H Friess

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi request reprint Differential expression of metastasis-associated genes in papilla of vater and pancreatic cancer correlates with disease stage
    H Friess
    Department of Visceral and Transplantation Surgery and Institute of Pathology, University of Bern, Inselspital, Bern, Switzerland
    J Clin Oncol 19:2422-32. 2001
  2. ncbi request reprint Doc-2/hDab2 expression is up-regulated in primary pancreatic cancer but reduced in metastasis
    Y Huang
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Bern, Switzerland
    Lab Invest 81:863-73. 2001
  3. ncbi request reprint Molecular versus conventional markers in pancreatic cancer
    H Friess
    Department of Visceral and Transplantation Surgery, University of Bern, Switzerland
    Digestion 58:557-63. 1997
  4. ncbi request reprint Growth factors and cytokines in pancreatic carcinogenesis
    H Friess
    Department of Visceral and Transplantation Surgery, University of Bern, Switzerland
    Ann N Y Acad Sci 880:110-21. 1999
  5. ncbi request reprint Comparative analysis of galectins in primary tumors and tumor metastasis in human pancreatic cancer
    P O Berberat
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Bern, Switzerland
    J Histochem Cytochem 49:539-49. 2001
  6. ncbi request reprint Altered expression and localization of the tight junction protein ZO-1 in primary and metastatic pancreatic cancer
    J Kleeff
    Department of Visceral and Transplantation Surgery, University of Bern, Switzerland
    Pancreas 23:259-65. 2001
  7. pmc Nerve growth factor and its high-affinity receptor in chronic pancreatitis
    H Friess
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland
    Ann Surg 230:615-24. 1999
  8. ncbi request reprint Activity of gemcitabine and continuous infusion fluorouracil in advanced pancreatic cancer
    D P Rauch
    Institute of Medical Oncology, University of Bern, Inselspital, Bern, Switzerland
    Oncology 60:43-8. 2001
  9. pmc Enhanced expression of urokinase plasminogen activator and its receptor in pancreatic carcinoma
    D Cantero
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland
    Br J Cancer 75:388-95. 1997
  10. ncbi request reprint Neurotensin receptor-1 mRNA analysis in normal pancreas and pancreatic disease
    L Wang
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland
    Clin Cancer Res 6:566-71. 2000

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Differential expression of metastasis-associated genes in papilla of vater and pancreatic cancer correlates with disease stage
    H Friess
    Department of Visceral and Transplantation Surgery and Institute of Pathology, University of Bern, Inselspital, Bern, Switzerland
    J Clin Oncol 19:2422-32. 2001
    ..Because metastasis formation is a critical step in tumor progression and a negative prognostic factor, we compared the expression of nm23-H1 and KAI1, two metastasis-suppressing genes, in papilla of Vater cancer and pancreatic cancer...
  2. ncbi request reprint Doc-2/hDab2 expression is up-regulated in primary pancreatic cancer but reduced in metastasis
    Y Huang
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Bern, Switzerland
    Lab Invest 81:863-73. 2001
    ..In conclusion, DOC-2 is overexpressed in primary pancreatic adenocarcinoma but down-regulated in metastatic disease, suggesting a tumor suppressor function of DOC-2 in the late steps of pancreatic carcinogenesis...
  3. ncbi request reprint Molecular versus conventional markers in pancreatic cancer
    H Friess
    Department of Visceral and Transplantation Surgery, University of Bern, Switzerland
    Digestion 58:557-63. 1997
    ....
  4. ncbi request reprint Growth factors and cytokines in pancreatic carcinogenesis
    H Friess
    Department of Visceral and Transplantation Surgery, University of Bern, Switzerland
    Ann N Y Acad Sci 880:110-21. 1999
    ..Pancreatic cancer cell biology consists of complex interactions of various factors, and a better understanding of the molecular pathogenesis of this disorder might lead to better treatment strategies in the near future...
  5. ncbi request reprint Comparative analysis of galectins in primary tumors and tumor metastasis in human pancreatic cancer
    P O Berberat
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Bern, Switzerland
    J Histochem Cytochem 49:539-49. 2001
    ..High levels of galectin-3 in metastatic cancer cells suggest an impact on metastasis formation...
  6. ncbi request reprint Altered expression and localization of the tight junction protein ZO-1 in primary and metastatic pancreatic cancer
    J Kleeff
    Department of Visceral and Transplantation Surgery, University of Bern, Switzerland
    Pancreas 23:259-65. 2001
    ..ZO-1 is a tight junction membrane protein that plays a critical role in cell-cell interaction, proliferation, and differ entiation...
  7. pmc Nerve growth factor and its high-affinity receptor in chronic pancreatitis
    H Friess
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland
    Ann Surg 230:615-24. 1999
    ..To study the mechanisms that are involved in nerve growth and contribute to pain generation in chronic pancreatitis (CP)...
  8. ncbi request reprint Activity of gemcitabine and continuous infusion fluorouracil in advanced pancreatic cancer
    D P Rauch
    Institute of Medical Oncology, University of Bern, Inselspital, Bern, Switzerland
    Oncology 60:43-8. 2001
    ..The combination is well tolerated and it will have to be shown whether oral fluoropyrimidines can increase the practicability of this treatment without impairing efficacy...
  9. pmc Enhanced expression of urokinase plasminogen activator and its receptor in pancreatic carcinoma
    D Cantero
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland
    Br J Cancer 75:388-95. 1997
    ....
  10. ncbi request reprint Neurotensin receptor-1 mRNA analysis in normal pancreas and pancreatic disease
    L Wang
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland
    Clin Cancer Res 6:566-71. 2000
    ..However, its relatively high levels in CP excludes NTR-1 mRNA as a specific parameter for pancreatic cancer and for the differentiation of pancreatic cancer from CP...
  11. ncbi request reprint Nerve growth factor exerts differential effects on the growth of human pancreatic cancer cells
    Z W Zhu
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland
    Clin Cancer Res 7:105-12. 2001
    ..These results point to a previously unknown autocrine/paracrine pathway in pancreatic cancer, suggesting that NGF-TrkA interactions are important factors influencing cell growth and spread in this malignancy...
  12. pmc Enhanced glypican-3 expression differentiates the majority of hepatocellular carcinomas from benign hepatic disorders
    Z W Zhu
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Bern, Switzerland
    Gut 48:558-64. 2001
    ..CONCLUSIONS: These findings suggest that glypican-3, in many cases, has the potential to differentiate between benign and malignant liver diseases...
  13. ncbi request reprint Mast cell distribution and activation in chronic pancreatitis
    I Esposito
    Department of Visceral and Transplantation Surgery, Institute of Pathology, University of Bern, Inselspital, Bern, Switzerland
    Hum Pathol 32:1174-83. 2001
    ..Their localization near degenerating acini and regenerating ducts might indicate that they play a crucial role in tissue destruction and remodeling in CP...
  14. ncbi request reprint NK-1 receptor gene expression is related to pain in chronic pancreatitis
    S V Shrikhande
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, CH-3010 Bern, Switzerland
    Pain 91:209-17. 2001
    ....
  15. ncbi request reprint Galectin-1 and galectin-3 in chronic pancreatitis
    L Wang
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland
    Lab Invest 80:1233-41. 2000
    ..Galectin-1 might participate in ECM changes, whereas galectin-3 seems to be involved in both ECM changes and ductular complex formation...
  16. ncbi request reprint Presence of two signaling TGF-beta receptors in human pancreatic cancer correlates with advanced tumor stage
    Z Lu
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland
    Dig Dis Sci 42:2054-63. 1997
    ..01). These findings show that in many human pancreatic cancers, increased levels of the two signaling TbetaRs are present. The presence of the signaling TbetaRs in advanced tumor stages indicates a role in disease progression...
  17. ncbi request reprint Bcl-x(L) antisense oligonucleotides induce apoptosis and increase sensitivity of pancreatic cancer cells to gemcitabine
    Z Xu
    Department of Visceral and Transplantation Surgery, University of Berne, Inselspital, Berne, Switzerland
    Int J Cancer 94:268-74. 2001
    ..Bcl-x(L) antisense oligonucleotides also increased the chemosensitivity of pancreatic cancer cells, suggesting that Bcl-x(L) antisense therapy might be a potential future approach in this disease...
  18. ncbi request reprint Serine proteinase activation in esophageal cancer
    W H Tang
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland
    Anticancer Res 21:2249-58. 2001
    ..However, up-regulation of these factors is not correlated with tumor differentiation or survival. These findings indicate that, unlike other tumors, uPA, uPAR and PAI-1 seem not to be prognostic markers for esophageal carcinomas...
  19. ncbi request reprint The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines
    Q Liao
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland
    FEBS Lett 503:151-7. 2001
    ..This characteristic of pancreatic cancer might contribute to its more aggressive growth behavior and poor responsiveness to treatment in vivo...
  20. pmc Identification of disease-specific genes in chronic pancreatitis using DNA array technology
    H Friess
    Department of Visceral and Transplantation Surgery, Inselspital, University of Bern, Bern, Switzerland
    Ann Surg 234:769-78; discussion 778-9. 2001
    ..To use DNA arrays to analyze the differential gene expression patterns in the normal pancreas and in pancreatic diseases...
  21. ncbi request reprint Brain-derived neurotrophic factor (BDNF) is upregulated and associated with pain in chronic pancreatitis
    Z W Zhu
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland
    Dig Dis Sci 46:1633-9. 2001
    ..BDNF is increased in CP. Its association with pain suggests that it functions as a peripheral and central pain modulator, as reported previously in other inflammatory disorders...
  22. ncbi request reprint Randomized clinical trial of pylorus-preserving duodenopancreatectomy versus classical Whipple resection-long term results
    C A Seiler
    Department of Visceral and Transplantation Surgery, University of Berne, Inselspital, Berne, Switzerland
    Br J Surg 92:547-56. 2005
    ..A prospective randomized trial was undertaken to compare the results of the two procedures...
  23. ncbi request reprint Pancreatic cancer: factors regulating tumor development, maintenance and metastasis
    X Shi
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, CH-3010 Bern, Switzerland
    Pancreatology 1:517-24. 2001
    ..A complex disturbance of factors is present in pancreatic cancer, resulting in a distinct growth advantage which clinically results in rapid tumor progression and poor patient survival...
  24. ncbi request reprint Real-time quantitative PCR of telomerase mRNA is useful for the differentiation of benign and malignant pancreatic disorders
    P Buchler
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland
    Pancreas 22:331-40. 2001
    ....
  25. ncbi request reprint Effect of preoperative biliary drainage on surgical outcome after pancreatoduodenectomy
    M E Martignoni
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, CH 3010, Bern, Switzerland
    Am J Surg 181:52-9; discussion 87. 2001
    ..Several authors failed to show any effect of preoperative biliary drainage, whereas others even reported an increased morbidity following pancreatoduodenectomy...
  26. ncbi request reprint Growth factors and their receptors in pancreatic cancer
    F Ozawa
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Bern, Switzerland
    Teratog Carcinog Mutagen 21:27-44. 2001
    ....
  27. ncbi request reprint Differential expression of TRAIL-R3 and TRAIL-R4 in human pancreatic cancer
    Q Liao
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland
    Anticancer Res 21:3153-9. 2001
    ..TRAIL-R3 and TRAIL-R4, which belong to the TRAIL receptor family, can inhibit TRAIL-induced apoptosis...
  28. ncbi request reprint Cyclooxygenase 2 expression in chronic pancreatitis: correlation with stage of the disease and diabetes mellitus
    A Koliopanos
    Department of Visceral and Transplantation Surgery, University of Bern, Switzerland
    Digestion 64:240-7. 2001
    ....
  29. ncbi request reprint Enhanced expression of Silencer of death domains (SODD/BAG-4) in pancreatic cancer
    F Ozawa
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Bern, CH 3010, Switzerland
    Biochem Biophys Res Commun 271:409-13. 2000
    ..These findings indicate that in contrast to other gastrointestinal malignancies, in pancreatic cancer SODD might block TNF-alpha-mediated apoptosis which may influence the growth of pancreatic cancer cells...
  30. ncbi request reprint Heparanase expression in primary and metastatic pancreatic cancer
    A Koliopanos
    Department of Visceral and Transplantation Surgery, Institute of Pathology, University of Bern, Inselspital, CH 3010 Bern, Switzerland
    Cancer Res 61:4655-9. 2001
    ..These results suggest that hpa overexpression in human pancreatic cancers facilitates cancer cell invasion, thereby enhancing the metastatic potential of the tumors...
  31. ncbi request reprint A modified technique of the Beger and Frey procedure in patients with chronic pancreatitis
    B Gloor
    Department of Visceral and Transplant Surgery, University of Bern, Inselspital, Bern, Switzerland
    Dig Surg 18:21-5. 2001
    ..Also, it represents the most minimal surgical trauma for resecting the head of the pancreas as compared to other commonly used techniques...
  32. pmc Acute necrotizing pancreatitis: treatment strategy according to the status of infection
    M W Buchler
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland
    Ann Surg 232:619-26. 2000
    ..To determine benefits of conservative versus surgical treatment in patients with necrotizing pancreatitis...
  33. ncbi request reprint Molecular aspects of pancreatic cancer and future perspectives
    H Friess
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Bern, Switzerland
    Dig Surg 16:281-90. 1999
    ....
  34. pmc Neural alterations in surgical stage chronic pancreatitis are independent of the underlying aetiology
    H Friess
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Bern, Switzerland
    Gut 50:682-6. 2002
    ....
  35. ncbi request reprint Carcinogenesis of cancer of the papilla and ampulla: pathophysiological facts and molecular biological mechanisms
    I Esposito
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland
    Langenbecks Arch Surg 386:163-71. 2001
    ....
  36. ncbi request reprint Treatment of pancreatic cancer: the role of surgery
    F Ozawa
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Bern, Switzerland
    Dig Dis 19:47-56. 2001
    ..It is hoped that progress in multimodality treatment and modern therapies, resulting from both clinical and advanced basic research, can improve the prognosis of this malignancy in the near future...
  37. ncbi request reprint Growth factors in pancreatic health and disease
    P Balaz
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Bern, Switzerland
    Pancreatology 1:343-55. 2001
    ..In summary, growth factors and their receptors are often altered in chronic pancreatitis and pancreatic cancer and contribute to various pathogenetic aspects in these disorders...
  38. ncbi request reprint Chronic pancreatitis--new pathophysiological concepts
    P O Berberat
    Department of Visceral and Transplantation Surgery, University of Berne, Inselspital
    Swiss Surg 6:227-30. 2000
    ....
  39. ncbi request reprint Immunohistochemical presentation in non-malignant and malignant Barrett's epithelium
    J Kleeff
    Department of Visceral and Transplantation Surgery, University of Bern, Switzerland
    Dis Esophagus 15:10-5. 2002
    ....
  40. ncbi request reprint Co-existent chronic pancreatitis and pancreatic neuroendocrine tumor. Case report and review of the literature
    S Shrikhande
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, CH-3010 Bern, Switzerland
    Pancreatology 1:117-22. 2001
    ..Questions remain with regard to the potential role of chronic pancreatitis in the pathogenesis of pancreatic neuroendocrine tumors...
  41. ncbi request reprint Surveillance of pre-malignant disease of the pancreatico-biliary system
    H Friess
    Department of Visceral and Transplantation Surgery, University of Bern, Bern, Inselspital, Switzerland
    Best Pract Res Clin Gastroenterol 15:285-300. 2001
    ....
  42. ncbi request reprint Carcinoid of the ampulla of Vater. Clinical characteristics and morphologic features
    E Hatzitheoklitos
    Department of Visceral and Transplantation Surgery, University of Berne, Switzerland
    Cancer 73:1580-8. 1994
    ..Carcinoid tumors of the gastrointestinal tract are most common localized in the appendix, followed by the small intestine, the rectum, and the stomach. The localization of these tumors at the ampulla of Vater is extremely seldom...
  43. ncbi request reprint Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptors
    H Friess
    Department of Visceral and Transplantation Surgery, University of Berne, Inselspital, Switzerland
    J Mol Med (Berl) 74:35-42. 1996
    ..These changes stimulate tumor growth and enhance the metastatic behavior of pancreatic cancer cells and thereby may contribute to shorter postoperative survival following tumor resection...
  44. ncbi request reprint Fundus rotation gastroplasty: rationale, technique and results
    W Uhl
    Department of Visceral and Transplantation Surgery, Inselspital, University of Bern, Switzerland
    Dis Esophagus 15:101-5. 2002
    ..the increase of remaining gastric reservoir supporting physiologic stomach and gut function. Therefore, the FRG seems to be an alternative and safe method for esophageal reconstruction, especially for high anastomotic locations...
  45. ncbi request reprint Timing and extent of surgical intervention in patients from hereditary pancreatic cancer kindreds
    P B Kekis
    Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, CH-3010 Bern, Switzerland
    Pancreatology 1:525-30. 2001
    ..Currently, prophylactic whole-organ resection in the absence of premalignant lesions cannot be recommended since we do not know the exact risk for the development of cancer...
  46. ncbi request reprint Activity of raltitrexed and gemcitabine in advanced pancreatic cancer
    E Kralidis
    Institute of Medical Oncology, Department of Visceral and Transplantation Surgery, University of Bern, Switzerland
    Ann Oncol 14:574-9. 2003
    ..The aim of this study was to assess the efficacy and safety of gemcitabine in combination with raltitrexed (Tomudex), a novel and selective TS inhibitor that has the advantage of a 3-weekly treatment interval and manageable toxicity...
  47. ncbi request reprint Curative resection is the single most important factor determining outcome in patients with pancreatic adenocarcinoma
    M Wagner
    Department of Visceral and Transplantation Surgery, University of Berne, Berne, Switzerland
    Br J Surg 91:586-94. 2004
    ..This prospective study evaluated risk factors for survival after resection for pancreatic adenocarcinoma...
  48. ncbi request reprint Differential expression of chemokines in normal pancreas and in chronic pancreatitis
    L Saurer
    Department of Pathology, University of Bern, Bern, Switzerland
    Gastroenterology 118:356-67. 2000
    ..The mechanisms responsible for their recruitment are unknown. Hence, we determined the differential expression of chemokine genes and their cellular sources in normal and affected pancreatic tissues...