Natacha Turck

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. doi request reprint A multiparameter panel method for outcome prediction following aneurysmal subarachnoid hemorrhage
    Natacha Turck
    Biomedical Proteomics Research Group, Department of Structural Biology and Bioinformatics, Medical University Centre, DBSB CMU, rue Michel Servet, 1, 1211 Geneva 4, Switzerland
    Intensive Care Med 36:107-15. 2010
  2. pmc Blood glutathione S-transferase-π as a time indicator of stroke onset
    Natacha Turck
    Biomedical Proteomics Research Group, Department of Human Protein Sciences, Faculty of Medicine, Geneva, Switzerland
    PLoS ONE 7:e43830. 2012
  3. doi request reprint Neopterin plasma concentrations in patients with aneurysmal subarachnoid hemorrhage: correlation with infection and long-term outcome
    Leire Azurmendi
    Department of Human Protein Sciences, University of Geneva, Geneva, Switzerland
    J Neurosurg 124:1287-99. 2016
  4. pmc Neopterin is a cerebrospinal fluid marker for treatment outcome evaluation in patients affected by Trypanosoma brucei gambiense sleeping sickness
    Natalia Tiberti
    Translational Biomarker Group, Department of Human Protein Sciences, University of Geneva, Geneva, Switzerland
    PLoS Negl Trop Dis 7:e2088. 2013
  5. doi request reprint The prognostic significance of the serum biomarker heart-fatty acidic binding protein in comparison with s100b in severe traumatic brain injury
    Bernhard Walder
    1 Division of Anaesthesiology, University Hospitals of Geneva, Geneva, Switzerland
    J Neurotrauma 30:1631-7. 2013
  6. pmc Cerebrospinal fluid neopterin as marker of the meningo-encephalitic stage of Trypanosoma brucei gambiense sleeping sickness
    Natalia Tiberti
    Biomedical Proteomics Research Group, Department of Human Protein Sciences, University of Geneva, Geneva, Switzerland
    PLoS ONE 7:e40909. 2012
  7. pmc Discovery and verification of osteopontin and Beta-2-microglobulin as promising markers for staging human African trypanosomiasis
    Natalia Tiberti
    Biomedical Proteomics Research Group, Medical University Centre, Geneva, Switzerland
    Mol Cell Proteomics 9:2783-95. 2010
  8. pmc Matrix metalloproteinase 9 and cellular fibronectin plasma concentrations are predictors of the composite endpoint of length of stay and death in the intensive care unit after severe traumatic brain injury
    Jean Christophe Copin
    Geneva Neuroscience Center, University of Geneva, Geneva, Switzerland
    Scand J Trauma Resusc Emerg Med 20:83. 2012
  9. pmc pROC: an open-source package for R and S+ to analyze and compare ROC curves
    Xavier Robin
    Biomedical Proteomics Research Group, Department of Structural Biology and Bioinformatics, Medical University Centre, Geneva, Switzerland
    BMC Bioinformatics 12:77. 2011
  10. doi request reprint Matrix metalloproteinase-9 and intercellular adhesion molecule 1 are powerful staging markers for human African trypanosomiasis
    Alexandre Hainard
    Biomedical Proteomics Research Group, Medical University Centre, Geneva, Switzerland
    Trop Med Int Health 16:119-26. 2011

Collaborators

Detail Information

Publications25

  1. doi request reprint A multiparameter panel method for outcome prediction following aneurysmal subarachnoid hemorrhage
    Natacha Turck
    Biomedical Proteomics Research Group, Department of Structural Biology and Bioinformatics, Medical University Centre, DBSB CMU, rue Michel Servet, 1, 1211 Geneva 4, Switzerland
    Intensive Care Med 36:107-15. 2010
    ....
  2. pmc Blood glutathione S-transferase-π as a time indicator of stroke onset
    Natacha Turck
    Biomedical Proteomics Research Group, Department of Human Protein Sciences, Faculty of Medicine, Geneva, Switzerland
    PLoS ONE 7:e43830. 2012
    ....
  3. doi request reprint Neopterin plasma concentrations in patients with aneurysmal subarachnoid hemorrhage: correlation with infection and long-term outcome
    Leire Azurmendi
    Department of Human Protein Sciences, University of Geneva, Geneva, Switzerland
    J Neurosurg 124:1287-99. 2016
    ..Furthermore, it is able to differentiate between infected and uninfected patients as early as 2 days before clinical signs of infection, facilitating earlier antibiotic therapy and better management. ..
  4. pmc Neopterin is a cerebrospinal fluid marker for treatment outcome evaluation in patients affected by Trypanosoma brucei gambiense sleeping sickness
    Natalia Tiberti
    Translational Biomarker Group, Department of Human Protein Sciences, University of Geneva, Geneva, Switzerland
    PLoS Negl Trop Dis 7:e2088. 2013
    ..New markers for treatment outcome evaluation are needed. We hypothesized that alternative CSF markers, able to diagnose the meningo-encephalitic stage of the disease, could also be useful for the evaluation of treatment outcome...
  5. doi request reprint The prognostic significance of the serum biomarker heart-fatty acidic binding protein in comparison with s100b in severe traumatic brain injury
    Bernhard Walder
    1 Division of Anaesthesiology, University Hospitals of Geneva, Geneva, Switzerland
    J Neurotrauma 30:1631-7. 2013
    ..Early blood levels of H-FABP after sTBI have prognostic significance for survival and disability...
  6. pmc Cerebrospinal fluid neopterin as marker of the meningo-encephalitic stage of Trypanosoma brucei gambiense sleeping sickness
    Natalia Tiberti
    Biomedical Proteomics Research Group, Department of Human Protein Sciences, University of Geneva, Geneva, Switzerland
    PLoS ONE 7:e40909. 2012
    ..In the present study we evaluated the potential of CXCL10, CXCL13, ICAM-1, VCAM-1, MMP-9, B2MG, neopterin and IgM to complement current methods for staging Trypanosoma brucei gambiense patients...
  7. pmc Discovery and verification of osteopontin and Beta-2-microglobulin as promising markers for staging human African trypanosomiasis
    Natalia Tiberti
    Biomedical Proteomics Research Group, Medical University Centre, Geneva, Switzerland
    Mol Cell Proteomics 9:2783-95. 2010
    ..8 and 5.5 respectively) make the two markers good candidates for the development of a test for staging HAT patients...
  8. pmc Matrix metalloproteinase 9 and cellular fibronectin plasma concentrations are predictors of the composite endpoint of length of stay and death in the intensive care unit after severe traumatic brain injury
    Jean Christophe Copin
    Geneva Neuroscience Center, University of Geneva, Geneva, Switzerland
    Scand J Trauma Resusc Emerg Med 20:83. 2012
    ..Secondary outcomes were the state of consciousness measured with the Glasgow Coma Scale (GCS) of survivors at 14 days and Glasgow Outcome Scale Extended (GOSE) at 3 months...
  9. pmc pROC: an open-source package for R and S+ to analyze and compare ROC curves
    Xavier Robin
    Biomedical Proteomics Research Group, Department of Structural Biology and Bioinformatics, Medical University Centre, Geneva, Switzerland
    BMC Bioinformatics 12:77. 2011
    ....
  10. doi request reprint Matrix metalloproteinase-9 and intercellular adhesion molecule 1 are powerful staging markers for human African trypanosomiasis
    Alexandre Hainard
    Biomedical Proteomics Research Group, Medical University Centre, Geneva, Switzerland
    Trop Med Int Health 16:119-26. 2011
    ....
  11. doi request reprint Relative quantification of proteins in human cerebrospinal fluids by MS/MS using 6-plex isobaric tags
    Loïc Dayon
    Biomedical Proteomics Group, Department of Structural Biology and Bioinformatics, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Anal Chem 80:2921-31. 2008
    ..ELISA for these proteins confirmed their elevated concentration in PM CSF. This work demonstrates the validity and robustness of the tandem mass tag (TMT) approach for quantitative MS-based proteomics...
  12. pmc New biomarkers for stage determination in Trypanosoma brucei rhodesiense sleeping sickness patients
    Natalia Tiberti
    Department of Human Protein Sciences, University of Geneva, Geneva, Switzerland
    Clin Transl Med 2:1. 2013
    ..b. rhodesiense patients. Further investigations are needed to better evaluate these molecules, alone or in panels, as alternatives to WBC to make reliable choice of treatment...
  13. doi request reprint Brain extracellular fluid protein changes in acute stroke patients
    Loï Dayon
    Biomedical Proteomics Group, Department of Structural Biology and Bioinformatics, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    J Proteome Res 10:1043-51. 2011
    ..Significant increases of 8- (p = 0.0002), 20- (p = 0.0001), and 11-fold (p = 0.0093) were found, respectively. This study highlights the value of ECF as an efficient source to further discover blood stroke markers...
  14. pmc Ubiquitin fusion degradation protein 1 as a blood marker for the early diagnosis of ischemic stroke
    Laure Allard
    Biomedical Proteomics Research Group, Department of Structural Biology and Bioinformatics, Medical University Center, CH 1211 Geneva 4, Switzerland
    Biomark Insights 2:155-64. 2007
    ..Ubiquitin fusion degradation protein 1 is increased in human postmortem CSF, a model of global brain insult, suggesting that its measurement in blood may prove useful as a biomarker of stroke...
  15. doi request reprint Isobaric tagging-based selection and quantitation of cerebrospinal fluid tryptic peptides with reporter calibration curves
    Loïc Dayon
    Biomedical Proteomics Group, Department of Structural Biology and Bioinformatics, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Anal Chem 82:848-58. 2010
    ..Assays for the concentration measurements of peptides from PARK7, GSTP1, NDKA, and S100B proteins in CSF were further characterized using this novel, efficient, and straightforward approach...
  16. doi request reprint Bioinformatics for protein biomarker panel classification: what is needed to bring biomarker panels into in vitro diagnostics?
    Xavier Robin
    Biomedical Proteomics Research Group, Department of Structural Biology and Bioinformatics, Medical University Centre, Geneva, Switzerland
    Expert Rev Proteomics 6:675-89. 2009
    ..In this article, we present a discussion of the bioinformatics aspects of biomarker panels and the concomitant challenges, including high dimensionality and low patient number and reproducibility...
  17. doi request reprint Proteomic analysis of human substantia nigra identifies novel candidates involved in Parkinson's disease pathogenesis
    Virginie Licker
    Neuroproteomics Group, University Medical Center, Faculty of Medicine, Geneva University, Geneva, Switzerland Translational Biomarker Group, University Medical Center, Faculty of Medicine, Geneva University, Geneva, Switzerland
    Proteomics 14:784-94. 2014
    ..All MS data have been deposited in the ProteomeXchange with identifier PXD000427 (http://proteomecentral.proteomexchange.org/dataset/PXD000427). ..
  18. doi request reprint Proteomic profiling of the substantia nigra demonstrates CNDP2 overexpression in Parkinson's disease
    Virginie Licker
    Neuroproteomics Group, University Medical Center, Geneva, Switzerland
    J Proteomics 75:4656-67. 2012
    ..This article is part of a Special Issue entitled: Translational Proteomics...
  19. ncbi request reprint Anti-(apolipoprotein A-1) IgGs are associated with high levels of oxidized low-density lipoprotein in acute coronary syndrome
    Nicolas Vuilleumier
    Division of Immunology and Allergy, Department of Internal Medicine, University Hospital, Geneva, Switzerland
    Clin Sci (Lond) 115:25-33. 2008
    ..These results emphasize the role of humoral autoimmunity as a mediator of inflammation and coronary atherogenesis...
  20. pmc A combined CXCL10, CXCL8 and H-FABP panel for the staging of human African trypanosomiasis patients
    Alexandre Hainard
    Biomedical Proteomics Research Group, Medical University Centre, Geneva, Switzerland
    PLoS Negl Trop Dis 3:e459. 2009
    ..We hypothesized that markers of brain damage discovered by proteomic strategies and inflammation-related proteins could individually or in combination indicate the CNS invasion by the parasite...
  21. ncbi request reprint Identification of brain cell death associated proteins in human post-mortem cerebrospinal fluid
    Jennifer A Burgess
    Biomedical Proteomics Research Group, Department of Structural Biology and Bioinformatics, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    J Proteome Res 5:1674-81. 2006
    ..Interestingly, among the proteins specifically identified in the post-mortem CSF, several have been previously described as biochemical markers of brain damage...
  22. doi request reprint Matrix metalloproteinase-9 concentration in the cerebral extracellular fluid of patients during the acute phase of aneurysmal subarachnoid hemorrhage
    Asita Sarrafzadeh
    Faculty of Medicine, University of Geneva, Switzerland
    Neurol Res 34:455-61. 2012
    ..The authors investigated MMP-9 concentration in brain extracellular fluid of aSAH patients and assessed whether this enzyme could have a predictive value for the risk of DCI...
  23. doi request reprint Measuring Serum Amyloid A for Infection Prediction in Aneurysmal Subarachnoid Hemorrhage
    Leire Azurmendi
    Department of Human Protein Sciences, University of Geneva, Rue Michel Servet 1, CH 1211 Geneva, Switzerland
    J Proteome Res 14:3948-56. 2015
    ..Its predictive capacity could lead to earlier antibiotherapy, improved patient management, and potentially better long-term outcomes. ..
  24. doi request reprint Quantitative analysis of human cerebrospinal fluid proteins using a combination of cysteine tagging and amine-reactive isobaric labeling
    Priscille Giron
    Biomedical Proteomics Group, Department of Structural Biology and Bioinformatics, University of Geneva, Geneva, Switzerland
    J Proteome Res 10:249-58. 2011
    ..e., without C³T cysteine-tagging and enrichment steps). Altogether, these results legitimate the use of this quantitative C³T strategy to enrich and relatively quantify cysteine-containing peptides in complex mixtures...
  25. doi request reprint Exploring the human tear fluid: discovery of new biomarkers in multiple sclerosis
    Cindy Salvisberg
    Translational Biomarker Group, Department of Human Protein Sciences, Medical University Center, Geneva, Switzerland
    Proteomics Clin Appl 8:185-94. 2014
    ..We proposed here that the exploration of tears from multiple sclerosis patients could lead to the discovery of new biomarkers...