A F Ochsenbein

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. pmc Immune surveillance against a solid tumor fails because of immunological ignorance
    A F Ochsenbein
    Institute for Experimental Immunology, University Hospital, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 96:2233-8. 1999
  2. pmc A comparison of T cell memory against the same antigen induced by virus versus intracellular bacteria
    A F Ochsenbein
    Institute for Experimental Immunology, University Hospital, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 96:9293-8. 1999
  3. pmc Protective T cell-independent antiviral antibody responses are dependent on complement
    A F Ochsenbein
    Institute for Experimental Immunology, University Hospital, CH 8091 Zurich, Switzerland
    J Exp Med 190:1165-74. 1999
  4. pmc Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice
    A Ciurea
    Institute for Experimental Immunology, Department of Pathology, University Hospital, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 96:11964-9. 1999
  5. pmc Viral persistence in vivo through selection of neutralizing antibody-escape variants
    A Ciurea
    Institute for Experimental Immunology, University Hospital, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 97:2749-54. 2000
  6. ncbi Correlation of T cell independence of antibody responses with antigen dose reaching secondary lymphoid organs: implications for splenectomized patients and vaccine design
    A F Ochsenbein
    Institute for Experimental Immunology, University Hospital, Zurich, Switzerland
    J Immunol 164:6296-302. 2000
  7. pmc Protective long-term antibody memory by antigen-driven and T help-dependent differentiation of long-lived memory B cells to short-lived plasma cells independent of secondary lymphoid organs
    A F Ochsenbein
    Institute of Experimental Immunology, University Hospital, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 97:13263-8. 2000
  8. ncbi Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction
    A F Ochsenbein
    Institute of Experimental Immunology, University Hospital, CH 8091 Zurich, Switzerland
    Nature 411:1058-64. 2001
  9. pmc Immunotherapy with dendritic cells directed against tumor antigens shared with normal host cells results in severe autoimmune disease
    B Ludewig
    Institute of Experimental Immunology, CH 8091 Zurich, Switzerland
    J Exp Med 191:795-804. 2000
  10. ncbi A Btk transgene restores the antiviral TI-2 antibody responses of xid mice in a dose-dependent fashion
    D D Pinschewer
    Institute of Experimental Immunology Department of Pathology, University Hospital of Zurich, Zurich, Switzerland
    Eur J Immunol 29:2981-7. 1999

Collaborators

Detail Information

Publications12

  1. pmc Immune surveillance against a solid tumor fails because of immunological ignorance
    A F Ochsenbein
    Institute for Experimental Immunology, University Hospital, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 96:2233-8. 1999
    ....
  2. pmc A comparison of T cell memory against the same antigen induced by virus versus intracellular bacteria
    A F Ochsenbein
    Institute for Experimental Immunology, University Hospital, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 96:9293-8. 1999
    ..These results document a striking difference in protective T cell memory between viral and bacterial vaccines and indicate that rapid T cell-dependent immune protection correlates with antigen persistence...
  3. pmc Protective T cell-independent antiviral antibody responses are dependent on complement
    A F Ochsenbein
    Institute for Experimental Immunology, University Hospital, CH 8091 Zurich, Switzerland
    J Exp Med 190:1165-74. 1999
    ..Absence of the early neutralizing antibody responses, together with the reduced efficiency of neutralizing IgM in C3(-/-) mice, led to a drastically enhanced susceptibility to disease after infection with VSV...
  4. pmc Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice
    A Ciurea
    Institute for Experimental Immunology, Department of Pathology, University Hospital, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 96:11964-9. 1999
    ....
  5. pmc Viral persistence in vivo through selection of neutralizing antibody-escape variants
    A Ciurea
    Institute for Experimental Immunology, University Hospital, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 97:2749-54. 2000
    ..In naive animals infected with these virus variants only low nAb responses were induced, resulting in an increased tendency of virus to persist...
  6. ncbi Correlation of T cell independence of antibody responses with antigen dose reaching secondary lymphoid organs: implications for splenectomized patients and vaccine design
    A F Ochsenbein
    Institute for Experimental Immunology, University Hospital, Zurich, Switzerland
    J Immunol 164:6296-302. 2000
    ....
  7. pmc Protective long-term antibody memory by antigen-driven and T help-dependent differentiation of long-lived memory B cells to short-lived plasma cells independent of secondary lymphoid organs
    A F Ochsenbein
    Institute of Experimental Immunology, University Hospital, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 97:13263-8. 2000
    ....
  8. ncbi Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction
    A F Ochsenbein
    Institute of Experimental Immunology, University Hospital, CH 8091 Zurich, Switzerland
    Nature 411:1058-64. 2001
    ..These rules of T-cell induction and maintenance not only change previous views but also rationales for anti-tumour immunotherapy...
  9. pmc Immunotherapy with dendritic cells directed against tumor antigens shared with normal host cells results in severe autoimmune disease
    B Ludewig
    Institute of Experimental Immunology, CH 8091 Zurich, Switzerland
    J Exp Med 191:795-804. 2000
    ..These results reveal the delicate balance between tumor immunity and autoimmunity and therefore point out important limitations for the use of not strictly tumor-specific antigens in antitumor vaccination with DCs...
  10. ncbi A Btk transgene restores the antiviral TI-2 antibody responses of xid mice in a dose-dependent fashion
    D D Pinschewer
    Institute of Experimental Immunology Department of Pathology, University Hospital of Zurich, Zurich, Switzerland
    Eur J Immunol 29:2981-7. 1999
    ..These studies show that the xid mutation in mice has no dominant negative effect and that a transgene - even when not provided in the natural genetic context - may be able to restore functional defects resulting from genetic mutation...
  11. ncbi Leflunomide-mediated suppression of antiviral antibody and Tcell responses: differential restoration by uridine
    D D Pinschewer
    Institute of Experimental Immunology, Department of Pathology, University Hospital Zurich, Switzerland
    Transplantation 72:712-9. 2001
    ..CONCLUSIONS: Leflunomide-mediated suppression of B cell and T helper cell activity but not of CTLs largely depends on inhibition of pyrimidine de novo synthesis...
  12. pmc Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions
    K P Knobeloch
    Department of Molecular Genetics, Institute of Molecular Pharmacology, Free University of Berlin, Berlin, Hamburg, Germany
    Mol Cell Biol 20:5363-9. 2000
    ..These poor antibody responses could be overcome by the immunization of antigen together with adjuvant. These results suggest a role for CD37 in T-cell-B-cell interactions which manifests itself under suboptimal costimulatory conditions...