- Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistanceBasil Honegger
Zoological Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
J Biol 7:10. 2008..In mammals, insulin-like growth factor binding proteins (IGFBPs) bind IGFs with high affinity and modulate their mitogenic, anti-apoptotic and metabolic actions, but no functional homologs have been identified in invertebrates so far...
- Drosophila ALS regulates growth and metabolism through functional interaction with insulin-like peptidesNathalie Arquier
Universite de Nice Sophia Antipolis, IBDC, CNRS UMR 6543, Parc Valrose, 06108 Nice Cedex 2, France
Cell Metab 7:333-8. 2008..These results lead us to propose an evolutionary perspective in which ALS function appeared prior to the separation between metabolic and growth effects that are associated with vertebrate insulin and IGFs...