Gilles Mentha

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. pmc Complete pathological response (ypT0N0M0) after preoperative chemotherapy alone for stage IV rectal cancer
    Surennaidoo P Naiken
    Services de chirurgie viscérale et transplantation, Departement de Chirurgie, Hopitaux Universitaires de Geneve, Rue Gabrielle Perret Gentil 4, Genève 14 1211, Suisse
    BMC Surg 14:4. 2014
  2. doi Operative management of colorectal liver metastases
    Gilles Mentha
    Divisions of Transplantation and Visceral Surgery, Department of Surgery, University Hospitals of Geneva, Switzerland
    Semin Liver Dis 33:262-72. 2013
  3. pmc A capillary blood ammonia bedside test following glutamine load to improve the diagnosis of hepatic encephalopathy in cirrhosis
    Saskia Ditisheim
    Gastroenterology and Hepatology, University Hospitals and Faculty of Medicine, 4, rue Gabrielle Perret Gentil, 1211 Geneva, Switzerland
    BMC Gastroenterol 11:134. 2011
  4. doi 'Liver first' approach in the treatment of colorectal cancer with synchronous liver metastases
    Gilles Mentha
    Department of Surgery, University Hospitals of Geneva, Geneva, Switzerland
    Dig Surg 25:430-5. 2008
  5. ncbi Treatment strategies for the management of advanced colorectal liver metastases detected synchronously with the primary tumour
    G Mentha
    Department of Surgery, University Hospital of Geneva, Geneva, Switzerland
    Eur J Surg Oncol 33:S76-83. 2007
  6. ncbi Neoadjuvant chemotherapy and resection of advanced synchronous liver metastases before treatment of the colorectal primary
    G Mentha
    Department of Visceral and Transplantation Surgery, University Hospitals of Geneva, 1211 Geneva 14, Switzerland
    Br J Surg 93:872-8. 2006
  7. doi Dangerous halo after neoadjuvant chemotherapy and two-step hepatectomy for colorectal liver metastases
    G Mentha
    Department of Visceral and Transplantation Surgery, University Hospitals of Geneva, 24 Rue Micheli du Crest, Geneve 14, Switzerland
    Br J Surg 96:95-103. 2009
  8. ncbi Liver transplantation for Budd-Chiari syndrome: A European study on 248 patients from 51 centres
    Gilles Mentha
    Transplantation Unit, Department of Surgery, University Hospitals, 1211 Geneva 14, Switzerland
    J Hepatol 44:520-8. 2006
  9. doi A model for dropout assessment of candidates with or without hepatocellular carcinoma on a common liver transplant waiting list
    Christian Toso
    Division of Transplant, Department of Surgery, University of Geneva Hospitals, Geneva, Switzerland
    Hepatology 56:149-56. 2012
  10. ncbi Improved long-term outcome of surgery for advanced colorectal liver metastases: reasons and implications for management on the basis of a severity score
    Axel Andres
    Unit of Visceral and Transplantation Surgery, University Hospitals of Geneva, 1211, Geneva 14, Switzerland
    Ann Surg Oncol 15:134-43. 2008

Detail Information

Publications121 found, 100 shown here

  1. pmc Complete pathological response (ypT0N0M0) after preoperative chemotherapy alone for stage IV rectal cancer
    Surennaidoo P Naiken
    Services de chirurgie viscérale et transplantation, Departement de Chirurgie, Hopitaux Universitaires de Geneve, Rue Gabrielle Perret Gentil 4, Genève 14 1211, Suisse
    BMC Surg 14:4. 2014
    ..The possibility that complete pathological response of rectal cancer can also occur with neoadjuvant chemotherapy alone (without radiation) is an intriguing hypothesis...
  2. doi Operative management of colorectal liver metastases
    Gilles Mentha
    Divisions of Transplantation and Visceral Surgery, Department of Surgery, University Hospitals of Geneva, Switzerland
    Semin Liver Dis 33:262-72. 2013
    ..These rates would have been unimaginable only two decades ago. ..
  3. pmc A capillary blood ammonia bedside test following glutamine load to improve the diagnosis of hepatic encephalopathy in cirrhosis
    Saskia Ditisheim
    Gastroenterology and Hepatology, University Hospitals and Faculty of Medicine, 4, rue Gabrielle Perret Gentil, 1211 Geneva, Switzerland
    BMC Gastroenterol 11:134. 2011
    ..Hepatic encephalopathy (HE) is a frequent and severe complication of cirrhosis. A single determination of ammonia in venous blood correlates poorly with neurological symptoms. Thus, a better biological marker is needed...
  4. doi 'Liver first' approach in the treatment of colorectal cancer with synchronous liver metastases
    Gilles Mentha
    Department of Surgery, University Hospitals of Geneva, Geneva, Switzerland
    Dig Surg 25:430-5. 2008
    ..The present series updates on a previously reported pilot experience...
  5. ncbi Treatment strategies for the management of advanced colorectal liver metastases detected synchronously with the primary tumour
    G Mentha
    Department of Surgery, University Hospital of Geneva, Geneva, Switzerland
    Eur J Surg Oncol 33:S76-83. 2007
    ....
  6. ncbi Neoadjuvant chemotherapy and resection of advanced synchronous liver metastases before treatment of the colorectal primary
    G Mentha
    Department of Visceral and Transplantation Surgery, University Hospitals of Geneva, 1211 Geneva 14, Switzerland
    Br J Surg 93:872-8. 2006
    ..The authors have investigated a management strategy that involves high-impact chemotherapy first, resection of liver metastases second and finally removal of the primary tumour in patients with adverse prognostic factors...
  7. doi Dangerous halo after neoadjuvant chemotherapy and two-step hepatectomy for colorectal liver metastases
    G Mentha
    Department of Visceral and Transplantation Surgery, University Hospitals of Geneva, 24 Rue Micheli du Crest, Geneve 14, Switzerland
    Br J Surg 96:95-103. 2009
    ..The aim of this study was to describe the clinical and histological outcomes of patients having neoadjuvant chemotherapy and two-step hepatectomy with right portal vein occlusion for advanced bilateral colorectal metastases...
  8. ncbi Liver transplantation for Budd-Chiari syndrome: A European study on 248 patients from 51 centres
    Gilles Mentha
    Transplantation Unit, Department of Surgery, University Hospitals, 1211 Geneva 14, Switzerland
    J Hepatol 44:520-8. 2006
    ..The aim of this study was to investigate the results of transplantation for BCS, focusing on overall outcome, on prognostic factors and on the impact of the underlying disease...
  9. doi A model for dropout assessment of candidates with or without hepatocellular carcinoma on a common liver transplant waiting list
    Christian Toso
    Division of Transplant, Department of Surgery, University of Geneva Hospitals, Geneva, Switzerland
    Hepatology 56:149-56. 2012
    ..Because this model and MELD did not share compatible scales, a correlation between both models was computed according to the predicted risk of dropout, and drop-out equivalent MELD (deMELD) points were calculated...
  10. ncbi Improved long-term outcome of surgery for advanced colorectal liver metastases: reasons and implications for management on the basis of a severity score
    Axel Andres
    Unit of Visceral and Transplantation Surgery, University Hospitals of Geneva, 1211, Geneva 14, Switzerland
    Ann Surg Oncol 15:134-43. 2008
    ..To quantify this assumption and to understand its causes we analyzed a series of patients on the basis of a standardized severity score and changes in management occurring over the years...
  11. doi Neoadjuvant chemotherapy in patients with stage IV colorectal cancer: a comparison of histological response in liver metastases, primary tumors, and regional lymph nodes
    Pascal Gervaz
    Department of Surgery, University Hospital Geneva, Geneva, Switzerland
    Ann Surg Oncol 17:2714-9. 2010
    ..This study was designed to compare the response to chemotherapy in liver metastases, primary tumors, and locoregional lymph nodes...
  12. doi A survival analysis of the liver-first reversed management of advanced simultaneous colorectal liver metastases: a LiverMetSurvey-based study
    Axel Andres
    Abdominal and Transplantation Surgery, Geneva University Hospital, Rue Gabrielle Perret Gentil 4, Geneva, Switzerland
    Ann Surg 256:772-8; discussion 778-9. 2012
    ..Retrospective data have shown that up to 80% of patients can successfully undergo a complete RM, whereas less than 30% of those undergoing classical management (CM) do so. This registry-based study compared the 2 approaches...
  13. doi A score predicting survival after liver retransplantation for hepatitis C virus cirrhosis
    Axel Andres
    Abdominal and Transplantation Surgery, Department of Surgery, University Hospital Geneva, Switzerland
    Transplantation 93:717-22. 2012
    ..Although the relisting decision can be difficult in these patients, a score could help in selection of candidates with the best potential outcomes...
  14. ncbi Conversion to sirolimus-based immunosuppression in maintenance liver transplantation patients
    Isabelle Morard
    Hepatogastroenterology, Geneva University Hospital, Geneva, Switzerland
    Liver Transpl 13:658-64. 2007
    ..Acute rejection (AR) occurred in 17% of the patients. SRL was withdrawn in 17% of the patients. In conclusion, conversion from CNI to SRL is safe and is associated with significant renal function improvement...
  15. pmc Factors predicting survival after post-transplant hepatocellular carcinoma recurrence
    Christian Toso
    Divisions of Transplant and Abdominal Surgery, Department of Surgery, University of Geneva Hospitals, rue Gabrielle Perret Gentil, 1211, Geneva, Switzerland
    J Hepatobiliary Pancreat Sci 20:342-7. 2013
    ..Although factors associated with an increased risk of recurrence after liver transplantation for hepatocellular carcinoma (HCC) have been extensively studied, the history of patients with a post-transplant recurrence is poorly known...
  16. doi Liver resection for colorectal metastases after chemotherapy: impact of chemotherapy-related liver injuries, pathological tumor response, and micrometastases on long-term survival
    Luca Vigano
    Departments of HPB and Digestive Surgery and Pathology, Ospedale Mauriziano Umberto I, Torino, Italy and Departments of Visceral and Transplantation Surgery and Clinical Pathology, University Hospitals, Geneva, Switzerland
    Ann Surg 258:731-40; discussion 741-2. 2013
    ....
  17. doi Complications of elective liver resections in a center with low mortality: a simple score to predict morbidity
    Axel Andres
    Department of Visceral and Transplantation Surgery, Geneva University Hospitals, Geneve, Switzerland
    Arch Surg 146:1246-52. 2011
    ..To develop a score predicting the morbidity of liver resections in a center with low mortality...
  18. doi Injection drug use before and after liver transplantation: a retrospective multicenter analysis on incidence and outcome
    Andrea De Gottardi
    Gastroenterology, Hepatology and Visceral Surgery, University Hospital, Geneva, Switzerland
    Clin Transplant 24:564-71. 2010
    ..Injecting drug use (IDU) before and after liver transplantation (LT) is poorly described. The aim of this study was to quantify relapse and survival in this population and to describe the causes of mortality after LT...
  19. ncbi Surgical management and long-term outcome of complicated liver hydatid cysts caused by Echinococcus granulosus
    Roland Chautems
    Department of Surgery, Clinic of Visceral Surgery, University Hospital of Geneva, Switzerland
    Surgery 137:312-6. 2005
    ..The aim of this retrospective study was to evaluate clinical presentation and long-term outcome of patients treated surgically for complicated liver hydatid cysts...
  20. doi Demographics and outcomes of severe herpes simplex virus hepatitis: a registry-based study
    Bogdan Moldovan
    Transplantation Division, Department of Surgery, Geneva, Switzerland
    J Hepatol 55:1222-6. 2011
    ..The present study was based on the SRTR registry, and included all listed patients for liver transplantation from 1985 to 2009 with a diagnosis of HSV hepatitis...
  21. ncbi Image-guided multipolar radiofrequency ablation of liver tumours: initial clinical results
    Sylvain Terraz
    Department of Radiology, Geneva University Hospital, Rue Micheli du Crest 24, 1211 Geneva 14, Switzerland
    Eur Radiol 17:2253-61. 2007
    ..Multipolar RF technique creates ablation zones of adequate size and tailored shape and is effective to treat most liver tumours, including those close to major hepatic vessels...
  22. doi The impact of wait list body mass index changes on the outcome after liver transplantation
    Lorenzo A Orci
    Divisions of visceral and transplantation surgery, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    Transpl Int 26:170-6. 2013
    ..5 kg/m(2) . Obesity does not constitute an absolute contraindication to liver transplantation...
  23. ncbi Long-term renal function after liver transplantation is related to calcineurin inhibitors blood levels
    Isabelle Morard
    Department of Hepato Gastroenterology, Geneva University Hospital, Geneva, Switzerland
    Clin Transplant 20:96-101. 2006
    ..Renal dysfunction is common after liver transplantation (LT). The aim of our study was to assess the prevalence of renal dysfunction 5 yr after LT and to identify risk factors for the development of this complication...
  24. doi Herpes simplex virus load to monitor antiviral treatment after liver transplantation for acute herpetic hepatitis
    Juan Ambrosioni
    Service of Infectious Diseases, Department of Medical Specialities, University Hospitals of Geneva, Geneva, Switzerland
    Antivir Ther 17:401-4. 2012
    ..We present a case of ALF complicating a primary HSV-1 infection in an immunocompetent host, who required emergency LT. We further discuss the value of measuring serial HSV DNA plasma loads to monitor antiviral therapy...
  25. pmc Predicting survival after pulmonary metastasectomy for colorectal cancer: previous liver metastases matter
    Ulrich Landes
    Department of Surgery, Geneva University Hospital and Medical School, Geneva, Switzerland
    BMC Surg 10:17. 2010
    ..The aim of this study was to determine the impact of various parameters on survival after pulmonary metastasectomy for CRC...
  26. ncbi A simple score for predicting alcohol relapse after liver transplantation: results from 387 patients over 15 years
    Andrea De Gottardi
    Divisions of Gastroenterology and Hepatology, University Hospital, Geneva, Switzerland
    Arch Intern Med 167:1183-8. 2007
    ..Alcohol relapse can negatively influence the outcome after liver transplantation (LT). The aim of our study was to identify factors that could be associated with the recurrence of harmful alcohol consumption after LT...
  27. ncbi Management of hepatocellular carcinoma on the waiting list before liver transplantation: time for controlled trials?
    Pietro Majno
    Geneva Liver Cancer Study Group, University Hospitals of Geneva, Geneva, Switzerland
    Liver Transpl 13:S27-35. 2007
  28. ncbi Importance of histological tumor response assessment in predicting the outcome in patients with colorectal liver metastases treated with neo-adjuvant chemotherapy followed by liver surgery
    L Rubbia-Brandt
    Unit of Gastrointestinal and Liver Pathology, University Hospital, Geneva, Switzerland
    Ann Oncol 18:299-304. 2007
    ....
  29. doi Rectal outcomes after a liver-first treatment of patients with stage IV rectal cancer
    Nicolas C Buchs
    Department of Surgery, Clinic for Visceral and Transplantation Surgery, University Hospital of Geneva, Geneva, Switzerland
    Ann Surg Oncol 22:931-7. 2015
    ..We developed a reverse strategy, the liver-first approach, to optimize the chance of a curative resection. The aim of this study was to assess rectal outcomes after reverse treatment of patients with metastatic rectal cancer...
  30. doi Assessment of sexual function and conjugal satisfaction prior to and after liver transplantation
    Jacques Klein
    Division of Urologic Surgery, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    Ann Transplant 18:136-45. 2013
    ..The aims of this study were to assess sexual function and conjugal satisfaction in patients prior to and after liver transplantation, and in comparison to healthy individuals...
  31. doi Posttransplant cellular immune reactivity against donor antigen correlates with clinical islet transplantation outcome: towards a better posttransplant monitoring
    Stéphanie Lacotte
    Department of Surgery, Geneva University Hospitals, Faculty of Medicine, University of Geneva, Rue Gabrielle Perret Gentil 4, Geneva, Switzerland
    Cell Transplant 21:2339-50. 2012
    ..Cellular immune reactivity against donor cells correlates with posttransplant islet function. The tested assays have the potential to be of substantial help in the management of islet graft recipients and deserve prospective validation...
  32. ncbi Percutaneous treatment of liver tumors with an adapted probe for cooled-tip, impedance-controlled radio-frequency ablation under open-magnet MR guidance: initial results
    Alexis D Kelekis
    Department of Diagnostic and Interventional Radiology, University Hospital, 24 Rue Micheli du Crest, 1211, Geneva, Switzerland
    Eur Radiol 13:1100-5. 2003
    ..No adverse effects were noted. Initial experience suggests that the probe we used allows to perform impedance-controlled cooled-tip RF ablation of liver tumors under open-magnet MR guidance...
  33. doi Humoral and cellular rejection after combined liver-kidney transplantation in low immunologic risk recipients
    Karine Hadaya
    Division of Nephrology, Geneva University Hospital, Geneva, Switzerland
    Transpl Int 22:242-6. 2009
    ..Indeed, the detection of C4d in the liver should be carefully followed after combined liver-kidney transplantation...
  34. ncbi Impact of HLA matching on the outcome of simultaneous pancreas-kidney transplantation
    Thierry Berney
    Division of Visceral and Transplantation Surgery, Geneva University Hospitals, Switzerland
    Nephrol Dial Transplant 20:ii48-53, ii62. 2005
    ..The current analysis examined the impact of human leukocyte antigen (HLA) matching on graft outcome following SPK transplantation. The study population was obtained from patients enrolled in the Euro-SPK 001 study...
  35. doi The place of downstaging for hepatocellular carcinoma
    Christian Toso
    Transplantation Unit, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    J Hepatol 52:930-6. 2010
    ..The present review discusses which treatments and strategies are available for downstaging HCC on the basis of the published literature...
  36. pmc Systematic review and meta-analysis of fibrin sealants for patients undergoing pancreatic resection
    Lorenzo A Orci
    Division of Visceral and Transplantation Surgery, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    HPB (Oxford) 16:3-11. 2014
    ..The role of fibrin sealants in decreasing the risk of POPF remains debatable. The aim of this study was to evaluate the literature regarding the effectiveness of fibrin sealants in pancreatic surgery...
  37. doi Initial cholecystectomy vs sequential common duct endoscopic assessment and subsequent cholecystectomy for suspected gallstone migration: a randomized clinical trial
    Pouya Iranmanesh
    Division of Digestive Surgery, Department of Surgery, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland2Division of Transplant Surgery, Department of Surgery, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland3He
    JAMA 312:137-44. 2014
    ..Many stones migrate spontaneously into the duodenum, making preoperative common duct investigations unnecessary...
  38. ncbi A 3-month course of long-acting repeatable octreotide (sandostatin LAR) improves portal hypertension in patients with cirrhosis: a randomized controlled study
    Laurent Spahr
    Transplantation Unit, University Hospital, Geneva, Switzerland
    Am J Gastroenterol 102:1397-405. 2007
    ..Information on long-term effects of octreotide is limited and controversial. We evaluated portal and systemic hemodynamics following a prolonged administration of long-acting octreotide in patients with cirrhosis...
  39. pmc Management of hepatocellular adenoma: solitary-uncomplicated, multiple and ruptured tumors
    Christian Toso
    Abdominal and Transplant Surgery, University Hospital, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    World J Gastroenterol 11:5691-5. 2005
    ..While hepatocellular adenomas (HAs) have often been studied as a unique entity, we aimed to better define current management of the various forms of HAs...
  40. doi Focal ischemic necrosis in advanced biliary atresia cirrhosis
    Barbara E Wildhaber
    Department of Pediatric Surgery, University Hospital of Geneva, Geneva, Switzerland
    Pediatr Transplant 12:487-91. 2008
    ..Because of precarious hepatic blood supply in such patients, close monitoring of portal and diastolic arterial flows is recommended...
  41. ncbi Management of hepatocellular carcinoma in the waiting list before liver transplantation
    Pietro Majno
    Clinics of Visceral Surgery and Transplantation, University Hospitals of Geneva, 1211 Geneva 14, Switzerland
    J Hepatol 42:S134-43. 2005
  42. doi Octreotide bolus injection and azygos blood flow in patients with cirrhosis: is the effect really predictable?
    Laurent Spahr
    Gastroenterology and Hepatology Unit, University Hospitals, Geneva, Switzerland
    J Clin Gastroenterol 44:e206-9. 2010
    ..Available data show a transient decrease in portal pressure and azygos blood flow (AzBF) after OCT bolus injection with desensitization at readministration...
  43. pmc Alloimmune activation promotes anti-cancer cytotoxicity after rat liver transplantation
    Stéphanie Lacotte
    Department of Surgery, Geneva University Hospitals, University of Geneva, Geneva, Switzerland
    PLoS ONE 9:e91515. 2014
    ....
  44. doi Risk factors for early and late biliary complications in pediatric liver transplantation
    Samuel C Lüthold
    Division of Pediatric Surgery, Geneva University Hospitals, Geneva, Switzerland
    Pediatr Transplant 18:822-30. 2014
    ..Operation time should be kept to a minimum, and HAT must by all means be prevented. Children with a high MELD score or receiving livers from older donors are at increased risk for intrahepatic strictures. ..
  45. doi Pre-retrieval reperfusion decreases cancer recurrence after rat ischemic liver graft transplantation
    Graziano Oldani
    Divisions of Transplant and Abdominal Surgery, Department of Surgery, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland Department of Surgery, University of Pavia, Italy
    J Hepatol 61:278-85. 2014
    ..Graft reperfusion prior to retrieval (as for extracorporeal membrane oxygenation--ECMO) can prevent I/R lesions. The impact of I/R on the risk of cancer recurrence was assessed on a syngeneic Fischer-rat liver transplantation model...
  46. doi Current status of robotic liver resection: a systematic review
    Nicolas C Buchs
    Department of Surgery, Clinic for Visceral and Transplantation Surgery, University Hospital of Geneva, Switzerland
    Expert Rev Anticancer Ther 14:237-46. 2014
    ..It could represent a bridge toward minimally invasive approaches for confirmed liver surgeons. By contrast, the long-term oncological outcomes remain uncertain and need further studies. ..
  47. doi Caroli disease, bilateral diffuse cystic renal dysplasia, situs inversus, postaxial polydactyly, and preauricular fistulas: a ciliopathy caused by a homozygous NPHP3 mutation
    Ana Maria Calinescu-Tuleasca
    Service of Pediatric Surgery, University Hospitals of Geneva, 6 Rue Willy Donze, 1205 Geneva, Switzerland
    Eur J Pediatr 172:877-81. 2013
    ..Combined liver-kidney transplantation was performed at the age of 4 years, with excellent outcome. DNA analysis showed a NPHP3 (coding nephrocystin-3) homozygote mutation, confirming that this malformation complex is a ciliopathy...
  48. doi Outcome of treated and untreated asymptomatic bacteriuria in renal transplant recipients
    Emmanuelle Boffi El Amari
    Department of Medical Specialities, University Hospital Geneva, Geneva, Switzerland
    Nephrol Dial Transplant 26:4109-14. 2011
    ..Because of scarce clinical symptoms and fear of complications, such episodes are frequently treated based on subjective criteria without clear clinical benefit, with the risk of selecting resistant pathogens...
  49. doi Donor hypernatremia influences outcomes following pediatric liver transplantation
    Neema Kaseje
    Department of Pediatric Surgery, University Children s Hospital Geneva, 6 Rue Willy Donze, Geneva, Switzerland
    Eur J Pediatr Surg 23:8-13. 2013
    ..Our aim was to investigate differences in outcome in patients receiving grafts from hypernatremic donors compared with patients receiving grafts from normonatremic donors in the pediatric population...
  50. pmc Interleukin-1 receptor antagonist modulates the early phase of liver regeneration after partial hepatectomy in mice
    Antonino Sgroi
    Surgical Research Unit, Department of Surgery, Geneva University Hospital and University of Geneva, Geneva, Switzerland
    PLoS ONE 6:e25442. 2011
    ..The aim of this study was to evaluate the role of interleukin-1 receptor antagonist (IL-1ra) during liver regeneration and to study the effect of a recombinant human IL-1ra on liver regeneration...
  51. doi Radiofrequency ablation of small liver malignancies under magnetic resonance guidance: progress in targeting and preliminary observations with temperature monitoring
    Sylvain Terraz
    Department of Radiology, University Hospitals of Geneva, Geneva, Switzerland
    Eur Radiol 20:886-97. 2010
    ....
  52. doi Biliary atresia: Swiss national study, 1994-2004
    Barbara E Wildhaber
    University Hospital of Geneva, Switzerland
    J Pediatr Gastroenterol Nutr 46:299-307. 2008
    ..To determine the epidemiology of biliary atresia (BA) in Switzerland, the outcome of the children from diagnosis, and the prognostic factors...
  53. ncbi Lessons learned from one thousand consecutive colonic resections in a teaching hospital
    Nicolas C Buchs
    Department of Surgery, University Hospital Geneva, 24 Rue Micheli du Crest, CH 1211 Geneva, Switzerland
    Swiss Med Wkly 137:259-64. 2007
    ..Elective colectomies are standard procedures carrying below 1% mortality; by contrast, emergency colonic resections remain surgical challenges in compromised and/or elderly patients and are associated with high complication rates...
  54. ncbi Is there a customised immunosuppressive regimen for patients transplanted with hepatocellular carcinoma?
    Pietro Majno
    Clinics of Visceral Surgery and Transplantation, Department of Surgery, University Hospitals of Geneva, 1211 Geneva 14, Switzerland
    J Hepatol 43:577-84. 2005
  55. doi Sinusoidal obstruction syndrome and nodular regenerative hyperplasia are frequent oxaliplatin-associated liver lesions and partially prevented by bevacizumab in patients with hepatic colorectal metastasis
    Laura Rubbia-Brandt
    Division of Pathology, Geneva University Hospital, Geneva, Switzerland
    Histopathology 56:430-9. 2010
    ....
  56. pmc Hyperimmune anti-HBs plasma as alternative to commercial immunoglobulins for prevention of HBV recurrence after liver transplantation
    Florian Bihl
    Department of Gastroenterology and Hepatology, University Hospital of Geneva, Switzerland
    BMC Gastroenterol 10:71. 2010
    ..However, associated treatment costs for HBIG are exceedingly high...
  57. ncbi Enoxaparin Attenuates Mouse Colon Cancer Liver Metastases by Inhibiting Heparanase and Interferon-γ-inducible Chemokines
    Souad Djaafar
    Department of Surgery, Geneva University Hospitals, Faculty of Medicine, Geneva, Switzerland
    Anticancer Res 36:4019-32. 2016
    ..The aim of the study was to investigate the anti-metastatic role of enoxaparin, a clinically-used LMWH, in a murine model of colon cancer and to explore its underlying mechanisms...
  58. doi The role of hepatic ischemia-reperfusion injury and liver parenchymal quality on cancer recurrence
    Lorenzo A Orci
    Division of Abdominal and Transplantation Surgery, Department of Surgery, Geneva University Hospitals and Faculty of Medicine, University of Geneva, 4 rue Gabrielle Perret Gentil, 1211, Geneva, Switzerland
    Dig Dis Sci 59:2058-68. 2014
    ..Therapeutic strategies tackling I/R injury could not only improve post-surgical organ function, but also allow a reduction in the risk of cancer recurrence. ..
  59. doi Validation of a dropout assessment model of candidates with/without hepatocellular carcinoma on a common liver transplant waiting list
    Christian Toso
    Divisions of Transplant and Abdominal Surgery, Department of Surgery, University of Geneva Hospitals, Geneva, Switzerland Hepato Pancreato Biliary Centre, University of Geneva Hospitals, Geneva, Switzerland
    Transpl Int 27:686-95. 2014
    ..2-73.7% vs. 52.7-56.6%). In addition, the model shows a similar distribution as MELD for patients with non-HCC, and both scores could be used in parallel for the management of waiting-list patients with and without HCC...
  60. ncbi Potential impact of in situ liver splitting on the number of available grafts
    Christian Toso
    Transplantation Unit, Clinic of Digestive and Transplantation Surgery, University Hospitals, Geneva, Switzerland
    Transplantation 74:222-6. 2002
    ..This study investigates the proportion of donors that should be considered for in situ split-liver harvesting according to strict criteria on which a consensus could be reached easily...
  61. doi Detecting rejection after mouse Islet transplantation utilizing islet protein-stimulated ELISPOT
    Christian Toso
    Transplant Unit, Department of Surgery, University of Geneva Hospitals, Switzerland
    Cell Transplant 20:955-62. 2011
    ..Overall, allogeneic rejection was associated to a transient increase in the reactivity of splenocytes against islet proteins. Such a strategy has the potential to improve islet graft monitoring in human and should be further explored...
  62. ncbi Perendoscopic variceal pressure measurement: a reliable estimation of portal pressure in patients with cirrhosis?
    Laurent Spahr
    Gastroenterogy and Hepatology, Hopitaux Universitaire de Geneve, 24 Rue Micheli du Crest, 1211 Geneva 4, Switzerland
    Gastroenterol Clin Biol 30:1012-8. 2006
    ..Variceal pressure (VP) may be measured at endoscopy, but its relationship to the HVPG remains controversial. The aim of the study was to retrospectively compare HVPG and VP values obtained in a cohort of patients with cirrhosis and PHT...
  63. ncbi Oxaliplatin combined with irinotecan and 5-fluorouracil/leucovorin (OCFL) in metastatic colorectal cancer: a phase I-II study
    Y Seium
    Oncosurgery, Services of Visceral Surgery and Radiooncology, Geneva University Hospital, Geneva, Switzerland
    Ann Oncol 16:762-6. 2005
    ....
  64. ncbi Blunt abdominal trauma: does the use of a second-generation sonographic contrast agent help to detect solid organ injuries?
    Pierre Alexandre Poletti
    Department of Radiology, University Hospital of Geneva, 24 Rue Micheli du Crest, 1211 Geneve 14, Switzerland
    AJR Am J Roentgenol 183:1293-301. 2004
    ....
  65. pmc Spontaneous Resolution of Brain Edema in Fulminant Hepatic Failure due to Hepatitis E
    Laurent Spahr
    Gastroenterology and Hepatology, University Hospital, Geneva, Switzerland
    Case Rep Gastroenterol 2:424-7. 2008
    ..We report a very unusual evolution of fulminant hepatic failure complicated by brain edema and hepatic coma in a 45-year-old woman admitted with acute viral hepatitis E infection...
  66. doi Cure of multifocal panhepatic hepatoblastoma: is liver transplantation always necessary?
    Reto Marc Baertschiger
    Pediatric Surgery Unit, University of Geneva Children s Hospital, 1211 Geneva 4, Switzerland
    J Pediatr Surg 45:1030-6. 2010
    ..This procedure is no longer recommended because of the risk of persistent viable tumor cells in the hepatic remnant. We report our experience with conservative surgery in such cases...
  67. doi Gene expression profiling provides insights into pathways of oxaliplatin-related sinusoidal obstruction syndrome in humans
    Laura Rubbia-Brandt
    Service de pathologie clinique, Hopitaux Universitaires de Geneve, 1211 Geneva, Switzerland
    Mol Cancer Ther 10:687-96. 2011
    ..Activation of VEGF and coagulation (vWF) pathways could partially explain at a molecular level the clinical observations that bevacizumab and aspirin have a preventive effect in SOS...
  68. ncbi Hepatocellular adenoma and polycystic ovary syndrome
    Christian Toso
    Clinique et Policlinique de Chirurgie Digestive, Departement de Chirurgie, Hôpitaux Universitaires Genève, Rue Michelidu Crest, 24 CH 1211, Geneve
    Liver Int 23:35-7. 2003
    ..In view of this complication, we recommend a close screening of patients with such hormonal imbalance, especially those who are treated with high doses of hormones, with repeated liver tests and ultrasonographies...
  69. ncbi Adult-to-adult living-donor liver transplantation. A summary of current status and an outline of the program in Geneva
    P Majno
    Transplantation Unit, Department of Surgery, University Hospital, Geneva, Switzerland
    Swiss Surg 9:227-36. 2003
    ..If these prerequisites are met, and within the framework of a structured multidisciplinary program, we believe that living-donor liver transplantation should be funded by health insurances as a recognized therapeutic option...
  70. ncbi Immunosuppression for pancreatic islet transplantation
    T Berney
    Division of Visceral and Transplantation Surgery, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    Transplant Proc 36:362S-366S. 2004
    ....
  71. ncbi Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer
    L Rubbia-Brandt
    Division of Clinical Pathology, University Hospital, Geneva, Switzerland
    Ann Oncol 15:460-6. 2004
    ..The objective of this study was to assess the effects of preoperative systemic chemotherapy on the morphology of non-tumoral liver...
  72. ncbi Left lobe splitting and full right-full left splitting: study of the portal anatomy on corrosion casts and on autopsy livers
    P Majno
    Transplantation Unit, Department of Surgery, University Hospitals, Geneva, Switzerland
    Transplant Proc 34:769-70. 2002
  73. ncbi Medical problems occurring during the long-term follow-up after liver transplantation
    A Demirag
    Clinic of Visceral and Transplantation Surgery, Department of Surgery, University Hospital, Geneva, Switzerland
    Swiss Surg 9:237-41. 2003
    ..The aim of this article is to analyze long-term results of several clinical trials reporting common medical dysfunctions after liver transplantation and to discuss their management...
  74. ncbi Hepatopulmonary syndrome increases the postoperative mortality rate following liver transplantation: a prospective study in 90 patients
    E Schiffer
    Service d anesthésiologie, Département APSI, Hopitaux Universitaires de Geneve, 1205 Geneva, Switzerland
    Am J Transplant 6:1430-7. 2006
    ..In conclusion, our study shows a high postoperative mortality rate following OLT even though the preoperative PaO(2) was >50 mmHg in all HPS patients transplanted...
  75. ncbi Vascular invasion in pancreatic cancer: evaluation of endoscopic ultrasonography, computed tomography, ultrasonography, and angiography
    N C Buchs
    Clinic for Visceral and Transplantation Surgery, Department of Surgery, University Hospitals of Geneva, Geneva, Switzerland
    Swiss Med Wkly 137:286-91. 2007
    ..The aim of this study is to assess the value of current imaging modalities in determining vascular invasion by pancreatic cancer...
  76. ncbi Detection of intrahepatic hepatitis C virus replication by strand-specific semi-quantitative RT-PCR: preliminary application to the liver transplantation model
    F Negro
    Division of Gastroenterology and Hepatology, University Hospital, Geneva, Switzerland
    J Hepatol 29:1-11. 1998
    ....
  77. ncbi IgM anti-hepatitis C virus core antibodies as marker of recurrent hepatitis C after liver transplantation
    F Negro
    Division of Gastroenterology and Hepatology, University Hospital, Geneva, Switzerland
    J Med Virol 56:224-9. 1998
    ..In conclusion, secretion of IgM anti-HCV core antibodies after OLT seems associated with recurrence of HCV-associated liver disease and may have diagnostic significance...
  78. ncbi [Management of patients after liver transplantation]
    A De Gottardi
    Service de gastroentérologie et hepatologie, HUG, Geneve
    Rev Med Suisse 2:1952-4, 1957-9. 2006
    ..The yearly influenza vaccination is strongly recommended. The survival and the quality of life of liver transplant patients also depend on a good communication between the general practitioner and the transplantation centre...
  79. ncbi Specificity of SPIO particles for characterization of liver hemangiomas using MRI
    X Montet
    Division de Radiodiagnostic et de Radiologie Interventionnelle, Hopital Universitaire de Geneve, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Abdom Imaging 29:60-70. 2004
    ..When using SPIO particles for liver imaging, it is useful to add a T1-weighted sequence to T2-weighted images, thereby providing additional information for lesion characterization...
  80. ncbi Primary hepatic diffuse large B-cell lymphoma in a patient with chronic hepatitis C
    L Rubbia-Brandt
    Division of Clinical Pathology, University Hospital, Geneva, Switzerland
    Am J Surg Pathol 23:1124-30. 1999
    ..High grade non-Hodgkin's lymphomas, although rare complications, have to be considered as part of the spectrum of hepatitis C virus-related hepatic lesions...
  81. ncbi Primary liver resection and salvage transplantation or primary liver transplantation in patients with single, small hepatocellular carcinoma and preserved liver function: an outcome-oriented decision analysis
    P E Majno
    Transplantation Unit, Department of Surgery, University Hospital, Geneva, Switzerland
    Hepatology 31:899-906. 2000
    ....
  82. ncbi Magnetic resonance imaging and proton spectroscopic alterations correlate with parkinsonian signs in patients with cirrhosis
    L Spahr
    Division of Gastroenterology and Hepatology, University Hospital, Geneva, Switzerland
    Gastroenterology 119:774-81. 2000
    ..Motor disturbances have been described, suggesting that basal ganglia (BG) are altered...
  83. ncbi Treatment of hepatocellular carcinoma at the dawn of the third millennium: liver transplantation and its alternatives
    P Majno
    Clinics of Visceral Surgery and Transplantation, University Hospitals of Geneva, Switzerland
    Acta Gastroenterol Belg 67:206-22. 2004
    ..This review summarizes the recent progress in the management of HCC and the practice in our unit...
  84. ncbi Living donor liver transplantation for early hepatocellular carcinoma: A life-expectancy and cost-effectiveness perspective
    F P Sarasin
    Department of Internal Medicine, Hopital Cantonal, University of Geneva Medical School, Geneva, Switzerland
    Hepatology 33:1073-9. 2001
    ..The gain in life expectancy and the cost-effectiveness of LDLT were more dependent on the drop-out rate and the outcome after transplantation than on donor's mortality...
  85. ncbi [Long-term followup of patients with alveolar echinococcosis]
    P Charbonnet
    Service de Chirurgie, Hopital Universitaire de Geneve, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Ann Chir 129:337-42. 2004
    ..There is no definitive medical therapy. Surgery remains the only option to assure a cure. This report is our surgical experience for the care of this affection...
  86. doi Anatomy of the liver: an outline with three levels of complexity--a further step towards tailored territorial liver resections
    Pietro Majno
    Hepatobiliary Center, Digestive Surgery and Transplantation Units, Department of Surgery, University Hospitals of Geneva, Switzerland Electronic address
    J Hepatol 60:654-62. 2014
    ....
  87. ncbi Treatment of fulminant liver failure by transplantation of microencapsulated primary or immortalized xenogeneic hepatocytes
    Gang Mai
    Surgical Research Unit, Department of Surgery, University Hospital Geneva, Switzerland
    Xenotransplantation 12:457-64. 2005
    ..The aim of this study was to evaluate in vitro and in vivo functions of isolated hepatocytes after immortalization, cryopreservation, encapsulation and xenotransplantation into mice with fulminant liver failure (FLF)...
  88. ncbi An unusual, presumably hepatic mass
    Axel Gamulin
    Clinic for Digestive and Transplant Surgery, Department of Surgery, University Hospital, 1211 Geneva, Switzerland
    Lancet 360:2066. 2002
  89. ncbi Ribavirin/interferon-alpha sequential treatment of recurrent hepatitis C after liver transplantation
    Emiliano Giostra
    Division of Gastroenterology and Hepatology, University Hospital of Geneva, Rue Micheli du Crest 24, 1211 Geneva, Switzerland
    Transpl Int 17:169-76. 2004
    ..In conclusion, patients with recurrent hepatitis C after LT might benefit from ribavirin/IFN-alpha therapy, provided that the treatment is tolerated for a sufficient duration of time...
  90. ncbi Infection and rejection in liver transplant patients: a 10-year Swiss single-centre experience
    Jorge Garbino
    Division of Infectious Diseases, University Hospitals of Geneva, 1211 Geneva 14, Switzerland
    Swiss Med Wkly 135:587-93. 2005
    ..Rejection treatment may be associated with an increased rate of infectious complications. The aim of this study was to determine the relationship between rejection, rejection therapy and the risk of associated infections...
  91. ncbi Pamidronate and osteoporosis prevention in liver transplant recipients
    Pietra Pennisi
    Service of Bone Diseases, WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, University Hospital of Geneva, 1211, Geneva 14, Switzerland
    Rheumatol Int 27:251-6. 2007
    ....
  92. ncbi Effect of hyperthermic preconditioning on cold preserved rat portal veins
    Catherine M Pastor
    Division d Hépatologie et de Gastro entérologie, Hopital Cantonal Universitaire de Geneve, Rue Micheli du Crest, 24, 1211 Geneva 14, Switzerland
    J Hepatol 37:640-7. 2002
    ..We then studied, after cold preservation, the in vitro contractile responses of rat portal veins (RPV) isolated from normal rats or from rats previously subjected to hyperthermia...
  93. ncbi Glomerular and tubular function following orthotopic liver transplantation in children
    Valerie A McLin
    Department of Pediatrics, University of Geneva Hospital, Geneva, Switzerland
    Pediatr Transplant 9:512-9. 2005
    ..The aims of this study were to examine glomerular and tubular function after orthotopic liver transplantation (OLT) in children, their correlation to CsA, and how they differed according to the underlying disease...
  94. ncbi Long term results after complete or incomplete surgical resection of liver hydatid disease
    Roland Chautems
    Department of Surgery, University Hospital, Geneva, Switzerland
    Swiss Med Wkly 133:258-62. 2003
    ..g. total pericystectomy or hepatectomy) to limited procedures (e.g. percutaneous aspiration or unroofing of cysts). The aim of this study was to determine the long-term outcome after complete or partial resection of liver hydatid cysts...
  95. ncbi Prostaglandin E(1) protects human liver sinusoidal endothelial cell from apoptosis induced by hypoxia reoxygenation
    Hong Yang
    Division of Investigative Surgery, Department of Surgery, University Hospital, University of Geneva, Geneva, Switzerland
    Microvasc Res 64:94-103. 2002
    ..These results indicate that the protection of LSECs from apoptosis by PGE(1) in hepatic ischemia-reperfusion injury is mediated by inhibiting inducible NO synthase and MMP release...
  96. pmc Management of a ruptured hydatid cyst involving the ribs: Dealing with a challenging case and review of the literature
    Theodoros Thomopoulos
    Department of Surgery, Clinics of Visceral and Transplantation Surgery, University Hospitals of Geneva HUG, 1211 Geneva 14, Geneva, Switzerland
    Int J Surg Case Rep 3:253-6. 2012
    ..Rarely, chest or abdominal wall involvement occurs that are challenging to manage. This case report and literature review describes the management of patients with chest wall and rib invasion...
  97. doi Extensive biliary intraepithelial neoplasia (BilIN) and multifocal early intrahepatic cholangiocarcinoma in non-biliary cirrhosis
    Anne Laure Rougemont
    Division of Clinical Pathology, Geneva University Hospitals, Rue Gabrielle Perret Gentil 4, 1211, Geneva 14, Switzerland
    Virchows Arch 456:711-7. 2010
    ....
  98. pmc Monitoring of cytomegalovirus infection in solid-organ transplant recipients by an ultrasensitive plasma PCR assay
    Karine Hadaya
    Division of Infectious Diseases, University Hospitals of Geneva, 1211 Geneva 14, Switzerland
    J Clin Microbiol 41:3757-64. 2003
    ..This test could improve the monitoring of CMV infection or reactivation in renal transplant recipients...
  99. ncbi Persistence of mild parkinsonism 4 months after liver transplantation in patients with preoperative minimal hepatic encephalopathy: a study on neuroradiological and blood manganese changes
    Francois Lazeyras
    Radiology Department, University Hospital, Geneva, Switzerland
    Transpl Int 15:188-95. 2002
    ..The role of blood manganese determination appears limited in the monitoring of MRI and parkinsonian signs changes after OLT...
  100. ncbi Ecstasy ingestion and fulminant hepatic failure: liver transplantation to be considered as a last therapeutic option
    J Garbino
    Department of Internal Medicine, University Hospital of Geneva, Switzerland
    Vet Hum Toxicol 43:99-102. 2001
    ..The outcome was successful, and the patient was discharged from ICU 20 d after surgery. Hepatotoxic effects of MDMA seem infrequent, but may be lethal; liver transplantation is the ultimate therapeutic option in some cases...
  101. ncbi Validation of color Doppler EUS for azygos blood flow measurement in patients with cirrhosis: application to the acute hemodynamic effects of somatostatin, octreotide, or placebo
    H Nishida
    Department of Gastroenterology and Hepatology, Geneva, Switzerland
    Gastrointest Endosc 54:24-30. 2001
    ..It confirmed the transient effects of somatostatin and octreotide on both AzBF and gastric mucosal perfusion. In addition, a significant rebound phenomenon after 60 minutes of continuous intravenous somatostatin infusion was observed...