Genomes and Genes
Affiliation: University of Bern
- Alcoholic steatohepatitisFelix Stickel
Department of Visceral Surgery and Medicine, Inselspital, University of Bern, Murtenstrasse 35, CH 3010 Bern, Switzerland
Best Pract Res Clin Gastroenterol 24:683-93. 2010..Treatment includes abstinence, enteral nutrition, corticosteroids, and possibly pentoxifylline. A debate is ongoing whether certain patients with severe alcoholic steatohepatitis could be eligible for liver transplantation...
- The genetics of alcohol dependence and alcohol-related liver diseaseFelix Stickel
Department of Gastroenterology and Hepatology, University Hospital of Zurich, Switzerland Electronic address
J Hepatol 66:195-211. 2017..The way in which this genetic information could potentially inform patient management has yet to be determined and tested...
- Alcoholic cirrhosis and hepatocellular carcinomaFelix Stickel
Department of Clinical Research, University of Bern, Murtenstrasse 35, CH 3010, Bern, Germany
Adv Exp Med Biol 815:113-30. 2015..Information presented in this chapter illustrates that the development of HCC in the context of ALD is multifaceted and suggests several molecular targets for prevention and markers for the screening of risk groups. ..
- Evaluation of genome-wide loci of iron metabolism in hereditary hemochromatosis identifies PCSK7 as a host risk factor of liver cirrhosisFelix Stickel
Department of Visceral Surgery and Medicine and
Hum Mol Genet 23:3883-90. 2014..PCSK7 variant rs236918 is a risk factor for cirrhosis in HH patients homozygous for the HFE C282Y mutation. ..
- Update on the management of alcoholic steatohepatitisFelix Stickel
Hepatology Unit, Klinik Beau Site, Department of Visceral Surgery and Medicine Inselspital, University of Bern, Bern, Switzerland
J Gastrointestin Liver Dis 22:189-97. 2013..Although considered a contraindication in most transplant centers, recent evidence indicates that carefully selected patients with AH could be good candidates for liver transplantation with a prognosis comparable to other indications. ..
- Critical review of the use of erythropoietin in the treatment of anaemia during therapy for chronic hepatitis CF Stickel
Department of Visceral Surgery and Medicine, Inselspital, University of Bern, Bern, Switzerland
J Viral Hepat 19:77-87. 2012..However, the evidence supporting its use in patients with pre-existing anaemia, non-1 viral genotypes, a former relapse or nonresponse, liver transplant recipients and cardiovascular or pulmonary disease is considered insufficient...
- Severe hepatotoxicity following ingestion of Herbalife nutritional supplements contaminated with Bacillus subtilisFelix Stickel
Institute of Clinical Pharmacology, University of Bern, Murtenstrasse 35, 3010 Bern, CH, Switzerland
J Hepatol 50:111-7. 2009..Nutritional supplements are widely used. Recently, liver injury after consumption of Herbalife preparations was reported but the underlying pathogenesis remained cryptic...
- Review of liver injury associated with dietary supplementsFelix Stickel
Department of Visceral Surgery and Medicine, Institute of Clinical Pharmacology and Visceral Research, Inselspital, University of Berne, Berne, Switzerland
Liver Int 31:595-605. 2011..Measures to reduce risk include tighter regulation of their production and distribution and increased awareness of users and professionals of the potential risks...
- No role of matrixmetalloproteinase-3 genetic promoter polymorphism 1171 as a risk factor for cirrhosis in alcoholic liver diseaseFelix Stickel
Institute of Clinical Pharmacology, University of Berne, Switzerland
Alcohol Clin Exp Res 32:959-65. 2008..We tested whether a functional promoter polymorphism in the gene encoding matrix metalloproteinase-3 (MMP-3; 1171 5A/6A) was associated liver cirrhosis in alcoholics...
- Role of nutrition in liver transplantation for end-stage chronic liver diseaseFelix Stickel
Institute of Clinical Pharmacology, Inselspital, University of Berne, Berne, Switzerland
Nutr Rev 66:47-54. 2008..Specific problems such as micronutrient deficiency, fluid balance, cholestasis, encephalopathy, and comorbid conditions need attention in order to optimize patient outcome...
- Genetic determinants of alcoholic liver diseaseFelix Stickel
Department of Visceral Surgery and Medicine, Inselspital, University of Berne, Murtenstrasse 35, 3010 Berne, Switzerland
Gut 61:150-9. 2012..Subsequently, the same variant was repeatedly confirmed as the first robust genetic risk factor for progressive ALD...
- The role of genetic polymorphisms in alcoholic liver diseaseFelix Stickel
Institute of Clinical Pharmacology, University of Berne, Murtenstrasse 35, CH 3010 Berne, Switzerland
Alcohol Alcohol 41:209-24. 2006....
- Potent antifibrotic activity of mTOR inhibitors sirolimus and everolimus but not of cyclosporine A and tacrolimus in experimental liver fibrosisEleonora Patsenker
Institute of Clinical Pharmacology and Visceral Research, University of Bern, Switzerland
J Hepatol 55:388-98. 2011..The aim of the present study was to compare the potential of the commonly used immunosuppressants to halt experimental liver fibrosis progression...
- Hepatic steatosis is associated with surgical-site infection after hepatic and colorectal surgeryAnita Kurmann
Department of Visceral Surgery and Medicine, Inselspital University Hospital Bern and University Bern, Bern, Switzerland
Surgery 156:109-16. 2014..The aim of the present study was to investigate the impact of hepatic steatosis on SSI in patients that underwent open abdominal surgery...
- Cannabinoid receptor type I modulates alcohol-induced liver fibrosisEleonora Patsenker
Department of Clinical Pharmacology and Visceral Research, University of Bern, Switzerland
Mol Med 17:1285-94. 2011..Inhibition of CB1 by SR141716, or via genetic knock-out protects against alcoholic-induced fibrosis in vitro and in vivo...
- Impact of genetic SLC28 transporter and ITPA variants on ribavirin serum level, hemoglobin drop and therapeutic response in patients with HCV infectionMonika Rau
Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland
J Hepatol 58:669-75. 2013..We aimed at studying genetic determinants of RBV kinetics, efficacy and treatment-associated anemia...
- Elevated liver regeneration in response to pharmacological reduction of elevated portal venous pressure by terlipressin after partial hepatectomyRene Fahrner
1 Division of Visceral Surgery and Medicine, Inselspital, University Hospital Bern, Bern, Switzerland 2 Department of Clinical Research, Inselspital, University Hospital Bern, Bern, Switzerland 3 Department of Pathology, Inselspital, University Hospital Bern, Bern, Switzerland 4 Address correspondence to Guido Beldi, M D, Division of Visceral Surgery and Medicine, University Hospital Bern, CH 3010 Bern, Switzerland
Transplantation 97:892-900. 2014..The aim of this study was to assess whether reduction of portal venous pressure by terlipressin improves postoperative liver regeneration in normal and steatotic livers after partial hepatectomy in a rodent model...
- Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasiansFelix Stickel
Institute of Clinical Pharmacology and Visceral Research, University of Bern, Bern, Switzerland
Hepatology 53:86-95. 2011..03). The population attributable risk of cirrhosis in alcoholic carriers of allele PNPLA3 rs738409(G) was estimated at 26.6%...
- Genetic variations in bile acid homeostasis are not overrepresented in alcoholic cirrhosis compared to patients with heavy alcohol abuse and absent liver diseaseNatalie Many
Department of Gastroenterology and Hepatology, University Hospital Zurich USZ, CH 8091 Zurich, Switzerland
Mutagenesis 27:567-72. 2012..We conclude that ABCB11 and NR1I1 polymorphisms are obviously not associated with development of cirrhosis in patients with ALD...
- Role of integrins in fibrosing liver diseasesEleonora Patsenker
Department of Visceral Surgery and Medicine, Inselspital, University of Bern, Switzerland
Am J Physiol Gastrointest Liver Physiol 301:G425-34. 2011..However, accumulating evidence points to an instrumental role of integrin-mediated signaling in a variety of chronic and acute noncancerous diseases, particularly of the liver...
- Repeat-dose sirolimus pharmacokinetics and pharmacodynamics in patients with hepatic allograftsJurg Reichen
University Clinic for Visceral Surgery and Medicine, University Hospital Inselspital, Berne, Switzerland
Eur J Clin Pharmacol 68:589-97. 2012....
- Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progressionEleonora Patsenker
Institute of Clinical Pharmacology, University of Bern, Bern, Switzerland
Gastroenterology 135:660-70. 2008..Because its role in liver fibrosis is unknown, we studied alphavbeta6 function in vitro and explored the antifibrotic potential of the specific alphavbeta6 antagonist EMD527040...
- Elevated levels of endocannabinoids in chronic hepatitis C may modulate cellular immune response and hepatic stellate cell activationEleonora Patsenker
Department of Clinical Research, University of Bern, Bern 3010, Switzerland
Int J Mol Sci 16:7057-76. 2015..In conclusion, ECs are increased in plasma of patients with CHC and might reveal immunosuppressive and profibrogenic effects. ..
- Relationship between renal resistance index and renal function in liver transplant recipients after cessation of calcineurin inhibitorUte Eisenberger
Department of Nephrology and Hypertension, University of Berne, Berne, Switzerland
Clin Transplant 23:499-504. 2009..016). Individual changes of RI correlated significantly with individual changes of crea (r = 0.54, p < 0.001). Conversion from CNI to SRL can ameliorate renal function accompanied by a reduction of intrarenal RI after OLT...
- Drug-induced acute liver injury mimicking autoimmune hepatitis after intake of dietary supplements containing glucosamine and chondroitin sulfateJohann von Felden
Department of Visceral Surgery and Medicine, University of Berne, Switzerland
Int J Clin Pharmacol Ther 51:219-23. 2013..Among the bestselling preparations are dietary supplement containing glucosamine and chondroitine sulfate taken to improve symptoms of osteoarthritis...
- Significance of serum adiponectin levels in patients with chronic liver diseaseMaria Luisa Balmer
Institute of Clinical Pharmacology and Visceral Research, University of Bern, Bern, Switzerland
Clin Sci (Lond) 119:431-6. 2010..In conclusion, adiponectin levels correlate positively with surrogate markers of hepatic fibrosis (transient elastography, fasting serum bile acids and hyaluronate) and are significantly elevated in cases of cirrhosis...
- Changes in biomarkers of liver disease during successful combination antiretroviral therapy in HIV-HCV-coinfected individualsJanine Rohrbach
Department of Infectious Diseases, Bern University Hospital and University of Bern, Bern, Switzerland
Antivir Ther 19:149-59. 2014....
- Alcohol dehydrogenase 1C*1 allele is a genetic marker for alcohol-associated cancer in heavy drinkersNils Homann
Department of Medicine I, University of Lubeck, Germany
Int J Cancer 118:1998-2002. 2006..11-4.36), respectively. The data identify genotype ADH1C*1/1 as an independent risk factor for the development of alcohol-associated tumors among heavy drinkers, indicating a genetic predisposition of individuals carrying this genotype...
- Serum hyaluronate correlates with histological progression in alcoholic liver diseaseFelix Stickel
Department of Medicine I, University of Erlangen Nuremberg, Erlangen, Germany
Eur J Gastroenterol Hepatol 15:945-50. 2003..In addition, serum hyaluronate was determined in 40 non-cirrhotic alcoholic patients with either a normal serum aspartate aminotransferase (AST) or an AST elevated at least two-fold...
- Association of myeloperoxidase promotor polymorphism with cirrhosis in patients with hereditary hemochromatosisChristoph H Osterreicher
Department of Internal Medicine IV, Gastroenterology and Hepatology, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Wien, Austria
J Hepatol 42:914-9. 2005..This study assessed the impact of polymorphisms of the MPO (-463G/A) and the HO-1 promotors of Vienna (GT)n on the evolution of cirrhosis in patients with HHC...
- TGF-beta1 codon 25 gene polymorphism is associated with cirrhosis in patients with hereditary hemochromatosisChristoph H Osterreicher
Department of Internal Medicine IV, Medical University of Vienna, Austria
Cytokine 31:142-8. 2005..8 (95% CI 1.4-5.7, p = 0.004). In conclusion, C282Y homozygotes carrying TGF-beta1 genotypes Arg/Pro and Pro/Pro are more likely to develop cirrhosis than those with genotype Arg/Arg...
- Prediction of progression to cirrhosis by a glutathione S-transferase P1 polymorphism in subjects with hereditary hemochromatosisFelix Stickel
Department of Medicine I, University of Erlangen Nurnberg, Erlangen, Germany
Arch Intern Med 165:1835-40. 2005..Our objective was to establish the role of the functional polymorphisms of GSTP1 (codon 105 Ile-->Val) and MnSOD (codon 16 of precursor protein Ala-->Val) on the evolution of cirrhosis in patients with HHC and CHC...
- Keratin variants associate with progression of fibrosis during chronic hepatitis C infectionPavel Strnad
Department of Medicine, Palo Alto VA Medical Center, Palo Alto, CA 94304, USA
Hepatology 43:1354-63. 2006..The unique 100% segregation of the most common K8 variant, R341H, with an intronic deletion suggests that one of these two genetic changes might lead to the other...
- Evaluation of the transforming growth factor beta1 codon 25 (Arg-->Pro) polymorphism in alcoholic liver diseaseChristoph H Osterreicher
Department of Medicine, University of California, San Diego, Leichtag Building, Room 349 I, 9500 Gilman Drive, 0702, La Jolla, CA 92093 0702, USA
Cytokine 42:18-23. 2008..Its contribution to the progression of ALD has not been investigated sufficiently so far...
- Copper availability contributes to iron perturbations in human nonalcoholic fatty liver diseaseElmar Aigner
General Hospital Oberndorf, Department of Internal Medicine, Oberndorf, Austria
Gastroenterology 135:680-8. 2008..Iron perturbations are frequently observed in nonalcoholic fatty liver disease (NAFLD). We aimed to investigate a potential association of copper status with disturbances of iron homeostasis in NAFLD...
- Genomics of liver fibrosis and cirrhosisChristoph H Osterreicher
Department of Medicine, Division of Digestive and Liver Diseases, Columbia University, New York, New York 10032, USA
Semin Liver Dis 27:28-43. 2007....
- Slimming at all costs: Herbalife-induced liver injuryFelix Stickel
J Hepatol 47:444-6. 2007
- Herbal hepatotoxicityFelix Stickel
Department of Medicine, Salem Medical Center, Heidelberg, Germany
J Hepatol 43:901-10. 2005
- Alcoholic liver disease in the elderlyHelmut K Seitz
Department of Medicine and Center of Alcohol Research, Liver Disease and Nutrition, Salem Medical Center, University of Heidelberg, Zeppelinstrasse 11 33, D 69121 Heidelberg, Germany
Clin Geriatr Med 23:905-21, viii. 2007..In addition, chronic alcohol consumption may enhance drug associated liver disease and may also act as a cofactor in other liver diseases, such as viral hepatitis and nonalcoholic fatty liver disease...
- Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapiesYury Popov
Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Hepatol 48:453-64. 2008..We studied alphavbeta6 expression in experimental and human liver fibrosis and the potential of its pharmacological inhibition for treatment of hepatic fibrosis...
- Alcoholic liver disease: from pathophysiology to therapyHelmut K Seitz
Department of Medicine, Salem Medical Center, Heidelberg, Germany
Alcohol Clin Exp Res 29:1276-81. 2005
- Hepatotoxicity of alcohol-induced polar retinol metabolites involves apoptosis via loss of mitochondrial membrane potentialZili Dan
Laboratory of Liver Research, Department of Medicine I, University of Erlangen Nuremberg, Erlangen, Germany
FASEB J 19:845-7. 2005..No toxicity was found with equivalent doses of the control extract from nonalcoholic rats. We demonstrate that polar retinol metabolites cause marked hepatocyte death through the induction of apoptosis...
- Hepatitis induced by Kava (Piper methysticum rhizoma)Felix Stickel
Department of Medicine I, Friedrich Alexander University Erlangen Nuremberg, Ulmenweg 18, D 91054 Erlangen, Germany
J Hepatol 39:62-7. 2003..Kava root (Piper methysticum rhizoma), used frequently in Europe as a remedy against anxiety, contains kavapyrones with sedative effects. Seven case reports suggested the development of hepatitis after the intake of Kava...