Malcolm Kohler

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. pmc Determinants of outcome of solitary fibrous tumors of the pleura: an observational cohort study
    Daniel Franzen
    Division of Pulmonology, University Hospital Zurich, Ramistrasse 100, 8091 Zurich, Switzerland
    BMC Pulm Med 14:138. 2014
  2. doi request reprint Mechanisms of vascular damage in obstructive sleep apnea
    Malcolm Kohler
    Sleep Disorders Centre and Pulmonary Division, University Hospital of Zurich, Raemistrasse 100, 8091 Zurich, Switzerland
    Nat Rev Cardiol 7:677-85. 2010
  3. doi request reprint [Cardiovascular consequences of obstructive sleep apnoea syndrome]
    M Kohler
    Klinik fur Pneumologie, Universitatsspital Zurich, Zurich
    Praxis (Bern 1994) 99:117-22. 2010
  4. doi request reprint The effects of Provent on moderate to severe obstructive sleep apnoea during continuous positive airway pressure therapy withdrawal: a randomised controlled trial
    Valentina A Rossi
    Sleep Disorders Centre and Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    Thorax 68:854-9. 2013
  5. doi request reprint Sleep respiratory disturbances and arousals at moderate altitude have overlapping electroencephalogram spectral signatures
    Katrin Stadelmann
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    J Sleep Res 23:463-8. 2014
  6. pmc Quantitative changes in the sleep EEG at moderate altitude (1630 m and 2590 m)
    Katrin Stadelmann
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland Zürich Center for Integrative Human Physiology ZIHP, University of Zurich, Zurich, Switzerland
    PLoS ONE 8:e76945. 2013
  7. doi request reprint Effect of acetazolamide and autoCPAP therapy on breathing disturbances among patients with obstructive sleep apnea syndrome who travel to altitude: a randomized controlled trial
    Tsogyal D Latshang
    Sleep Disorders Center, Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    JAMA 308:2390-8. 2012
  8. doi request reprint Effects of continuous positive airway pressure therapy withdrawal in patients with obstructive sleep apnea: a randomized controlled trial
    Malcolm Kohler
    Sleep Disorders Centre and Pulmonary Division, University Hospital Zurich, Zurich, Switzerland
    Am J Respir Crit Care Med 184:1192-9. 2011
  9. doi request reprint Quantifying the speed of fluctuations in systolic blood pressure
    Arnoldus J R VAN Gestel
    1 Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland 2 Department of Health, Zurich University of Applied Sciences, Winterthur, Switzerland
    Hypertens Res 36:1039-44. 2013
  10. doi request reprint The effects of simulated obstructive apnea and hypopnea on arrhythmic potential in healthy subjects
    Giovanni Camen
    Sleep Disorders Center and Pulmonary Division, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland
    Eur J Appl Physiol 113:489-96. 2013

Collaborators

Detail Information

Publications68

  1. pmc Determinants of outcome of solitary fibrous tumors of the pleura: an observational cohort study
    Daniel Franzen
    Division of Pulmonology, University Hospital Zurich, Ramistrasse 100, 8091 Zurich, Switzerland
    BMC Pulm Med 14:138. 2014
    ..Thus the aim of this study was to describe the outcome and possible determinants of malignant behavior of SFTPs...
  2. doi request reprint Mechanisms of vascular damage in obstructive sleep apnea
    Malcolm Kohler
    Sleep Disorders Centre and Pulmonary Division, University Hospital of Zurich, Raemistrasse 100, 8091 Zurich, Switzerland
    Nat Rev Cardiol 7:677-85. 2010
    ..More clinical interventional trials are needed to determine the magnitude of the effect OSA has on cardiovascular damage and to enable a comparison with conventional vascular risk factors...
  3. doi request reprint [Cardiovascular consequences of obstructive sleep apnoea syndrome]
    M Kohler
    Klinik fur Pneumologie, Universitatsspital Zurich, Zurich
    Praxis (Bern 1994) 99:117-22. 2010
    ..The results of multiple ongoing international multi-centre studies investigating the effects of OSAS therapy on cardiovascular event rate and mortality are thus anxiously awaited...
  4. doi request reprint The effects of Provent on moderate to severe obstructive sleep apnoea during continuous positive airway pressure therapy withdrawal: a randomised controlled trial
    Valentina A Rossi
    Sleep Disorders Centre and Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    Thorax 68:854-9. 2013
    ..The aim of this study was to test the effectiveness of Provent, an expiratory nasal resistance valve, to prevent the recurrence of OSA following CPAP withdrawal...
  5. doi request reprint Sleep respiratory disturbances and arousals at moderate altitude have overlapping electroencephalogram spectral signatures
    Katrin Stadelmann
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    J Sleep Res 23:463-8. 2014
    ....
  6. pmc Quantitative changes in the sleep EEG at moderate altitude (1630 m and 2590 m)
    Katrin Stadelmann
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland Zürich Center for Integrative Human Physiology ZIHP, University of Zurich, Zurich, Switzerland
    PLoS ONE 8:e76945. 2013
    ..Furthermore, the relationship between sleep EEG variables and central apneas and oxygen saturation are of great interest to understand the impact of hypoxia at moderate altitude on sleep...
  7. doi request reprint Effect of acetazolamide and autoCPAP therapy on breathing disturbances among patients with obstructive sleep apnea syndrome who travel to altitude: a randomized controlled trial
    Tsogyal D Latshang
    Sleep Disorders Center, Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    JAMA 308:2390-8. 2012
    ..Many patients with obstructive sleep apnea syndrome (OSA) living near sea level travel to altitude, but this may expose them to hypoxemia and exacerbation of sleep apnea. The treatment in this setting is not established...
  8. doi request reprint Effects of continuous positive airway pressure therapy withdrawal in patients with obstructive sleep apnea: a randomized controlled trial
    Malcolm Kohler
    Sleep Disorders Centre and Pulmonary Division, University Hospital Zurich, Zurich, Switzerland
    Am J Respir Crit Care Med 184:1192-9. 2011
    ..To establish a new approach to investigate the physiological effects of obstructive sleep apnea (OSA), and to evaluate novel treatments, during a period of continuous positive airway pressure (CPAP) withdrawal...
  9. doi request reprint Quantifying the speed of fluctuations in systolic blood pressure
    Arnoldus J R VAN Gestel
    1 Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland 2 Department of Health, Zurich University of Applied Sciences, Winterthur, Switzerland
    Hypertens Res 36:1039-44. 2013
    ..The speed of fluctuations in SBP rather than the degree of BPV is pronounced in patients with elevated cardiovascular risk. Increased speed of BP fluctuations may thus be a contributing mechanism to cardiovascular morbidity...
  10. doi request reprint The effects of simulated obstructive apnea and hypopnea on arrhythmic potential in healthy subjects
    Giovanni Camen
    Sleep Disorders Center and Pulmonary Division, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland
    Eur J Appl Physiol 113:489-96. 2013
    ..Therefore, negative intrathoracic pressure changes may be a contributory mechanism for the association between OSA and cardiac dysrhythmias...
  11. pmc Predicting daily physical activity in patients with chronic obstructive pulmonary disease
    Arnoldus J R VAN Gestel
    Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    PLoS ONE 7:e48081. 2012
    ..In routine clinical practice it would be useful to estimate PA in patients with chronic obstructive pulmonary disease (COPD) with more simple methods...
  12. ncbi request reprint Actigraphy of Wrist and Ankle for Measuring Sleep Duration in Altitude Travelers
    Tsogyal Daniela Latshang
    1 Pulmonary Division, Sleep Disorders Center, University Hospital of Zurich, Zurich, Switzerland
    High Alt Med Biol 17:194-202. 2016
    ..Maurizio Lo Cascio, Anne-Christin Stöwhas, Katrin Stadelmann, Noemi Tesler, Peter Achermann, Reto Huber, Malcolm Kohler, and Konrad Ernst Bloch. Actigraphy of wrist and ankle for measuring sleep duration in altitude travelers...
  13. doi request reprint Impact of comorbidities on physical activity in COPD
    Noriane A Sievi
    Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    Respirology 20:413-8. 2015
    ..We hypothesized that the comorbid status predicts the level of daily physical activity (PA) in COPD...
  14. pmc Effects of acute exposure to moderate altitude on vascular function, metabolism and systemic inflammation
    Anne Christin Stöwhas
    Pulmonary Division, University Hospital Zurich, Zurich, Switzerland
    PLoS ONE 8:e70081. 2013
    ..Travel to mountain areas is popular. However, the effects of acute exposure to moderate altitude on the cardiovascular system and metabolism are largely unknown...
  15. doi request reprint Effect of CPAP Withdrawal on myocardial perfusion in OSA: A randomized controlled trial
    Esther I Schwarz
    Sleep Disorders Center and Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    Respirology 21:1126-33. 2016
    ..CPAP withdrawal was recently shown to lead to peripheral endothelial dysfunction. However, it is not known whether short-term CPAP withdrawal reduces myocardial perfusion in OSA...
  16. pmc Simulated Obstructive Sleep Apnea Increases P-Wave Duration and P-Wave Dispersion
    Thomas Gaisl
    Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland
    PLoS ONE 11:e0152994. 2016
    ..We tested the hypothesis of whether a short-term increase of P-wave duration and Pd can be induced by respiratory manoeuvres simulating OSA in healthy subjects and in patients with PAF...
  17. doi request reprint Intrathoracic pressure swings induced by simulated obstructive sleep apnoea promote arrhythmias in paroxysmal atrial fibrillation
    Christian Schlatzer
    Sleep Disorders Centre and Pulmonary Division, University Hospital Zurich, Raemistrasse 100, Zurich 8091, Switzerland
    Europace 18:64-70. 2016
    ..There is preliminary evidence for a link between obstructive sleep apnoea (OSA) and arrhythmias such as paroxysmal atrial fibrillation (PAF) and sudden cardiac death but underlying mechanisms remain largely unknown...
  18. pmc Impaired postural control in healthy men at moderate altitude (1630 m and 2590 m): data from a randomized trial
    Katrin Stadelmann
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    PLoS ONE 10:e0116695. 2015
    ..We tested whether exposure to hypobaric hypoxia at moderate altitude impairs the static postural control of healthy subjects...
  19. pmc Impact of acetazolamide and CPAP on cortical activity in obstructive sleep apnea patients
    Katrin Stadelmann
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    PLoS ONE 9:e93931. 2014
    ..2) To examine alterations in the sleep EEG after short-term discontinuation of continuous positive airway pressure (CPAP) therapy...
  20. doi request reprint The speed of blood pressure fluctuations in patients with chronic obstructive pulmonary disease
    Arnoldus J R VAN Gestel
    Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland Department of Health, Zurich University of Applied Sciences, Winterthur, Switzerland Electronic address
    Heart Lung Circ 23:280-6. 2014
    ..Therefore, the purpose of this study was to evaluate whether there is an association between severity of COPD and vSBP...
  21. doi request reprint Comparison of photoplethysmographic and arterial tonometry-derived indices of arterial stiffness
    Christian F Clarenbach
    Pulmonary Clinic, University Hospital Zurich, Zurich, Switzerland
    Hypertens Res 35:228-33. 2012
    ..Therefore, digital pulse wave analysis may be a valuable tool to estimate arterial stiffness in large clinical studies...
  22. doi request reprint Effect of rituximab on pulmonary function in patients with rheumatoid arthritis
    Daniel Franzen
    Division of Pulmonology, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland Electronic address
    Pulm Pharmacol Ther 37:24-9. 2016
    ..It has been reported to cause pulmonary toxicity, though mainly during polychemotherapy of malignant lymphoma. Prospective data on RTX-induced pulmonary complications in patients with rheumatoid arthritis (RA) are lacking...
  23. pmc Sedation during bronchoscopy: data from a nationwide sedation and monitoring survey
    Thomas Gaisl
    Department of Pulmonology, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    BMC Pulm Med 16:113. 2016
    ..The purpose of this study was to assess the current practice patterns of FBs and to focus on the use of propofol, the education of the proceduralist, and the involvement of anaesthesiologists during FB...
  24. doi request reprint Obstructive sleep apnoea and quality of life in Ehlers-Danlos syndrome: a parallel cohort study
    Thomas Gaisl
    Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland
    Thorax . 2017
    ..Obstructive sleep apnoea (OSA) may be an underlying cause for these symptoms but its prevalence in this population is unclear...
  25. pmc High prevalence of altered cardiac repolarization in patients with COPD
    Noriane A Sievi
    Pulmonary Division, University Hospital Zurich, Zurich, Switzerland
    BMC Pulm Med 14:55. 2014
    ..The prevalence of and the mechanisms contributing to altered cardiac repolarization are currently unknown in COPD...
  26. pmc Effect of simulated obstructive hypopnea and apnea on thoracic aortic wall transmural pressures
    Christian F Clarenbach
    Sleep Disorders Center and Pulmonary Division, University Hospital Zurich, Zurich, Switzerland
    J Appl Physiol (1985) 115:613-7. 2013
    ..Thus OSA may mechanically promote thoracic aortic dilatation and should be further investigated as a risk factor for the development or accelerated progression of thoracic aortic aneurysms. ..
  27. doi request reprint Effects of obstructive sleep apnoea on heart rhythm
    Valentina A Rossi
    Sleep Disorders Centre and Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    Eur Respir J 41:1439-51. 2013
    ..In conclusion, there is preliminary evidence that OSA is associated with the development of cardiac arrhythmias. Data from randomised controlled studies are needed to definitively clarify the role of OSA in arrhythmogenesis...
  28. doi request reprint The effects of continuous positive airway pressure therapy withdrawal on cardiac repolarization: data from a randomized controlled trial
    Valentina A Rossi
    Sleep Disorders Centre and Pulmonary Division, University Hospital of Zurich, Raemistrasse 100, Zurich, Switzerland
    Eur Heart J 33:2206-12. 2012
    ..The aim of the current trial was to assess the effects of continuous positive airway pressure (CPAP) therapy withdrawal on the measures of cardiac repolarization in patients with OSA...
  29. ncbi request reprint Is obstructive sleep apnea a risk factor for diabetes?
    Christian F Clarenbach
    Pulmonary Division, University Hospital Zurich, Switzerland
    Discov Med 12:17-24. 2011
    ..Further carefully conducted clinical studies and randomized controlled interventional CPAP trials are needed to determine the extent to which OSA is a risk factor for diabetes and its effect on glucose metabolism...
  30. pmc Patients with Obstructive Sleep Apnea Have Cardiac Repolarization Disturbances when Travelling to Altitude: Randomized, Placebo-Controlled Trial of Acetazolamide
    Tsogyal Daniela Latshang
    Sleep Disorders Center and Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    Sleep 39:1631-7. 2016
    ....
  31. doi request reprint Effect of CPAP Withdrawal on BP in OSA: Data from Three Randomized Controlled Trials
    Esther I Schwarz
    Sleep Disorders Center and Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    Chest 150:1202-1210. 2016
    ..We analyzed morning BP data from three randomized controlled CPAP withdrawal trials, which included only patients with optimal CPAP compliance...
  32. doi request reprint Real-Time Quantification of Amino Acids in the Exhalome by Secondary Electrospray Ionization-Mass Spectrometry: A Proof-of-Principle Study
    Diego García-Gómez
    Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, Zurich, Switzerland
    Clin Chem 62:1230-7. 2016
    ..A novel breath analysis technique described here allows such measurements to be carried out in real-time and noninvasively, which should facilitate efficient diagnostics and give insights into human physiology...
  33. doi request reprint Expanding metabolite coverage of real-time breath analysis by coupling a universal secondary electrospray ionization source and high resolution mass spectrometry--a pilot study on tobacco smokers
    Martin Thomas Gaugg
    Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland
    J Breath Res 10:016010. 2016
    ..Most of these compounds correlated significantly with smoking frequency and allowed accurate discrimination of smokers and non-smokers...
  34. doi request reprint Effects of CPAP therapy withdrawal on exhaled breath pattern in obstructive sleep apnoea
    Esther I Schwarz
    Department of Pulmonology and Sleep Disorders Centre, University Hospital of Zurich, Zurich, Switzerland
    Thorax 71:110-7. 2016
    ..The objective of this study was to identify a breath profile in OSA recurrence by use of secondary-electrospray-ionization-mass spectrometry (SESI-MS)...
  35. ncbi request reprint Sympathetic overactivity and cardiovascular disease in patients with chronic obstructive pulmonary disease (COPD)
    Arnoldus J R VAN Gestel
    Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    Discov Med 14:359-68. 2012
    ....
  36. doi request reprint Target-controlled versus fractionated propofol sedation in flexible bronchoscopy: A randomized noninferiority trial
    Daniel Franzen
    Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland
    Respirology 21:1445-1451. 2016
    ..The purpose of this randomized noninferiority trial was to evaluate whether target-controlled infusion (TCI) of propofol is noninferior to FPA in terms of safety in FB...
  37. pmc ECG risk markers for atrial fibrillation and sudden cardiac death in minimally symptomatic obstructive sleep apnoea: the MOSAIC randomised trial
    Christian Schlatzer
    Sleep Disorders Centre and Pulmonary Division, University Hospital Zurich, Zurich, Switzerland
    BMJ Open 6:e010150. 2016
    ..Whether or not CPAP therapy improves ECG risk markers of AF and SCD in patients with minimally symptomatic OSA as well, is unknown...
  38. doi request reprint Comparison of the effects of continuous positive airway pressure and mandibular advancement devices on sleepiness in patients with obstructive sleep apnoea: a network meta-analysis
    Daniel J Bratton
    Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland
    Lancet Respir Med 3:869-78. 2015
    ....
  39. pmc Physical inactivity and arterial stiffness in COPD
    Noriane A Sievi
    Division of Pulmonology, University Hospital of Zurich, Zurich, Switzerland
    Int J Chron Obstruct Pulmon Dis 10:1891-7. 2015
    ..Since physical inactivity is frequently observed in patients with COPD and exercise training may improve arterial stiffness, we hypothesized that low daily physical activity may be associated with increased arterial stiffness...
  40. doi request reprint Effect of CPAP therapy on endothelial function in obstructive sleep apnoea: A systematic review and meta-analysis
    Esther I Schwarz
    Sleep Disorders Center and Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    Respirology 20:889-95. 2015
    ..87% (95% confidence interval: 1.93-5.80, P < 0.001). In patients with OSA, CPAP therapy improves endothelial function significantly and to a clinically important extent. ..
  41. pmc Coronary artery calcification, epicardial fat burden, and cardiovascular events in chronic obstructive pulmonary disease
    Thomas Gaisl
    Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland
    PLoS ONE 10:e0126613. 2015
    ..The aim of this study was to determine whether COPD patients have a higher coronary artery calcium score (CACS) and epicardial fat burden, compared to control subjects, and their association with cardiovascular events...
  42. doi request reprint Kinetics of microRNA Expression in Bronchoalveolar Lavage Fluid Samples
    Matthias Brock
    Division of Pulmonology, University Hospital Zurich, Zurich, Switzerland
    Lung 193:381-5. 2015
    ..24 h after collection miRNAs faced substantial alterations in their expression profile. These data emphasize that BAL samples intended for further miRNA analysis can be handled at room temperature within the first 8 h after bronchoscopy...
  43. pmc Circadian variation of the human metabolome captured by real-time breath analysis
    Pablo Martínez-Lozano Sinues
    Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland
    PLoS ONE 9:e114422. 2014
    ....
  44. doi request reprint [Differences and similarities in the evaluation and diagnostic workup]
    Christian F Clarenbach
    Klinik fur Pneumologie, Universitatsspital Zurich
    Ther Umsch 71:262-6. 2014
    ..Apart from spirometry, additional diagnostic tests are presented that facilitate differentiation between COPD and Asthma. ..
  45. doi request reprint Severe metabolic acidosis in adult patients with Duchenne muscular dystrophy
    Christian M Lo Cascio
    Division of Pulmonology, Zurich University Hospital, Zurich, Switzerland
    Respiration 87:499-503. 2014
    ..Early recognition, subsequent administration of fluids, nutrition and antibiotics and regulation of bowel movements seem to be essential...
  46. doi request reprint Is continuous positive airway pressure necessarily an everyday therapy in patients with obstructive sleep apnoea?
    Valentina A Rossi
    University Hospital of Zurich, Zurich
    Eur Respir J 43:1387-93. 2014
    ..Thus, a significant proportion of patients may be able to stop CPAP for short periods. ..
  47. doi request reprint The impact of obstructive sleep apnea on aortic disease in Marfan's syndrome
    Malcolm Kohler
    Sleep Disorders Center and Pulmonary Division, University Hospital Zurich, Zurich, Switzerland
    Respiration 86:39-44. 2013
    ..Aortic dissection is a life-threatening manifestation of Marfan's syndrome. Preliminary evidence suggests that obstructive sleep apnea (OSA) is associated with aortic disease in Marfan's syndrome...
  48. doi request reprint Vascular dysfunction in chronic obstructive pulmonary disease: current evidence and perspectives
    Christian F Clarenbach
    Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    Expert Rev Respir Med 6:37-43. 2012
    ....
  49. doi request reprint Patients with obstructive sleep apnea syndrome benefit from acetazolamide during an altitude sojourn: a randomized, placebo-controlled, double-blind trial
    Yvonne Nussbaumer-Ochsner
    Sleep Disorders Center, Pulmonary Division, University Hospital of Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland
    Chest 141:131-8. 2012
    ..Because the treatment of OSA at altitude has not been established, we tested the hypothesis that acetazolamide improves hypoxemia, sleep, and breathing disturbances in otherwise untreated patients with OSA at altitude...
  50. doi request reprint Does nasal decongestion improve obstructive sleep apnea?
    Christian F Clarenbach
    Pulmonary Division, University Hospital Zurich, Zurich, Switzerland
    J Sleep Res 17:444-9. 2008
    ..The reduced apnea/hypopnea index during maximal nasal decongestion by xylometazoline suggests a pathophysiologic link but the efficacy of nasal decongestion was not sufficient to provide a clinically substantial improvement of OSA...
  51. doi request reprint Predictors of long-term compliance with continuous positive airway pressure
    Malcolm Kohler
    Sleep Disorders Centre and Pulmonary Division, University Hospital of Zurich, Raemistrasse 100, 8091 Zurich, Switzerland
    Thorax 65:829-32. 2010
    ..There are very few data on objectively assessed long-term compliance with continuous positive airway pressure (CPAP). No single factor has been consistently identified as predictive of continued CPAP use...
  52. ncbi request reprint Pharmacological approaches to the treatment of obstructive sleep apnoea
    Malcolm Kohler
    University Hospital of Zurich, Sleep Disorders Centre and Pulmonary Division, Raemistrasse 100, Zurich 8091, Switzerland
    Expert Opin Investig Drugs 18:647-56. 2009
    ..Some patients with OSA do not tolerate CPAP or have insufficiently severe symptoms to justify its use; for these patients, drug therapy would be a desirable potential therapeutic alternative...
  53. doi request reprint Chronic Obstructive Pulmonary Disease and Cardiac Repolarization: Data from a Randomized Controlled Trial
    Noriane A Sievi
    Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    Respiration 91:288-95. 2016
    ..Altered cardiac repolarization is a risk factor for sudden cardiac death and seems to be increased in chronic obstructive pulmonary disease (COPD) patients...
  54. pmc In patients with minimally symptomatic OSA can baseline characteristics and early patterns of CPAP usage predict those who are likely to be longer-term users of CPAP
    Christopher D Turnbull
    1 Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Trust, Oxford, UK 2 Oxford Biomedical Research Centre, National Institute for Health Research, Oxford, UK 3 Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland
    J Thorac Dis 8:276-81. 2016
    ..Second, we explored if early CPAP usage was predictive of longer-term usage, as has been shown in more symptomatic OSA patients...
  55. doi request reprint The Roles of the Charlson Comorbidity Index and Time to First Antibiotic Dose as Predictors of Outcome in Pneumococcal Community-Acquired Pneumonia
    Daniel Franzen
    Department of Pulmonology, University Hospital and University of Zurich, Raemistrasse 100, 8091, Zurich, Switzerland
    Lung 194:769-75. 2016
    ..In this retrospective study, we aimed to investigate the role of comorbidities using the Charlson comorbidity index (CCI) and time to first antibiotic dose (TFAD) in patients with pneumococcal community-acquired pneumonia (PCAP)...
  56. doi request reprint Diagnostic Value of Bronchoalveolar Lavage for Diagnosis of Suspected Peripheral Lung Cancer
    Pascal Bezel
    Division of Pulmonology, University Hospital Zurich, Zurich, Switzerland
    Clin Lung Cancer 17:e151-e156. 2016
    ..The aim of this study was to investigate the diagnostic value of BAL for the diagnosis of suspected PLC...
  57. doi request reprint CPAP vs Mandibular Advancement Devices and Blood Pressure in Patients With Obstructive Sleep Apnea: A Systematic Review and Meta-analysis
    Daniel J Bratton
    Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland
    JAMA 314:2280-93. 2015
    ..Obstructive sleep apnea is associated with higher levels of blood pressure (BP), which can lead to increased cardiovascular risk...
  58. doi request reprint Real-Time Chemical Analysis of E-Cigarette Aerosols By Means Of Secondary Electrospray Ionization Mass Spectrometry
    Diego García-Gómez
    Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, 8093, Zurich, Switzerland, Fax
    Chemistry 22:2452-7. 2016
    ..The method also allows proper quantification of several chemical components such as alkaloids and flavor compounds. ..
  59. doi request reprint Breath analysis in real time by mass spectrometry in chronic obstructive pulmonary disease
    Pablo Martínez-Lozano Sinues
    Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland
    Respiration 87:301-10. 2014
    ..It has been suggested that exhaled breath contains relevant information on health status...
  60. doi request reprint Severity of peripheral arterial disease is associated with aortic pressure augmentation and subendocardial viability ratio
    Kathrin Mosimann
    Clinic for Angiology, University Hospital Zurich, Zurich, Switzerland
    J Clin Hypertens (Greenwich) 14:855-60. 2012
    ..036). Severity of lower limb perfusion impairment is related to central aortic pressure augmentation and to subendocardial viability ratio. This may be a potential pathophysiologic link that impacts cardiac prognosis in patients with PAD...
  61. doi request reprint Pitfalls of clinical trials on pharmacological treatment for obstructive sleep apnoea: future directions
    Malcolm Kohler
    University Hospital of Zurich, Sleep Disorders Center and Pulmonary Division, Raemistrasse, Switzerland
    Expert Opin Investig Drugs 20:1033-7. 2011
    ..In this article, the pitfalls of clinical trials on pharmacological OSA therapy are summarised and potential solutions and directions for future studies are given...
  62. doi request reprint The effect of simulated obstructive apnea and hypopnea on aortic diameter and BP
    Anne Christin Stöwhas
    Sleep Disorders Center and Pulmonary Division, University Hospital Zurich, Zurich, Switzerland
    Chest 140:675-80. 2011
    ..The mechanisms through which OSA may promote thoracic aortic dilatation are incompletely understood. Therefore, we studied the acute effects of simulated apnea and hypopnea on aortic diameter and BP in humans...
  63. doi request reprint The impact of obstructive sleep apnoea on the aorta
    Thomas Gaisl
    Dept of Pulmonology, University Hospital Zurich, Zurich, Switzerland
    Eur Respir J 46:532-44. 2015
    ..Further well controlled studies are needed in order to define the exact role of OSA as a risk factor for aortic disease. ..
  64. doi request reprint Repeated lung volume reduction surgery is successful in selected patients
    Arthur Kostron
    Department of Thoracic Surgery and Division of Pulmonology, University Hospital, Zurich, Switzerland
    Eur J Cardiothorac Surg 48:710-5. 2015
    ..Data on repeated surgical treatment of emphysema are scarce. The aim of this study was to evaluate the safety, effects and outcomes of repeated LVRS (Re-LVRS) in patients no longer benefiting from their initial LVRS...
  65. doi request reprint The hypoxia-induced microRNA-130a controls pulmonary smooth muscle cell proliferation by directly targeting CDKN1A
    Matthias Brock
    Division of Pulmonology, University Hospital Zurich, University of Zurich, Zurich, Switzerland Institute of Veterinary Physiology, University of Zürich and Zürich Center for Integrative Human Physiology ZIHP, Zurich, Switzerland Electronic address
    Int J Biochem Cell Biol 61:129-37. 2015
    ..miR-130 enhances hypoxia-induced smooth muscle proliferation and might be involved in the development of right ventricular hypertrophy and vascular remodeling in pulmonary hypertension. ..
  66. pmc Accuracy of the Hospital Anxiety and Depression Scale for identifying depression in chronic obstructive pulmonary disease patients
    Christoph Nowak
    Division of Pulmonology, University Hospital of Zurich, 8091 Zurich, Switzerland Medical Sciences Department, Uppsala University, 75237 Uppsala, Sweden
    Pulm Med 2014:973858. 2014
    ..Age, comorbidities, sex, and lower airflow limitation predicted depression. The HADS exhibits low diagnostic accuracy for depression in COPD patients. Younger men with comorbidities are at increased risk for depression. ..
  67. doi request reprint The role of the nose in the pathogenesis of obstructive sleep apnea
    Malcolm Kohler
    Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
    Curr Opin Otolaryngol Head Neck Surg 17:33-7. 2009
    ....
  68. doi request reprint Children at high altitude have less nocturnal periodic breathing than adults
    M Kohler
    Pulmonary Division, Dept of Internal Medicine, University Hospital of Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Eur Respir J 32:189-97. 2008
    ....