Matthias Hamburger

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. ncbi request reprint New approaches in analyzing the pharmacological properties of herbal extracts
    Matthias Hamburger
    Institute of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
    Proc West Pharmacol Soc 50:156-61. 2007
  2. ncbi request reprint A protocol for HPLC-based activity profiling for natural products with activities against tropical parasites
    Michael Adams
    Institute of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Nat Prod Commun 4:1377-81. 2009
  3. pmc Ethnoveterinary herbal remedies used by farmers in four north-eastern Swiss cantons (St. Gallen, Thurgau, Appenzell Innerrhoden and Appenzell Ausserrhoden)
    Monika Disler
    Departement of Livestock Science, Research Institute of Organic Agriculture, Ackerstrasse 113, Postfach, CH 5070 Frick, Switzerland
    J Ethnobiol Ethnomed 10:32. 2014
  4. pmc Anti-protozoal activity of aporphine and protoberberine alkaloids from Annickia kummeriae (Engl. & Diels) Setten & Maas (Annonaceae)
    Hamisi M Malebo
    Department of Traditional Medicine Research, National Institute for Medical Research, P O Box 9653, Dar es Salaam, Tanzania
    BMC Complement Altern Med 13:48. 2013
  5. pmc Gene expression profiling reveals effects of Cimicifuga racemosa (L.) NUTT. (black cohosh) on the estrogen receptor positive human breast cancer cell line MCF-7
    Friedemann Gaube
    Institute of Pharmacy, Department of Pharmaceutical Biology, University of Jena, Semmelweisstr, 10, 07743 Jena, Germany
    BMC Pharmacol 7:11. 2007
  6. doi request reprint Abietane diterpenoids from Salvia sahendica--antiprotozoal activity and determination of their absolute configurations
    Samad N Ebrahimi
    Division of Pharmaceutical Biology, University of Basel, Basel, Switzerland
    Planta Med 79:150-6. 2013
  7. doi request reprint Cynaropicrin: the first plant natural product with in vivo activity against Trypanosoma brucei
    Stefanie Zimmermann
    Department of Pharmaceutical Sciences, Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, Basel, Switzerland
    Planta Med 78:553-6. 2012
  8. doi request reprint HPLC-based activity profiling for GABA(A) receptor modulators: a new dihydroisocoumarin from Haloxylon scoparium
    Yanfang Li
    Institute of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    J Nat Prod 73:768-70. 2010
  9. doi request reprint Phytochemical profiling of Curcuma kwangsiensis rhizome extract, and identification of labdane diterpenoids as positive GABAA receptor modulators
    Anja Schramm
    Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland
    Phytochemistry 96:318-29. 2013
  10. doi request reprint HPLC-based activity profiling--discovery of sanggenons as GABAA receptor modulators in the traditional Chinese drug Sang bai pi (Morus alba root bark)
    Hyun Jung Kim
    Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
    Planta Med 78:440-7. 2012

Collaborators

Detail Information

Publications98

  1. ncbi request reprint New approaches in analyzing the pharmacological properties of herbal extracts
    Matthias Hamburger
    Institute of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
    Proc West Pharmacol Soc 50:156-61. 2007
    ..These methods are illustrated with selected axamples from our labs, including woad (Isatis tinctoria), the traditional Chinese herb Danshen (Salvia miltiorrhiza) and black cohosh (Cimicifuga racemosa)...
  2. ncbi request reprint A protocol for HPLC-based activity profiling for natural products with activities against tropical parasites
    Michael Adams
    Institute of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Nat Prod Commun 4:1377-81. 2009
    ..The protocol was validated with extracts and positive controls such as Artemisia annua...
  3. pmc Ethnoveterinary herbal remedies used by farmers in four north-eastern Swiss cantons (St. Gallen, Thurgau, Appenzell Innerrhoden and Appenzell Ausserrhoden)
    Monika Disler
    Departement of Livestock Science, Research Institute of Organic Agriculture, Ackerstrasse 113, Postfach, CH 5070 Frick, Switzerland
    J Ethnobiol Ethnomed 10:32. 2014
    ..Therefore the aim of this study was to document and analyse the traditional knowledge and use of homemade herbal remedies for livestock by farmers in four Swiss cantons...
  4. pmc Anti-protozoal activity of aporphine and protoberberine alkaloids from Annickia kummeriae (Engl. & Diels) Setten & Maas (Annonaceae)
    Hamisi M Malebo
    Department of Traditional Medicine Research, National Institute for Medical Research, P O Box 9653, Dar es Salaam, Tanzania
    BMC Complement Altern Med 13:48. 2013
    ..Consequently, there is an urgent need for research aimed at the discovery and development of new effective and safe anti-plasmodial, anti-trypanosomal and anti-leishmanial drugs...
  5. pmc Gene expression profiling reveals effects of Cimicifuga racemosa (L.) NUTT. (black cohosh) on the estrogen receptor positive human breast cancer cell line MCF-7
    Friedemann Gaube
    Institute of Pharmacy, Department of Pharmaceutical Biology, University of Jena, Semmelweisstr, 10, 07743 Jena, Germany
    BMC Pharmacol 7:11. 2007
    ..We, therefore, investigated the effects of a lipophilic black cohosh rhizome extract and cycloartane-type triterpenoids on the estrogen receptor positive human breast cancer cell line MCF-7...
  6. doi request reprint Abietane diterpenoids from Salvia sahendica--antiprotozoal activity and determination of their absolute configurations
    Samad N Ebrahimi
    Division of Pharmaceutical Biology, University of Basel, Basel, Switzerland
    Planta Med 79:150-6. 2013
    ..falciparum, and from 1.8 µM to over 32.3 µM against T. brucei rhodesiense. The cytotoxic IC50 values ranged from 0.5-15.5 µM. Selectivity indices for P. falciparum were 0.1 to 18.2, and 0.1 to 1.2 for T. brucei rhodesiense...
  7. doi request reprint Cynaropicrin: the first plant natural product with in vivo activity against Trypanosoma brucei
    Stefanie Zimmermann
    Department of Pharmaceutical Sciences, Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, Basel, Switzerland
    Planta Med 78:553-6. 2012
    ..8, 62, and 9.5 were determined. This is the first report of a plant natural product with potent IN VIVO activity against TRYPANOSOMA BRUCEI...
  8. doi request reprint HPLC-based activity profiling for GABA(A) receptor modulators: a new dihydroisocoumarin from Haloxylon scoparium
    Yanfang Li
    Institute of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    J Nat Prod 73:768-70. 2010
    ..Compound 1 induced a maximum potentiation of the chloride currents by 144.6 +/- 35.3% with an EC(50) of 140.2 +/- 51.2 muM...
  9. doi request reprint Phytochemical profiling of Curcuma kwangsiensis rhizome extract, and identification of labdane diterpenoids as positive GABAA receptor modulators
    Anja Schramm
    Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland
    Phytochemistry 96:318-29. 2013
    ..The highest efficiency was observed for zerumin A (maximum potentiation of IGABA by 309.4±35.6%, and EC50 of 24.9±8.8 μM)...
  10. doi request reprint HPLC-based activity profiling--discovery of sanggenons as GABAA receptor modulators in the traditional Chinese drug Sang bai pi (Morus alba root bark)
    Hyun Jung Kim
    Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
    Planta Med 78:440-7. 2012
    ..The structurally related compound kuwanon L (1) was inactive. The sanggenons represent a new scaffold of positive GABA (A) receptor modulators...
  11. doi request reprint Pharmacokinetics and In Vitro Blood-Brain Barrier Screening of the Plant-Derived Alkaloid Tryptanthrin
    Evelyn A Jähne
    Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
    Planta Med 82:1021-9. 2016
    ..P-glycoprotein interaction of tryptanthrin was assessed by calculation of the efflux ratio in bidirectional permeability assays. An efflux ratio below 2 indicated that tryptanthrin is not subjected to active efflux. ..
  12. doi request reprint Antitrypanosomal isoflavan quinones from Abrus precatorius
    Yoshie Hata
    Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland Department of Pharmacy, Faculty of Sciences, National University of Colombia, Carrera 30 No 45 03, Bogota D C 111321, Colombia
    Fitoterapia 93:81-7. 2014
    ..Compounds 2 to 5 showed high in vitro activity against T. b. rhodesiense (IC50 of 0.01, 0.02, 0.02 and 0.01 μM, respectively), and remarkable SIs of 508, 374, 1379, and 668, respectively...
  13. doi request reprint HPLC-based activity profiling for GABAA receptor modulators in Adenocarpus cincinnatus
    Diana C Rueda
    Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland
    J Nat Prod 77:640-9. 2014
    ..8 ± 1.4 and 18.8 ± 2.3 μM. Maximal potentiation of IGABA ranged between 490% and 640%. This is the first report of pterocarpans as GABAA receptor modulators. ..
  14. doi request reprint Antiplasmodial and antitrypanosomal activity of pyrethrins and pyrethroids
    Yoshie Hata
    Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland
    J Agric Food Chem 59:9172-6. 2011
    ..Both pyrethrins and pyrethroids showed moderate cytotoxicity against L6 cells. Pyrethrin II (1) was the most selective antiplasmodial compound, with a selectivity index of 24...
  15. doi request reprint Renaissance remedies: Antiplasmodial protostane triterpenoids from Alisma plantago-aquatica L. (Alismataceae)
    Michael Adams
    Institute of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    J Ethnopharmacol 135:43-7. 2011
    ..Alismataceae) was active against Plasmodium falciparum K1 strain with 77% growth inhibition at 4.9μg/ml. The aim of this study was to isolate and identify the substances responsible for this antiplasmodial activity...
  16. pmc HPLC-based activity profiling: discovery of piperine as a positive GABA(A) receptor modulator targeting a benzodiazepine-independent binding site
    Janine Zaugg
    Institute of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland
    J Nat Prod 73:185-91. 2010
    ..These data show that piperine (5) represents a new scaffold of positive allosteric GABA(A) receptor modulators targeting a benzodiazepine-independent binding site...
  17. doi request reprint Antiplasmodial lanostanes from the Ganoderma lucidum mushroom
    Michael Adams
    Institute of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland
    J Nat Prod 73:897-900. 2010
    ..The lanostanes exhibited in vitro antiplasmodial activity with IC(50) values from 6 to greater than 20 microM...
  18. doi request reprint HPLC-based activity profiling for antiplasmodial compounds in the traditional Indonesian medicinal plant Carica papaya L
    Tasqiah Julianti
    Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, Basel 4056, Switzerland Faculty of Pharmacy, Pancasila University, Jakarta 12640, Indonesia
    J Ethnopharmacol 155:426-34. 2014
    ..Leaf decoctions of Carica papaya have been traditionally used in some parts of Indonesia to treat and prevent malaria. Leaf extracts and fraction have been previously shown to possess antiplasmodial activity in vitro and in vivo...
  19. doi request reprint Cynaropicrin targets the trypanothione redox system in Trypanosoma brucei
    Stefanie Zimmermann
    Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
    Bioorg Med Chem 21:7202-9. 2013
    ..At the same time, the study provides a novel extraction and analysis protocol for components of the trypanosomal thiol metabolism. ..
  20. doi request reprint Discovery of GABA(A) receptor modulator aristolactone in a commercial sample of the Chinese herbal drug "Chaihu" (Bupleurum chinense roots) unravels adulteration by nephrotoxic Aristolochia manshuriensis roots
    Diana C Rueda
    Division of Pharmaceutical Biology, University of Basel, Basel, Switzerland
    Planta Med 78:207-10. 2012
    ..This finding was corroborated by macroscopic inspection of the drug. This case of adulteration with a highly nephrotoxic drug raises concerns about adequate quality control of TCM drugs commercialized in Europe...
  21. doi request reprint Bicyclononane aldehydes and antiproliferative constituents from Amomum tsao-ko
    Xinzhou Yang
    Institute of Pharmaceutical Biology, University of Basel, Basel, Switzerland
    Planta Med 75:543-6. 2009
    ..The structure of 1 was determined on the basis of extensive spectroscopic analysis, including 1D and 2D NMR data. The antiproliferative activity of compounds 1-13 was assessed in the murine neuroblastoma cell line N2a...
  22. pmc Positive GABA(A) receptor modulators from Acorus calamus and structural analysis of (+)-dioxosarcoguaiacol by 1D and 2D NMR and molecular modeling
    Janine Zaugg
    Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland
    J Nat Prod 74:1437-43. 2011
    ..9%; EC₅₀: 109.4 ± 46.6 μM and 6: 241% ± 23.1%; EC₅₀: 34.0 ± 6.7 μM). The relative configuration of 2 was established as 4R*8S*10R* by NOESY experiments and conformational analysis...
  23. doi request reprint Validation of UHPLC-MS/MS methods for the determination of kaempferol and its metabolite 4-hydroxyphenyl acetic acid, and application to in vitro blood-brain barrier and intestinal drug permeability studies
    Fahimeh Moradi-Afrapoli
    Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland Department of Pharmacognosy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    J Pharm Biomed Anal 128:264-74. 2016
    ..99. Data obtained with all barrier models showed high intestinal and blood-brain barrier permeation of KMF, and no permeability of 4-HPAA, when compared to barrier integrity markers. ..
  24. doi request reprint Antiprotozoal isoflavan quinones from Abrus precatorius ssp. africanus
    Yoshie Hata
    Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
    Planta Med 79:492-8. 2013
    ..Compounds 3 and 4 showed strong activity against T. b. rhodesiense (IC50 values of 0.30 and 0.16 µM, respectively) and good selectivity (selectivity indices of 73.7 and 50.5, respectively)...
  25. doi request reprint Comprehensive analysis of Phyteuma orbiculare L., a wild Alpine food plant
    Christian Abbet
    Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Food Chem 136:595-603. 2013
    ..The antioxidant capacity was determined with an ORAC assay, and total phenolic compounds were quantified. Finally, the phytochemical profile was compared to that of the related species P. spicatum, P. hemisphaericum and P. ovatum...
  26. doi request reprint Library-based discovery of DYRK1A/CLK1 inhibitors from natural product extracts
    Patrick Grabher
    Division of Pharmaceutical Biology, University of Basel, Basel, Switzerland
    Planta Med 78:951-6. 2012
    ....
  27. pmc Identification of GABA A receptor modulators in Kadsura longipedunculata and assignment of absolute configurations by quantum-chemical ECD calculations
    Janine Zaugg
    Division of Pharmaceutical Biology, University of Basel, Basel, Switzerland
    Phytochemistry 72:2385-95. 2011
    ..1±2.6% potentiation of I(GABA) at 100 μg/ml, n=2), and Schisandra chinensis fruits (inactive at 100 μg/ml) were compared by HPLC-PDA-ESIMS with that of K. longipedunculata...
  28. doi request reprint Antitrypanosomal sesquiterpene lactones from Saussurea costus
    Tasqiah Julianti
    Division of Pharmaceutical Biology, University of Basel, CH 4056 Basel, Switzerland
    Fitoterapia 82:955-9. 2011
    ..8 and 22 μM. Cytotoxic IC(50)s were from 1.6 to 19 μM, and selectivity indices from 0.5 to 6.5...
  29. doi request reprint A comprehensive metabolite profiling of Isatis tinctoria leaf extracts
    Tobias Mohn
    Institute of Pharmaceutical Biology, University of Basel, Klingelbergstrabetae 50, CH 4056 Basel, Switzerland
    Phytochemistry 70:924-34. 2009
    ..Numerous compounds were identified for the first time in the genus Isatis, and an indolic alkaloid was discovered...
  30. doi request reprint Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice
    Janine Zaugg
    Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland
    J Nat Prod 74:1764-72. 2011
    ..No significant anxiolytic-like activity was observed in doses between 1 and 30 mg/kg body weight in mice...
  31. doi request reprint Caco-2 Permeability Studies and In Vitro hERG Liability Assessment of Tryptanthrin and Indolinone
    Evelyn A Jähne
    Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
    Planta Med 82:1192-201. 2016
    ..96 µM). The analysis of compounds using various in silico methods confirmed favorable pharmacokinetic properties, as well as a slight inhibition of the human ether-a-go-go-related gene potassium channel at micromolar concentrations. ..
  32. doi request reprint Epilepsy in the Renaissance: a survey of remedies from 16th and 17th century German herbals
    Michael Adams
    Department of Pharmaceutical Sciences, Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    J Ethnopharmacol 143:1-13. 2012
    ..Hundreds of different plants for this indication can be found in German herbals of the 16th and 17th centuries. Here we compile these plants and discuss their use from a pharmacological perspective...
  33. doi request reprint HPLC-based activity profiling of Angelica pubescens roots for new positive GABAA receptor modulators in Xenopus oocytes
    Janine Zaugg
    Institute of Pharmaceutical Biology, University of Basel, Basel, Switzerland
    Fitoterapia 82:434-40. 2011
    ..The example demonstrates that HPLC-based activity profiling is a simple and efficient method to rapidly identify GABA(A) receptor modulators in a bioactive plant extract...
  34. doi request reprint Identification of dehydroabietc acid from Boswellia thurifera resin as a positive GABAA receptor modulator
    Diana C Rueda
    Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Fitoterapia 99:28-34. 2014
    ..5% ± 34.0%, and EC₅₀ of 8.7 μM ± 1.3 μM. This is the first report of dehydroabietic acid as a positive GABAA receptor modulator...
  35. pmc HPLC-based activity profiling for GABAA receptor modulators from the traditional Chinese herbal drug Kushen (Sophora flavescens root)
    Xinzhou Yang
    Institute of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, 4056, Basel, Switzerland
    Mol Divers 15:361-72. 2011
    ..Among these, kushenol Y (4) was identified as a new natural product. The 8-lavandulyl flavonoids are first representatives of a novel scaffold for the target...
  36. doi request reprint Profiling of isoflavonoids in Iris germanica rhizome extracts by microprobe NMR and HPLC-PDA-MS analysis
    Cornelia Schütz
    Division of Pharmaceutical Biology, University of Basel, Switzerland
    Fitoterapia 82:1021-6. 2011
    ..This study demonstrates the applicability of the HPLC/off-line microprobe NMR approach as a robust means for rapid phytochemical profiling of plant extracts...
  37. doi request reprint Malaria in the Renaissance: remedies from European herbals from the 16th and 17th century
    Michael Adams
    Institute of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    J Ethnopharmacol 133:278-88. 2011
    ..Hundreds of different remedies against malaria can be found in herbals from the Renaissance...
  38. doi request reprint Composition of Indigo naturalis
    Inken Plitzko
    Institute of Pharmaceutical Biology, University of Basel, Basel, Switzerland
    Planta Med 75:860-3. 2009
    ....
  39. doi request reprint Medicinal herbs for the treatment of rheumatic disorders--a survey of European herbals from the 16th and 17th century
    Michael Adams
    Institute of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    J Ethnopharmacol 121:343-59. 2009
    ..For the most part modern science has neglected this source of knowledge and old remedies have not been systematically evaluated pharmacologically...
  40. doi request reprint Seasonal changes and effect of harvest on glucosinolates in Isatis leaves
    Tobias Mohn
    Institute of Pharmaceutical Biology, University of Basel, Basel, Switzerland
    Planta Med 74:582-7. 2008
    ..Glucosinolates could not be detected in woad leaves submitted to conventional drying...
  41. ncbi request reprint Morinda citrifolia (Noni) fruit--phytochemistry, pharmacology, safety
    Olivier Potterat
    Institute of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
    Planta Med 73:191-9. 2007
    ..While the European Food Safety Authority sees no link between adverse effects on liver and consumption of Noni juice, a continuing monitoring of the situation is desirable and some vigilance advised...
  42. ncbi request reprint Identification of TLC markers and quantification by HPLC-MS of various constituents in noni fruit powder and commercial noni-derived products
    Olivier Potterat
    Institute of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    J Agric Food Chem 55:7489-94. 2007
    ..Scopoletin was mainly found in juices. The anthraquinone alizarin, which has been reported from roots and leaves, was not detected in the samples investigated...
  43. doi request reprint Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy
    Karin Fürer
    Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
    Planta Med 82:930-41. 2016
    ..Taken together, current data support the use of B. pinnatum for the mentioned indications, but further studies are needed to fully understand the modes of action, and to identify the pharmacologically active constituents. ..
  44. doi request reprint In vitro blood-brain barrier permeability predictions for GABAA receptor modulating piperine analogs
    Daniela Elisabeth Eigenmann
    Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Eur J Pharm Biopharm 103:118-26. 2016
    ..Efflux ratios (ER) calculated from bidirectional permeability experiments indicated that the compounds were likely not substrates of active efflux transporters. ..
  45. doi request reprint Development and full validation of an UPLC-MS/MS method for the quantification of the plant-derived alkaloid indirubin in rat plasma
    Evelyn A Jähne
    Institute of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    J Pharm Biomed Anal 128:247-52. 2016
    ..w.) and blood sampling up to 12h after injection. PK parameters were determined by non-compartmental analysis. Indirubin had a half-life (t1/2) of 35min, and a relatively high clearance (CL) of 2.71L/h/kg. ..
  46. doi request reprint Quantification of Bufadienolides in Bryophyllum pinnatum Leaves and Manufactured Products by UHPLC-ESIMS/MS
    Mouhssin Oufir
    Department of Pharmaceutical Sciences, Division of Pharmaceutical Biology, University of Basel, Basel, Switzerland
    Planta Med 81:1190-7. 2015
    ..Bersaldegenin-1,3,5-orthoacetate (4) was predominant in the leaves of B. daigremontianum and in the stems of B. tubiflorum, while the leaves of B. tubiflorum contained very low amounts of 1-4. ..
  47. doi request reprint Natural products as potential human ether-a-go-go-related gene channel inhibitors - outcomes from a screening of widely used herbal medicines and edible plants
    Anja Schramm
    Division of Pharmaceutical Biology, University of Basel, Basel, Switzerland
    Planta Med 80:1045-50. 2014
    ..Major European medicinal plants and frequently consumed food plants were found to have a low risk for human ether-a-go-go-related gene toxicity. ..
  48. doi request reprint Structure-activity relationship study of sesquiterpene lactones and their semi-synthetic amino derivatives as potential antitrypanosomal products
    Stefanie Zimmermann
    Department Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland
    Molecules 19:3523-38. 2014
    ..The dimethylamino derivative of cynaropicrin was prepared and tested orally in the T. b. rhodesiense acute mouse model, where it showed reduced toxicity over cynaropicrin, but also lost antitrypanosomal activity. ..
  49. doi request reprint Comprehensive analysis of Cirsium spinosissimum Scop., a wild alpine food plant
    Christian Abbet
    Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Food Chem 160:165-70. 2014
    ..In addition, substances relevant for nutrition, such as β-carotene, fatty acids, ascorbic acid, and minerals, were quantified. The ethanolic extract of the receptacles showed no sign of cytotoxicity when tested in Caco-2 cells. ..
  50. doi request reprint Metabolite profiling of the leaves of the Brazilian folk medicine Sideroxylon obtusifolium
    Adriana Passos Oliveira
    Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, Basel, Switzerland
    Planta Med 78:703-10. 2012
    ..In addition, catechin and a glycerogalactolipid, gingerglycolipid A, were obtained from the ethyl acetate-soluble fraction. The isolated compounds could be used in the future as chemical markers for quality control of this herbal drug...
  51. ncbi request reprint Extraction and analysis of intact glucosinolates--a validated pressurized liquid extraction/liquid chromatography-mass spectrometry protocol for Isatis tinctoria, and qualitative analysis of other cruciferous plants
    Tobias Mohn
    Institute of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    J Chromatogr A 1166:142-51. 2007
    ..Analysis of cruciferous vegetables and spices such as broccoli (Brassica oleracea L. var. italica), garden cress (Lepidium sativum L.) and black mustard (Sinapis nigra L.) demonstrated the general applicability of the method...
  52. ncbi request reprint Drug discovery and development with plant-derived compounds
    Olivier Potterat
    University of Basel, Institute of Pharmaceutical Biology, Klingelbergstrasse 50, 4056 Basel, Switzerland
    Prog Drug Res 65:45, 47-118. 2008
    ..Aspects which are specific to plant-based drug discovery and development are also addressed, such as supply issues in the commercial development, and the Convention on Biological Diversity...
  53. doi request reprint Pharmacokinetics of dietary kaempferol and its metabolite 4-hydroxyphenylacetic acid in rats
    Volha Zabela
    Pharmaceutical Biology Laboratory, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland Electronic address
    Fitoterapia 115:189-197. 2016
    ..4-Hydroxyphenylacetic acid (4-HPAA), which possesses anxiolytic effects when administered intraperitoneally, is a major intestinal metabolite of kaempferol. Pharmacokinetic properties of the compounds are currently not clear...
  54. doi request reprint Identification of dihydrostilbenes in Pholidota chinensis as a new scaffold for GABAA receptor modulators
    Diana C Rueda
    Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Bioorg Med Chem 22:1276-84. 2014
    ..Dihydrostilbenes represent a new scaffold for GABA(A) receptor modulators...
  55. doi request reprint Natural products as potential human ether-a-go-go-related gene channel inhibitors - screening of plant-derived alkaloids
    Anja Schramm
    Division of Pharmaceutical Biology, University of Basel, Basel, Switzerland
    Planta Med 80:740-6. 2014
    ..Our data show that some widely occurring plant-derived alkaloids carry a potential risk for human ether-a-go-go-related gene toxicity...
  56. doi request reprint Concepts and technologies for tracking bioactive compounds in natural product extracts: generation of libraries, and hyphenation of analytical processes with bioassays
    Olivier Potterat
    Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
    Nat Prod Rep 30:546-64. 2013
    ..In addition, compatibility issues of natural product extracts and HTS are addressed, and selected protocols for the generation of high quality libraries are presented...
  57. doi request reprint Case study of the Swiss flora for prior phytochemical and biological investigations
    Michael Adams
    Department of Pharmaceutical Sciences, Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, Basel, Switzerland
    J Nat Prod 76:209-15. 2013
    ..The predictive value of random sampling of subsets of plants is compared to the study of the entire Swiss flora, to show that a credible estimate of the extent of prior studies can be achieved with just 5% of these species...
  58. doi request reprint Library-based discovery and characterization of daphnane diterpenes as potent and selective HIV inhibitors in Daphne gnidium
    Vincent Vidal
    InPheno AG, Basel, Switzerland
    J Nat Prod 75:414-9. 2012
    ..Mode of action studies that narrowed the site of activity to viral entry events suggested a direct interference with the expression of the two main HIV co-receptors, CCR5 and CXCR4, at the cell surface by daphnetoxin (1)...
  59. pmc Screening and HPLC-Based Activity Profiling for New Antiprotozoal Leads from European Plants
    Stefanie Zimmermann
    Departement of Pharmaceutical Sciences, Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, 4056, Basel, Switzerland
    Sci Pharm 80:205-13. 2012
    ..With an IC(50) of 0.37 μM, onopordopicrin was one of the most potent natural products reported so far. Cytotoxicity was determined against rat myoblast L6 cells (IC(50): 3.06)...
  60. doi request reprint Glucosinolate pattern in Isatis tinctoria and I. indigotica seeds
    Tobias Mohn
    Institute of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
    Planta Med 74:885-8. 2008
    ..Qualitative and quantitative differences in glucosinolate patterns between both ISATIS species were found for seed samples, enabling a differentiation of the two medicinal plants at the level of seed material...
  61. ncbi request reprint Quantification of active principles and pigments in leaf extracts of Isatis tinctoria by HPLC/UV/MS
    Tobias Mohn
    Institute of Pharmaceutical Biology, University of Basel, Basel, Switzerland
    Planta Med 73:151-6. 2007
    ..30, 0.035, 2.48 and 0.84%, respectively). Compound 3 was not detected in the methanolic extract and only traces of compounds 1, 4 and 5 and low amount of alpha-linolenic acid (0.39%) were present in this extract...
  62. doi request reprint Separation and detection of all phosphoinositide isomers by ESI-MS
    Sabine Kiefer
    Institute of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland
    J Pharm Biomed Anal 53:552-8. 2010
    ..We applied the method to various cell types to study the PI levels upon specific stimulation...
  63. doi request reprint HERG channel inhibitors in extracts of Coptidis rhizoma
    Anja Schramm
    Division of Pharmaceutical Biology, University of Basel, Basel, Switzerland
    Planta Med 77:692-7. 2011
    ..Among other structurally related protoberberines tested, dihydroberberine (30.1 ± 10.1% at 100 µM) was the most potent hERG inhibitor...
  64. doi request reprint Mechanism of chemical degradation and determination of solubility by kinetic modeling of the highly unstable sesquiterpene lactone nobilin in different media
    Ursula Thormann
    Institute of Pharma Technology, School of Life Sciences, University of Applied Sciences Northwestern Switzerland, Muttenz, Switzerland Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
    J Pharm Sci 103:3139-52. 2014
    ..The developed kinetic model is proposed to be a useful tool for deducing solubility under dynamic conditions...
  65. doi request reprint Development and validation of a LC-MS/MS method for assessment of an anti-inflammatory indolinone derivative by in vitro blood-brain barrier models
    Evelyn A Jähne
    Institute of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    J Pharm Biomed Anal 98:235-46. 2014
    ..In porcine brain capillary endothelial cells (PBCECs), the calcein-AM uptake assay demonstrated that indolinone is neither a P-gp substrate nor a P-gp inhibitor and is accumulated into cells at high extent. ..
  66. doi request reprint Quantification of the antiplasmodial alkaloid carpaine in papaya (Carica papaya) leaves
    Tasqiah Julianti
    Division of Pharmaceutical Biology, University of Basel, Basel, Switzerland
    Planta Med 80:1138-42. 2014
    ..9908). A total of 29 papaya leaf samples were analyzed, and carpaine concentration in dry leaves was found to range from 0.02 to 0.31%. No obvious dependence on geographic origin and leaf maturity was observed...
  67. doi request reprint Ethnobotanical survey on wild alpine food plants in Lower and Central Valais (Switzerland)
    Christian Abbet
    Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    J Ethnopharmacol 151:624-34. 2014
    ..Aim of the study was to identify wild edible plants used today and during the last two centuries by the alpine population of Valais (Switzerland)...
  68. doi request reprint Two new flavonol glycosides and a metabolite profile of Bryophyllum pinnatum, a phytotherapeutic used in obstetrics and gynaecology
    Karin Fürer
    Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
    Planta Med 79:1565-71. 2013
    ..daigremontianum, the presence of four bufadienolides, bersaldegenin-1-acetate (12), bryophyllin A (13), bersaldegenin-3-acetate (14), and bersaldegenin-1,3,5-orthoacetate (15) was detected in B. pinnatum. ..
  69. doi request reprint Development and full validation of an UPLC-MS/MS method for the determination of an anti-allergic indolinone derivative in rat plasma, and application to a preliminary pharmacokinetic study
    Mouhssin Oufir
    Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
    J Chromatogr B Analyt Technol Biomed Life Sci 902:27-34. 2012
    ..v.). Blood samples taken from 0 to 12 h after injection were collected, and data analyzed with WinNonlin. A short half-life (4.30±0.14 min) and a relatively high clearance (3.83±1.46 L/h/kg) were found...
  70. pmc Ginkgo biloba extract ameliorates oxidative phosphorylation performance and rescues abeta-induced failure
    Virginie Rhein
    Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics, University of Basel, Basel, Switzerland
    PLoS ONE 5:e12359. 2010
    ..Therefore, the aim of the present study was to investigate whether standardized Ginkgo biloba extract LI 1370 (GBE) is able to rescue Abeta-induced defects in energy metabolism...
  71. doi request reprint Flash chromatography on cartridges for the separation of plant extracts: rules for the selection of chromatographic conditions and comparison with medium pressure liquid chromatography
    Petra Weber
    Division of Pharmaceutical Biology, University of Basel, Switzerland
    Fitoterapia 82:155-61. 2011
    ..The chromatographic resolution remained, however, lower than that achieved on classical columns packed with material of smaller particle size. For poorly soluble extracts, solid introduction gave better results than liquid injection...
  72. doi request reprint Hydrangenone, a new isoprenoid with an unprecedented skeleton from Salvia hydrangea
    M Moridi Farimani
    Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G C, Evin, Tehran, Iran
    Org Lett 14:166-9. 2012
    ..Compound 1 showed in vitro antiplasmodial activity, with an IC(50) value of 1.4 μM against P. falciparum. A plausible biosynthetic pathway of 1 was also proposed...
  73. doi request reprint Phyteumosides A and B: new saponins with unique triterpenoid aglycons from Phyteuma orbiculare L
    Christian Abbet
    Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Org Lett 13:1354-7. 2011
    ..The aglycon of 1 can be considered as an incompletely cyclized onoceroid or gammaceroid triterpene with two additional tetrahydropyran rings arising from oxygen bridges. Compound 2 possesses a new 17-polypodene aglycon...
  74. pmc HPLC-based activity profiling approach for the discovery of GABAA receptor ligands using an automated two microelectrode voltage clamp assay on Xenopus oocytes
    Hyun Jung Kim
    Institute of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, Basel, Switzerland
    Planta Med 74:521-6. 2008
    ..This dereplication protocol was validated with plant and fungal extracts which had been previously tested active or inactive in the oocyte assay and with spiking experiments...
  75. doi request reprint Gram-scale purification of dehydroevodiamine from Evodia rutaecarpa fruits, and a procedure for selective removal of quaternary indoloquinazoline alkaloids from Evodia extracts
    Anja Schramm
    Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland
    Fitoterapia 94:127-33. 2014
    ..A daily intake of up to mg amounts of DHE was calculated from recommended doses of these products. A method for the selective removal of quaternary indoloquinazoline alkaloids from Evodia extracts was developed. ..
  76. ncbi request reprint Noniosides E - H, new trisaccharide fatty acid esters from the fruit of Morinda citrifolia (Noni)
    Petur W Dalsgaard
    Institute of Pharmaceutical Biology, University of Basel, Basel, Switzerland
    Planta Med 72:1322-7. 2006
    ..In addition, an HPLC-MS analysis of a methanolic extract of the fruit powder revealed the presence of further derivatives including new disaccharide and trisaccharide esters with fatty acid residues of various lengths...
  77. doi request reprint Traditional use of herbal remedies in livestock by farmers in 3 Swiss cantons (Aargau, Zurich, Schaffhausen)
    Kathrin Schmid
    Institute of Pharmacentical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
    Forsch Komplementmed 19:125-36. 2012
    ..This study investigated the extent of traditional knowledge and use of homemade herbal remedies for livestock by farmers in 3 Swiss cantons (Aargau, Zurich, Schaffhausen). The study focused on organic farms...
  78. doi request reprint Regulation of secretases by all-trans-retinoic acid
    Anna Koryakina
    Institute of Pharmaceutical Biology, University of Basel, Switzerland
    FEBS J 276:2645-55. 2009
    ..Additionally, we report enhanced secretion of soluble amyloid precursor protein alpha after ATRA exposure, possibly due to PKC activation, as pretreatment with the PKC inhibitor Gö6976 abolished all these events...
  79. ncbi request reprint Plants traditionally used in age related brain disorders--a survey of ethnobotanical literature
    Michael Adams
    Institute of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    J Ethnopharmacol 113:363-81. 2007
    ....
  80. ncbi request reprint Are extraction methods in quantitative assays of pharmacopoeia monographs exhaustive? A comparison with pressurized liquid extraction
    Carlos Basalo
    Institute of Pharmaceutical Biology, University of Basel, Basel, Switzerland
    Planta Med 72:1157-62. 2006
    ..PLE was in all cases superior to the extraction protocol of the pharmacopoeia monographs (taken as 100 %), with differences ranging from 108 % in case of parthenolide in Tanaceti herba to 343 % in case of alkaloids in Boldo folium...
  81. ncbi request reprint Quantitative analysis of anti-inflammatory and radical scavenging triterpenoid esters in evening primrose seeds
    Janine Zaugg
    Institute of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    J Agric Food Chem 54:6623-8. 2006
    ..Three types of qualitative patterns were observed for the triterpenoidal esters. The influence of different harvest times and plant treatments was studied with the cultivar Anothera. Variations between 1.5 and 2.3 mg/g were found...
  82. ncbi request reprint Tryptanthrin content in Isatis tinctoria leaves--a comparative study of selected strains and post-harvest treatments
    Christine Oberthür
    Institute of Pharmacy, University of Jena, Germany
    Planta Med 70:642-5. 2004
    ..Tryptanthrin content in fermented woad leaves was below the limit of quantification. Tryptanthrin appears thus to be a product of post-harvest processes, but details of its formation remain to be elucidated...
  83. ncbi request reprint Constituents in evening primrose oil with radical scavenging, cyclooxygenase, and neutrophil elastase inhibitory activities
    Matthias Hamburger
    Institute of Pharmacy, Friedrich Schiller University Jena, Semmelweisstrasse 10, Germany
    J Agric Food Chem 50:5533-8. 2002
    ..Commercial samples of evening primrose oils contained only traces of these lipophilic antioxidants...
  84. ncbi request reprint Quantitative analysis of anti-inflammatory and radical scavenging triterpenoid esters in evening primrose oil
    Roland Knorr
    Institute of Pharmacy, Friedrich Schiller University Jena, Semmelweisstrasse 10, D 07743 Jena, Germany
    J Agric Food Chem 52:3319-24. 2004
    ..There was a difference between O. biennis and O. lamarckiana oils with respect to the relative amounts of the three esters. The temperature of the extraction process had no effect on the ratio of the compounds...
  85. ncbi request reprint Prevention of experimentally induced irritant contact dermatitis by extracts of Isatis tinctoria compared to pure tryptanthrin and its impact on UVB-induced erythema
    Christian Heinemann
    Department of Dermatology and Dermatological Allergology, University of Jena, Germany
    Planta Med 70:385-90. 2004
    ..When treatment was performed after completing the eliciting phase, accelerated resolution of the irritant reaction could not be observed. In the UVB erythema model anti-inflammatory effects of the test substances were not observed...
  86. ncbi request reprint Analysis of aspartyl peptide degradation products by high-performance liquid chromatography and high-performance liquid chromatography-mass spectrometry
    Silvia De Boni
    Department of Pharmaceutical Chemistry, School of Pharmacy, University of Jena, Philosophenweg 14, D 07743 Jena, Germany
    J Chromatogr A 1022:95-102. 2004
    ....
  87. ncbi request reprint A comparative study on the skin penetration of pure tryptanthrin and tryptanthrin in Isatis tinctoria extract by dermal microdialysis coupled with isotope dilution ESI-LC-MS
    Christine Oberthür
    Institute of Pharmacy, University of Jena, Germany
    Planta Med 69:385-9. 2003
    ..Microscopic analysis showed that the pure compound crystallized from the solution but remained in an amorphous state in the extracts...
  88. ncbi request reprint Inhibitory activity of tryptanthrin on prostaglandin and leukotriene synthesis
    Henning Danz
    Institute of Pharmacy, University of Jena, Jena, Germany
    Planta Med 68:875-80. 2002
    ..Tryptanthrin and the extract ZE550 inhibited LTB(4) release in a dose dependent manner and with a potency comparable to that of the clinically used 5-LOX inhibitor zileuton...
  89. ncbi request reprint Supercritical carbon dioxide extraction of marigold at high pressures: comparison of analytical and pilot-scale extraction
    Dietmar Baumann
    Institute of Pharmacy, University of Jena, Scmmelweisstrasse 10, D 07743 Jena, Germany
    Phytochem Anal 15:226-30. 2004
    ..The HPLC fingerprints of the extracts, the yields of total extract and the concentration of faradiol esters obtained with analytical and pilot scale extractors under the same conditions were comparable...
  90. ncbi request reprint The elusive indigo precursors in woad (Isatis tinctoria L.)--identification of the major indigo precursor, isatan A, and a structure revision of isatan B
    Christine Oberthür
    Institute of Pharmacy, University of Jena, Semmelweisstrasse 10, D 07743 Jena
    Chem Biodivers 1:174-82. 2004
    ..Isatan A (4) was identified as 1H-indol-3-yl 6'-O-(carboxyacetyl)-beta-D-ribohex-3'-ulopyranoside. In aqueous solution, glycosides 3 and 4 occur as hydrates and undergo rapid hydrolysis under very mild acidic or basic conditions...
  91. ncbi request reprint Anti-inflammatory and antiallergic activity in vivo of lipophilic Isatis tinctoria extracts and tryptanthrin
    María Carmen Recio
    Department of Pharmacology, Faculty of Pharmacy, University of Valencia, Valencia, Spain
    Planta Med 72:539-46. 2006
    ..The extract had no effect in this model when administered orally. The DCM extract (200 mg/kg P. O.) inhibited the acetic acid-induced writhing by 49%...
  92. ncbi request reprint Anti-arthritic activity of a lipophilic woad (Isatis tinctoria) extract
    María Carmen Recio
    Department of Pharmacology, Faculty of Pharmacy, University of Valencia, Spain
    Planta Med 72:715-20. 2006
    ..High dose treatment with Isatis extract for two weeks did not result in macroscopic lesions of the gastric mucosa...
  93. ncbi request reprint Method development spurs scientific progress
    Matthias Hamburger
    Planta Med 71:689-90. 2005
  94. ncbi request reprint HPLC-based bioactivity profiling of plant extracts: a kinetic assay for the identification of monoamine oxidase-A inhibitors using human recombinant monoamine oxidase-A
    Kathrin Dittmann
    Institute of Pharmacy, Friedrich Schiller University Jena, Semmelweisstrasse 10, D 07743 Jena, Germany
    Phytochemistry 65:2885-91. 2004
    ..The applicability of the assay to HPLC-based activity profiling was tested with plant extracts spiked with small amounts of known MAO inhibitors...
  95. ncbi request reprint HPLC-based activity profiling of Salvia miltiorrhiza for MAO A and iNOS inhibitory activities
    Kathrin Dittmann
    Institute of Pharmacy, University of Jena, Germany
    Planta Med 70:909-13. 2004
    ..The IC50 of the most active compound, 15,16-dihydrotanshinone I, on human recombinant MAO A was at 23 microM, and 2.4 microM on lipopolysaccharide-mediated iNOS induction in Raw 267.4 cells...
  96. ncbi request reprint Quantitative determination of the dual COX-2/5-LOX inhibitor tryptanthrin in Isatis tinctoria by ESI-LC-MS
    Henning Danz
    Institute of Pharmacy, Friedrich Schiller University, Jena, Germany
    Planta Med 68:152-7. 2002
    ..More than 70 Isatis samples of different origin were analyzed. The tryptanthrin content in leaf samples varied from 0.56 to 16.74 x 10(-3) %...
  97. ncbi request reprint The content of indigo precursors in Isatis tinctoria leaves--a comparative study of selected accessions and post-harvest treatments
    Christine Oberthür
    Institute of Pharmacy, Friedrich Schiller University Jena, Germany
    Phytochemistry 65:3261-8. 2004
    ..The concentration of indican, in contrast, was 3- to 5-fold higher in leaf samples submitted to drying at ambient and 40 degrees C, respectively...
  98. ncbi request reprint Rapid analysis of nucleotide-activated sugars by high-performance liquid chromatography coupled with diode-array detection, electrospray ionization mass spectrometry and nuclear magnetic resonance
    Michael Ramm
    Institute of Pharmacy, Friedrich Schiller University Jena, Semmelweisstrasse 10, D 07743 Jena, Germany
    J Chromatogr A 1034:139-48. 2004
    ..Nucleotide co-factors of enzymatic reactions such as ATP and NADH did not interfere with the analysis of nucleotide-activated sugars...