Joachim Muller

Summary

Affiliation: University of Bern
Country: Switzerland

Publications

  1. ncbi Neospora caninum: functional inhibition of protein disulfide isomerase by the broad-spectrum anti-parasitic drug nitazoxanide and other thiazolides
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Exp Parasitol 118:80-8. 2008
  2. doi Identification of a host cell target for the thiazolide class of broad-spectrum anti-parasitic drugs
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Exp Parasitol 128:145-50. 2011
  3. doi Thioureides of 2-(phenoxymethyl)benzoic acid 4-R substituted: a novel class of anti-parasitic compounds
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Parasitol Int 58:128-35. 2009
  4. doi Identification of differentially expressed genes in a Giardia lamblia WB C6 clone resistant to nitazoxanide and metronidazole
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    J Antimicrob Chemother 62:72-82. 2008
  5. doi Stable expression of Escherichia coli beta-glucuronidase A (GusA) in Giardia lamblia: application to high-throughput drug susceptibility testing
    Joachim Muller
    Institute of Parasitology, University of Berne, Berne, Switzerland
    J Antimicrob Chemother 64:1187-91. 2009
  6. ncbi Characterization of Giardia lamblia WB C6 clones resistant to nitazoxanide and to metronidazole
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    J Antimicrob Chemother 60:280-7. 2007
  7. pmc A novel Giardia lamblia nitroreductase, GlNR1, interacts with nitazoxanide and other thiazolides
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Antimicrob Agents Chemother 51:1979-86. 2007
  8. doi Metabolism of nitro drugs metronidazole and nitazoxanide in Giardia lamblia: characterization of a novel nitroreductase (GlNR2)
    Joachim Muller
    Institute of Parasitology, Vetsuisse Faculty, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    J Antimicrob Chemother 68:1781-9. 2013
  9. doi Nitroreductase (GlNR1) increases susceptibility of Giardia lamblia and Escherichia coli to nitro drugs
    Dorothea Nillius
    Institute of Parasitology, University of Berne, Berne, Switzerland
    J Antimicrob Chemother 66:1029-35. 2011
  10. ncbi Characterization of a Giardia lamblia WB C6 clone resistant to the isoflavone formononetin
    Maaike Sterk
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Microbiology 153:4150-8. 2007

Collaborators

Detail Information

Publications31

  1. ncbi Neospora caninum: functional inhibition of protein disulfide isomerase by the broad-spectrum anti-parasitic drug nitazoxanide and other thiazolides
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Exp Parasitol 118:80-8. 2008
    ..Thus, thiazolides readily interfere with NcPDI, and possibly also with PDIs from other microorganisms susceptible to thiazolides...
  2. doi Identification of a host cell target for the thiazolide class of broad-spectrum anti-parasitic drugs
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Exp Parasitol 128:145-50. 2011
    ..The thiazolides NTZ, tizoxanide and RM4847 inhibited recQR activity on menadione in a concentration-dependent manner. Moreover, a small residual reducing activity was observed when these thiazolides were offered as substrates...
  3. doi Thioureides of 2-(phenoxymethyl)benzoic acid 4-R substituted: a novel class of anti-parasitic compounds
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Parasitol Int 58:128-35. 2009
    ..Thioureides may thus present a promising class of anti-infective agents...
  4. doi Identification of differentially expressed genes in a Giardia lamblia WB C6 clone resistant to nitazoxanide and metronidazole
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    J Antimicrob Chemother 62:72-82. 2008
    ..The characterization of differential gene expression in Giardia lamblia WB C6 strain C4 resistant to metronidazole and nitazoxanide using microarray technology and quantitative real-time PCR...
  5. doi Stable expression of Escherichia coli beta-glucuronidase A (GusA) in Giardia lamblia: application to high-throughput drug susceptibility testing
    Joachim Muller
    Institute of Parasitology, University of Berne, Berne, Switzerland
    J Antimicrob Chemother 64:1187-91. 2009
    ....
  6. ncbi Characterization of Giardia lamblia WB C6 clones resistant to nitazoxanide and to metronidazole
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    J Antimicrob Chemother 60:280-7. 2007
    ....
  7. pmc A novel Giardia lamblia nitroreductase, GlNR1, interacts with nitazoxanide and other thiazolides
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Antimicrob Agents Chemother 51:1979-86. 2007
    ..In this assay system, NR activity was severely inhibited by NTZ and other thiazolides, demonstrating that the antigiardial activity of these drugs could be, at least partially, mediated through inhibition of GlNR1...
  8. doi Metabolism of nitro drugs metronidazole and nitazoxanide in Giardia lamblia: characterization of a novel nitroreductase (GlNR2)
    Joachim Muller
    Institute of Parasitology, Vetsuisse Faculty, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    J Antimicrob Chemother 68:1781-9. 2013
    ..Nitroreductases may play a role in activating these drugs. G. lamblia contains two nitroreductases, GlNR1 and GlNR2. The aim of this work was to elucidate the role of GlNR2...
  9. doi Nitroreductase (GlNR1) increases susceptibility of Giardia lamblia and Escherichia coli to nitro drugs
    Dorothea Nillius
    Institute of Parasitology, University of Berne, Berne, Switzerland
    J Antimicrob Chemother 66:1029-35. 2011
    ..lamblia nitroreductase 1 (GlNR1) was identified as a nitazoxanide-binding protein. The aim of the present project was to elucidate the role of this enzyme in the mode of action of the nitro drugs nitazoxanide and metronidazole...
  10. ncbi Characterization of a Giardia lamblia WB C6 clone resistant to the isoflavone formononetin
    Maaike Sterk
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Microbiology 153:4150-8. 2007
    ..However, the capacity of Giardia to develop resistance to isoflavones can potentially interfere with this alternative treatment of the disease...
  11. pmc In vitro effects of thiazolides on Giardia lamblia WB clone C6 cultured axenically and in coculture with Caco2 cells
    Joachim Muller
    Institute of Parasitology, University of Bern, Langgass strasse 122, CH 3012 Bern, Switzerland
    Antimicrob Agents Chemother 50:162-70. 2006
    ..Trophozoites treated with NTZ showed distinct lesions on the ventral disk as soon as 2 to 3 h after treatment, whereas treatment with metronidazole resulted in severe damage to the dorsal surface membrane at later time points...
  12. doi Echinococcus multilocularis phosphoglucose isomerase (EmPGI): a glycolytic enzyme involved in metacestode growth and parasite-host cell interactions
    Britta Stadelmann
    Institute of Parasitology, Vetsuisse Faculty, University of Berne, Berne, Switzerland
    Int J Parasitol 40:1563-74. 2010
    ..Thus, besides its role in glycolysis, EmPGI could also act as a factor that stimulates parasite growth and potentially induces the formation of novel blood vessels around the developing metacestode in vivo...
  13. ncbi Drug target identification in intracellular and extracellular protozoan parasites
    Joachim Muller
    Institute of Parasitology, University of Berne, Länggass Strasse, Switzerland
    Curr Top Med Chem 11:2029-38. 2011
    ..In this review, we provide an overview of strategies for target identification, and present examples of selected drug targets, ranging from proteins to nucleic acids to intermediary metabolism...
  14. doi Tritrichomonas foetus isolates from cats and cattle show minor genetic differences in unrelated loci ITS-2 and EF-1α
    Karin Reinmann
    Institute of Parasitology, Vetsuisse Faculty, University of Berne, Langgassstrasse 122, 3012 Berne, Switzerland
    Vet Parasitol 185:138-44. 2012
    ..foetus from feline isolates and also from other trichomonads. The implications these minor genetic differences may have on the biological properties of the distinct isolates remain to be investigated...
  15. doi Vaccination with recombinant NcROP2 combined with recombinant NcMIC1 and NcMIC3 reduces cerebral infection and vertical transmission in mice experimentally infected with Neospora caninum tachyzoites
    Karim Debache
    Institute of Parasitology, Vetsuisse Faculty, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Int J Parasitol 39:1373-84. 2009
    ..In conclusion, a mixture of recombinant antigens representing important secretory micronemal and rhoptry proteins leads to a significant protection against vertical transmission of N. caninum in mice...
  16. doi Application of an in vitro drug screening assay based on the release of phosphoglucose isomerase to determine the structure-activity relationship of thiazolides against Echinococcus multilocularis metacestodes
    Britta Stadelmann
    Institute of Parasitology, Vetsuisse Faculty, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    J Antimicrob Chemother 65:512-9. 2010
    ..multilocularis metacestode cultivation, we aimed to develop a rapid and reliable drug screening test, which enables efficient screening of a large number of compounds in a relatively short time frame...
  17. pmc Hepatic gene expression profile in mice perorally infected with Echinococcus multilocularis eggs
    Bruno Gottstein
    Vetsuisse Faculty, Institute of Parasitology, University of Bern, Bern, Switzerland
    PLoS ONE 5:e9779. 2010
    ..Despite this severe course and outcome of disease, the genetic program that regulates the host response leading to organ damage as a consequence of hepatic alveolar echinococcosis is largely unknown...
  18. pmc Treatment of echinococcosis: albendazole and mebendazole--what else?
    Andrew Hemphill
    Vetsuisse Faculty, Institute of Parasitology, University of Berne, Langgass strasse 122, 3012 Berne, Switzerland
    Parasite 21:70. 2014
    ..The key to success is to identify, target and exploit those parasite molecules that orchestrate activities essential to parasite survival. ..
  19. ncbi Induction of tachyzoite egress from cells infected with the protozoan Neospora caninum by nitro- and bromo-thiazolides, a class of broad-spectrum anti-parasitic drugs
    Marco Esposito
    Institute of Parasitology, Vetsuisse Faculty, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Int J Parasitol 37:1143-52. 2007
    ..This demonstrated that bromo- and nitro-thiazolides exhibit differential effects against the intracellular protozoan N. caninum and bromo-thiazolides could represent a valuable alternative to the nitro-thiazolyl-salicylamide drugs...
  20. pmc In Vitro and In Vivo Effects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninum
    Pablo Winzer
    Institute of Parasitology, Vetsuisse Faculty, University of Berne, Berne, Switzerland
    Antimicrob Agents Chemother 59:6361-74. 2015
    ..The observed deregulated antigen expression effect may enhance the immune response during BKI-1294 therapy and will be the subject of future studies. ..
  21. doi N-terminal fusion of a toll-like receptor 2-ligand to a Neospora caninum chimeric antigen efficiently modifies the properties of the specific immune response
    Adriana Aguado-Martínez
    Institute for Parasitology, Vetsuisse Faculty, University of Berne, Langgass strasse 122, CH 3012 Bern, Switzerland
    Parasitology 143:606-16. 2016
    ..Antigen linkage to TLR2-ligands, such as OprI, is a useful tool to investigate this enigma by reorienting the innate and adaptive immune responses against other candidate antigens in future studies. ..
  22. pmc Repurposing of antiparasitic drugs: the hydroxy-naphthoquinone buparvaquone inhibits vertical transmission in the pregnant neosporosis mouse model
    Joachim Muller
    Institute of Parasitology, Vetsuisse Faculty, University of Berne, Langgass strasse 122, 3012, Bern, Switzerland
    Vet Res 47:32. 2016
    ..This demonstrates proof-of-concept that drug repurposing may lead to the discovery of an effective compound against neosporosis that can protect offspring from vertical transmission and disease...
  23. doi In vitro and in vivo effects of 2-methoxyestradiol, either alone or combined with albendazole, against Echinococcus metacestodes
    Martin Spicher
    Institute of Parasitology, Vetsuisse Faculty, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Exp Parasitol 119:475-82. 2008
    ....
  24. doi Thiazolides inhibit growth and induce glutathione-S-transferase Pi (GSTP1)-dependent cell death in human colon cancer cells
    Joachim Muller
    Institute of Parasitology, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Int J Cancer 123:1797-806. 2008
    ..Thiazolides may thus represent an interesting novel class of future cancer therapeutics...
  25. pmc Comparative characterisation of two nitroreductases from Giardia lamblia as potential activators of nitro compounds
    Joachim Muller
    Institute of Parasitology, Vetsuisse Faculty, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Int J Parasitol Drugs Drug Resist 5:37-43. 2015
    ..Activation by GlNR1 or inactivation by GlNR2 of nitro drugs may be the consequence of a secondary enzymatic activity either yielding (GlNR1) or eliminating (GlNR2) toxic intermediates after reduction of these compounds. ..
  26. doi Oral treatments of Echinococcus multilocularis-infected mice with the antimalarial drug mefloquine that potentially interacts with parasite ferritin and cystatin
    Tatiana Küster
    Institute of Parasitology, Vetsuisse Faculty, University of Bern, Langgassstrasse 122, CH 3012 Bern, Switzerland
    Int J Antimicrob Agents 46:546-51. 2015
    ..This indicates that MEF could potentially interact with different proteins in parasites and human cells...
  27. pmc Profound activity of the anti-cancer drug bortezomib against Echinococcus multilocularis metacestodes identifies the proteasome as a novel drug target for cestodes
    Britta Stadelmann
    Institute of Parasitology, University of Berne, Vetsuisse Faculty, Berne, Switzerland
    PLoS Negl Trop Dis 8:e3352. 2014
    ..However, translation of these findings into in vivo efficacy requires further adjustments of treatment regimens using BTZ, or possibly other proteasome inhibitors. ..
  28. doi New approaches for the identification of drug targets in protozoan parasites
    Joachim Muller
    Institute of Parasitology, University of Berne, Berne, Switzerland
    Int Rev Cell Mol Biol 301:359-401. 2013
    ..Target-based drug design supported by genomics and proteomics of protozoan parasites has not produced any antiparasitic drug so far. The reason for this is discussed and a synthesis of both methods is proposed...
  29. doi Approaches for the vaccination and treatment of Neospora caninum infections in mice and ruminant models
    Andrew Hemphill
    Institute of Parasitology, University of Berne, Berne, Switzerland
    Parasitology 143:245-59. 2016
    ..In this review, the current status of vaccine and drug development is presented and novel strategies against neosporosis are discussed. ..
  30. doi In vitro culture systems for the study of apicomplexan parasites in farm animals
    Joachim Muller
    Institute of Parasitology, Vetsuisse Faculty, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Int J Parasitol 43:115-24. 2013
    ....
  31. doi In vitro effects of new artemisinin derivatives in Neospora caninum-infected human fibroblasts
    Joachim Muller
    Institute of Parasitology, Vetsuisse Faculty, University of Berne, Langgass strasse 122, CH 3012 Berne, Switzerland
    Int J Antimicrob Agents 46:88-93. 2015
    ..Drugs induced the expression of elevated levels of NcBAG1 and NcSAG4 mRNA, but only NcBAG1 could be detected by immunofluorescence. Thus, artemisinin derivatives represent interesting leads that should be investigated further. ..