Markus H Heim

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. doi request reprint Host - hepatitis C viral interactions: The role of genetics
    Markus H Heim
    Division of Gastroenterology and Hepatology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland Department of Biomedicine, University of Basel, Hebelstrasse 20, 4031 Basel, Switzerland Electronic address
    J Hepatol 65:S22-32. 2016
  2. doi request reprint Innate and adaptive immune responses in HCV infections
    Markus H Heim
    Division of Gastroenterology and Hepatology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland Department of Biomedicine, University of Basel, Hebelstrasse 20, 4031 Basel, Switzerland Electronic address
    J Hepatol 61:S14-25. 2014
  3. pmc HCV innate immune responses
    Markus H Heim
    Clinic for Gastroenterology and Hepatology, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Viruses 1:1073-88. 2009
  4. doi request reprint 25 years of interferon-based treatment of chronic hepatitis C: an epoch coming to an end
    Markus H Heim
    Department of Biomedicine, University of Basel, 4031 Basel, Switzerland
    Nat Rev Immunol 13:535-42. 2013
  5. doi request reprint Innate immunity and HCV
    Markus H Heim
    Division of Gastroenterology and Hepatology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    J Hepatol 58:564-74. 2013
  6. doi request reprint Interferons and hepatitis C virus
    Markus H Heim
    University Hospital Basel, Switzerland
    Swiss Med Wkly 142:w13586. 2012
  7. ncbi request reprint Intracellular signalling and antiviral effects of interferons
    M H Heim
    Department of Gastroenterology, University Hospital Basel, Switzerland
    Dig Liver Dis 32:257-63. 2000
  8. ncbi request reprint RIG-I: an essential regulator of virus-induced interferon production
    M H Heim
    Division of Gastroenterology and Hepatology, Department of Research, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    J Hepatol 42:431-3. 2005
  9. doi request reprint Interferon-γ-stimulated genes, but not USP18, are expressed in livers of patients with acute hepatitis C
    Michael T Dill
    Department of Biomedicine, Hepatology Laboratory, University of Basel, Basel, Switzerland
    Gastroenterology 143:777-86.e1-6. 2012
  10. doi request reprint Interferon-induced gene expression is a stronger predictor of treatment response than IL28B genotype in patients with hepatitis C
    Michael T Dill
    Department of Biomedicine, Hepatology Laboratory, University of Basel, Basel, Switzerland
    Gastroenterology 140:1021-31. 2011

Collaborators

Detail Information

Publications51

  1. doi request reprint Host - hepatitis C viral interactions: The role of genetics
    Markus H Heim
    Division of Gastroenterology and Hepatology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland Department of Biomedicine, University of Basel, Hebelstrasse 20, 4031 Basel, Switzerland Electronic address
    J Hepatol 65:S22-32. 2016
    ..In this review, we summarize current knowledge about the role of genetics in the host response to viral hepatitis and the potential future evolution of knowledge in understanding host-viral interactions. ..
  2. doi request reprint Innate and adaptive immune responses in HCV infections
    Markus H Heim
    Division of Gastroenterology and Hepatology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland Department of Biomedicine, University of Basel, Hebelstrasse 20, 4031 Basel, Switzerland Electronic address
    J Hepatol 61:S14-25. 2014
    ..In this review, we will summarize current knowledge about the role of innate and adaptive immune responses in determining the outcome of HCV infection...
  3. pmc HCV innate immune responses
    Markus H Heim
    Clinic for Gastroenterology and Hepatology, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Viruses 1:1073-88. 2009
    ..These in vitro findings will have to be confirmed in clinical trials investigating the molecular mechanisms of HCV interference with the innate immune system in liver samples...
  4. doi request reprint 25 years of interferon-based treatment of chronic hepatitis C: an epoch coming to an end
    Markus H Heim
    Department of Biomedicine, University of Basel, 4031 Basel, Switzerland
    Nat Rev Immunol 13:535-42. 2013
    ..This Timeline article summarizes the history of CHC treatment using recombinant IFNα with an emphasis on the mechanisms of action and the causes of non-response. ..
  5. doi request reprint Innate immunity and HCV
    Markus H Heim
    Division of Gastroenterology and Hepatology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    J Hepatol 58:564-74. 2013
    ..The present review article attempts to summarize current knowledge of some central aspects of the interactions of HCV with the innate immune system...
  6. doi request reprint Interferons and hepatitis C virus
    Markus H Heim
    University Hospital Basel, Switzerland
    Swiss Med Wkly 142:w13586. 2012
    ..Further insights into the viral escape strategies that allow hepatitis C virus to persist for decades despite an ongoing innate and adaptive immune response will eventually allow the rational development of preventive vaccines...
  7. ncbi request reprint Intracellular signalling and antiviral effects of interferons
    M H Heim
    Department of Gastroenterology, University Hospital Basel, Switzerland
    Dig Liver Dis 32:257-63. 2000
    ..A better understanding of these signalling defects might lead to new therapeutic strategies making interferons more effective in a larger percentage of patients...
  8. ncbi request reprint RIG-I: an essential regulator of virus-induced interferon production
    M H Heim
    Division of Gastroenterology and Hepatology, Department of Research, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    J Hepatol 42:431-3. 2005
  9. doi request reprint Interferon-γ-stimulated genes, but not USP18, are expressed in livers of patients with acute hepatitis C
    Michael T Dill
    Department of Biomedicine, Hepatology Laboratory, University of Basel, Basel, Switzerland
    Gastroenterology 143:777-86.e1-6. 2012
    ..Treatment of patients with acute hepatitis C (AHC) is more effective, with sustained virologic response rates greater than 90%. We investigated mechanisms of the different responses of patients with CHC and AHC to pegIFN-α therapy...
  10. doi request reprint Interferon-induced gene expression is a stronger predictor of treatment response than IL28B genotype in patients with hepatitis C
    Michael T Dill
    Department of Biomedicine, Hepatology Laboratory, University of Basel, Basel, Switzerland
    Gastroenterology 140:1021-31. 2011
    ..We investigated whether IL28B genotype determines the constitutive expression of ISGs in the liver and compared the abilities of ISG levels and IL28B genotype to predict treatment outcome...
  11. ncbi request reprint S-Adenosylmethionine and betaine correct hepatitis C virus induced inhibition of interferon signaling in vitro
    Francois H T Duong
    Department of Research and Division of Gastroenterology and Hepatology, University Hospital Basel, Switzerland
    Hepatology 43:796-806. 2006
    ..In conclusion, we propose that the addition of these drugs to the standard therapy of patients with chronic hepatitis C could overcome treatment resistance...
  12. pmc Genetic analyses reveal a role for vitamin D insufficiency in HCV-associated hepatocellular carcinoma development
    Christian M Lange
    Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
    PLoS ONE 8:e64053. 2013
    ..We therefore aimed to determine the relationship between genetic determinants of vitamin D serum levels and the risk of developing hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC)...
  13. ncbi request reprint Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A
    Francois H T Duong
    Department of Research, University Hospital Basel, Basel, Switzerland
    Gastroenterology 126:263-77. 2004
    ..It is not known if interferon-alpha signaling is inhibited in patients with chronic hepatitis C as well, and the molecular mechanisms are not well defined...
  14. doi request reprint Constitutive Notch2 signaling induces hepatic tumors in mice
    Michael T Dill
    Department of Biomedicine, Hepatology Laboratory, University of Basel, Basel, Switzerland
    Hepatology 57:1607-19. 2013
    ..CCC formation in patients and DEN(N2ICD) mice is accompanied by re-expression of hepatocyte nuclear factor 4α(HNF4α), possibly indicating dedifferentiation of BECs...
  15. doi request reprint Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy
    Christian M Lange
    Division of Gastroenterology and Hepatology, University Hospital Lausanne, Lausanne, Switzerland
    Hepatology 55:1038-47. 2012
    ..0001, OR = 2.67, 95% CI = 1.68-4.25) and steatosis (P = 0.002, OR = 2.29, 95% CI = 1.35-3.91), but not with necroinflammatory activity (P = 0.3). Genetic variations had only a limited impact on serum ferritin levels...
  16. pmc S-adenosyl-methionine and betaine improve early virological response in chronic hepatitis C patients with previous nonresponse
    Magdalena Filipowicz
    Hepatology Laboratory, Department of Biomedicine, University Hospital Basel, Basel, Switzerland
    PLoS ONE 5:e15492. 2010
    ..We have performed a clinical study with the aim to evaluate efficacy and safety of the addition of SAMe and betaine to treatment of CHC with pegIFNα/ribavirin...
  17. pmc A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C
    Christian M Lange
    Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
    PLoS ONE 7:e40159. 2012
    ..To perform a comprehensive study on the relationship between vitamin D metabolism and the response to interferon-α-based therapy of chronic hepatitis C...
  18. doi request reprint Virus-induced over-expression of protein phosphatase 2A inhibits insulin signalling in chronic hepatitis C
    Christine Bernsmeier
    Department of Biomedicine, Division of Gastroenterology and Hepatology, University Hospital Basel, Hebelstrasse 20, CH 4031 Basel, Switzerland
    J Hepatol 49:429-40. 2008
    ..We have shown previously that protein phosphatase 2A (PP2A) is over-expressed in biopsies from patients with CHC. In this study, we tested if PP2A over-expression leads to insulin resistance...
  19. doi request reprint Generation of a murine hepatic angiosarcoma cell line and reproducible mouse tumor model
    Sonja Rothweiler
    Department of Biomedicine, University Basel, Basel, Switzerland
    Lab Invest 95:351-62. 2015
    ..In addition, AS cell transplantation provides a subcutaneous tumor model useful for in vivo preclinical drug testing. ..
  20. pmc Inhibition of alpha interferon signaling by hepatitis B virus
    Verena Christen
    Department of Research, University Hospital Basel, Hebelstrasse 20, CH 4031 Basel, Switzerland
    J Virol 81:159-65. 2007
    ..The molecular mechanisms involved are similar to those found in chronic hepatitis C...
  21. doi request reprint Comparative genetic analyses point to HCP5 as susceptibility locus for HCV-associated hepatocellular carcinoma
    Christian M Lange
    Division of Gastroenterology and Hepatology, University Hospital Lausanne, CH 1011 Lausanne, Switzerland
    J Hepatol 59:504-9. 2013
    ..In the present study, we sought to determine whether this SNP is predictive of HCC development in the Caucasian population as well...
  22. pmc Alpha interferon induces long-lasting refractoriness of JAK-STAT signaling in the mouse liver through induction of USP18/UBP43
    Magdalena Sarasin-Filipowicz
    Department of Biomedicine, University Hospital Basel, Basel, Switzerland
    Mol Cell Biol 29:4841-51. 2009
    ..Targeting USP18 expression may allow to exploit the full therapeutic potential of recombinant IFN-alpha...
  23. pmc Interferon signaling and treatment outcome in chronic hepatitis C
    Magdalena Sarasin-Filipowicz
    Department of Biomedicine, University of Basel, CH 4031 Basel, Switzerland
    Proc Natl Acad Sci U S A 105:7034-9. 2008
    ....
  24. doi request reprint Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c
    Asami Hagiwara
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Cell Metab 15:725-38. 2012
    ..Thus, mTORC2 regulates hepatic glucose and lipid metabolism via insulin-induced Akt signaling to control whole-body metabolic homeostasis. These findings have implications for emerging drug therapies that target mTORC2...
  25. doi request reprint Disruption of Notch1 induces vascular remodeling, intussusceptive angiogenesis, and angiosarcomas in livers of mice
    Michael T Dill
    Department of Biomedicine, University Basel, Basel, Switzerland
    Gastroenterology 142:967-977.e2. 2012
    ..The pathogenesis of NRH is unclear, but has been associated with vascular injury in the liver sinusoids in clinical studies. We investigated the role of Notch1 signaling in liver sinusoidal endothelial cells (LSECs)...
  26. doi request reprint Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy
    Magdalena Sarasin-Filipowicz
    Department of Biomedicine, University of Basel, Basel, Switzerland
    Nat Med 15:31-3. 2009
    ..These data have implications for the prospect of targeting miRNAs for CHC therapy...
  27. pmc Upregulation of protein phosphatase 2Ac by hepatitis C virus modulates NS3 helicase activity through inhibition of protein arginine methyltransferase 1
    Francois H T Duong
    Department of Research and Division of Gastroenterology and Hepatology, University Hospital Basel, CH 4031 Basel, Switzerland
    J Virol 79:15342-50. 2005
    ..We conclude that up-regulation of PP2A might be crucial for the efficient replication of HCV and propose PP2A as a potential target for anti-HCV treatment strategies...
  28. doi request reprint Hepatic Notch1 deletion predisposes to diabetes and steatosis via glucose-6-phosphatase and perilipin-5 upregulation
    Christine Bernsmeier
    Hepatology Laboratory, Department of Biomedicine, University and University Hospital Basel, Basel, Switzerland
    Lab Invest 96:972-80. 2016
    ..Notch1 is a regulator of hepatic glucose and lipid homeostasis. Hepatic impairment of Notch1 expression may be involved in the pathogenesis of human NAFLD/NASH. ..
  29. pmc IFN-λ receptor 1 expression is induced in chronic hepatitis C and correlates with the IFN-λ3 genotype and with nonresponsiveness to IFN-α therapies
    Francois H T Duong
    Department of Biomedicine and 2 Division of Gastroenterology and Hepatology, University Hospital Basel University of Basel, 4031 Basel, Switzerland
    J Exp Med 211:857-68. 2014
    ..The findings provide a missing link between the IFN-λ3 genotype and the associated phenotype of treatment nonresponse. ..
  30. pmc Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients
    Luca Quagliata
    Institute of Pathology, Molecular Pathology Division, University Hospital of Basel, Basel, Switzerland
    Hepatology 59:911-23. 2014
    ..In addition, taking advantage of gain and loss of function experiments in liver cancer-derived cell lines (HuH-6 and HuH-7), we uncover a novel bidirectional regulatory loop between HOTTIP/HOXA13...
  31. doi request reprint SH2D4A is frequently downregulated in hepatocellular carcinoma and cirrhotic nodules
    Luca Quagliata
    Institute of Pathology, University Hospital of Basel, Basel, Switzerland
    Eur J Cancer 50:731-8. 2014
    ..In addition, we provide new evidence for SH2D4A involvement in HCC pathogenesis demonstrating for the first time its deregulation in cirrhotic nodules...
  32. doi request reprint Sequential induction of type I and II interferons mediates a long-lasting gene induction in the liver in response to a novel toll-like receptor 9 agonist
    Zuzanna Makowska
    Department of Biomedicine, University of Basel, Basel, Switzerland
    J Hepatol 58:743-9. 2013
    ..The aim of this study was to investigate the in vivo mode of action of a closely related compound, referred to as immunomodulatory oligonucleotide (IMO)...
  33. ncbi request reprint Activation of endoplasmic reticulum stress response by hepatitis viruses up-regulates protein phosphatase 2A
    Verena Christen
    Department of Research, University Hospital Basel, Basel, Switzerland
    Hepatology 46:558-65. 2007
    ....
  34. doi request reprint Downregulation of the endothelial genes Notch1 and ephrinB2 in patients with nodular regenerative hyperplasia
    Sonja Rothweiler
    Department of Biomedicine, University Hospital Basel, University Basel, Basel, Switzerland
    Liver Int 34:594-603. 2014
    ..The aim of this study was to analyse histological and clinical data of NRH patients and to explore if the endothelial pathways identified in our NRH mouse model are also regulated in human NRH...
  35. doi request reprint Interferon signaling in the liver during hepatitis C virus infection
    Zuzanna Makowska
    Department of Biomedicine, Hepatology Laboratory, University of Basel, Basel, Switzerland
    Cytokine 59:460-6. 2012
    ....
  36. doi request reprint Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system
    Pantxika Bellecave
    Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
    Hepatology 51:1127-36. 2010
    ..We conclude that the pre-activation status of the endogenous IFN system in the liver of patients with CHC is in part regulated by cleavage of MAVS...
  37. ncbi request reprint Interleukin 6 is important for survival after partial hepatectomy in mice
    Alex Blindenbacher
    Department of Research, University Hospital Basel, Basel, Switzerland
    Hepatology 38:674-82. 2003
    ..We conclude that the major role of IL-6 is the induction of an adaptive response to PH that ensures body homeostasis and survival...
  38. doi request reprint Insulin resistance in chronic hepatitis C: mechanisms and clinical relevance
    Christine Bernsmeier
    Department of Gastroenterology and Hepatology, University Hospital Basel, Basel, Switzerland
    Swiss Med Wkly 139:678-84. 2009
    ..We further summarise the preliminary pathogenetic models that explain the development of hepatitis C virus-induced insulin resistance. Finally, we draw conclusions for the clinical management of these patients...
  39. doi request reprint Hepatitis C virus-induced up-regulation of protein phosphatase 2A inhibits histone modification and DNA damage repair
    Francois H T Duong
    Department of Biomedicine, Hepatology Laboratory, University Hospital Basel, 4031 Basel, Switzerland
    Hepatology 51:741-51. 2010
    ..Overexpression of PP2Ac in NIH-3T3 cells increased anchorage-independent growth. These changes were partially reversed by the treatment of cells with the methyl-group donor S-adenosyl-L-methionine (SAMe)...
  40. pmc Sleep Disruption and Daytime Sleepiness Correlating with Disease Severity and Insulin Resistance in Non-Alcoholic Fatty Liver Disease: A Comparison with Healthy Controls
    Christine Bernsmeier
    Division of Gastroenterology and Hepatology, University Hospital Basel, Basel, Switzerland
    PLoS ONE 10:e0143293. 2015
    ..We sought to detail sleep characteristics, daytime sleepiness and meal times in relation to disease severity in patients with NAFLD...
  41. pmc Quantitative proteomics and phosphoproteomics on serial tumor biopsies from a sorafenib-treated HCC patient
    Eva Dazert
    Biozentrum, University of Basel, 4056 Basel, Switzerland
    Proc Natl Acad Sci U S A 113:1381-6. 2016
    ..This protocol will allow elucidation of mechanisms of resistance and enable precision medicine. ..
  42. doi request reprint Interferon-β and interferon-λ signaling is not affected by interferon-induced refractoriness to interferon-α in vivo
    Zuzanna Makowska
    Department of Biomedicine, University Basel, Basel, Switzerland
    Hepatology 53:1154-63. 2011
    ..IFN-λ treatment of human liver biopsies ex vivo resulted in strong and maintained phosphorylation of STAT1, whereas IFN-α-induced STAT1 activation was transient...
  43. ncbi request reprint A new survival trick of hepatitis C virus: blocking the activation of interferon regulatory factor-3
    Markus H Heim
    Department of Research, University Hospital Basel, Basel, Switzerland
    Hepatology 38:1582-4. 2003
  44. ncbi request reprint Interferon-gamma receptor signaling is not required in the effector phase of the alloimmune response
    J U Steiger
    Department of Research, University Hospital Basel, Switzerland
    Transplantation 65:1649-52. 1998
    ..Recently, we have shown that IL-2-deficient mice reject islet allografts. In the IL-2-deficient system, IFN-gamma gene transcripts are abundantly expressed...
  45. pmc HMGA1 Expression in Human Hepatocellular Carcinoma Correlates with Poor Prognosis and Promotes Tumor Growth and Migration in in vitro Models
    Mariacarla Andreozzi
    Institute of Pathology, University Hospital Basel, Basel, Switzerland
    Neoplasia 18:724-731. 2016
    ..In this study we sought to explore the expression of HMGA1 in HCCs and cirrhotic tissues, and its effect in in vitro models...
  46. ncbi request reprint Expression of hepatitis c virus proteins inhibits interferon alpha signaling in the liver of transgenic mice
    Alex Blindenbacher
    Department of Research, University Hospital Basel, Switzerland
    Gastroenterology 124:1465-75. 2003
    ..Interference of viral proteins with the Jak-STAT pathway could be responsible for interferon resistance in patients with chronic HCV...
  47. pmc Glucose-induced glucagon-like Peptide 1 secretion is deficient in patients with non-alcoholic fatty liver disease
    Christine Bernsmeier
    Division of Gastroenterology and Hepatology, University Hospital Basel, Basel, Switzerland Department of Biomedicine, University Hospital Basel, Basel, Switzerland
    PLoS ONE 9:e87488. 2014
    ..Studies in mice suggest improvement of hepatic steatosis by GLP-1 agonism. We determined the secretion of incretins after oral glucose administration in non-diabetic NAFLD patients...
  48. doi request reprint Notch2 signaling promotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice
    Jan S Tchorz
    Department of Biomedicine, Institute of Physiology, University of Basel, Switzerland
    Hepatology 50:871-9. 2009
    ..Ectopic ducts in lobular regions did not persist into adulthood, indicating that local signals in the portal environment are important for maintaining bile ducts...
  49. ncbi request reprint Hepatitis C: a concise review
    D Moradpour
    Department of Medicine II, University of Freiburg, Germany
    Minerva Med 92:329-39. 2001
    ..Here, we briefly review current concepts of the epidemiology, molecular virology, pathogenesis, natural history, diagnosis, therapy, and prevention of hepatitis C...
  50. ncbi request reprint Hepatitis C: an update
    D Moradpour
    Department of Medicine II, University of Freiburg, Freiburg i. Br, Germany
    Swiss Med Wkly 131:291-8. 2001
    ..Here, we briefly review current concepts of the epidemiology, molecular virology, pathogenesis, natural history, diagnosis, therapy, and prevention of hepatitis C...
  51. pmc Defective STAT signaling by the leptin receptor in diabetic mice
    N Ghilardi
    Department of Pharmacology, Biozentrum, University of Basel, Switzerland
    Proc Natl Acad Sci U S A 93:6231-5. 1996
    ..These data provide further evidence that the mutation in OB-R causes the db/db phenotype and identify three STAT proteins as potential mediators of the anti-obesity effects of leptin...