Javier Lopez-Rios

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. doi request reprint The many lives of SHH in limb development and evolution
    Javier Lopez-Rios
    Development and Evolution, Department of Biomedicine, University of Basel, 4058 Basel, Switzerland Electronic address
    Semin Cell Dev Biol 49:116-24. 2016
  2. doi request reprint Sensing BMP pathway activity by immune detection of phosphorylated R-Smad proteins in mouse embryonic kidney
    Javier Lopez-Rios
    Developmental Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
    Methods Mol Biol 886:267-73. 2012
  3. pmc The Netrin-related domain of Sfrp1 interacts with Wnt ligands and antagonizes their activity in the anterior neural plate
    Javier Lopez-Rios
    Departamento de Neurobiología Molecular Celular y del Desarrollo, Instituto Cajal, CSIC, Dr Arce 37, Madrid, 28002, Spain
    Neural Dev 3:19. 2008
  4. pmc Human intronic enhancers control distinct sub-domains of Gli3 expression during mouse CNS and limb development
    Amir A Abbasi
    Department of Human Genetics, Philipps Universitat Marburg, 35037 Marburg, Germany
    BMC Dev Biol 10:44. 2010
  5. pmc GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis
    Javier Lopez-Rios
    Developmental Genetics, Department of Biomedicine, University of Basel, 4058 Basel, Switzerland
    Dev Cell 22:837-48. 2012
  6. pmc Conserved cis-regulatory regions in a large genomic landscape control SHH and BMP-regulated Gremlin1 expression in mouse limb buds
    Aimee Zuniga
    Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058, Basel, Switzerland
    BMC Dev Biol 12:23. 2012
  7. ncbi request reprint Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis
    Odysse Michos
    Developmental Genetics, DKBW Centre for Biomedicine, University of Basel Medical Faculty, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Development 134:2397-405. 2007
  8. ncbi request reprint Six3 and Six6 activity is modulated by members of the groucho family
    Javier Lopez-Rios
    Instituto Cajal, CSIC, Avenida Doctor Arce 37, 28002 Madrid, Spain
    Development 130:185-95. 2003
  9. ncbi request reprint SFRP1 is required for the proper establishment of the eye field in the medaka fish
    Pilar Esteve
    Departamento de Neurobiologia del Desarrollo, Instituto Cajal, CSIC, Avenida Dr Arce 37, Madrid 28002, Spain
    Mech Dev 121:687-701. 2004
  10. pmc Dual RMCE for efficient re-engineering of mouse mutant alleles
    Marco Osterwalder
    Developmental Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
    Nat Methods 7:893-5. 2010

Collaborators

Detail Information

Publications13

  1. doi request reprint The many lives of SHH in limb development and evolution
    Javier Lopez-Rios
    Development and Evolution, Department of Biomedicine, University of Basel, 4058 Basel, Switzerland Electronic address
    Semin Cell Dev Biol 49:116-24. 2016
    ....
  2. doi request reprint Sensing BMP pathway activity by immune detection of phosphorylated R-Smad proteins in mouse embryonic kidney
    Javier Lopez-Rios
    Developmental Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
    Methods Mol Biol 886:267-73. 2012
    ....
  3. pmc The Netrin-related domain of Sfrp1 interacts with Wnt ligands and antagonizes their activity in the anterior neural plate
    Javier Lopez-Rios
    Departamento de Neurobiología Molecular Celular y del Desarrollo, Instituto Cajal, CSIC, Dr Arce 37, Madrid, 28002, Spain
    Neural Dev 3:19. 2008
    ..Due to its structural relationship with Fz, it is believed that SfrpCRD interferes with Wnt signalling by binding and sequestering the ligand. In contrast, the functional relevance of the SfrpNTR has been barely addressed...
  4. pmc Human intronic enhancers control distinct sub-domains of Gli3 expression during mouse CNS and limb development
    Amir A Abbasi
    Department of Human Genetics, Philipps Universitat Marburg, 35037 Marburg, Germany
    BMC Dev Biol 10:44. 2010
    ..From these studies it has emerged, that Gli3 expression must be subject to a tight spatiotemporal regulation. However, the genetic mechanisms and the cis-acting elements controlling the expression of Gli3 remained largely unknown...
  5. pmc GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis
    Javier Lopez-Rios
    Developmental Genetics, Department of Biomedicine, University of Basel, 4058 Basel, Switzerland
    Dev Cell 22:837-48. 2012
    ..Thus, Gli3 is a negative regulator of the proliferative expansion of digit progenitors and acts as a gatekeeper for the exit to chondrogenic differentiation...
  6. pmc Conserved cis-regulatory regions in a large genomic landscape control SHH and BMP-regulated Gremlin1 expression in mouse limb buds
    Aimee Zuniga
    Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058, Basel, Switzerland
    BMC Dev Biol 12:23. 2012
    ..Previous analysis identified a distant cis-regulatory landscape within the neighbouring Formin1 (Fmn1) locus that is required for Grem1 expression, reminiscent of the genomic landscapes controlling HoxD and Shh expression in limb buds...
  7. ncbi request reprint Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis
    Odysse Michos
    Developmental Genetics, DKBW Centre for Biomedicine, University of Basel Medical Faculty, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Development 134:2397-405. 2007
    ....
  8. ncbi request reprint Six3 and Six6 activity is modulated by members of the groucho family
    Javier Lopez-Rios
    Instituto Cajal, CSIC, Avenida Doctor Arce 37, 28002 Madrid, Spain
    Development 130:185-95. 2003
    ..These data indicate that both Tle1 and Aes participate in the molecular network that control eye development and are consistent with the view that both Six3 and Six6 act in combination with either Tle1 and/or Aes...
  9. ncbi request reprint SFRP1 is required for the proper establishment of the eye field in the medaka fish
    Pilar Esteve
    Departamento de Neurobiologia del Desarrollo, Instituto Cajal, CSIC, Avenida Dr Arce 37, Madrid 28002, Spain
    Mech Dev 121:687-701. 2004
    ..In addition, olSfrp1 may contribute to the control of mesodermal convergence extension movements that take place during gastrulation...
  10. pmc Dual RMCE for efficient re-engineering of mouse mutant alleles
    Marco Osterwalder
    Developmental Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
    Nat Methods 7:893-5. 2010
    ..dRMCE is a scalable, flexible tool to introduce tags, reporters and mutant coding regions into an endogenous locus of interest in an easy and highly efficient manner...
  11. doi request reprint Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease
    Paola Bovolenta
    Departamento de Neurobiología Molecular, Celular y del Desarrollo, Instituto Cajal, CSIC, Dr Arce 37, Madrid 28002, Spain
    J Cell Sci 121:737-46. 2008
    ..Here we review some of the debated aspects of SFRP-Wnt interactions and discuss the new and emerging roles of SFRPs...
  12. doi request reprint Vertebrate limb bud development: moving towards integrative analysis of organogenesis
    Rolf Zeller
    Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Nat Rev Genet 10:845-58. 2009
    ..The resulting integrative model provides insights into how the specification and proliferative expansion of the anteroposterior and proximodistal limb bud axes are coordinately controlled in time and space...
  13. pmc HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme
    Marco Osterwalder
    Developmental Genetics, Department of Biomedicine, University of Basel, 4058 Basel, Switzerland
    Dev Cell 31:345-57. 2014
    ..Our analysis uncovers the transcriptional circuits that function in establishing distinct mesenchymal compartments downstream of HAND2 and upstream of SHH signaling. ..