Klara M Posfay-Barbe
Affiliation: University Hospital
- Parental functioning improves the developmental quotient of pediatric liver transplant recipientsKlara M Posfay-Barbe
Department of Pediatrics, Children s Hospital of Geneva, University Hospitals of Geneva, 6 Rue Willy Donze, Geneva, Switzerland
Pediatr Transplant 17:355-61. 2013..03). Paternal performance scores were higher than maternal scores. Children transplanted after two yr of age suffer greater long-term deficits than those transplanted as infants...
- Varicella-zoster immunization in pediatric liver transplant recipients: safe and immunogenicK M Posfay-Barbe
Department of Pediatrics, Division of General Pediatrics, Children s Hospital of Geneva, University Hospitals of Geneva, Switzerland
Am J Transplant 12:2974-85. 2012..7 years). No breakthrough disease was reported during follow-up (median 4.1 years). Thereby, VZV vaccine appears to be safe, immunogenic and provide protection against disease in pediatric LT patients...
- Infections in pediatrics: old and new diseasesKlara M Posfay-Barbe
Children s Hospital of Geneva, University Hospitals of Geneva, Switzerland
Swiss Med Wkly 142:w13654. 2012..This overview gives a general idea on some topics that are currently significant and specific to paediatric infectious diseases...
- Immunity to pneumococcal surface proteins in children with community-acquired pneumonia: a distinct pattern of responses to pneumococcal choline-binding protein AK M Posfay-Barbe
Departments of Child and Adolescent Medicine and Pathology Immunology, University of Geneva, Geneva, Switzerland
Clin Microbiol Infect 17:1232-8. 2011..002) of P-CAP. Novel PSPs facilitate the demonstration of recent pneumococcal exposure in CAP children. Low anti-PcpA antibody titres at admission distinguished children with P-CAP from those with CAP with a non-pneumococcal origin...
- Food poisoning as a cause of acute liver failureKlara M Posfay-Barbe
Division of Pediatrics, Department of Pediatrics, Children s Hospital of Geneva, Geneva, Switzerland
Pediatr Infect Dis J 27:846-7. 2008..As a result of rapid identification of the microorganism and supportive care, liver transplantation was avoided, and she recovered fully...
- ListeriosisKlara M Posfay-Barbe
Department of Pediatrics, Children s Hospital of Geneva, University Hospitals of Geneva, 6 Rue Willy Donze, 1211 Geneva 14, Switzerland
Semin Fetal Neonatal Med 14:228-33. 2009..Clinical manifestations of infection in the newborn fall into the traditional categories of early- and late-onset sepsis. Therapeutic recommendations include ampicillin and gentamicin for 14-21 days...
- [Recurrent lower respiratory tract infection in children: when and how should they be investigated?]K M Posfay Barbe
Departement de Pediatrie, Hopital des Enfants, Hopitaux Universitaires de Geneve, 1211 Geneve 14
Rev Med Suisse 1:493-8. 2005..Finally, this article also describes an upcoming study in Switzerland which will evaluate in 2005 the clinical and immunological outcome of these young patients...
- [Whooping cough: a diagnosis one shouldn't forget]K M Posfay-Barbe
Service et Département de pédiatrie Maladies infectieuses pédiatriques, Hôpital des enfants HUG, 1211 Geneve 14
Rev Med Suisse 2:503-6, 509-11. 2006..This strategy would not only protect these individuals from whooping cough, but most importantly protect, by herd immunity, the infants too young to be (fully) immunized...
- Immunization and transplantation--what is new and what is coming?Klara M Posfay-Barbe
Department of Pediatrics and Adolescent Medicine, Children s Hospital of Geneva, University Hospitals of Geneva, Switzerland
Pediatr Transplant 13:404-10. 2009..We also review less common vaccines (such as encephalitis vaccines), and possible vaccines of the future that could have an important clinical impact in these children, such as CMV or EBV vaccines...
- Vaccine-induced immunity in children after orthotopic liver transplantation: a 12-yr review of the Swiss national reference centerAlessandro Diana
Department of Pediatrics, Children s Hospital of Geneva, University Hospitals of Geneva, Switzerland
Pediatr Transplant 11:31-7. 2007....
- Determinants of vaccine immunity in the cohort of human immunodeficiency virus-infected children living in SwitzerlandCatherine Myers
Department of Pediatrics, Geneva Medical School and University Hospitals of Geneva, Switzerland
Pediatr Infect Dis J 28:996-1001. 2009..Human immunodeficiency virus (HIV)-infected children are at increased risk of infections caused by vaccine preventable pathogens, and specific immunization recommendations have been issued...
- Bordetella holmesii: an under-recognised Bordetella speciesLaure F Pittet
Department of Paediatrics, Division of General Paediatrics, Children s Hospital, University Hospitals of Geneva, University of Geneva, Geneva, Switzerland
Lancet Infect Dis 14:510-9. 2014..B holmesii's adaptation to human beings is continuing, and virulence might increase, causing the need for better diagnostic assays and epidemiological surveillance. ..
- Comparison of clinical presentation of respiratory tract infections in H1N1/09-positive and H1N1/09-negative patientsPierre Alex Crisinel
Department of Pediatrics, Children s Hospital of Geneva, University Hospitals of Geneva, Geneva 14, Switzerland
Eur J Pediatr 171:159-66. 2012..24%) and myalgias (41% vs. 20%). H1N1/09-negative patients had more wheezing episodes (29% vs. 9%), higher rates of dyspnea (28% vs. 20%) and of hospital admissions (35% vs. 16%)...
- Secular trends in antibiotic use among neonates: 2001-2008Walter Zingg
Infection Control Program, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland
Pediatr Infect Dis J 30:365-70. 2011..Few data exist on time trends of antibiotic consumption among neonates...
- Imipenem-resistant Nocardia cyriacigeorgica infection in a child with chronic granulomatous diseaseAndres Hagerman
Department of Pediatrics, Children s Hospital of Geneva, University Hospital of Geneva, 6 Rue Willy Donze, 1211 Geneva, Switzerland
J Clin Microbiol 49:1185-7. 2011..We describe a patient with imipenem-resistant Nocardia cyriacigeorgica, which, to our knowledge, has not been previously reported among isolates of this species...
- How do physicians immunize their own children? Differences among pediatricians and nonpediatriciansKlara M Posfay-Barbe
Centre for Vaccinology and Neonatal Immunology, Department of Pathology Immunology, University of Geneva, Switzerland
Pediatrics 116:e623-33. 2005..Physicians are known to exert a direct influence on immunization rates by answering questions and clarifying misconceptions. Yet, it is unknown how they immunize their own children...
- Recurrence of cardiorespiratory events following repeat DTaP-based combined immunization in very low birth weight premature infantsAline Flatz-Jequier
Department of Pediatrics, Children s Hospital, University Hospitals of Geneva and Medical Faculty of the University of Geneva, Geneva, Switzerland
J Pediatr 153:429-31. 2008..A cardiorespiratory event associated with the first vaccination was the sole risk factor for recurrence identified...
- Memory B cell compartment constitution and susceptibility to recurrent lower respiratory tract infections in young childrenJohan N Siebert
Department of Pediatrics, University Hospitals of Geneva and Medical School, University of Geneva, Geneva, Switzerland
J Leukoc Biol 93:951-62. 2013..However, the waning of antibodies might predispose children to recurrent infections in the absence of revaccination...
- Infectious diseases in pediatric transplantation: review of the literature 2007-2008Arnaud G L'huillier
Department of Pediatrics, Children s Hospital of Geneva, University Hospitals of Geneva, Switzerland
Pediatr Transplant 14:23-32. 2010..It also examines novel markers to discriminate between infection and rejection. Comments to each manuscript have been added, but we strongly encourage the reader to refer to the original work for more in depth evaluation...
- Immune reconstitution inflammatory syndrome and solid organ transplant recipients: are children protected?Valerie A McLin
Department of Pediatrics, Children s Hospital of Geneva, University Hospitals of Geneva, Geneva, Switzerland
Pediatr Transplant 14:19-22. 2010..However, IRIS has to date not been reported in pediatric SOT recipients. Here we review what is known and speculated about the pathogenesis of IRIS and propose that children may be relatively protected from IRIS...
- Tetanus immunity as a surrogate for past diphtheria-tetanus-pertussis immunization in migrant childrenIsabel Garcia de la Fuente
Division of General Pediatrics, Department of Pediatrics, University Hospitals of Geneva and University of Geneva Medical School, Geneva, Switzerland
Pediatr Infect Dis J 32:274-7. 2013..Overimmunizing" is costly and associated with risks of hyperimmunization, whereas assuming up-to-date immunizations may be misleading...
- Severe autoimmune hemolytic anemia in a liver transplanted childMichela G Schäppi
Division of Paediatric Gastroenterology and Transplantation, Children s Hospital of Geneva, Geneva, Switzerland
Pediatr Transplant 12:809-12. 2008..In this report, the etiologies of HA occurring in post-transplant pediatric patients are reviewed and the different treatment strategies are discussed...
- Frequent failure of adolescent booster responses to tetanus toxoid despite infant immunization: waning of infancy-induced immune memory?Klara M Posfay-Barbe
Department of Pediatrics, University Hospitals of Geneva, Switzerland
Vaccine 28:4356-61. 2010..Thus, early life immune immaturity may limit the persistence of infant-induced immunity and subsequent boosters may be required for sustained protection...
- ABCB1 polymorphisms and neuropsychiatric adverse events in oseltamivir-treated children during influenza H1N1/09 pandemiaArnaud G L'huillier
Geneva Medical Faculty and University Hospitals of Geneva, Department of Pediatrics, Geneva, Switzerland
Pharmacogenomics 12:1493-501. 2011..To examine the safety profile of oseltamivir in children and evaluate the impact of P-glycoprotein polymorphisms on the incidence of neuropsychiatric adverse events (NPAE) in oseltamivir-treated children...
- Protective antibody responses to influenza A/H1N1/09 vaccination in children with celiac diseaseMichela G Schäppi
Department of Pediatrics, University Hospitals of Geneva, Geneva, Switzerland
J Pediatr Gastroenterol Nutr 54:817-9. 2012..All of the children with celiac disease reached protective antibody titers (≥40) and showed a geometric mean titer comparable with the control group (530 vs 573)...
- Individualized catheter surveillance among neonates: a prospective, 8-year, single-center experienceWalter Zingg
University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland
Infect Control Hosp Epidemiol 32:42-9. 2011..To monitor trends in central line-associated bloodstream infections and clinical sepsis (CLABICS) among neonates and to determine risk factors for infection, especially dwell time...
- Diagnosis of whooping cough in Switzerland: differentiating Bordetella pertussis from Bordetella holmesii by polymerase chain reactionLaure F Pittet
Department of Paediatrics, Division of General Paediatrics, Children s Hospital, University Hospitals of Geneva, Geneva, Switzerland
PLoS ONE 9:e88936. 2014..holmesii seems to be circulating less than in neighboring countries and that specific diagnostic procedures are not necessary routinely. However, as the epidemiological situation may change rapidly, periodic reevaluation is suggested. ..
- Electrogastrography abnormalities appear early in children with diabetes type 1Klara M Posfay-Barbe
Department of Paediatrics, University Hospital of Geneva, Switzerland
Eur J Gastroenterol Hepatol 23:881-5. 2011....
- Validation of SYBR Green based quantification assay for the detection of human Torque Teno virus titers from plasmaAnuj Kumar Tyagi
Department of Pediatrics, Onco Hematology Unit, Geneva University Hospital, Rue Willy Donze 6, 1211 Geneva, Switzerland
Virol J 10:191. 2013..We hereby describe the validation of a SYBR Green-based TTV quantification method for plasma samples...
- Increased incidence of apparently life-threatening events due to supine positionAlbane B R Maggio
Department of Paediatrics, HCUG, Faculty of Medicine, Geneva, Switzerland
Paediatr Perinat Epidemiol 20:491-6; discussion 496-7. 2006..The worldwide marked decrease in SIDS since the implementation of the supine position possibly masks the negative effect of an increase in ALTE...
- Acute disseminated fatal toxoplasmosis after haploidentical stem cell transplantation despite atovaquone prophylaxis in a young manIsabel Garcia de la Fuente
Department of Pediatrics, Division of General Pediatrics, University Hospitals of Geneva, Geneva, Switzerland
Pediatr Infect Dis J 29:1059-60. 2010..This report illustrates the need for protozoal monitoring despite atovaquone prophylaxis, in severely immunocompromised patients with intolerance to standard treatment...
- Immunization in transplantation: review of the recent literatureLaure F Pittet
Department of Pediatrics, Division of General Pediatrics, Children s Hospital of Geneva, University Hospitals of Geneva, Geneva, Switzerland
Curr Opin Organ Transplant 18:543-8. 2013..Because of previously reported differences, vaccine-specific studies are needed for each type of SOT recipients...
- Pediatric Chagas disease in Europe: 45 cases from Spain and SwitzerlandLuciana Rodriguez-Guerineau
From the Department of Pediatrics, University Hospitals of Geneva and University of Geneva, Switzerland Department of Pediatrics Laboratory of Microbiology, Sant Joan de Déu Hospital, University of Barcelona, Spain Department of Gynecology and Obstetrics Division of International and Humanitarian Medicine, Department of Community Medicine, Primary Care and Emergency Medicine and Division of Primary Care, Department of Community Medicine, Primary Care and Emergency Medicine, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland
Pediatr Infect Dis J 33:458-62. 2014..To date, there is no published information about clinical characteristics in children...
- Antibiotic use in children - off-label useWalter Zingg
Infection Control Program, University of Geneva Hospitals, 4 rue Gabrielle Perret Gentil, 1211 Geneva 14, Switzerland
Curr Drug Targets 13:885-92. 2012..This is of concern in the light of emerging multidrug-resistant pathogens...
- Human herpes virus type 8 seroprevalence in pregnant women in Geneva, SwitzerlandB Martinez de Tejada
Department of Obstetrics and Gynecology, Faculty of Medicine, University Hospitals of Geneva, Geneva, Switzerland
J Matern Fetal Neonatal Med 24:183-5. 2011..43%; p = 0.023, respectively. In conclusion, HHV-8 infection is present in European pregnant women. Attention should be given to the emergence of infectious diseases, such as HHV-8, and their impact on health in nonendemic countries...
- Infection control in paediatricsKlara M Posfay-Barbe
Children s Hospital of Geneva, University of Geneva Hospitals, Geneva, Switzerland
Lancet Infect Dis 8:19-31. 2008..We review the emergence of antimicrobial-resistant organisms and strategies to prevent health-care-associated infections in the paediatric setting...