Ramin Radpour

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. pmc Decreased mitochondrial DNA content in blood samples of patients with stage I breast cancer
    Peng Xia
    Department of Surgical Oncology, First Affiliated Hospital of Medical College, Xi an Jiaotong University, 710061 Xi an, PR China
    BMC Cancer 9:454. 2009
  2. doi request reprint Identification of a critical novel mutation in the exon 1 of androgen receptor gene in 2 brothers with complete androgen insensitivity syndrome
    Ramin Radpour
    Laboratory for Prenatal Medicine and Gynecologic Oncology, Department of Medicine, University of Basel, Basel, Switzerland
    J Androl 30:230-2. 2009
  3. ncbi request reprint Novel cause of hereditary obstructive azoospermia: a T2 allele in the CFTR gene
    Ramin Radpour
    Laboratory for Prenatal Medicine and Gynecologic Oncology, Department of Medicine, University of Basel, Switzerland
    Reprod Biomed Online 18:327-32. 2009
  4. doi request reprint Genetic investigations of CFTR mutations in congenital absence of vas deferens, uterus, and vagina as a cause of infertility
    Ramin Radpour
    Laboratory for Prenatal Medicine and Gynecologic Oncolocy, Women s Hospital Department of Medicine, University of Basel, Switzerland
    J Androl 29:506-13. 2008
  5. pmc Hypermethylation of tumor suppressor genes involved in critical regulatory pathways for developing a blood-based test in breast cancer
    Ramin Radpour
    Laboratory for Gynecological Oncology, Department of Biomedicine, Women s Hospital, University of Basel, Basel, Switzerland
    PLoS ONE 6:e16080. 2011
  6. pmc Methylation signature of lymph node metastases in breast cancer patients
    Zeinab Barekati
    Laboratory for Gynecological Oncology, Women s Hospital Department of Biomedicine, University of Basel, Hebelstrasse 20, CH 4031 Basel, Switzerland
    BMC Cancer 12:244. 2012
  7. pmc Levels of plasma circulating cell free nuclear and mitochondrial DNA as potential biomarkers for breast tumors
    Corina Kohler
    Laboratory for Prenatal Medicine and Gynecologic Oncology, Women s Hospital Department of Biomedicine, University of Basel, Switzerland
    Mol Cancer 8:105. 2009
  8. doi request reprint Correlation of telomere length shortening with promoter methylation profile of p16/Rb and p53/p21 pathways in breast cancer
    Ramin Radpour
    Laboratory for Prenatal Medicine and Gynecologic Oncology, Women s Hospital Department of Biomedicine, University of Basel, Basel, Switzerland
    Mod Pathol 23:763-72. 2010
  9. ncbi request reprint Mitochondrial DNA content in paired normal and cancerous breast tissue samples from patients with breast cancer
    Alex Xiu Cheng Fan
    Laboratory for Prenatal Medicine and Gynecologic Oncology, Department of Biomedicine, Women s Hospital, University of Basel, Hebelstrasse 20, Room Nr 416, 4031 Basel, Switzerland
    J Cancer Res Clin Oncol 135:983-9. 2009
  10. pmc Integrated epigenetics of human breast cancer: synoptic investigation of targeted genes, microRNAs and proteins upon demethylation treatment
    Ramin Radpour
    Laboratory for Gynecological Oncology, Department of Biomedicine Women s Hospital, University of Basel, Basel, Switzerland
    PLoS ONE 6:e27355. 2011

Collaborators

Detail Information

Publications26

  1. pmc Decreased mitochondrial DNA content in blood samples of patients with stage I breast cancer
    Peng Xia
    Department of Surgical Oncology, First Affiliated Hospital of Medical College, Xi an Jiaotong University, 710061 Xi an, PR China
    BMC Cancer 9:454. 2009
    ..We sought to investigate whether mtDNA content in the peripheral blood of breast cancer patients is associated with clinical and pathological parameters...
  2. doi request reprint Identification of a critical novel mutation in the exon 1 of androgen receptor gene in 2 brothers with complete androgen insensitivity syndrome
    Ramin Radpour
    Laboratory for Prenatal Medicine and Gynecologic Oncology, Department of Medicine, University of Basel, Basel, Switzerland
    J Androl 30:230-2. 2009
    ..We conclude that the novel Y514X mutation in the androgen receptor is the cause of complete androgen insensitivity syndrome in this family...
  3. ncbi request reprint Novel cause of hereditary obstructive azoospermia: a T2 allele in the CFTR gene
    Ramin Radpour
    Laboratory for Prenatal Medicine and Gynecologic Oncology, Department of Medicine, University of Basel, Switzerland
    Reprod Biomed Online 18:327-32. 2009
    ..According to the data, the longer (TG)(m) polymorphic tract increases the proportion of transcripts with exon 9 deletion (9-), but only when activated by the short T allele...
  4. doi request reprint Genetic investigations of CFTR mutations in congenital absence of vas deferens, uterus, and vagina as a cause of infertility
    Ramin Radpour
    Laboratory for Prenatal Medicine and Gynecologic Oncolocy, Women s Hospital Department of Medicine, University of Basel, Switzerland
    J Androl 29:506-13. 2008
    ..Around 10% of obstructive azoospermia is congenital and due to mutations in the CF gene. This review highlights the relationship of mutations in the CFTR gene with CBAVD and CAUV...
  5. pmc Hypermethylation of tumor suppressor genes involved in critical regulatory pathways for developing a blood-based test in breast cancer
    Ramin Radpour
    Laboratory for Gynecological Oncology, Department of Biomedicine, Women s Hospital, University of Basel, Basel, Switzerland
    PLoS ONE 6:e16080. 2011
    ..Aberrant DNA methylation patterns might be used as a biomarker for diagnosis and management of cancer patients...
  6. pmc Methylation signature of lymph node metastases in breast cancer patients
    Zeinab Barekati
    Laboratory for Gynecological Oncology, Women s Hospital Department of Biomedicine, University of Basel, Hebelstrasse 20, CH 4031 Basel, Switzerland
    BMC Cancer 12:244. 2012
    ....
  7. pmc Levels of plasma circulating cell free nuclear and mitochondrial DNA as potential biomarkers for breast tumors
    Corina Kohler
    Laboratory for Prenatal Medicine and Gynecologic Oncology, Women s Hospital Department of Biomedicine, University of Basel, Switzerland
    Mol Cancer 8:105. 2009
    ..In this connection, circulating cell-free DNA (ccf DNA) seems to be a promising candidate. Altered levels of ccf nuclear DNA (nDNA) and mitochondrial DNA (mtDNA) have been found in several cancer types and might have a diagnostic value...
  8. doi request reprint Correlation of telomere length shortening with promoter methylation profile of p16/Rb and p53/p21 pathways in breast cancer
    Ramin Radpour
    Laboratory for Prenatal Medicine and Gynecologic Oncology, Women s Hospital Department of Biomedicine, University of Basel, Basel, Switzerland
    Mod Pathol 23:763-72. 2010
    ..Thus, telomere shortening and promoter hypermethylation of related genes both might serve as breast cancer biomarkers...
  9. ncbi request reprint Mitochondrial DNA content in paired normal and cancerous breast tissue samples from patients with breast cancer
    Alex Xiu Cheng Fan
    Laboratory for Prenatal Medicine and Gynecologic Oncology, Department of Biomedicine, Women s Hospital, University of Basel, Hebelstrasse 20, Room Nr 416, 4031 Basel, Switzerland
    J Cancer Res Clin Oncol 135:983-9. 2009
    ..We develop a multiplex quantitative real-time PCR for synchronized analysis of mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) to investigate relative mtDNA abundance in paired normal and cancerous breast tissues...
  10. pmc Integrated epigenetics of human breast cancer: synoptic investigation of targeted genes, microRNAs and proteins upon demethylation treatment
    Ramin Radpour
    Laboratory for Gynecological Oncology, Department of Biomedicine Women s Hospital, University of Basel, Basel, Switzerland
    PLoS ONE 6:e27355. 2011
    ..Since these epigenetic alterations are reversible, it became of interest to determine the effects of the 5-aza-2'-deoxycytidine (DAC) demethylation therapy in breast cancer at different molecular levels...
  11. ncbi request reprint Circulating cell-free DNA as a potential biomarker for minimal and mild endometriosis
    Rebecca Zachariah
    Laboratory for Prenatal Medicine and Gynecologic Oncology, Women s Hospital, Department of Biomedicine, University of Basel, Switzerland
    Reprod Biomed Online 18:407-11. 2009
    ..The finding of significantly increased concentrations of ccf nDNA in plasma of patients with endometriosis suggests that ccf nDNA might be a potential biomarker for developing non-invasive diagnostic test in endometriosis...
  12. doi request reprint Assessing the value of CAN-gene mutations using MALDI-TOF MS
    Corina Kohler
    Laboratory for Gynecological Oncology, Women s Hospital Department Research, Department of Biomedicine, University of Basel, Hebelstrasse 20, Room Nr 420, 4031 Basel, Switzerland
    J Cancer Res Clin Oncol 137:1239-44. 2011
    ..140 CAN-genes were found in breast cancer, which in turn contained overall 334 mutations. These mutations could prove useful for diagnostic and therapeutic purposes...
  13. ncbi request reprint Proteomics and biomarkers for ovarian cancer diagnosis
    Bei Zhang
    Department of Biomedicine, Women s Hospital, University of Basel, Basel, Switzerland
    Ann Clin Lab Sci 40:218-25. 2010
    ..This article reviews recently published data on the diagnosis of ovarian cancer with proteomics, including the major proteomics technologies and promising strategies for biomarker discovery and development...
  14. doi request reprint Methylation profile of TP53 regulatory pathway and mtDNA alterations in breast cancer patients lacking TP53 mutations
    Zeinab Barekati
    Laboratory for Gynecological Oncology, Women s Hospital Department of Biomedicine, University of Basel, Switzerland
    Hum Mol Genet 19:2936-46. 2010
    ..Additionally, release of significant aberrant methylated PTEN in matched serum samples might represent a promising biomarker for breast cancer...
  15. doi request reprint High-throughput hacking of the methylation patterns in breast cancer by in vitro transcription and thymidine-specific cleavage mass array on MALDI-TOF silico-chip
    Ramin Radpour
    Laboratory for Prenatal Medicine and Gynecologic Oncology, Women s Hospital Department of Biomedicine, University of Basel, Basel, Switzerland
    Mol Cancer Res 6:1702-9. 2008
    ..Each individual contributed a breast cancer specimen and corresponding adjacent normal tissue. We evaluated the accuracy of the approach and implemented critical improvements in experimental design...
  16. ncbi request reprint New trends in molecular biomarker discovery for breast cancer
    Ramin Radpour
    Laboratory for Prenatal Medicine and Gynecologic Oncology, Women s Hospital Department of Biomedicine, University of Basel, Basel, Switzerland
    Genet Test Mol Biomarkers 13:565-71. 2009
    ..This review highlights the new trends and approaches in breast cancer biomarker discovery, which could be potentially used for early diagnosis, development of new therapeutic approaches, and follow-up of patients...
  17. doi request reprint Simultaneous isolation of DNA, RNA, and proteins for genetic, epigenetic, transcriptomic, and proteomic analysis
    Ramin Radpour
    Laboratory for Prenatal Medicine and Gynecologic Oncology, Women s Hospital Department of Biomedicine, University of Basel, Switzerland
    J Proteome Res 8:5264-74. 2009
    ..This methodological improvement enables to execute such experiments that were not performable with standard procedure, and ensures reproducible outcome...
  18. doi request reprint A selected pre-amplification strategy for genetic analysis using limited DNA targets
    Peng Xia
    Women s Hospital, Department of Biomedicine, University of Basel, Basel, Switzerland
    Clin Chem Lab Med 47:288-93. 2009
    ..Limited DNA resources or limited DNA targets in predominant backgrounds for genetic tests can lead to misdiagnosis. We developed a strategy to selectively increase the amount of minor targets through a specific pre-amplification procedure...
  19. doi request reprint Current understanding of mitochondrial DNA in breast cancer
    Ramin Radpour
    Laboratory for Prenatal Medicine and Gynecology Oncology, Women s Hospital Department of Biomedicine, University of Basel, Basel CH 4031, Switzerland
    Breast J 15:505-9. 2009
    ....
  20. ncbi request reprint Cell-free DNA in the circulation as a potential cancer biomarker
    Corina Kohler
    Laboratory for Gynecological Oncology, Women s Hospital, Department of Research, University of Basel, Switzerland
    Anticancer Res 31:2623-8. 2011
    ..This review evaluates the potential of ccf-DNA alterations as a biomarker for cancer management by addressing the question of how large the gap between ccf-DNA and the ideal cancer biomarker is...
  21. doi request reprint Levels of circulating cell-free nuclear and mitochondrial DNA in benign and malignant ovarian tumors
    Rebecca R Zachariah
    Laboratory for Prenatal Medicine and Gynaecologic Oncology, Women s Hospital Department of Biomedicine, University of Basel, Basel, Switzerland
    Obstet Gynecol 112:843-50. 2008
    ....
  22. ncbi request reprint Correlation between CFTR gene mutations in Iranian men with congenital absence of the vas deferens and anatomical genital phenotype
    Ramin Radpour
    Department of Reproductive Genetics, Reproductive Biomedicine Research Center of Royan Institute, PO Box 19395 4644, Tehran, Iran
    J Androl 29:35-40. 2008
    ..Further studies using common diagnostic criteria are required to confirm our observations...
  23. ncbi request reprint Molecular study of (TG)m(T)n polymorphisms in Iranian males with congenital bilateral absence of the vas deferens
    Ramin Radpour
    Department of Reproductive Genetics, Reproductive Biomedicine Research Center of Royan Institute, Tehran, Iran
    J Androl 28:541-7. 2007
    ....
  24. ncbi request reprint Two novel missense and one novel nonsense CFTR mutations in Iranian males with congenital bilateral absence of the vas deferens
    Ramin Radpour
    Department of Reproductive, Reproductive Biomedicine Research Center of Royan Institute, Tehran, Iran
    Mol Hum Reprod 12:717-21. 2006
    ..Because Y122H and T338A mutations were compound heterozygote with the IVS8-5T, it is difficult to judge the severity of these mutations and their role in the CBAVD phenotype...
  25. ncbi request reprint Molecular analysis of the IVS8-T splice variant 5T and M470V exon 10 missense polymorphism in Iranian males with congenital bilateral absence of the vas deferens
    Ramin Radpour
    Department of Reproductive Genetics, Department of Male Infertility and Department of Stem Cell, Reproductive Biomedicine Research Center, Royan Institute, Tehran, Iran
    Mol Hum Reprod 12:469-73. 2006
    ..The 5T allele mutation has a wide range of clinical presentations and revealed a high frequency, occurring in patients with CBAVD or moderate forms of CF and infertile men...
  26. ncbi request reprint Association of long polyglycine tracts (GGN repeats) in exon 1 of the androgen receptor gene with cryptorchidism and penile hypospadias in Iranian patients
    Ramin Radpour
    Department of Reproductive Genetics, Reproductive Biomedicine Research Center of Royan Institute, PO Box 19395 4644, Tehran, Iran
    J Androl 28:164-9. 2007
    ....