Roger P Lauener
Affiliation: University of Zurich
- Pattern recognition receptors and their involvement in the pathogenesis of arthritisReinhart Seibl
Zurich University Children s Hospital, Division for Immunology, Zurich, Switzerland
Curr Opin Rheumatol 16:411-8. 2004..This review summarizes recent advances in research trying to elucidate the link between different pattern recognition receptors and inflammatory autoimmune disorders...
- Expression of CD14 and Toll-like receptor 2 in farmers' and non-farmers' childrenRoger P Lauener
Zurich University Children s Hospital, CH 8032 Zurich, Switzerland
Lancet 360:465-6. 2002..11 vs 0.04, p<0.0001) than those from non-farmers' children. We propose that the innate immune system responds to the microbial burden in the environment and modulates the development of allergic disease...
- Expression and regulation of Toll-like receptor 2 in rheumatoid arthritis synoviumReinhart Seibl
Division for Immunology, Zurich University Children s Hospital, Zurich
Am J Pathol 162:1221-7. 2003..TLR-associated signaling pathways may contribute to the pathogenesis of RA, either by initiating or perpetuating activation of SFs...
- Environmental exposure to endotoxin and its relation to asthma in school-age childrenCharlotte Braun-Fahrlander
Institute of Social and Preventive Medicine, Basel, Switzerland
N Engl J Med 347:869-77. 2002..Immune activation may direct the immune response, thus conferring tolerance to allergens such as animal dander or tree and grass pollen...
- Why Old McDonald had a farm but no allergies: genes, environments, and the hygiene hypothesisMichael Kabesch
University Children s Hospital Munich, Ludwig Maximilians University, Germany
J Leukoc Biol 75:383-7. 2004
- New visions for basic research and primary prevention of pediatric allergy: an iPAC summary and future trendsEckard Hamelmann
Children s Hospital of Ruhr University, Bochum, Germany
Pediatr Allergy Immunol 19:4-16. 2008..The benefit of efficient allergy prevention, based on focusing resources on novel and promising research lines, will be of prime importance to both affluent countries and other parts of the world where allergy is only currently emerging...
- Prenatal exposure to a farm environment modifies atopic sensitization at birthMarkus Johannes Ege
University Children s Hospital, Munich, Germany
J Allergy Clin Immunol 122:407-12, 412.e1-4. 2008..Previous cross-sectional surveys have suggested that maternal exposure to animal sheds during pregnancy exerted a protective effect on atopic sensitization in children lasting until school age...