Ronald Simon

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. ncbi request reprint Tissue microarrays
    Ronald Simon
    University of Basel, Institut fur Pathologie, Schonbeinstrasse 40, Basel, Switzerland
    Biotechniques 36:98-105. 2004
  2. ncbi request reprint Tissue microarray (TMA) applications: implications for molecular medicine
    Ronald Simon
    Institute of Pathology, University of Basel, Schoenbeinstrasse 40, CH 4031 Basel, Switzerland
    Expert Rev Mol Med 5:1-12. 2003
  3. ncbi request reprint Tissue microarrays in cancer diagnosis
    Ronald Simon
    Institute of Pathology, Division of Molecular Pathology, University of Basel, Switzerland
    Expert Rev Mol Diagn 3:421-30. 2003
  4. ncbi request reprint Close association between HER-2 amplification and overexpression in human tumors of non-breast origin
    Coya Tapia
    Institute of Pathology, University of Basel, Basel, Switzerland
    Mod Pathol 20:192-8. 2007
  5. pmc TRIO amplification and abundant mRNA expression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer
    Min Zheng
    Institute of Pathology, University of Basel, Schoenbeinstrasse 40, CH 4031 Basel, Switzerland
    Am J Pathol 165:63-9. 2004
  6. ncbi request reprint Expression and amplification of therapeutic target genes in retinoblastoma
    Doris Bösch
    Universitäts Augenklinik Basel, Mittlere Strasse 91, 4056, Basel, Switzerland
    Graefes Arch Clin Exp Ophthalmol 243:156-62. 2005
  7. ncbi request reprint HER2 analysis in breast cancer: reduced immunoreactivity in FISH non-informative cancer biopsies
    Coya Tapia
    Institute of Pathology, University of Basel, Basel, Switzerland
    Int J Oncol 25:1551-7. 2004
  8. ncbi request reprint Tissue microarrays for comparing molecular features with proliferation activity in breast cancer
    Christian Ruiz
    Institute of Pathology, University Hospital Basel, 4031 Basel, Switzerland
    Int J Cancer 118:2190-4. 2006
  9. ncbi request reprint Prevalence of KIT expression in human tumors
    Philip Th Went
    Institute of Pathology, University of Basel, Basel, Switzerland
    J Clin Oncol 22:4514-22. 2004
  10. ncbi request reprint E2F3 amplification and overexpression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer
    Martin Oeggerli
    Institute of Pathology, Schoenbeinstrasse 40, CH 4031 Basel, Switzerland
    Oncogene 23:5616-23. 2004

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Tissue microarrays
    Ronald Simon
    University of Basel, Institut fur Pathologie, Schonbeinstrasse 40, Basel, Switzerland
    Biotechniques 36:98-105. 2004
    ..The TMA technology is a fast, cost-effective, and statistically powerful method that will substantially facilitate translational research...
  2. ncbi request reprint Tissue microarray (TMA) applications: implications for molecular medicine
    Ronald Simon
    Institute of Pathology, University of Basel, Schoenbeinstrasse 40, CH 4031 Basel, Switzerland
    Expert Rev Mol Med 5:1-12. 2003
    ..Thus, TMA technology will markedly accelerate the transition from basic research to clinical applications...
  3. ncbi request reprint Tissue microarrays in cancer diagnosis
    Ronald Simon
    Institute of Pathology, Division of Molecular Pathology, University of Basel, Switzerland
    Expert Rev Mol Diagn 3:421-30. 2003
    ..Current applications and the future potential of tissue microarray technology in cancer research and diagnosis are discussed...
  4. ncbi request reprint Close association between HER-2 amplification and overexpression in human tumors of non-breast origin
    Coya Tapia
    Institute of Pathology, University of Basel, Basel, Switzerland
    Mod Pathol 20:192-8. 2007
    ..Such tumor entities should be carefully evaluated for a possible utility of trastuzumab treatment...
  5. pmc TRIO amplification and abundant mRNA expression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer
    Min Zheng
    Institute of Pathology, University of Basel, Schoenbeinstrasse 40, CH 4031 Basel, Switzerland
    Am J Pathol 165:63-9. 2004
    ..It is concluded that TRIO up-regulation through amplification has a potential role in bladder cancer progression...
  6. ncbi request reprint Expression and amplification of therapeutic target genes in retinoblastoma
    Doris Bösch
    Universitäts Augenklinik Basel, Mittlere Strasse 91, 4056, Basel, Switzerland
    Graefes Arch Clin Exp Ophthalmol 243:156-62. 2005
    ..We set out to evaluate alterations of the therapeutic target genes KIT (CD 117), EGFR, and HER-2 in human retinoblastoma...
  7. ncbi request reprint HER2 analysis in breast cancer: reduced immunoreactivity in FISH non-informative cancer biopsies
    Coya Tapia
    Institute of Pathology, University of Basel, Basel, Switzerland
    Int J Oncol 25:1551-7. 2004
    ..Poor tissue quality can be easily identified in FISH analyses because of a lack of hybridization signals. Inappropriate tissue handling is more dangerous in IHC because an artificial lack of staining can be regarded as 'negative' result...
  8. ncbi request reprint Tissue microarrays for comparing molecular features with proliferation activity in breast cancer
    Christian Ruiz
    Institute of Pathology, University Hospital Basel, 4031 Basel, Switzerland
    Int J Cancer 118:2190-4. 2006
    ..6 mm in diameter. We conclude that associations with cell proliferation can be reliably analyzed in a TMA format...
  9. ncbi request reprint Prevalence of KIT expression in human tumors
    Philip Th Went
    Institute of Pathology, University of Basel, Basel, Switzerland
    J Clin Oncol 22:4514-22. 2004
    ..Because recent studies in GISTs suggest that KIT-activating mutations predict response to imatinib therapy, we also sequenced a subset of positive tumors...
  10. ncbi request reprint E2F3 amplification and overexpression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer
    Martin Oeggerli
    Institute of Pathology, Schoenbeinstrasse 40, CH 4031 Basel, Switzerland
    Oncogene 23:5616-23. 2004
    ..E2F3 expression appears to provide a growth advantage to tumor cells by activating cell proliferation in a subset of bladder tumors...
  11. ncbi request reprint Tissue microarrays
    Ronald Simon
    Institute of Pathology, University Hospital, Basel, Switzerland
    Methods Mol Med 97:377-89. 2004
  12. ncbi request reprint KIT (CD117)-positive breast cancers are infrequent and lack KIT gene mutations
    Ronald Simon
    Institute of Pathology, University of Basel, Basel, Switzerland
    Clin Cancer Res 10:178-83. 2004
    ..KIT (CD117) is a transmembrane tyrosine kinase representing a target for STI571 (Glivec) therapy. Some KIT-overexpressing solid tumors have responded favorably to STI571, potentially because of the presence of KIT-activating mutations...
  13. ncbi request reprint Influence of slide aging on results of translational research studies using immunohistochemistry
    Martina Mirlacher
    Institute for Pathology, University of Basel, CH 1031 Basel, Switzerland
    Mod Pathol 17:1414-20. 2004
    ....
  14. ncbi request reprint Tissue microarrays for miniaturized high-throughput molecular profiling of tumors
    Ronald Simon
    Institute of Pathology, University of Basel, Schoenbeinstrasse 40, CH 4031 Basel, Switzerland
    Exp Hematol 30:1365-72. 2002
    ..Thus, TMA technology allows miniaturized high-throughput molecular epidemiologic studies. The TMA technique will markedly accelerate the transition from basic research to clinical applications...
  15. ncbi request reprint HER-2 and TOP2A coamplification in urinary bladder cancer
    Ronald Simon
    Institute for Pathology and Urologic Clinics, University of Basel, Basel, Switzerland
    Int J Cancer 107:764-72. 2003
    ..In summary, our data suggest that HER-2 amplifications are frequently linked to alterations of the TOP2A gene in bladder cancer. The anatomy of the 17q12-q21 amplicon may be important for response to therapies targeting HER-2 or TOP2A...
  16. ncbi request reprint Impaired expression of the cell cycle regulator BTG2 is common in clear cell renal cell carcinoma
    Kirsten Struckmann
    Institute for Pathology, University of Basel, Basel, Switzerland
    Cancer Res 64:1632-8. 2004
    ..In both experiments, BTG2 mRNA levels did not reach values observed in normal renal tissue. These data suggest that down-regulation of BTG2 is an important step in renal cancer development...
  17. ncbi request reprint Predictive molecular pathology
    Guido Sauter
    University of Basel, CH 4003 Basel, Switzerland
    N Engl J Med 347:1995-6. 2002
  18. ncbi request reprint Tissue microarrays in drug discovery
    Guido Sauter
    Institut of Pathology, University of Basel, Schoenbeinstrasse 40, CH 4031 Basel, Switzerland
    Nat Rev Drug Discov 2:962-72. 2003
  19. ncbi request reprint Sequence analysis and high-throughput immunohistochemical profiling of KIT (CD 117) expression in uveal melanoma using tissue microarrays
    Mona Pache
    University Eye Clinic of Basel, Basel, Switzerland
    Virchows Arch 443:741-4. 2003
    ..In conclusion, human posterior uveal melanoma frequently expresses CD117 at high levels. Although KIT mutations could not be found, it appears justified to investigate the utility of imatinib mesylate in the treatment of these patients...
  20. ncbi request reprint Prognostic relevance of MAGE-A4 tumor antigen expression in transitional cell carcinoma of the urinary bladder: a tissue microarray study
    Thomas Kocher
    General Surgery Service, Department of Surgery, University Hospital of Basel, Hebelstrasse 20, CH 4031 Basel, Switzerland
    Int J Cancer 100:702-5. 2002
    ..0001). These data suggest that evaluation of MAGE-A4 protein expression is useful in the identification of groups of TCCs characterized by severe prognosis, thus possibly providing indications for early MAGE TAA-targeted immunotherapy...
  21. ncbi request reprint Amplification pattern of 12q13-q15 genes (MDM2, CDK4, GLI) in urinary bladder cancer
    Ronald Simon
    Institute for Pathology and Urologic Clinics, University of Basel, Schoenbeinstrasse 40, CH 4003 Basel, Switzerland
    Oncogene 21:2476-83. 2002
    ..04) and from low to high grade (P<0.005). These data are consistent with a high level of genetic instability in invasively growing and high-grade bladder tumors...
  22. ncbi request reprint Selective expression of a splice variant of decay-accelerating factor in c-erbB-2-positive mammary carcinoma cells showing increased transendothelial invasiveness
    Burkhard Brandt
    Institute of Clinical Chemistry and Laboratory Medicine, University of Muenster, Germany
    Biochem Biophys Res Commun 329:318-23. 2005
    ..Due to the fact that it could thereby not be detected in normal mammary tissues, it has to be confirmed in larger studies that the DAF splice variant might be a specific tumour marker for invasive breast cancer...
  23. ncbi request reprint Gene expression profiling of progressive papillary noninvasive carcinomas of the urinary bladder
    Peter J Wild
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Clin Cancer Res 11:4415-29. 2005
    ....
  24. pmc HER2, TOP2A, CCND1, EGFR and C-MYC oncogene amplification in colorectal cancer
    Khawla Al-Kuraya
    Department of Human Cancer Genomic Research, Research Centre at King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    J Clin Pathol 60:768-72. 2007
    ..In this study, the molecular differences between the incidences of colorectal carcinoma in Saudi and Swiss populations are investigated...
  25. ncbi request reprint Microsatellite DNA alterations of gastrointestinal stromal tumors are predictive for outcome
    Paulus Schurr
    Department of General, Visceral, and Thoracic Surgery and Institute of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 12:5151-7. 2006
    ..In gastrointestinal stromal tumors (GIST), loss of heterozygosity (LOH) on chromosome 22 and its presumptive biological function has been described. The prognostic value of these and other DNA regions for patient survival remains unclear...
  26. ncbi request reprint Frequent homogeneous HER-2 amplification in primary and metastatic adenocarcinoma of the esophagus
    Uta Reichelt
    Department of Pathology, University Medical Center Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
    Mod Pathol 20:120-9. 2007
    ..The strong concordance of the HER-2 status in primary and metastatic cancers argues for a possible response of metastases from patients with HER-2-positive primary tumors to Herceptin...
  27. pmc The expression and action of decay-accelerating factor (CD55) in human malignancies and cancer therapy
    Jan Henrik Mikesch
    Department of Haematology Oncology, University of Muenster, Germany
    Cell Oncol 28:223-32. 2006
    ..Therefore, DAF has already become a target for therapy. In this paper we review the role of DAF in human malignancies as described in different basic, diagnostic and experimental therapeutic studies...
  28. ncbi request reprint High-throughput tissue microarray analysis of 11q13 gene amplification (CCND1, FGF3, FGF4, EMS1) in urinary bladder cancer
    Boriana M Zaharieva
    Department of Medical Genetics, Medical University, Zdrave 2, 1431 Sofia, Bulgaria
    J Pathol 201:603-8. 2003
    ..6% and FGF4 in 0.8%. Overall, the amplification frequency decreased with increasing genomic distance from CCND1, suggesting that, among the genes examined, CCND1 is the major target gene in the 11q13 amplicon in bladder cancer...
  29. ncbi request reprint Marked gene transcript level alterations occur early during radical prostatectomy
    Thorsten Schlomm
    Martini Clinic, Prostate Cancer Center, University Medical Center, Hamburg Eppendorf, Germany
    Eur Urol 53:333-44. 2008
    ..However, transcript level patterns and RNA quality could rapidly change in response to ischemic and mechanical stress. Studies have shown that this occurs both perioperatively and after surgical removal of organs...
  30. ncbi request reprint Decay-accelerating factor (CD55): a versatile acting molecule in human malignancies
    Jan Henrik Mikesch
    Department of Haematology Oncology, University Hospital, Westf Wilhelms Univ Münster, Germany
    Biochim Biophys Acta 1766:42-52. 2006
    ..Furthermore, DAF has already been included in diagnostic or therapeutic studies. Thereby, studies applying monoclonal anti-DAF antibodies and anti-DAF vaccination for a targeted therapy have been enrolled recently...
  31. ncbi request reprint High throughput tissue microarray analysis of FHIT expression in diffuse large cell B-cell lymphoma from Saudi Arabia
    Khawla Al Kuraya
    Cancer Genomics, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia
    Mod Pathol 19:1124-9. 2006
    ....
  32. ncbi request reprint Colorectal carcinoma from Saudi Arabia. Analysis of MLH-1, MSH-2 and p53 genes by immunohistochemistry and tissue microarray analysis
    Khawla S Al-Kuraya
    Research Research Centre, King Faisal Specialist Hospital, Riyadh, Kingdom of Saudi Arabia
    Saudi Med J 27:323-8. 2006
    ..To document the incidence and role of p53 and DNA mismatch repair proteins in colorectal carcinomas, and to evaluate the relative frequency of major molecular pathways in colorectal cancers from Saudi Arabia...
  33. ncbi request reprint The role of CXCR4 receptor expression in breast cancer: a large tissue microarray study
    Ombretta Salvucci
    Department of Biomedical Sciences and Biotechnology, Division of Human Anatomy, University of Brescia, Brescia, Italy
    Breast Cancer Res Treat 97:275-83. 2006
    ..Its cytoplasmic expression is associated with breast tumor progression, suggesting potential value as a diagnostic marker...
  34. ncbi request reprint Tissue microarrays for high-throughput molecular pathology
    Khawla Al Kuraya
    King Faisal Hospital and Research Center, Riyadh, Saudi Arabia
    Ann Saudi Med 24:169-74. 2004
    ..Because of its beneficial economic aspects and ability to differentiate ethnic differences in tumor biology, TMA applications may become particularly important in developing countries...
  35. ncbi request reprint Tissue microarrays
    Ronald Simon
    Department of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Methods Mol Med 114:257-68. 2005
    ..Because all tissues are analyzed simultaneously with the same batch of reagents, TMA studies provide an unprecedented degree of standardization, speed, and cost efficiency...
  36. ncbi request reprint High-throughput tissue microarray analysis of CMYC amplificationin urinary bladder cancer
    Boriana Zaharieva
    Department of Medical Genetics, Medical University of Sofia, Sofia, Bulgaria
    Int J Cancer 117:952-6. 2005
    ..Patient prognosis was not affected by CMYC gene copy number changes...
  37. ncbi request reprint High Ep-CAM expression is associated with poor prognosis in node-positive breast cancer
    Gilbert Spizzo
    Division of Haematology and Oncology, University of Innsbruck, Innsbruck, Austria
    Breast Cancer Res Treat 86:207-13. 2004
    ....
  38. doi request reprint Distinct gene expression profiles: nodal versus extranodal diffuse large B-cell lymphoma
    Zeenath Jehan
    Human Cancer Genomic Research, King Fahad National Centre for Children s Cancer and Research, Riyadh, Saudi Arabia
    Oncology 75:71-80. 2008
    ..Perceived differences in outcome between extranodal and nodal DLBCL raise the possibility that these subgroups may represent different biological and clinical entities...