Genomes and Genes
Affiliation: University Hospital
- Fibrinogen gamma375 arg-->trp mutation (fibrinogen aguadilla) causes hereditary hypofibrinogenemia, hepatic endoplasmic reticulum storage disease and cirrhosisLaura Rubbia-Brandt
Gastrointestinal and Liver Pathology Unit, University Hospital, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
Am J Surg Pathol 30:906-11. 2006..Our results suggest that familial hypofibrinogenemia should be considered in the differential diagnosis of a progressive liver disease associated to hepatocellular intracytoplasmic globular inclusions...
- Liver steatosis in chronic hepatitis C: a morphological sign suggesting infection with HCV genotype 3L Rubbia-Brandt
Division of Clinical Pathology, University Hospital, 1 rue Michel Servet, 1211 Geneva, Switzerland
Histopathology 39:119-24. 2001..To identify factors associated with liver steatosis in chronic hepatitis C...
- Sinusoidal obstruction syndrome and nodular regenerative hyperplasia are frequent oxaliplatin-associated liver lesions and partially prevented by bevacizumab in patients with hepatic colorectal metastasisLaura Rubbia-Brandt
Division of Pathology, Geneva University Hospital, Geneva, Switzerland
Histopathology 56:430-9. 2010....
- Sinusoidal obstruction syndromeLaura Rubbia-Brandt
Division of Clinical Pathology of University Hospital, Geneva, Switzerland
Clin Liver Dis 14:651-68. 2010....
- [Hepatic lesions induced by systemic chemotherapy for digestive cancer]Laura Rubbia-Brandt
Hopitaux Universitaires de Geneve, Suisse
Ann Pathol 30:421-5. 2010..The new targeted molecules do not seem to modify the postoperative course. Hepatic injury and postoperative complications associated with chemotherapies used in the treatment of digestive cancers are summarized in this review...
- Gene expression profiling provides insights into pathways of oxaliplatin-related sinusoidal obstruction syndrome in humansLaura Rubbia-Brandt
Service de pathologie clinique, Hopitaux Universitaires de Geneve, 1211 Geneva, Switzerland
Mol Cancer Ther 10:687-96. 2011..Activation of VEGF and coagulation (vWF) pathways could partially explain at a molecular level the clinical observations that bevacizumab and aspirin have a preventive effect in SOS...
- Lymphatic vessel density and vascular endothelial growth factor-C expression correlate with malignant behavior in human pancreatic endocrine tumorsLaura Rubbia-Brandt
Services of Clinical Pathology, Gastroenterology and Hepatology, and Digestive Surgery, Geneva University Hospital, Geneva, Switzerland
Clin Cancer Res 10:6919-28. 2004..These findings strongly suggest that lymphangiogenesis occurs in pancreatic endocrine tumors and that lymphatic invasion and the development of metastases are associated with VEGF-C expression...
- Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancerL Rubbia-Brandt
Division of Clinical Pathology, University Hospital, Geneva, Switzerland
Ann Oncol 15:460-6. 2004..The objective of this study was to assess the effects of preoperative systemic chemotherapy on the morphology of non-tumoral liver...
- Neoadjuvant chemotherapy in patients with stage IV colorectal cancer: a comparison of histological response in liver metastases, primary tumors, and regional lymph nodesPascal Gervaz
Department of Surgery, University Hospital Geneva, Geneva, Switzerland
Ann Surg Oncol 17:2714-9. 2010..This study was designed to compare the response to chemotherapy in liver metastases, primary tumors, and locoregional lymph nodes...
- Liver resection for colorectal metastases after chemotherapy: impact of chemotherapy-related liver injuries, pathological tumor response, and micrometastases on long-term survivalLuca Vigano
Departments of HPB and Digestive Surgery and Pathology, Ospedale Mauriziano Umberto I, Torino, Italy and Departments of Visceral and Transplantation Surgery and Clinical Pathology, University Hospitals, Geneva, Switzerland
Ann Surg 258:731-40; discussion 741-2. 2013....
- Early liver biopsy, intraparenchymal cholestasis, and prognosis in patients with alcoholic steatohepatitisLaurent Spahr
Gastroenterology and Hepatology, Specialities Department, University Hospitals of Geneva, 4, rue Gabrielle Perret Gentil, CH 1211 Geneva, Switzerland
BMC Gastroenterol 11:115. 2011..Whether these lesions, in addition to other histological features observed in liver tissue specimens, have prognostic significance is unclear...
- Severe acute pancreatitis and reduced acinar cell apoptosis in the exocrine pancreas of mice deficient for the Cx32 geneJean Louis Frossard
Divisions of Gastroenterology, University Hospitals, Geneva, Switzerland
Gastroenterology 124:481-93. 2003....
- Intrahepatic mRNA levels of SOCS1 and SOCS3 are associated with cirrhosis but do not predict virological response to therapy in chronic hepatitis CStéphanie Pascarella
Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
Liver Int 33:94-103. 2013..The suppressor of cytokine signalling (SOCS) family members have been suggested to affect the rate of virological response to therapy, but the published evidence is conflicting...
- Autologous bone marrow mononuclear cell transplantation in patients with decompensated alcoholic liver disease: a randomized controlled trialLaurent Spahr
Division of Gastroenterology and Hepatology, University Hospitals and Faculty of Medicine, Geneva, Switzerland
PLoS ONE 8:e53719. 2013..We assessed whether autologous bone marrow mononuclear cell transplantation (BMMCT) improved liver function in decompensated ALD...
- Lack of in vivo blockade of Fas- and TNFR1-mediated hepatocyte apoptosis by the hepatitis C virusLaura Rubbia-Brandt
Division of Clinical Pathology, University Hospital, 1211 Geneva, Switzerland
J Pathol 197:617-23. 2002..In conclusion, an HCV-mediated, in vivo blockade of hepatocyte apoptosis via the Fas- or TNFR1-dependent pathways seems unlikely...
- Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid dropletsSophie Clement
Division of Clinical Pathology, University Hospital, Geneva, Switzerland
Hepatology 54:38-49. 2011..However, IRS1 knockdown per se did not alter the morphology of lipid droplets, and this suggests that other PTEN-dependent mechanisms are involved in this process...
- Hepatic regeneration is decreased in a rat model of sinusoidal obstruction syndromeEduardo Schiffer
Laboratoire de Physiopathologie Hépatique et Imagerie Moléculaire, Hopitaux Universitaires de Geneve, Geneva 1205, Switzerland
J Surg Oncol 99:439-46. 2009..However, the drug may severely injure hepatic sinusoids, inducing a sinusoidal obstruction syndrome in non-tumoral parenchyma with a risk of decreased regeneration in the remnant liver following partial hepatectomy...
- Soluble TNF-R1, but not tumor necrosis factor alpha, predicts the 3-month mortality in patients with alcoholic hepatitisLaurent Spahr
Gastroenterology and Hepatology, University Hospital, Geneva, Switzerland
J Hepatol 41:229-34. 2004..In patients with AH, we determined the prognostic value of TNF alpha, sTNF-R1, and lipopolysaccharide binding protein (LBP) and CD14, both involved in endotoxemia-associated inflammation...
- 'Liver first' approach in the treatment of colorectal cancer with synchronous liver metastasesGilles Mentha
Department of Surgery, University Hospitals of Geneva, Geneva, Switzerland
Dig Surg 25:430-5. 2008..The present series updates on a previously reported pilot experience...
- Impaired hepatic mitochondrial oxidation using the 13C-methionine breath test in patients with macrovesicular steatosis and patients with cirrhosisLaurent Spahr
Division of Gastroenterology and Hepatology, University Hospital, Geneva, Switzerland
Med Sci Monit 9:CR6-11. 2003..In human steatosis, ultrastructural changes are reported in the absence of ethanol. Routine evaluation of mitochondrial function is difficult. We used a breath test to explore hepatic mitochondrial oxidation in vivo...
- Combination of steroids with infliximab or placebo in severe alcoholic hepatitis: a randomized controlled pilot studyLaurent Spahr
Gastroenterology and Hepatology, University Hospital, 24 Rue Micheli du Crest, 1211, Geneva, Switzerland
J Hepatol 37:448-55. 2002..The aim of this study is to evaluate the tolerance and effects of infliximab combined with steroids in severe alcoholic hepatitis (AH)...
- Improved liver function after portal vein embolization and an elective right hepatectomyRaphael P H Meier
Hepato Pancreato Biliary Centre, Visceral and Transplantation Surgery, Department of Surgery, University Hospitals of Geneva and Faculty of Medicine, Geneva, Switzerland
HPB (Oxford) 17:1009-18. 2015..6% of the patient's weight). The objective was to determine whether pre-operative PVE impacts on post-operative liver function independently from the increase in liver volume...
- An in vitro model of hepatitis C virus genotype 3a-associated triglycerides accumulationKarim Abid
Division of Gastroenterology and Hepatology, University Hospital, 24 Rue Micheli du Crest, CH 1211 Geneva, Switzerland
J Hepatol 42:744-51. 2005..To extend these observations, we established an in vitro model expressing the HCV core of different genotypes...
- Fat diet and alcohol-induced steatohepatitis after LPS challenge in mice: role of bioactive TNF and Th1 type cytokinesMaria L Olleros
Department of Pathology and Immunology, Centre Medical Universitaire, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
Cytokine 44:118-25. 2008..In this model, changes in the regulation of TNF are associated with increased expression of IL-6, IFN-gamma, and iNOS...
- Granulocyte-colony stimulating factor induces proliferation of hepatic progenitors in alcoholic steatohepatitis: a randomized trialLaurent Spahr
Department of Gastroenterology and Hepatology, University Hospital, Geneva, Switzerland
Hepatology 48:221-9. 2008..003). Changes in Ki67+/cytokeratin 7+ cells correlated with changes in CD34+ cells (r = 0.65, P < 0.03). Neutrophils and histological changes were similar in both groups...
- Hepatic cell proliferation plays a pivotal role in the prognosis of alcoholic hepatitisNicolas Lanthier
Gastroenterology and Hepatology, University Hospitals and Faculty of Medicine, Geneva, Switzerland Laboratory of Hepato Gastroenterology, Institut de Recherche Expérimentale et Clinique, Universite Catholique de Louvain, Brussels, Belgium
J Hepatol 63:609-21. 2015..We aimed to characterize the LPC and macrophage compartments in alcoholic hepatitis (AH), as well as gene expression patterns to identify predictors of a good prognosis in this setting...
- Complete pathological response (ypT0N0M0) after preoperative chemotherapy alone for stage IV rectal cancerSurennaidoo P Naiken
Services de chirurgie viscérale et transplantation, Departement de Chirurgie, Hopitaux Universitaires de Geneve, Rue Gabrielle Perret Gentil 4, Genève 14 1211, Suisse
BMC Surg 14:4. 2014..The possibility that complete pathological response of rectal cancer can also occur with neoadjuvant chemotherapy alone (without radiation) is an intriguing hypothesis...
- Rectal outcomes after a liver-first treatment of patients with stage IV rectal cancerNicolas C Buchs
Department of Surgery, Clinic for Visceral and Transplantation Surgery, University Hospital of Geneva, Geneva, Switzerland
Ann Surg Oncol 22:931-7. 2015..We developed a reverse strategy, the liver-first approach, to optimize the chance of a curative resection. The aim of this study was to assess rectal outcomes after reverse treatment of patients with metastatic rectal cancer...
- Expression of the bile acid receptor FXR in Barrett's esophagus and enhancement of apoptosis by guggulsterone in vitroAndrea De Gottardi
Division of Gastroenterology, University Hospital, Micheli du Crest 24, 1205 Geneva, Switzerland
Mol Cancer 5:48. 2006..The aim of this study was to assess the expression of bile acid receptors in the esophagus (normal, esophagitis, Barrett's esophagus and adenocarcinoma) and to investigate their possible function...
- Herpes simplex virus load to monitor antiviral treatment after liver transplantation for acute herpetic hepatitisJuan Ambrosioni
Service of Infectious Diseases, Department of Medical Specialities, University Hospitals of Geneva, Geneva, Switzerland
Antivir Ther 17:401-4. 2012..We present a case of ALF complicating a primary HSV-1 infection in an immunocompetent host, who required emergency LT. We further discuss the value of measuring serial HSV DNA plasma loads to monitor antiviral therapy...
- Focal ischemic necrosis in advanced biliary atresia cirrhosisBarbara E Wildhaber
Department of Pediatric Surgery, University Hospital of Geneva, Geneva, Switzerland
Pediatr Transplant 12:487-91. 2008..Because of precarious hepatic blood supply in such patients, close monitoring of portal and diastolic arterial flows is recommended...
- Operative management of colorectal liver metastasesGilles Mentha
Divisions of Transplantation and Visceral Surgery, Department of Surgery, University Hospitals of Geneva, Switzerland
Semin Liver Dis 33:262-72. 2013..These rates would have been unimaginable only two decades ago. ..
- Liver progenitor cells and therapeutic potential of stem cells in human chronic liver diseasesNicolas Lanthier
Gastroenterology and Hepatology, Specialities Department, University Hospitals of Geneva, Geneva, Switzerland
Acta Gastroenterol Belg 76:3-9. 2013..Present data on stem cell therapy are heterogeneous in terms of methods and endpoints; thus, results need to be carefully examined prior to drawing a conclusion on possible benefits...
- Echovirus 11 infection induces dramatic changes in the actin cytoskeleton of polarized Caco-2 cellsKomla Sobo
Department of Clinical Pathology, University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
J Gen Virol 93:475-87. 2012....
- Mice deficient in hepatocyte-specific IL-1Ra show delayed resolution of concanavalin A-induced hepatitisCeline Lamacchia
Division of Rheumatology, University Hospital and Department of Pathology and Immunology, University of Geneva School of Medicine, Geneva, Switzerland
Eur J Immunol 42:1294-303. 2012..In conclusion, our results show that the local production of IL-1Ra by hepatocytes contributes to the resolution of hepatitis...
- Extensive biliary intraepithelial neoplasia (BilIN) and multifocal early intrahepatic cholangiocarcinoma in non-biliary cirrhosisAnne Laure Rougemont
Division of Clinical Pathology, Geneva University Hospitals, Rue Gabrielle Perret Gentil 4, 1211, Geneva 14, Switzerland
Virchows Arch 456:711-7. 2010....
- Circulating concentrations of interleukin-18, interleukin-18 binding protein, and gamma interferon in patients with alcoholic hepatitisLaurent Spahr
Gastroenterology and Hepatology Unit, Geneva, Switzerland
Liver Int 24:582-7. 2004....
- Management of hepatocellular adenoma: solitary-uncomplicated, multiple and ruptured tumorsChristian Toso
Abdominal and Transplant Surgery, University Hospital, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
World J Gastroenterol 11:5691-5. 2005..While hepatocellular adenomas (HAs) have often been studied as a unique entity, we aimed to better define current management of the various forms of HAs...
- Insulin resistance is associated with liver fibrosis in non-diabetic chronic hepatitis C patientsAlba Muzzi
Division of Gastroenterology and Hepatology, University Hospital, Geneva, Switzerland
J Hepatol 42:41-6. 2005..Liver steatosis is a frequent finding in chronic hepatitis C. An association has been suggested between steatosis and fibrosis progression rate, but the pathogenetic mechanisms linking fatty infiltration and collagen deposition are unknown...
- PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanismManlio Vinciguerra
Department of Cell Physiology and Metabolism, Geneva Medical Faculty, Geneva University Hospital, Switzerland
Gastroenterology 134:268-80. 2008..Here, we investigated the pathophysiologic mechanisms regulating PTEN expression in the liver and the development of steatosis...
- Hepatocellular adenoma and polycystic ovary syndromeChristian Toso
Clinique et Policlinique de Chirurgie Digestive, Departement de Chirurgie, Hôpitaux Universitaires Genève, Rue Michelidu Crest, 24 CH 1211, Geneve
Liver Int 23:35-7. 2003..In view of this complication, we recommend a close screening of patients with such hormonal imbalance, especially those who are treated with high doses of hormones, with repeated liver tests and ultrasonographies...
- Cure of multifocal panhepatic hepatoblastoma: is liver transplantation always necessary?Reto Marc Baertschiger
Pediatric Surgery Unit, University of Geneva Children s Hospital, 1211 Geneva 4, Switzerland
J Pediatr Surg 45:1030-6. 2010..This procedure is no longer recommended because of the risk of persistent viable tumor cells in the hepatic remnant. We report our experience with conservative surgery in such cases...
- [Biliary, pancreatic and systemic diseases associated with IgG4]Jean Louis Frossard
Division de gastroentérologie et hépatologie, HUG, 1211 Geneve 14
Rev Med Suisse 4:1856-8. 2008..This paper is aimed at reviewing all new aspects of diseases associated with high levels of IgG4...
- Bile Ducts in Regenerative Liver Nodules of Alagille Patients Are Not the Result of Genetic MosaicismAnne Laure Rougemont
Department of Pathology, Sainte Justine Hospital, Montreal, Canada Division of Clinical Pathology, Geneva University Hospitals, Geneva, Switzerland Division of Gastroenterology, Hepatology and Nutrition, Sainte Justine Hospital, Montreal, Canada Pediatric Gastroenterology Unit, Geneva University Hospitals, Geneva, Switzerland Génétique Moléculaire, Pharmacogénétique et Hormonologie, Hopital Bicetre, Faculté de Médecine de Bicêtre, Universite Paris Sud, Paris, France Division of Pediatric Surgery, Geneva University Hospitals, Geneva, Switzerland
J Pediatr Gastroenterol Nutr 61:91-3. 2015..Thus, JAG1 mosaicism and differential haploinsufficiency do not explain the presence of bile ducts in centrally located regenerative nodules...
- Alloimmune activation promotes anti-cancer cytotoxicity after rat liver transplantationStéphanie Lacotte
Department of Surgery, Geneva University Hospitals, University of Geneva, Geneva, Switzerland
PLoS ONE 9:e91515. 2014....
- Acoustic radiation force impulse (ARFI) elastography for the noninvasive diagnosis of liver fibrosis in childrenSylviane Hanquinet
Department of Pediatric Radiology, University Hospitals Geneva, Geneva, Switzerland
Pediatr Radiol 43:545-51. 2013..Acoustic radiation force impulse (ARFI) imaging) is correlated with histopathological findings using METAVIR and semiquantitative scoring system (SSS) criteria for liver fibrosis...
- Acute partial Budd-Chiari syndrome and portal vein thrombosis in cytomegalovirus primary infection: a case reportLaurent Spahr
Gastroenterology and Hepatology, Ospedale Regionale, Lugano, Switzerland
BMC Gastroenterol 6:10. 2006..Acute cytomegalovirus infection is a rare cause of acquired venous thrombosis in the portal or mesenteric territory, but has never been described extending into a main hepatic vein...
- Acute hepatitis due to brivudin: a case reportAlexandre Mottu
General Internal Medicine, University Hospitals, Geneva, Switzerland
J Hepatol 51:967-9. 2009..Brivudin is licensed in several European countries for the treatment of herpetic infections, and is considered safe (approximately 1% of patients with transient elevation of liver enzymes) in large multicenter trials...
- An unusual case of gastric heterotopic pancreasLaura Rubbia-Brandt
Division of Clinical Pathology, Clinic of Digestive Surgery, Geneva University Hospitals, Geneva, Switzerland
JOP 5:484-7. 2004..Submucosal lesions of the gastrointestinal tract represent a diagnostic challenge for the physician. Endoscopic ultrasonography may provide useful information before deciding on therapeutic strategy...
- Humoral and cellular rejection after combined liver-kidney transplantation in low immunologic risk recipientsKarine Hadaya
Division of Nephrology, Geneva University Hospital, Geneva, Switzerland
Transpl Int 22:242-6. 2009..Indeed, the detection of C4d in the liver should be carefully followed after combined liver-kidney transplantation...
- Do eosinophil numbers differentiate eosinophilic esophagitis from gastroesophageal reflux disease?Muriel Genevay
Department of Clinical Pathology, Geneva University Hospitals, Geneva, Switzerland
Arch Pathol Lab Med 134:815-25. 2010....
- Applications of mass spectrometry for quantitative protein analysis in formalin-fixed paraffin-embedded tissuesCarine Steiner
Division of Laboratory Medicine, Geneva University Hospital, Geneva, Switzerland Human Protein Sciences Department, University of Geneva, Geneva, Switzerland Translational Technologies and Bioinformatics, Pharma Research and Early Development, F Hoffmann La Roche AG, Basel, Switzerland
Proteomics 14:441-51. 2014..We also discuss the limitations and perspectives of the technique, particularly with regard to application in clinical diagnosis and drug discovery. ..
- Management of a ruptured hydatid cyst involving the ribs: Dealing with a challenging case and review of the literatureTheodoros Thomopoulos
Department of Surgery, Clinics of Visceral and Transplantation Surgery, University Hospitals of Geneva HUG, 1211 Geneva 14, Geneva, Switzerland
Int J Surg Case Rep 3:253-6. 2012..Rarely, chest or abdominal wall involvement occurs that are challenging to manage. This case report and literature review describes the management of patients with chest wall and rib invasion...
- Immunological and virological effects of ribavirin in hepatitis C after liver transplantationRafael Quadri
Division of Gastroenterology and Hepatology, University Hospital, 1211 Geneva, Switzerland
Transplantation 73:373-8. 2002..A better understanding of the mechanisms of action of drugs currently used to manage hepatitis C would be helpful...
- Decay-accelerating factor binding determines the entry route of echovirus 11 in polarized epithelial cellsKomla Sobo
Department of Clinical Pathology, University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
J Virol 85:12376-86. 2011..These data strongly indicate that in the case of infection of polarized epithelial cells by echovirus 11, DAF binding appears be a key determinant in the choice of entry pathway, at least in cell culture...
- An unusual, presumably hepatic massAxel Gamulin
Clinic for Digestive and Transplant Surgery, Department of Surgery, University Hospital, 1211 Geneva, Switzerland
Lancet 360:2066. 2002
- Role of macrophage inflammatory peptide-2 in cerulein-induced acute pancreatitis and pancreatitis-associated lung injuryCatherine M Pastor
Division of Gastroenterology and Hepatology, Geneva University Hospital, Geneva, Switzerland
Lab Invest 83:471-8. 2003..These results show that MIP-2 plays a key role in the pathophysiology of acute pancreatitis and that MIP-2 blockade may improve the outcome of the disease...
- DOME/GALT type adenocarcimoma of the colon: a case report, literature review and a unified phenotypic categorizationHala Kannuna
Department of Clinical Pathology, Geneva University Hospital, 1 rue Michel Servet, 1211, Geneva, Switzerland
Diagn Pathol 10:92. 2015..The two variants might therefore be grouped into a unified category...
- Severe immune-mediated drug-induced liver injury linked to ibandronate: a case reportNicolas Goossens
Division of Gastroenterology and Hepatology, Geneva University Hospital, Geneva, Switzerland Electronic address
J Hepatol 59:1139-42. 2013..We report the first case of ibandronate-related hepatotoxicity and, to our knowledge, the first case of immune-mediated drug-induced liver injury (DILI) related to bisphosphonates. ..
- The prognostic value of expression of HIF1α, EGFR and VEGF-A, in localized prostate cancer for intermediate- and high-risk patients treated with radiation therapy with or without androgen deprivation therapyDamien C Weber
Department of Radiation Oncology, Geneva University Hospital, Geneva, Switzerland
Radiat Oncol 7:66. 2012....
- Severe hemochromatosis in a Portuguese family associated with a new mutation in the 5'-UTR of the HAMP geneThomas Matthes
Division of Hematology, University Hospital, Geneva, Switzerland
Blood 104:2181-3. 2004..The decrease of hepcidin production would thus lead to increased iron absorption, resulting in iron deposition in parenchymal tissues. Phlebotomy therapy of the 2 patients resulted in impressive clinical improvement...
- Peritoneal schistosomiasis: an unusual laparoscopic findingVirginie Masserey Spicher
Department of Paediatrics, University Hospital, Geneva, Switzerland
J Pediatr Surg 39:631-3. 2004..This uncommon and rare presentation deserves to be reported, especially to physicians of nonendemic areas, in an era in which people travel extensively...
- Improved long-term outcome of surgery for advanced colorectal liver metastases: reasons and implications for management on the basis of a severity scoreAxel Andres
Unit of Visceral and Transplantation Surgery, University Hospitals of Geneva, 1211, Geneva 14, Switzerland
Ann Surg Oncol 15:134-43. 2008..To quantify this assumption and to understand its causes we analyzed a series of patients on the basis of a standardized severity score and changes in management occurring over the years...
- In vivo evidence for the role of GM-CSF as a mediator in acute pancreatitis-associated lung injuryJean Louis Frossard
Department of Surgery, Beth Israel Hospital Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Physiol Lung Cell Mol Physiol 283:L541-8. 2002..Our findings indicate that GM-CSF plays a critical role in coupling pancreatitis to ALI and suggest that GM-CSF may act indirectly by regulating the release of other proinflammatory factors including MIP-2...
- Relationship between steatosis, inflammation, and fibrosis in chronic hepatitis C: a meta-analysis of individual patient dataGioacchino Leandro
IRCSS de Bellis, Castellana Grotte, Italy
Gastroenterology 130:1636-42. 2006..We evaluated the association between steatosis and fibrosis and their common correlates in persons with CHC and in subgroup analyses according to hepatitis C virus (HCV) genotype and body mass index...
- Sinusoidal obstruction syndrome is a major feature of hepatic lesions associated with oxaliplatin neoadjuvant chemotherapy for liver colorectal metastasesLaura Rubbia-Brandt
J Am Coll Surg 202:199-200. 2006
- Inhibition of inducible nitric oxide synthase protects against liver injury induced by mycobacterial infection and endotoxinsReto Guler
Department of Pathology, CMU, Faculty of Medicine, University of Geneva, 1, rue Michel Servet, CH 1211 Geneva 4, Switzerland
J Hepatol 41:773-81. 2004..This work investigates the role of inducible nitric oxide synthase (iNOS) in liver damage induced by BCG and endotoxins in BCG-infected mice...
- Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humansYoungmi Jung
Department of Medicine, Duke University, Durham, North Carolina
Gastroenterology 134:1532-43. 2008..Hedgehog (Hh) pathway activation promotes expansion of progenitor populations in other tissues. We evaluated the hypothesis that chronic EtOH exposure activates Hh signaling in liver...
- Connective tissue growth factor, steatosis and fibrosis in patients with chronic hepatitis CCaroline Hora
Department of Clinical Pharmacology, University of Bern, Bern, Switzerland
Liver Int 28:370-6. 2008..We hypothesized that CTGF may link steatosis, insulin resistance and fibrosis...
- [Nonalcoholic fatty liver: does it have to be biopsed?]Laura Rubbia-Brandt
Unité de pathologie gastro intestinale et hépatique, Département de pathologie clinique, HUG, 1211 Geneve 14
Rev Med Suisse 1:2804-8. 2005....
- Hepatocellular carcinoma in a liver-cell adenoma within a non-cirrhotic liverEmanuel Burri
Department of Gastroenterology, University Hospital Liestal, Switzerland
Eur J Gastroenterol Hepatol 18:437-41. 2006..Mechanisms of transformation remain unclear. The imaging findings as well as histological features are presented in detail and the literature is discussed...