
    Claes B Wollheim
    Division of Clinical Biochemistry, Department of Internal Medicine, University Medical Center, Geneva, Switzerland
    Diabetes 51:S37-42. 2002
    ..The evidence for the implication of these and other putative messengers in metabolism-secretion coupling is discussed in this review...
  4. pmc Modulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stress
    Domitille Schvartz
    Biomedical Proteomics Research Group, Department of Human Protein Sciences, University Medical Center, Geneva 1211, Switzerland
    Mol Cell Proteomics 11:244-54. 2012
    ....
  5. ncbi Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells
    Hisamitsu Ishihara
    Division of Clinical Biochemistry, Department of Internal Medicine, University Medical Center, 1211 Geneva 4, Switzerland
    Nat Cell Biol 5:330-5. 2003
    ..Zinc released from beta-cells may be implicated in this suppression. Our results define the fundamental mechanisms of differential responses to identical stimuli between cells in a microorgan...
  6. ncbi Does chasing selected 'Fox' to the nucleus prevent diabetes?
    Haiyan Wang
    Department of Cell Physiology and Metabolism, University Medical Center, CH 1211 Geneva 4, Switzerland
    Trends Mol Med 11:262-5. 2005
    ..Accordingly, the prevention of phosphorylation of Foxa2 was suggested as a pharmacological target for the treatment of obesity and diabetes...
  7. doi Mitochondrial matrix calcium is an activating signal for hormone secretion
    Andreas Wiederkehr
    Department of Cell Physiology and Metabolism, University of Geneva, University Medical Center, Switzerland
    Cell Metab 13:601-11. 2011
    ..Our dissection of cytosolic and mitochondrial Ca(2+) signals reveals the physiological importance of matrix Ca(2+) in energy metabolism required for signal-dependent hormone secretion...
  8. ncbi Synaptotagmin VII splice variants alpha, beta, and delta are expressed in pancreatic beta-cells and regulate insulin exocytosis
    Benoit R Gauthier
    Department of Cell Physiology and Metabolism, University Medical Center, 1211 Geneva 4, Switzerland
    FASEB J 22:194-206. 2008
    ..Our results demonstrate that SYTVII is expressed on insulin granules and that only SYTVII alpha is implicated in exocytosis under physiological conditions...
  9. ncbi The transcription factor SREBP-1c is instrumental in the development of beta-cell dysfunction
    Haiyan Wang
    Department of Internal Medicine, University Medical Centre, Geneva 4 CH 1211, Switzerland
    J Biol Chem 278:16622-9. 2003
    ..However, 2-day exposure to these agents promoted SREBP-1c processing. Therefore, the SREBP-1c maturation could be implicated in the pathogenesis of beta-cell glucolipotoxicity...
  10. pmc Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice
    Fabrizio Thorel
    Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Diabetes 60:2872-82. 2011
    ..To evaluate whether healthy or diabetic adult mice can tolerate an extreme loss of pancreatic α-cells and how this sudden massive depletion affects β-cell function and blood glucose homeostasis...
  11. ncbi Adenovirus-mediated silencing of synaptotagmin 9 inhibits Ca2+-dependent insulin secretion in islets
    Mariella Iezzi
    Department of Cell Physiology and Metabolism, University Medical Center, 1211 Geneva 4, Switzerland
    FEBS Lett 579:5241-6. 2005
    ..Insulin release in response to glucose or tolbutamide was strongly inhibited in Syt 9 deficient islets, whereas exocytosis potentiated by raising cAMP levels, was unaltered. Thus, Syt 9 may act as Ca(2+) sensor for beta-cell secretion...
  12. ncbi SV2A and SV2C are not vesicular Ca2+ transporters but control glucose-evoked granule recruitment
    Mariella Iezzi
    Department of Cell Physiology and Metabolism, University Medical Center, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Cell Sci 118:5647-60. 2005
    ..Like capacitance, evoked and basal hormone release are attenuated more by silencing of SV2C compared with SV2A. This indicates only partial redundancy and highlights a key role for SV2C in the secretory process...
  13. pmc PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression
    Benoit R Gauthier
    Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
    Cell Metab 10:110-8. 2009
    ..Thus, the genetic control by the beta cell-specific factor Pdx1 of the ubiquitous gene TFAM maintains beta cell mtDNA vital for ATP production and normal GSIS...
  14. doi Improved characterization of the insulin secretory granule proteomes
    Domitille Schvartz
    Biomedical Proteomics Research Group, Department of Human Protein Sciences, University Medical Center, Geneva, Switzerland
    J Proteomics 75:4620-31. 2012
    ..This article is part of a special issue entitled: Translational Proteomics...
  15. ncbi Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells
    Arnaud Merglen
    Division of Clinical Biochemistry, Department of Internal Medicine, DBC 9100, University Medical Center, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
    Endocrinology 145:667-78. 2004
    ..As in native beta-cells, tolbutamide induced electrical activity, indicating that the K(ATP)conductance is important in setting the resting potential. Therefore, INS-1E cells represent a stable and valuable beta-cell model...
  16. doi Pyruvate dehydrogenase E1α phosphorylation is induced by glucose but does not control metabolism-secretion coupling in INS-1E clonal β-cells
    Dmitry Akhmedov
    Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
    Biochim Biophys Acta 1823:1815-24. 2012
    ..In conclusion, although glucose stimulates E1α phosphorylation and therefore inhibits PDH activity, this control mechanism by itself does not alter metabolism-secretion coupling in INS-1E clonal β-cells...
  17. doi Early activation of the fatty acid metabolism pathway by chronic high glucose exposure in rat insulin secretory beta-cells
    Yohann Coute
    Biomedical Proteomics Research Group, Structural Biology and Bioinformatics Department, Centre Medical Universitaire, Geneva, Switzerland
    Proteomics 10:59-71. 2010
    ..The results obtained reinforce the link between glucotoxicity and lipogenesis and suggest that the fatty acid metabolism pathway may rapidly be stimulated in beta-cells submitted to chronic high glucose concentrations...
  18. doi Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells
    Dmitry Akhmedov
    Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
    FASEB J 24:4613-26. 2010
    ..We propose that matrix pH serves a novel signaling role in sustained cell activation...
  19. doi Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion in the pancreatic beta-cell
    Andreas Wiederkehr
    Department of Cell Physiology and Metabolism, University Medical Center, 1 rue Michel Servet, Geneva 4, Switzerland
    Cell Calcium 44:64-76. 2008
    ....
  20. ncbi ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity
    Haiyan Wang
    Department of Cell Physiology and Metabolism, University Medical Center, Geneva, CH 1211, Switzerland
    J Cell Sci 118:3905-15. 2005
    ..These results suggest that SREBP-1 activation caused by ER stress is implicated in beta-cell glucolipotoxicity...
  21. doi Synaptotagmins bind calcium to release insulin
    Benoit R Gauthier
    Dept of Cell Physiology and Metabolism, University Medical Center, 1211 Geneva 4, Switzerland
    Am J Physiol Endocrinol Metab 295:E1279-86. 2008
    ..Cumulating evidence emphasizes the crucial role of synaptotagmin VII and IX as mediators of glucose-induced insulin secretion...
  22. doi Reduction of plasma membrane glutamate transport potentiates insulin but not glucagon secretion in pancreatic islet cells
    Nicole Feldmann
    Department of Cell Physiology and Metabolism, University Medical Centre, Geneva, Switzerland
    Mol Cell Endocrinol 338:46-57. 2011
    ..In conclusion, intra-cellular glutamate-derived metabolite pools are linked to glucose-stimulated insulin but not glucagon secretion...
  23. pmc Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic beta-cell activation
    Andreas Wiederkehr
    Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
    EMBO J 28:417-28. 2009
    ..We propose that the mitochondrial pH and DeltapH are key determinants of mitochondrial energy metabolism and metabolite transport important for cell activation...
  24. ncbi Minireview: implication of mitochondria in insulin secretion and action
    Andreas Wiederkehr
    Department of Cell Physiology and Metabolism, University Medical Center, Geneva, Switzerland
    Endocrinology 147:2643-9. 2006
    ..Both prevention and treatment of type 2 diabetes should focus on mitochondrial targets for the improvement of nutrient-stimulated insulin secretion and their utilization in peripheral tissues...
  25. pmc The diabetes-linked transcription factor PAX4 promotes {beta}-cell proliferation and survival in rat and human islets
    Thierry Brun
    Department of Cell Physiology and Metabolism, University Medical Center, Geneva, Switzerland
    J Cell Biol 167:1123-35. 2004
    ..We propose that Pax4 is implicated in beta-cell plasticity through the activation of c-myc and potentially protected from apoptosis through Bcl-xL gene expression...
  26. doi Evidence against a direct role of klotho in insulin resistance
    Olivier Lorenzi
    Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Pflugers Arch 459:465-73. 2010
    ..However, the hypothesis that klotho indirectly regulates insulin sensitivity via FGF23 activation remains to be investigated...
  27. ncbi ChREBP rather than USF2 regulates glucose stimulation of endogenous L-pyruvate kinase expression in insulin-secreting cells
    Haiyan Wang
    Division of Clinical Biochemistry, Department of Internal Medicine, University Medical Center, CH 1211 Geneva 4, Switzerland
    J Biol Chem 277:32746-52. 2002
    ..These unprecedented results suggest that ChREBP rather than USF mediates glucose-promoted L-PK expression in insulin-secreting cells...
  28. pmc In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice
    Kai Hui Hu He
    Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
    Diabetes 60:1705-15. 2011
    ....
  29. ncbi Experimental models of transcription factor-associated maturity-onset diabetes of the young
    Haiyan Wang
    Department of Internal Medicine, Division of Clinical Biochemistry, University Medical Centre, Geneva, Switzerland
    Diabetes 51:S333-42. 2002
    ..The presented experimental models are important tools for the elucidation of the beta-cell pathogenesis in MODY syndromes...
  30. pmc Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells
    Sharon Epstein
    Department of Biochemistry, University of Geneva, Geneva, Switzerland
    J Lipid Res 53:412-20. 2012
    ..Therefore, our study reveals a novel connection between UPR induction and ceramide synthesis that seems to be conserved between yeast and mammalian cells...
  31. pmc Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: correlations with age or BMI of islet donors
    Clare L Kirkpatrick
    Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
    PLoS ONE 5:e11053. 2010
    ..We also aimed to correlate expression of these transcripts in both alpha and beta cell types with phenotypic traits of the islet donors and to compare diabetic and non-diabetic cells...
  32. ncbi Proteomics analysis of insulin secretory granules
    Yannick Brunner
    Biomedical Proteomics Research Group, University Medical Center, 1211 Geneva 4, Switzerland
    Mol Cell Proteomics 6:1007-17. 2007
    ..The elucidation of their role will further help in the understanding of the mechanisms governing impaired insulin secretion during diabetes...
  33. doi Dual effect of cell-cell contact disruption on cytosolic calcium and insulin secretion
    Fabienne Jaques
    Department of Genetic Medicine and Development, University of Geneva Medical Center, 1211 Geneva 4, Switzerland
    Endocrinology 149:2494-505. 2008
    ....
  34. ncbi Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets
    Benoit R Gauthier
    Department of Cell Physiology and Metabolism and Genomics Platform, National Center of Competence in Research Frontiers in Genetics, University of Geneva, 1211 Geneva 4, Switzerland
    J Biol Chem 279:31121-30. 2004
    ..In conclusion, loss of PDX1 function alters expression of mitochondrially encoded genes through regulation of TFAM leading to impaired insulin secretion...
  35. ncbi Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release
    Haiyan Wang
    Division of Clinical Biochemistry, Department of Internal Medicine, University Medical Center, CH 1211 Geneva 4, Switzerland
    J Biol Chem 277:17564-70. 2002
    ..These results suggest that Foxa2 is a vital transcription factor evolved to control the expression of genes essential for maintaining beta-cell glucose sensing and glucose homeostasis...
  36. ncbi Implication of glutamate in the kinetics of insulin secretion in rat and mouse perfused pancreas
    Pierre Maechler
    Division of Clinical Biochemistry, Department of Internal Medicine, University Medical Center, Geneva, Switzerland
    Diabetes 51:S99-102. 2002
    ..0 and 16.7 mmol/l glucose. These results are compatible with a role for glucose-derived glutamate principally in the sustained phase of nutrient-stimulated insulin secretion...
  37. pmc GABA in the endocrine pancreas: its putative role as an islet cell paracrine-signalling molecule
    Isobel K Franklin
    Experimental Diabetology Group, Department of Cell Physiology and Metabolism, University Medical Center, Geneva, Switzerland
    J Gen Physiol 123:185-90. 2004
  38. ncbi Hepatocyte nuclear factor-1alpha modulates pancreatic beta-cell growth by regulating the expression of insulin-like growth factor-1 in INS-1 cells
    Qin Yang
    Department of Internal Medicine and Molecular Science, Biomedical Research Center, Graduate School of Medicine, Osaka University, Osaka, Japan
    Diabetes 51:1785-92. 2002
    ..Our data suggest that HNF-1alpha is critical for modulating pancreatic beta-cell growth by regulating IGF-1 expression. IGF-1 might be a potential therapeutic target for the treatment of MODY3...
  39. ncbi Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy
    David M Keller
    Vollum Institute, and Division of Biostatistics, Department of Public Health and Preventative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Biol Chem 282:32084-92. 2007
    ..We additionally show that many Pdx-1 targets also interact with NeuroD1/BETA2, including the micro-RNA miR-375, a known regulator of insulin secretion...
  40. pmc Mitochondrial GTP regulates glucose-stimulated insulin secretion
    Richard G Kibbey
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell Metab 5:253-64. 2007
    ..Furthermore, in light of its tight coupling to TCA oxidation rates, mtGTP production may serve as an important molecular signal of TCA-cycle activity...
  41. pmc Adenovirus-mediated overexpression of liver carnitine palmitoyltransferase I in INS1E cells: effects on cell metabolism and insulin secretion
    Blanca Rubi
    Department of Biochemistry and Molecular Biology, University of Barcelona, School of Pharmacy, Diagonal 643, E 08028 Barcelona, Spain
    Biochem J 364:219-26. 2002
    ..They also indicate that up-regulation of CPT I contributes to the loss of response to high glucose in beta-cells exposed to fatty acids...
  42. ncbi Activation of the insulin gene promoter through a direct effect of hepatocyte nuclear factor 4 alpha
    Reut Bartoov-Shifman
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 277:25914-9. 2002
    ....
  43. ncbi Increase in cellular glutamate levels stimulates exocytosis in pancreatic beta-cells
    Marianne Høy
    Islet Discovery Research, Novo Nordisk A S, Novo Alle, Bagsvaerd, Denmark
    FEBS Lett 531:199-203. 2002
    ..The results suggest that stimulation of exocytosis is associated with accumulation of glutamate in the secretory granules, a process that is dependent on the transgranular proton gradient...
  44. ncbi Inhibition of mitochondrial Na+-Ca2+ exchanger increases mitochondrial metabolism and potentiates glucose-stimulated insulin secretion in rat pancreatic islets
    Bumsup Lee
    Division of Metabolic Diseases, MitoKor, San Diego, California 92121, USA
    Diabetes 52:965-73. 2003
    ..These results illustrate the potential utility of agents that affect mitochondrial metabolism as novel insulin secretagogues...
  45. pmc Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice
    Verena Schulla
    Institut fur Pharmakologie und Toxikologie, TU Munchen, Biedersteiner Strasse 29, D 80802 München, Germany
    EMBO J 22:3844-54. 2003
    ..2 channel. Thus, the conduit of Ca(2+) entry determines the ability of the cation to elicit secretion...
  46. ncbi Beta-cell-targeted expression of a dominant-negative mutant of hepatocyte nuclear factor-1alpha in mice: diabetes model with beta-cell dysfunction partially rescued by nonglucose secretagogues
    Maria Sörhede Winzell
    Department of Medicine, Lund University, B11 BMC, SE 221 84 Lund, Sweden
    Diabetes 53:S92-6. 2004
    ..In contrast, the insulin responses to nonglucose stimuli are not suppressed when the islet insulin content is taken into account...
  47. ncbi Loss of connexin36 channels alters beta-cell coupling, islet synchronization of glucose-induced Ca2+ and insulin oscillations, and basal insulin release
    Magalie A Ravier
    Department of Cell Physiology and Metabolism, University of Geneva, C M U, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Diabetes 54:1798-807. 2005
    ..These data show that Cx36-dependent signaling is essential for the proper functioning of beta-cells, particularly for the pulsatility of [Ca(2+)](i) and insulin secretion during glucose stimulation...
  48. ncbi Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release
    Isobel Franklin
    Department of Cell PhysiologyMetabolism, University Medical Centre, 1211 Geneva 4, Switzerland
    Diabetes 54:1808-15. 2005
    ..beta-Cell secretory products zinc and insulin therefore inhibit glucagon secretion most probably by direct activation of K(ATP) channels, thereby masking an alpha-cell metabolism secretion coupling pathway similar to beta-cells...
  49. ncbi Glucose stimulates glucagon release in single rat alpha-cells by mechanisms that mirror the stimulus-secretion coupling in beta-cells
    Hervør Lykke Olsen
    Lilly Research Laboratories, Essener Bogen 7, D 22419 Hamburg, Germany
    Endocrinology 146:4861-70. 2005
    ..The stimulatory action of glucose in isolated alpha-cells contrasts with the suppressive effect of the sugar in intact islets and highlights the primary importance of islet paracrine signaling in the regulation of glucagon release...
  50. pmc The Fas pathway is involved in pancreatic beta cell secretory function
    Desiree M Schumann
    Clinic of Endocrinology and Diabetes, and Department of Pathology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 104:2861-6. 2007
    ..This led to increased PDX-1 and insulin production independent of changes in cell turnover. The results support a previously undescribed role for the Fas pathway in regulating insulin production and release...
  51. ncbi The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation
    Kenji Fukui
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita Osaka 565 0871, Japan
    Cell Metab 2:373-84. 2005
    ..Therefore, collectrin is a regulator of SNARE complex function, which thereby controls insulin exocytosis...
  52. ncbi MicroRNAs: 'ribo-regulators' of glucose homeostasis
    Benoit R Gauthier
    Nat Med 12:36-8. 2006
  53. ncbi [Glucose homeostasis ribo-regulated by microRNA]
    Benoit R Gauthier
    Med Sci (Paris) 22:463-5. 2006
  54. ncbi Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets
    Kathrin Maedler
    Larry L Hillblom Islet Research Center, University of California, Los Angeles, CA, USA
    Diabetes 55:2713-22. 2006
    ..These findings indicate that low IL-1beta levels positively influence beta-cell function and turnover through the Fas-FLIP pathway and that IL-1Ra production prevents harmful effects of high IL-1beta concentrations...
  55. ncbi Dominant-negative suppression of HNF-1 alpha results in mitochondrial dysfunction, INS-1 cell apoptosis, and increased sensitivity to ceramide-, but not to high glucose-induced cell death
    Hella Wobser
    Interdisciplinary Center for Clinical Research IZKF, Research Group Apoptosis and Cell Death, Westphalian Wilhelms University, D 48149 Munster, Germany
    J Biol Chem 277:6413-21. 2002
    ..Therefore, our data indicate that increased sensitivity to the mitochondrial apoptosis pathway and decreased cell proliferation may account for the progressive loss of beta-cell function seen in MODY 3 subjects...
  56. ncbi Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains
    Jesper Gromada
    Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, Massachusetts 02139, USA
    Endocr Rev 28:84-116. 2007
    ..Therapeutic inhibition of glucagon action in patients with type 2 diabetes remains an exciting prospect...
  57. ncbi [Pax4, islet plasticity and diabetes]
    Thierry Brun
    Département de Physiologie Cellulaire et Métabolisme, Centre Medical Universitaire, 1, rue Michel Servet, 1211 Geneve 4, Suisse thierry brun medecine unige ch
    Med Sci (Paris) 21:358-9. 2005