Daniel Haussinger

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. pmc Anti-protozoal activity of aporphine and protoberberine alkaloids from Annickia kummeriae (Engl. & Diels) Setten & Maas (Annonaceae)
    Hamisi M Malebo
    Department of Traditional Medicine Research, National Institute for Medical Research, P O Box 9653, Dar es Salaam, Tanzania
    BMC Complement Altern Med 13:48. 2013
  2. doi request reprint DOTA-M8: An extremely rigid, high-affinity lanthanide chelating tag for PCS NMR spectroscopy
    Daniel Haussinger
    Department of Chemistry, University of Basel, St Johanns Ring 19, 4056 Basel, Switzerland
    J Am Chem Soc 131:14761-7. 2009
  3. ncbi request reprint Biophysical chemistry
    Daniel Haussinger
    Department of Chemistry, St Johanns Ring 19, CH 4056 Basel
    Chimia (Aarau) 64:874-6. 2010
  4. ncbi request reprint Determination of a high-precision NMR structure of the minicollagen cysteine rich domain from Hydra and characterization of its disulfide bond formation
    Sebastian Meier
    Division of Structural Biology, Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    FEBS Lett 569:112-6. 2004
  5. ncbi request reprint The structure of the Cys-rich terminal domain of Hydra minicollagen, which is involved in disulfide networks of the nematocyst wall
    Elena Pokidysheva
    Department of Biophysical Chemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    J Biol Chem 279:30395-401. 2004
  6. doi request reprint Insights into the low adhesive capacity of human T-cadherin from the NMR structure of Its N-terminal extracellular domain
    Sonja A Dames
    Department of Structural Biology, University of Basel, Klingelbergstr 70, 4056 Basel, Switzerland
    J Biol Chem 283:23485-95. 2008
  7. ncbi request reprint High-accuracy residual 1HN-13C and 1HN-1HN dipolar couplings in perdeuterated proteins
    Sebastian Meier
    Biozentrum, University of Basel, Basel 4056, Switzerland
    J Am Chem Soc 125:44-5. 2003
  8. pmc Proteolytic E-cadherin activation followed by solution NMR and X-ray crystallography
    Daniel Haussinger
    Division of Structural Biology, Biozentrum, University of Basel, Basel, Switzerland
    EMBO J 23:1699-708. 2004
  9. ncbi request reprint Charged acrylamide copolymer gels as media for weak alignment
    Sebastian Meier
    Department of Structural Biology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Biomol NMR 24:351-6. 2002
  10. ncbi request reprint Metallohosts with a heart of carbon
    Edwin C Constable
    Department of Chemistry, University of Basel, Spitalstrasse 51, CH 4056 Basel, Switzerland
    J Am Chem Soc 133:10776-9. 2011

Collaborators

Detail Information

Publications19

  1. pmc Anti-protozoal activity of aporphine and protoberberine alkaloids from Annickia kummeriae (Engl. & Diels) Setten & Maas (Annonaceae)
    Hamisi M Malebo
    Department of Traditional Medicine Research, National Institute for Medical Research, P O Box 9653, Dar es Salaam, Tanzania
    BMC Complement Altern Med 13:48. 2013
    ..Consequently, there is an urgent need for research aimed at the discovery and development of new effective and safe anti-plasmodial, anti-trypanosomal and anti-leishmanial drugs...
  2. doi request reprint DOTA-M8: An extremely rigid, high-affinity lanthanide chelating tag for PCS NMR spectroscopy
    Daniel Haussinger
    Department of Chemistry, University of Basel, St Johanns Ring 19, 4056 Basel, Switzerland
    J Am Chem Soc 131:14761-7. 2009
    ....
  3. ncbi request reprint Biophysical chemistry
    Daniel Haussinger
    Department of Chemistry, St Johanns Ring 19, CH 4056 Basel
    Chimia (Aarau) 64:874-6. 2010
    ....
  4. ncbi request reprint Determination of a high-precision NMR structure of the minicollagen cysteine rich domain from Hydra and characterization of its disulfide bond formation
    Sebastian Meier
    Division of Structural Biology, Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    FEBS Lett 569:112-6. 2004
    ..The redox equilibrium of the structure has been characterized from a titration with glutathione. No local native structures are detectable in the reduced form. Thus, oxidation and folding are tightly coupled...
  5. ncbi request reprint The structure of the Cys-rich terminal domain of Hydra minicollagen, which is involved in disulfide networks of the nematocyst wall
    Elena Pokidysheva
    Department of Biophysical Chemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    J Biol Chem 279:30395-401. 2004
    ....
  6. doi request reprint Insights into the low adhesive capacity of human T-cadherin from the NMR structure of Its N-terminal extracellular domain
    Sonja A Dames
    Department of Structural Biology, University of Basel, Klingelbergstr 70, 4056 Basel, Switzerland
    J Biol Chem 283:23485-95. 2008
    ..The apparent low adhesiveness of T-cadherin suggests that it is likely to be involved in reversible and dynamic cellular adhesion-deadhesion processes, which are consistent with its role in cell growth and migration...
  7. ncbi request reprint High-accuracy residual 1HN-13C and 1HN-1HN dipolar couplings in perdeuterated proteins
    Sebastian Meier
    Biozentrum, University of Basel, Basel 4056, Switzerland
    J Am Chem Soc 125:44-5. 2003
    ..1 A crystal structure of protein G are mainly found in two surface-exposed loop regions. The deviations show a strong correlation to the B-factor of the crystal structure...
  8. pmc Proteolytic E-cadherin activation followed by solution NMR and X-ray crystallography
    Daniel Haussinger
    Division of Structural Biology, Biozentrum, University of Basel, Basel, Switzerland
    EMBO J 23:1699-708. 2004
    ..72 mM, k(off)=0.7 s(-1)) and concomitant intermolecular exchange of the betaA-strands and the tryptophan-2 side-chains. Thus, the cleavage represents the switch from a nonadhesive to the functional form of cadherin...
  9. ncbi request reprint Charged acrylamide copolymer gels as media for weak alignment
    Sebastian Meier
    Department of Structural Biology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Biomol NMR 24:351-6. 2002
    ..The alignment can be modulated by the variation of pH, ionic strength, and gel concentration. The high mechanical stability of the swollen gels makes it possible to obtain alignment at polymer concentrations of less than 1% (w/v)...
  10. ncbi request reprint Metallohosts with a heart of carbon
    Edwin C Constable
    Department of Chemistry, University of Basel, Spitalstrasse 51, CH 4056 Basel, Switzerland
    J Am Chem Soc 133:10776-9. 2011
    ..For the naphthalen-2-ylmethyl-substituted host, NMR spectroscopic titration data confirmed a 1:1 host-C(60) guest complex in 1,2-Cl(2)C(6)D(4) solution...
  11. ncbi request reprint Racemisation dynamics of torsion angle restricted biphenyl push-pull cyclophanes
    Jürgen Rotzler
    Department of Chemistry, University of Basel, St Johannsring 19, 4056 Basel, Switzerland
    Org Biomol Chem 9:86-91. 2011
    ..The difference in the free energy of rotation around the central C-C bond probably reflects the crowdedness of the transition states...
  12. ncbi request reprint Calcium-dependent homoassociation of E-cadherin by NMR spectroscopy: changes in mobility, conformation and mapping of contact regions
    Daniel Haussinger
    Division of Structural Biology and Division of Biophysical Chemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    J Mol Biol 324:823-39. 2002
    ..According to weak alignment and relaxation data, the symmetry of a predominantly dimeric solution aggregate at 0.6 mM ECAD12 differs from the approximate C2-symmetry of the crystalline dimer...
  13. doi request reprint Inducing axial chirality in a "Geländer" oligomer by length mismatch of the oligomer strands
    Michel Rickhaus
    Department of Chemistry, University of Basel, St Johanns Ring 19, 4056 Basel Switzerland
    Angew Chem Int Ed Engl 53:14587-91. 2014
    ..The isolation of pure enantiomers enabled the racemization process to be studied by circular dichroism spectroscopy. ..
  14. doi request reprint Atropisomerization of di-para-substituted propyl-bridged biphenyl cyclophanes
    Jürgen Rotzler
    Department of Chemistry, University of Basel, St Johannsring 19, 4056 Basel, Switzerland
    Org Biomol Chem 11:110-8. 2013
    ..Density functional theory calculations show a planar transition state of the isomerization process and the calculated energy barriers based on this reaction mechanism are in good agreement with the experimentally obtained free energies...
  15. doi request reprint Molecular daisy chains: synthesis and aggregation studies of an amphiphilic molecular rod
    Jürgen Rotzler
    Department of Chemistry, University of Basel, St Johanns Ring 19, 4056 Basel Switzerland, Fax 41 61 267 10 16
    Chemistry 19:2089-101. 2013
    ..Furthermore, evidence for the formation of higher mechanically interlinked oligomers above the critical aggregation concentration has been obtained...
  16. ncbi request reprint Analysis of heterophilic and homophilic interactions of cadherins using the c-Jun/c-Fos dimerization domains
    Thomas Ahrens
    Department of Biophysical Chemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, Basel 4056, Switzerland
    J Biol Chem 277:19455-60. 2002
    ..Neither cis nor trans interaction was found for heterodimers of ECADJun and PCADFos suggesting that specificity for homophilic interactions already exists at the level of cis dimerization...
  17. doi request reprint Hydrogen-bond and solvent dynamics in transition metal complexes: a combined simulation and NMR-investigation
    Jing Huang
    Department of Chemistry, University of Basel, Klingelbergstrasse 80, 4056 Basel, Switzerland
    J Phys Chem B 116:14406-15. 2012
    ..8 kcal/mol for double proton transfer. A mechanistic interpretation is provided and the distribution of the solvent shell surrounding the catalyst is characterized from extensive simulations...
  18. ncbi request reprint Porphyrin-DNA: a supramolecular scaffold for functional molecules on the nanometre scale
    Imenne Bouamaied
    Department of Chemistry, University of Basel, Basel, Switzerland
    Nucleosides Nucleotides Nucleic Acids 26:1533-8. 2007
    ..Up to 11 porphyrins were incorporated into DNA, reaching a length of approximately 4 nm in the array. The spectroscopic data are consistent with a porphyrin induced secondary structure stabilisation in the single strands...
  19. ncbi request reprint Recognition of RANTES by extracellular parts of the CCR5 receptor
    Luminita Duma
    Division of Structural Biology, Biozentrum, University of Basel, Klingelbergstr 70, Basel, Switzerland
    J Mol Biol 365:1063-75. 2007
    ..These data offer new insights into the structure-function relation of the RANTES-CCR5 interaction and may be helpful for the design of novel HIV-1 inhibitors...