Haiyan Wang

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi request reprint Polypyrrole-based optical probe for a hydrogen peroxide assay
    Haiyan Wang
    Department of Chemistry and Center for Integrated Molecular Systems, Pohang University of Science and Technology, San 31, Hyoja Dong, Pohang, Gyeongbuk 790 784, Korea
    Anal Chem 79:240-5. 2007
  2. ncbi request reprint ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity
    Haiyan Wang
    Department of Cell Physiology and Metabolism, University Medical Center, Geneva, CH 1211, Switzerland
    J Cell Sci 118:3905-15. 2005
  3. ncbi request reprint Does chasing selected 'Fox' to the nucleus prevent diabetes?
    Haiyan Wang
    Department of Cell Physiology and Metabolism, University Medical Center, CH 1211 Geneva 4, Switzerland
    Trends Mol Med 11:262-5. 2005
  4. ncbi request reprint Experimental models of transcription factor-associated maturity-onset diabetes of the young
    Haiyan Wang
    Department of Internal Medicine, Division of Clinical Biochemistry, University Medical Centre, Geneva, Switzerland
    Diabetes 51:S333-42. 2002
  5. pmc Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress
    Clare L Kirkpatrick
    Department of Cell Physiology and Metabolism, Centre Medical Universitaire, Universite de Geneve, 1 rue Michel Servet, 1211 Geneve 4, Switzerland
    J Biol Chem 286:32300-12. 2011
  6. ncbi request reprint ChREBP rather than USF2 regulates glucose stimulation of endogenous L-pyruvate kinase expression in insulin-secreting cells
    Haiyan Wang
    Division of Clinical Biochemistry, Department of Internal Medicine, University Medical Center, CH 1211 Geneva 4, Switzerland
    J Biol Chem 277:32746-52. 2002
  7. ncbi request reprint The transcription factor SREBP-1c is instrumental in the development of beta-cell dysfunction
    Haiyan Wang
    Department of Internal Medicine, University Medical Centre, Geneva 4 CH 1211, Switzerland
    J Biol Chem 278:16622-9. 2003
  8. ncbi request reprint Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release
    Haiyan Wang
    Division of Clinical Biochemistry, Department of Internal Medicine, University Medical Center, CH 1211 Geneva 4, Switzerland
    J Biol Chem 277:17564-70. 2002
  9. ncbi request reprint Dominant-negative suppression of HNF-1 alpha results in mitochondrial dysfunction, INS-1 cell apoptosis, and increased sensitivity to ceramide-, but not to high glucose-induced cell death
    Hella Wobser
    Interdisciplinary Center for Clinical Research IZKF, Research Group Apoptosis and Cell Death, Westphalian Wilhelms University, D 48149 Munster, Germany
    J Biol Chem 277:6413-21. 2002
  10. ncbi request reprint Inhibition of VEGF expression by targeting HIF-1 alpha with small interference RNA in human RPE cells
    Peng Zhang
    Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, PR China
    Ophthalmologica 221:411-7. 2007

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Polypyrrole-based optical probe for a hydrogen peroxide assay
    Haiyan Wang
    Department of Chemistry and Center for Integrated Molecular Systems, Pohang University of Science and Technology, San 31, Hyoja Dong, Pohang, Gyeongbuk 790 784, Korea
    Anal Chem 79:240-5. 2007
    ..The novel methodology is expected to provide a general protocol for the determination of H2O2 as well as for numerous other oxidase-based reactions producing H2O2 as a product...
  2. ncbi request reprint ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity
    Haiyan Wang
    Department of Cell Physiology and Metabolism, University Medical Center, Geneva, CH 1211, Switzerland
    J Cell Sci 118:3905-15. 2005
    ..These results suggest that SREBP-1 activation caused by ER stress is implicated in beta-cell glucolipotoxicity...
  3. ncbi request reprint Does chasing selected 'Fox' to the nucleus prevent diabetes?
    Haiyan Wang
    Department of Cell Physiology and Metabolism, University Medical Center, CH 1211 Geneva 4, Switzerland
    Trends Mol Med 11:262-5. 2005
    ..Accordingly, the prevention of phosphorylation of Foxa2 was suggested as a pharmacological target for the treatment of obesity and diabetes...
  4. ncbi request reprint Experimental models of transcription factor-associated maturity-onset diabetes of the young
    Haiyan Wang
    Department of Internal Medicine, Division of Clinical Biochemistry, University Medical Centre, Geneva, Switzerland
    Diabetes 51:S333-42. 2002
    ..The presented experimental models are important tools for the elucidation of the beta-cell pathogenesis in MODY syndromes...
  5. pmc Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress
    Clare L Kirkpatrick
    Department of Cell Physiology and Metabolism, Centre Medical Universitaire, Universite de Geneve, 1 rue Michel Servet, 1211 Geneve 4, Switzerland
    J Biol Chem 286:32300-12. 2011
    ..Rat insulin 2 promoter-DN HNF1α mouse islets express lower levels of BiP mRNA, synthesize less insulin, and are sensitized to ER stress relative to matched control mouse islets, suggesting that this mechanism is also operating in vivo...
  6. ncbi request reprint ChREBP rather than USF2 regulates glucose stimulation of endogenous L-pyruvate kinase expression in insulin-secreting cells
    Haiyan Wang
    Division of Clinical Biochemistry, Department of Internal Medicine, University Medical Center, CH 1211 Geneva 4, Switzerland
    J Biol Chem 277:32746-52. 2002
    ..These unprecedented results suggest that ChREBP rather than USF mediates glucose-promoted L-PK expression in insulin-secreting cells...
  7. ncbi request reprint The transcription factor SREBP-1c is instrumental in the development of beta-cell dysfunction
    Haiyan Wang
    Department of Internal Medicine, University Medical Centre, Geneva 4 CH 1211, Switzerland
    J Biol Chem 278:16622-9. 2003
    ..However, 2-day exposure to these agents promoted SREBP-1c processing. Therefore, the SREBP-1c maturation could be implicated in the pathogenesis of beta-cell glucolipotoxicity...
  8. ncbi request reprint Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release
    Haiyan Wang
    Division of Clinical Biochemistry, Department of Internal Medicine, University Medical Center, CH 1211 Geneva 4, Switzerland
    J Biol Chem 277:17564-70. 2002
    ..These results suggest that Foxa2 is a vital transcription factor evolved to control the expression of genes essential for maintaining beta-cell glucose sensing and glucose homeostasis...
  9. ncbi request reprint Dominant-negative suppression of HNF-1 alpha results in mitochondrial dysfunction, INS-1 cell apoptosis, and increased sensitivity to ceramide-, but not to high glucose-induced cell death
    Hella Wobser
    Interdisciplinary Center for Clinical Research IZKF, Research Group Apoptosis and Cell Death, Westphalian Wilhelms University, D 48149 Munster, Germany
    J Biol Chem 277:6413-21. 2002
    ..Therefore, our data indicate that increased sensitivity to the mitochondrial apoptosis pathway and decreased cell proliferation may account for the progressive loss of beta-cell function seen in MODY 3 subjects...
  10. ncbi request reprint Inhibition of VEGF expression by targeting HIF-1 alpha with small interference RNA in human RPE cells
    Peng Zhang
    Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, PR China
    Ophthalmologica 221:411-7. 2007
    ..HIF-1 alpha is the inducible subunit of the HIF-1...
  11. ncbi request reprint Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy
    David M Keller
    Vollum Institute, and Division of Biostatistics, Department of Public Health and Preventative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Biol Chem 282:32084-92. 2007
    ..We additionally show that many Pdx-1 targets also interact with NeuroD1/BETA2, including the micro-RNA miR-375, a known regulator of insulin secretion...
  12. ncbi request reprint The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation
    Kenji Fukui
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita Osaka 565 0871, Japan
    Cell Metab 2:373-84. 2005
    ..Therefore, collectrin is a regulator of SNARE complex function, which thereby controls insulin exocytosis...
  13. ncbi request reprint Activation of the insulin gene promoter through a direct effect of hepatocyte nuclear factor 4 alpha
    Reut Bartoov-Shifman
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 277:25914-9. 2002
    ....
  14. ncbi request reprint Adrenomedullin impairs the profibrotic effects of transforming growth factor-beta1 through recruiting Smad6 protein in human renal tubular cells
    Haichang Huang
    Division of Nephrology, Peking University First Hospital and Institute of Nephrology, China
    Cell Physiol Biochem 15:117-24. 2005
    ..Our results suggest that AM can attenuate TGF-beta1-mediated renal tubulointerstitial ECM turnover via an antagonistic mechanism of inhibitory Smad in TGF-beta1-elicited signaling...
  15. ncbi request reprint AngRem104, an angiotensin II-induced novel upregulated gene in human mesangial cells, is potentially involved in the regulation of fibronectin expression
    Xiubin Liang
    Renal Division of Peking University First Hospital, Institute of Nephrology, Peking University, Beijing, China
    J Am Soc Nephrol 14:1443-51. 2003
    ..It is concluded that AngRem104 is a novel human gene potentially involved in the regulation of FN induced by AngII in human MC. These findings may provide new insights into mechanisms of glomerular sclerosis associated with AngII...
  16. ncbi request reprint Screening and identification of the up-regulated genes in human mesangial cells exposed to angiotensin II
    Xiubin Liang
    Renal Division of Peking University First Hospital, Institute of Nephrology, Peking University, Beijing, China
    Hypertens Res 26:225-35. 2003
    ..These findings may lead to new insights into the mechanisms of glomerular sclerosis associated with Ang II...
  17. ncbi request reprint Hepatocyte nuclear factor-1alpha modulates pancreatic beta-cell growth by regulating the expression of insulin-like growth factor-1 in INS-1 cells
    Qin Yang
    Department of Internal Medicine and Molecular Science, Biomedical Research Center, Graduate School of Medicine, Osaka University, Osaka, Japan
    Diabetes 51:1785-92. 2002
    ..Our data suggest that HNF-1alpha is critical for modulating pancreatic beta-cell growth by regulating IGF-1 expression. IGF-1 might be a potential therapeutic target for the treatment of MODY3...
  18. ncbi request reprint Tyrosine phosphorylation of the LDL receptor-related protein (LRP) and activation of the ERK pathway are required for connective tissue growth factor to potentiate myofibroblast differentiation
    Min Yang
    Division of Nephrology, First Hospital and Institute of Nephrology, Peking University, Beijing, China
    FASEB J 18:1920-1. 2004
    ..Our in vitro studies provide evidence that CTGF potentiates TGFbeta1-mediated myofibroblast differentiation and activates differentiated myofibroblasts...
  19. doi request reprint The novel gene AngRem104 downregulates glucocorticoid receptor expression and activates NF-kappaB in human mesangial cells
    Yanling Zhang
    Renal Division, Peking University First Hospital, Institute of Nephrology, Peking University, no 8, Xishiku Street, Beijing 100034, China
    Biochem Biophys Res Commun 369:1057-60. 2008
    ..These results indicate that the novel gene AngRem104 is involved in the in vivo regulation of GR expression and the activation of NF-kappaB through interaction with GR-EF in human MCs...
  20. ncbi request reprint Connective tissue growth factor increases matrix metalloproteinase-2 and suppresses tissue inhibitor of matrix metalloproteinase-2 production by cultured renal interstitial fibroblasts
    Min Yang
    Division of Nephrology, Peking University First Hospital, Beijing, China
    Wound Repair Regen 15:817-24. 2007
    ..These results provide evidence that CTGF augments activation of MMP-2 through an effect on MMP-2 protein expression and TIMP-2 suppression, and that these effects are dependent on the activation of the ERK1/2 pathway...
  21. ncbi request reprint [Serum IgA(1) from patients with IgA nephropathy induces phosphorylation of extracellular signal-regulated kinase and proliferation of human mesangial cells]
    Yue Wang
    Institute of Nephrology, Peking University, Beijing 100034, China
    Zhonghua Yi Xue Za Zhi 82:1406-9. 2002
    ..To study the effects of serum IgA(1) from patients with IgA nephropathy (IgAN) on the phosphorylation of extracellular signal-regulated kinase (ERK) and proliferation of human mesangial cells (HMC)...
  22. ncbi request reprint Molecular modeling of zinc and copper binding with Alzheimer's amyloid beta-peptide
    Daxiong Han
    Department of Pharmacy, Medical College of Xiamen University, Xiamen, China
    Biometals 21:189-96. 2008
    ..These results would be helpful to put insight on revealing the formation mechanism of pathogenic Abeta aggregates in brain...
  23. ncbi request reprint A combination of Chinese herbs, Astragalus membranaceus var. mongholicus and Angelica sinensis, enhanced nitric oxide production in obstructed rat kidney
    Liqiang Meng
    Renal Division, Department of Medicine, Peking University First Hospital, Beijing 100034 PR China
    Vascul Pharmacol 47:174-83. 2007
    ..In the present study, we investigated the effects and possible mechanisms of A&A on vasoactivators in the process of renal interstitial fibrosis...
  24. ncbi request reprint Mathematical modeling and qualitative analysis of insulin therapies
    Haiyan Wang
    Department of Mathematical Sciences and Applied Computing, Arizona State University, Phoenix, AZ 85069 7100, USA
    Math Biosci 210:17-33. 2007
    ..Numerically we simulate the insulin administration based on our model. The numerical simulation results are in agreement with findings of clinical studies...
  25. ncbi request reprint Induction of monocyte chemoattractant protein-1 release from A549 cells by agonists of protease-activated receptor-1 and -2
    Haiyan Wang
    Allergy and Inflammation Research Institute, The Key Immunopharmacology Laboratory of Guangdong Province, Shantou University Medical College, Shantou 515041, China
    Eur J Cell Biol 86:233-42. 2007
    ..In conclusion, serine proteases can stimulate MCP-1 release from A549 cells possibly through a PARs-related mechanism, suggesting that they are likely to contribute to MCP-1-related airway inflammatory disorders in man...
  26. pmc Induction of release and up-regulated gene expression of interleukin (IL)-8 in A549 cells by serine proteinases
    Haiyan Wang
    Allergy and Inflammation Research Institute, The Key Immunopharmacology Laboratory of Guangdong Province, Shantou University Medical College, Shantou 515031, China
    BMC Cell Biol 7:22. 2006
    ....
  27. ncbi request reprint High ambient glucose levels modulates the production of MMP-9 and alpha5(IV) collagen by cultured podocytes
    Yaling Bai
    Division of Nephrology, Peking University First Hospital, Beijing, China
    Cell Physiol Biochem 17:57-68. 2006
    ....
  28. ncbi request reprint [Anti-inflammatory effect of peroxisome proliferator-activated receptor-gamma incultured human mesangial cells]
    Zuying Xiong
    Renal Division of First Hospital, Institute of Nephrology, Peking University, Beijing 100034, China
    Zhonghua Yi Xue Za Zhi 82:1351-4. 2002
    ..To investigate whether peroxisome proliferator-activator receptor-gamma (PPARgamma) could retard the inflammatory challenge from human mesangial cells...
  29. ncbi request reprint [Expression of vascular endothelial growth factor and its receptors, flt-1 and kinase insert domain-containing receptor in normal human endometrium during menstrual cycle]
    Haiyan Wang
    Department of Obstetrics and Gynecology, Third Hospital, Peking University, Beijing 100083, China
    Zhonghua Fu Chan Ke Za Zhi 37:729-32. 2002
    ....
  30. ncbi request reprint [Relationship between insulin resistance and cardiovascular risk factors clustering: an epidemiological study]
    Enzhi Jia
    Department of Cardiovascular Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    Zhonghua Yi Xue Za Zhi 82:1183-6. 2002
    ..To study the relationship between insulin resistance and cardiovascular risk factor clustering...