Genomes and Genes
Affiliation: University of Geneva
- Growth control: function follows formRobbie Loewith
Department of Molecular Biology, University of Geneva, 1211 Geneva, Switzerland
Curr Biol 23:R607-9. 2013..Less obvious is the reciprocal regulation of growth by the cell division cycle. In budding yeast, this link is mediated by the cell-cycle-dependent polarization of actin. ..
- A brief history of TORRobbie Loewith
Department of Molecular Biology, National Centres of Competence in Research Frontiers in Genetics and Chemical Biology, University of Geneva, Sciences III, 30 Quai Ernest Ansermet, CH 1211 Geneva, Switzerland
Biochem Soc Trans 39:437-42. 2011..These studies emphasize the central importance of TOR and highlight its many previously unrecognized functions. One of these, the regulation of intermediary metabolism, is discussed...
- Target of rapamycin (TOR) in nutrient signaling and growth controlRobbie Loewith
Department of Molecular Biology and National Centers of Competence in Research and Frontiers in Genetics and Chemical Biology, University of Geneva, Geneva, CH 1211, Switzerland
Genetics 189:1177-201. 2011..The yeast Saccharomyces cerevisiae has played a prominent role in both the discovery of TOR and the elucidation of its function. Here we review the TOR signaling network in S. cerevisiae...
- Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signalingHarri Lempiäinen
Department of Molecular Biology, University of Geneva, 30 Quai Ernest Ansermet, CH 1211 Geneva 4, Switzerland
Mol Cell 33:704-16. 2009..Finally, we show that the Sfp1-interacting protein Mrs6, a Rab escort protein involved in membrane trafficking, regulates both Sfp1 nuclear localization and TORC1 signaling...
- Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesisAlexandre Huber
Department of Molecular Biology, University of Geneva, Geneva, Switzerland
Genes Dev 23:1929-43. 2009..This demonstrates that Sch9 is a master regulator of protein synthesis...
- Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3LAlexandre Huber
Department of Molecular Biology and National Center for Competence in Research Program Frontiers in Genetics, University of Geneva, Geneva, Switzerland
EMBO J 30:3052-64. 2011..Taken together with previous studies, these results suggest that Sch9 is a master regulator of ribosome biogenesis through the control of Ribi, RP, ribosomal RNA and tRNA gene transcription...
- The TOR signalling network from yeast to manClaudio De Virgilio
Department of Microbiology and Molecular Medicine, University of Geneva, 1211 Geneva 4, Switzerland
Int J Biochem Cell Biol 38:1476-81. 2006..Consequently the efficacies of rapamycin and related compounds in treating such diseases are being evaluated in clinical trials...
- Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple PathwaysDelphine Rispal
From the Department of Molecular Biology and Institute of Genetics and Genomics of Geneva iGE3, University of Geneva, 1211 Geneva
J Biol Chem 290:14963-78. 2015..Additional hits in our phosphoproteomic screens highlight the intricate control TORC2 exerts over diverse aspects of eukaryote cell physiology. ..
- Sch9 is a major target of TORC1 in Saccharomyces cerevisiaeJörg Urban
Department of Molecular Biology, University of Geneva, Geneva, CH 1211, Switzerland
Mol Cell 26:663-74. 2007..Our results suggest that Sch9 functions analogously to the mammalian TORC1 substrate S6K1 rather than the mTORC2 substrate PKB/Akt...
- Systematic lipidomic analysis of yeast protein kinase and phosphatase mutants reveals novel insights into regulation of lipid homeostasisAline Xavier da Silveira Dos Santos
Department of Biochemistry, University of Geneva, Geneva CH 1211, Switzerland National Centre of Competence in Research Chemical Biology, University of Geneva, Geneva CH 1211, Switzerland
Mol Biol Cell 25:3234-46. 2014..This robust, systematic lipidomic approach constitutes a rich, new source of biological information and can be used to identify novel gene associations and function. ..
- Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2Christl Gaubitz
Department of Molecular Biology and Institute of Genetics and Genomics of Geneva iGE3, University of Geneva, 30 Quai Ernest Ansermet, CH1211 Geneva, Switzerland
Mol Cell 58:977-88. 2015..Removal of this sequence generated a FKBP12-rapamycin-sensitive TORC2 variant, which provides a powerful tool for deciphering TORC2 function in vivo. Using this variant, we demonstrate a role for TORC2 in G2/M cell-cycle progression...