R Crameri

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. doi Cross-reactivity among fungal allergens: a clinically relevant phenomenon?
    Reto Crameri
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Mycoses 52:99-106. 2009
  2. ncbi Recombinant Aspergillus fumigatus allergens: from the nucleotide sequences to clinical applications
    R Crameri
    Swiss Institute of Allergy and Asthma Research, Davos
    Int Arch Allergy Immunol 115:99-114. 1998
  3. ncbi Fungal allergies: a yet unsolved problem
    Reto Crameri
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Chem Immunol Allergy 91:121-33. 2006
  4. ncbi The future of post-genomic biology at the proteomic level: an outlook
    Reto Crameri
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Comb Chem High Throughput Screen 8:807-10. 2005
  5. ncbi Allergy diagnosis, allergen repertoires, and their implications for allergen-specific immunotherapy
    Reto Crameri
    Molecular Allergology, Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Immunol Allergy Clin North Am 26:179-89, v. 2006
  6. ncbi Novel vaccines and adjuvants for allergen-specific immunotherapy
    Reto Crameri
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Curr Opin Immunol 18:761-8. 2006
  7. ncbi Impact of native, recombinant, and cross-reactive allergens on humoral and T-cell-mediated immune responses
    Reto Crameri
    Division of Molecular Allergology, Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Immunol Allergy Clin North Am 27:65-78. 2007
  8. pmc Correlating IgE reactivity with three-dimensional structure
    Reto Crameri
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Biochem J 376:e1-2. 2003
  9. ncbi Molecular cloning of Aspergillus fumigatus allergens and their role in allergic bronchopulmonary aspergillosis
    Reto Crameri
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    Chem Immunol 81:73-93. 2002
  10. ncbi Tapping allergen repertoires by advanced cloning technologies
    R Crameri
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Int Arch Allergy Immunol 124:43-7. 2001

Collaborators

Detail Information

Publications83

  1. doi Cross-reactivity among fungal allergens: a clinically relevant phenomenon?
    Reto Crameri
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Mycoses 52:99-106. 2009
    ..These studies indicate that cross-reactivity is an important component of fungal sensitisation...
  2. ncbi Recombinant Aspergillus fumigatus allergens: from the nucleotide sequences to clinical applications
    R Crameri
    Swiss Institute of Allergy and Asthma Research, Davos
    Int Arch Allergy Immunol 115:99-114. 1998
    ..fumigatus sensitization with high specificity and sensitivity demonstrating the power of recombinant allergens for the differential diagnosis of A. fumigatus-related pulmonary complications...
  3. ncbi Fungal allergies: a yet unsolved problem
    Reto Crameri
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Chem Immunol Allergy 91:121-33. 2006
    ..Recombinant fungal allergens might create new perspectives in diagnosis and therapy of fungal allergy...
  4. ncbi The future of post-genomic biology at the proteomic level: an outlook
    Reto Crameri
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Comb Chem High Throughput Screen 8:807-10. 2005
    ....
  5. ncbi Allergy diagnosis, allergen repertoires, and their implications for allergen-specific immunotherapy
    Reto Crameri
    Molecular Allergology, Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Immunol Allergy Clin North Am 26:179-89, v. 2006
    ....
  6. ncbi Novel vaccines and adjuvants for allergen-specific immunotherapy
    Reto Crameri
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Curr Opin Immunol 18:761-8. 2006
    ....
  7. ncbi Impact of native, recombinant, and cross-reactive allergens on humoral and T-cell-mediated immune responses
    Reto Crameri
    Division of Molecular Allergology, Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Immunol Allergy Clin North Am 27:65-78. 2007
    ..A deep understanding of these mechanisms will fundamentally change the current practice of allergy diagnosis, treatment, and prevention...
  8. pmc Correlating IgE reactivity with three-dimensional structure
    Reto Crameri
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Biochem J 376:e1-2. 2003
    ....
  9. ncbi Molecular cloning of Aspergillus fumigatus allergens and their role in allergic bronchopulmonary aspergillosis
    Reto Crameri
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    Chem Immunol 81:73-93. 2002
  10. ncbi Tapping allergen repertoires by advanced cloning technologies
    R Crameri
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Int Arch Allergy Immunol 124:43-7. 2001
    ....
  11. ncbi Selective enrichment and high-throughput screening of phage surface-displayed cDNA libraries from complex allergenic systems
    R Crameri
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Comb Chem High Throughput Screen 2:63-72. 1999
    ..Here we discuss construction of cDNA libraries displayed on the phage surface, selective enrichment of clones and robotics-based high-throughput screening of enriched libraries...
  12. ncbi [Molecular aspects and diagnostic value of fungal allergens]
    R Crameri
    Schweizerisches Institut für Allergie und Asthmaforschung SIAF, Davos, Schweiz
    Mycoses 41:56-60. 1998
    ..These fungal allergens show extended sequence similarity, a high level of IgE cross-reactivity and in some cases also cross-reactivity with homologous human proteins indicating autoimmune reactions involved in fungal allergy...
  13. ncbi The powerful combination of phage surface display of cDNA libraries and high throughput screening
    R Crameri
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, Davos, CH 7270, Switzerland
    Comb Chem High Throughput Screen 4:145-55. 2001
    ..The subsequent application of functional enrichment and robotics-based screening will facilitate the rapid generation of information about the repertoire of protein structures involved in allergic diseases...
  14. doi Cloning, production and characterization of antigen 5 like proteins from Simulium vittatum and Culicoides nubeculosus, the first cross-reactive allergen associated with equine insect bite hypersensitivity
    A Schaffartzik
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Obere Strasse 22, CH 7270 Davos, Switzerland
    Vet Immunol Immunopathol 137:76-83. 2010
    ..coli-expressed recombinant proteins. In conclusion our data demonstrate that IgE-mediated cross-reactivity to homologous allergens, a well-known clinically relevant phenomenon in human allergy, also occurs in veterinary allergy...
  15. doi Molecular and immunological characterization of Asp f 34, a novel major cell wall allergen of Aspergillus fumigatus
    A G Glaser
    Department Molecular Allergology, Swiss Institute of Allergy and Asthma Research, University of Zurich, Zurich, Switzerland
    Allergy 64:1144-51. 2009
    ..Although fungal spores have been recognized as triggers of respiratory allergy and asthma, only two allergenic fungal cell wall components have so far been described...
  16. doi Equine insect bite hypersensitivity: what do we know?
    A Schaffartzik
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Obere Strasse 22, CH 7270 Davos, Switzerland
    Vet Immunol Immunopathol 147:113-26. 2012
    ..Characterization of the main allergens for IBH and understanding what mechanisms induce a healthy or allergic immune response towards these allergens may help to develop new treatment strategies, such as immunotherapy...
  17. ncbi Skin test reactivity to 2 recombinant Aspergillus fumigatus allergens in A fumigatus-sensitized asthmatic subjects allows diagnostic separation of allergic bronchopulmonary aspergillosis from fungal sensitization
    S Hemmann
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    J Allergy Clin Immunol 104:601-7. 1999
    ..A clear distinction between allergic sensitization to A fumigatus and ABPA is essential for therapy to prevent deterioration of pulmonary function in subjects with ABPA...
  18. ncbi Nuclear transport factor 2 represents a novel cross-reactive fungal allergen
    M Weichel
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Allergy 58:198-206. 2003
    ..Limited information is available about the molecular structures involved in cross-reactivity. We aimed to clone and characterize cross-reactive mould allergens...
  19. ncbi Disease-specific recombinant allergens for the diagnosis of allergic bronchopulmonary aspergillosis
    R Crameri
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Int Immunol 10:1211-6. 1998
    ..The dissection of IgE-mediated immune responses to single recombinant A. fumigatus allergens in asthmatic patients allow a discrimination between ABPA and A. fumigatus sensitization with high specificity (100%) and sensitivity (90%)...
  20. doi Auto- and cross-reactivity to thioredoxin allergens in allergic bronchopulmonary aspergillosis
    A G Glaser
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Allergy 63:1617-23. 2008
    ..Thioredoxins are cross-reactive allergens involved in the pathogenesis of atopic eczema and asthma. Cross-reactivity to human thioredoxin can contribute to the exacerbation of severe atopic diseases...
  21. ncbi Immunoglobulin E-binding and skin test reactivity to hydrophobin HCh-1 from Cladosporium herbarum, the first allergenic cell wall component of fungi
    M Weichel
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    Clin Exp Allergy 33:72-7. 2003
    ..All fungal allergens cloned so far represent either secreted or cytoplasmatic proteins, but nothing is known about the involvement of fungal surface proteins in allergic diseases...
  22. ncbi Phage display as a tool for rapid cloning of allergenic proteins
    U Appenzeller
    Swiss Institute of Allergy and Asthma Research, Davos
    Arch Immunol Ther Exp (Warsz) 49:19-25. 2001
    ..The biotechnological production of recombinant allergens derived from these sequences bears a high potential for the improvement of the diagnosis of allergic diseases...
  23. ncbi Recombinant allergens for skin testing
    P Schmid-Grendelmeier
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Int Arch Allergy Immunol 125:96-111. 2001
    ....
  24. doi Cloning of IgE-binding proteins from Simulium vittatum and their potential significance as allergens for equine insect bite hypersensitivity
    A Schaffartzik
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Vet Immunol Immunopathol 132:68-77. 2009
    ..Optimization of the ELISA system will be required to determine reliable cut-off values for the IBH-related allergens. Their in vivo relevance needs to be carefully assessed...
  25. ncbi Targeting the MHC II presentation pathway in allergy vaccine development
    C Rhyner
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Biochem Soc Trans 35:833-4. 2007
    ..The technology is applicable not only for the treatment of allergies, but also for the development of preventive vaccines in general...
  26. ncbi Design, engineering and in vitro evaluation of MHC class-II targeting allergy vaccines
    R Crameri
    Swiss Institute of Allergy and Asthma Research SIAF, Davos Platz, Switzerland
    Allergy 62:197-206. 2007
    ..Current allergen-specific immunotherapy protocols suffer from limited efficacy and a long treatment time...
  27. ncbi Screening the allergenic repertoires of wheat and maize with sera from double-blind, placebo-controlled food challenge positive patients
    M Weichel
    Swiss Institute of Allergy and Asthma Research SIAF, Davos Platz, Switzerland
    Allergy 61:128-35. 2006
    ..Although omega-5 gliadin from wheat and maize lipid transfer protein have been characterized as major cereal allergens on the molecular level, the list of food allergens is far to be complete...
  28. ncbi High throughput screening: a rapid way to recombinant allergens
    R Crameri
    Swiss Institute of Allergy and Asthma Research (SIAF, Davos, Switzerland
    Allergy 56:30-4. 2001
    ..They cover secreted, cytoplasmic and structural proteins with or without enzymatic activity and offer a rational explanation for the IgE-mediated cross-reactivity frequently encountered in clinical practice...
  29. doi T cells and eosinophils in bronchial smooth muscle cell death in asthma
    K Solarewicz-Madejek
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Clin Exp Allergy 39:845-55. 2009
    ..Bronchial smooth muscle cells (SMC) proliferate, express adhesion molecules, secrete cytokines and thus efficiently contribute to the pathogenesis of asthma...
  30. ncbi Determinants and mechanisms of human immune responses to bee venom phospholipase A2
    K Blaser
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Int Arch Allergy Immunol 117:1-10. 1998
    ....
  31. ncbi Allergy and immunity to fungal infections and colonization
    R Crameri
    Swiss Institute of Allergy and Asthma Research, Davos
    Eur Respir J 19:151-7. 2002
    ..Molecular cloning and characterization of fungal antigens reveals the involvement of related cross-reactive molecular structures produced by different fungi as pathological molecules involved in development of allergic reactions...
  32. ncbi Direct selection of cDNAs by phage display
    R Crameri
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    Methods Mol Biol 185:461-9. 2002
  33. ncbi The potential of proteomics and peptidomics for allergy and asthma research
    R Crameri
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Allergy 60:1227-37. 2005
    ..Proteomics and peptidomics have a great potential to speed up allergy and asthma research, where disease- and tissue-specific samples are easy to obtain...
  34. doi Allergen-loaded strontium-doped hydroxyapatite spheres improve allergen-specific immunotherapy in mice
    M Garbani
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos Platz, Switzerland
    Allergy . 2016
    ....
  35. doi Immunoglobulin E-binding autoantigens: biochemical characterization and clinical relevance
    R Crameri
    Department Molecular Allergology, Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos, Switzerland
    Clin Exp Allergy 42:343-51. 2012
    ..However, because most of the described IgE-binding self-antigens are intracellular proteins normally not accessible for antigen-antibody interactions, local release of the antigens is required to explain the induction of symptoms...
  36. doi Fungi: the neglected allergenic sources
    R Crameri
    Swiss Institute of Allergy and Asthma Research SIAF, University of Zurich, Davos, Switzerland
    Allergy 69:176-85. 2014
    ..This review aims to highlight the impact of fungal allergens with focus on asthma and atopic dermatitis. ..
  37. doi Microbiota and dietary interactions: an update to the hygiene hypothesis?
    R Frei
    Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland
    Allergy 67:451-61. 2012
    ....
  38. ncbi The Malassezia sympodialis allergen Mala s 11 induces human dendritic cell maturation, in contrast to its human homologue manganese superoxide dismutase
    Monica Vilhelmsson
    Karolinska Institutet, Department of Medicine, Clinical Allergy Research Unit, Stockholm, Sweden
    Int Arch Allergy Immunol 143:155-62. 2007
    ..The objective of the current study was to compare the influence of Mala s 11 and hMnSOD on human dendritic antigen-presenting cells...
  39. ncbi Immunological and structural analysis of IgE-mediated cross-reactivity between manganese superoxide dismutases
    Sabine Flückiger
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Int Arch Allergy Immunol 128:292-303. 2002
    ..We found that phylogenetically highly conserved proteins, including human manganese superoxide dismutase (MnSOD), are involved in IgE-mediated autoreactivity...
  40. ncbi IL-10 controls Aspergillus fumigatus- and Pseudomonas aeruginosa-specific T-cell response in cystic fibrosis
    Carmen Casaulta
    Department of Pediatrics, University Children s Hospital, Inselspital, Bern, Switzerland
    Pediatr Res 53:313-9. 2003
    ..Together, these data demonstrate an important role of IL-10-mediated peripheral T-cell tolerance to P. aeruginosa and A. fumigatus in the control of the intensity of the inflammatory T-cell response in CF...
  41. pmc Conidial hydrophobins of Aspergillus fumigatus
    Sophie Paris
    Unite des Aspergillus, Département Structure et Dynamique des Génomes, Institut Pasteur, 25 rue du Docteur Roux, F 75724 Paris, France
    Appl Environ Microbiol 69:1581-8. 2003
    ..Moreover, rodletless mutants are more sensitive to killing by alveolar macrophages, suggesting that RodAp or the rodlet structure is involved in the resistance to host cells...
  42. ncbi Cross-reactivity and 1.4-A crystal structure of Malassezia sympodialis thioredoxin (Mala s 13), a member of a new pan-allergen family
    Andreas Limacher
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    J Immunol 178:389-96. 2007
    ....
  43. ncbi Rapid identification of allergen-encoding cDNA clones by phage display and high-density arrays
    Rimantas Kodzius
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Comb Chem High Throughput Screen 6:147-54. 2003
    ..This approach represents a widely applicable method for rapid high-throughput identification of all individual cDNAs present in selectively enriched libraries...
  44. ncbi Effect of allergic bronchopulmonary aspergillosis on lung function in children with cystic fibrosis
    Richard Kraemer
    Division of Human Genetics, Department of Paediatrics, University of Bern, Inselspital, CH 3010 Bern, Switzerland
    Am J Respir Crit Care Med 174:1211-20. 2006
    ..The relationship between sensitization to Aspergillus fumigatus and progression of pulmonary function is not yet established in cystic fibrosis (CF)...
  45. ncbi Sensitization to the yeast Malassezia sympodialis is specific for extrinsic and intrinsic atopic eczema
    Barbra Fischer Casagrande
    Allergy Unit, Department of Dermatology, Zurich, Switzerland
    J Invest Dermatol 126:2414-21. 2006
    ..Recombinant yeast allergens represent a useful tool to study molecular structures and differential sensitization patterns in the pathogenesis of AE...
  46. ncbi Allergen motifs and the prediction of allergenicity
    Pamela Marti
    Institute of Immunology, Inselspital, 3010 Bern, Switzerland
    Immunol Lett 109:47-55. 2007
    ..Our results suggest that the motif-generating algorithm may be used for identifying major IgE binding structures of coiled-coil proteins...
  47. ncbi Crystal structure of the major Malassezia sympodialis allergen Mala s 1 reveals a beta-propeller fold: a novel fold among allergens
    Monica Vilhelmsson
    Department of Medicine, Clinical Allergy Research Unit, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden
    J Mol Biol 369:1079-86. 2007
    ..The crystal structure of Mala s 1 will provide insights into the role of this major allergen in the host-microbe interactions and induction of an allergic response in AE...
  48. ncbi Intracutaneous tests with recombinant allergens in cystic fibrosis patients with allergic bronchopulmonary aspergillosis and Aspergillus allergy
    Wilfried H Nikolaizik
    Department of Paediatrics, University Hospital, Essen, Germany
    Am J Respir Crit Care Med 165:916-21. 2002
    ..Early diagnosis of the disease might help to prevent irreversible lung damage and minimize possible steroid-mediated side effects as a consequence of an optimized control of the disease...
  49. ncbi Immunoglobulin-E-mediated reactivity to self antigens: a controversial issue
    Sabine Zeller
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    Int Arch Allergy Immunol 145:87-93. 2008
    ..However, the only observation supporting a clinical role of IgE-mediated autoreactivity is confined to the fact that IgE levels against self antigens correlate with disease severity...
  50. doi Allergy vaccines: dreams and reality
    Reto Crameri
    Professor, Swiss Institute of Allergy and Asthma Research SIAF, Head Molecular Allergology Department, Obere Strasse 22, CH 7270 Davos, Switzerland
    Expert Rev Vaccines 6:991-9. 2007
    ..The dream would be to develop highly efficient allergy vaccines able to cure the disease with a few injections...
  51. pmc Targeting the extracellular membrane-proximal domain of membrane-bound IgE by passive immunization blocks IgE synthesis in vivo
    Stefan Feichtner
    Department of Molecular Biology, University of Salzburg, Salzburg, Austria
    J Immunol 180:5499-505. 2008
    ..The decrease of allergen-specific serum IgE might be related to tolerance-inducing mechanisms stopping mIgE-displaying B cells in their proliferation and differentiation...
  52. ncbi Unfolding and double-stranded DNA binding of the cold shock protein homologue Cla h 8 from Cladosporium herbarum
    S Fabio Falsone
    Department of Protein Chemistry and Biophysics, Institute of Pharmaceutical Chemistry and Pharmaceutical Technology, University of Graz, A 8010 Graz, Austria
    J Biol Chem 277:16512-6. 2002
    ..The enhanced affinity for DNA at low temperatures together with the low unfolding transition refer to the functional significance of Cla h 8 at reduced temperatures...
  53. ncbi Microarrayed allergen molecules: diagnostic gatekeepers for allergy treatment
    Reinhard Hiller
    VBC GENOMICS, A 1030 Vienna, Austria
    FASEB J 16:414-6. 2002
    ..This method may change established practice in allergy diagnosis, prevention, and therapy. In addition, microarrayed antigens may be applied to the diagnosis of autoimmune and infectious diseases...
  54. ncbi Cyclophilins, a new family of cross-reactive allergens
    Sabine Flückiger
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Eur J Immunol 32:10-7. 2002
    ..The molecular definition of pan-allergen families may substantially contribute to reduce the number of structures needed for diagnosis and therapy of allergic diseases based on highly pure, standardized recombinant allergens...
  55. ncbi Native Art v 1 and recombinant Art v 1 are able to induce humoral and T cell-mediated in vitro and in vivo responses in mugwort allergy
    Peter Schmid-Grendelmeier
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    J Allergy Clin Immunol 111:1328-36. 2003
    ..Mugwort pollen is an important allergen source in hay fever and pollen-related food allergy. Little is known about the clinical relevance of the major mugwort allergen Art v 1 and its importance in allergy...
  56. ncbi NADP-dependent mannitol dehydrogenase, a major allergen of Cladosporium herbarum
    Birgit Simon-Nobbe
    Department of Cell Biology, University of Salzburg, Hellbrunnerstrasse 34, A 5020 Salzburg, Austria
    J Biol Chem 281:16354-60. 2006
    ..This protein therefore is a new major allergen of C. herbarum...
  57. ncbi IgE-mediated and T cell-mediated autoimmunity against manganese superoxide dismutase in atopic dermatitis
    Peter Schmid-Grendelmeier
    Swiss Institute of Allergy and Asthma Research, Davos, Switherland
    J Allergy Clin Immunol 115:1068-75. 2005
    ..Autoreactivity of patients with atopic dermatitis (AD) to human proteins has been postulated as a decisive pathogenetic factor for AD...
  58. ncbi Time course of antibody response to recombinant Aspergillus fumigatus antigens in cystic fibrosis with and without ABPA
    Carmen Casaulta
    Department of Pediatrics, University Childrens Hospital, Inselspital, Berne, Switzerland
    Pediatr Allergy Immunol 16:217-25. 2005
    ..In the follow-up of CF patients with ABPA under therapy the determination of total or specific IgE serum levels were of limited value to guide therapy...
  59. ncbi Comparison of the crystal structures of the human manganese superoxide dismutase and the homologous Aspergillus fumigatus allergen at 2-A resolution
    Sabine Flückiger
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos, Switzerland
    J Immunol 168:1267-72. 2002
    ..We identified conserved amino acids that are solvent exposed in the fungal and the human crystal structure and are therefore potentially involved in IgE-mediated cross-reactivity...
  60. ncbi A major allergen gene-fusion protein for potential usage in allergen-specific immunotherapy
    Fatimah Kussebi
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Allergy Clin Immunol 115:323-9. 2005
    ..Differences between epitopes of IgE that recognize the 3-dimensional structure of allergens and T cells that recognize linear amino acid sequences provide a suitable tool for novel vaccine development for specific immunotherapy...
  61. pmc Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells
    Mubeccel Akdis
    Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH 7270 Davos
    J Exp Med 199:1567-75. 2004
    ..These results indicate that the balance between allergen-specific Tr1 cells and Th2 cells may be decisive in the development of allergy...
  62. ncbi Cloning, expression and characterization of two new IgE-binding proteins from the yeast Malassezia sympodialis with sequence similarities to heat shock proteins and manganese superoxide dismutase
    Anna Andersson
    Department of Medicine, Clinical Allergy Research Unit, Karolinska Institutet and Hospital, Stockholm, Sweden
    Eur J Biochem 271:1885-94. 2004
    ..The high frequency of sera from AEDS patients, showing IgE binding to both HSP and MnSOD, indicates that these allergens, designated Mala s 10 and Mala s 11, could play a role in AEDS...
  63. ncbi Cloning allergens via phage display
    Claudio Rhyner
    Swiss Institute of Allergy and Asthma Research SIAF, Obere Strasse 22, CH 7270 Davos, Switzerland
    Methods 32:212-8. 2004
    ..In spite of some biological limitations imposed by Escherichia coli as expression host, phage surface display technology has strongly contributed to the rapid isolation of a vast variety of IgE-binding structures...
  64. ncbi Serological cloning of cancer/testis antigens expressed in prostate cancer using cDNA phage surface display
    Alexander Fosså
    Department of Immunology, Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Cancer Immunol Immunother 53:431-8. 2004
    ..Furthermore, candidate TAAs for vaccine development of PC were identified...
  65. ncbi The role of sensitization to Malassezia sympodialis in atopic eczema
    Peter Schmid-Grendelmeier
    Allergy Unit, Department of Dermatology, University Hospital, Zurich, Switzerland
    Chem Immunol Allergy 91:98-109. 2006
    ....
  66. pmc Phage display based cloning of proteins interacting with the cytoplasmic tail of membrane immunoglobulins
    Roland Geisberger
    Department of Genetics and General Biology, Hellbrunnerstrasse 34, A 5020 Salzburg, Austria
    Dev Immunol 9:127-34. 2002
    ....
  67. ncbi Wheat and maize thioredoxins: a novel cross-reactive cereal allergen family related to baker's asthma
    Michael Weichel
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Allergy Clin Immunol 117:676-81. 2006
    ..Although several wheat allergens related to baker's asthma have been described, standardized reagents for a reliable diagnosis are not yet available...
  68. pmc Analysis of the cross-reactivity and of the 1.5 A crystal structure of the Malassezia sympodialis Mala s 6 allergen, a member of the cyclophilin pan-allergen family
    Andreas G Glaser
    Swiss Institute of Allergy and Asthma Research SIAF, CH 7270 Davos, Switzerland
    Biochem J 396:41-9. 2006
    ..We identified conserved solvent-exposed residues in the fungal and human structures that are potentially involved in the IgE-mediated cross-reactivity...
  69. ncbi HS1-associated protein X-1 interacts with membrane-bound IgE: impact on receptor-mediated internalization
    Iris Oberndorfer
    Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, A 5020 Salzburg, Austria
    J Immunol 177:1139-45. 2006
    ..In functional assays, we clearly showed that HS1-associated protein X-1 expression levels influence the efficiency of BCR-mediated Ag internalization...
  70. ncbi The crystal structure of Aspergillus fumigatus cyclophilin reveals 3D domain swapping of a central element
    Andreas Limacher
    Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, 8093 Zurich, Switzerland
    Structure 14:185-95. 2006
    ..The two hinge loops leave the protein prone to misfolding. In this context, alternative forms of 3D domain swapping that can lead to N- or C-terminally swapped dimers, oligomers, and aggregates are discussed...
  71. pmc Identification of Borrelia burgdorferi ribosomal protein L25 by the phage surface display method and evaluation of the protein's value for serodiagnosis
    Markus Mueller
    University of Konstanz, Biochemical Pharmacology, 78457 Konstanz, Germany
    J Clin Microbiol 44:3778-80. 2006
    ....
  72. pmc Models of signal transduction through the B-cell antigen receptor
    Roland Geisberger
    Department of Genetics and General Biology, Institute for Genetics, Salzburg, Austria
    Immunology 110:401-10. 2003
  73. ncbi T cells and eosinophils cooperate in the induction of bronchial epithelial cell apoptosis in asthma
    Axel Trautmann
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    J Allergy Clin Immunol 109:329-37. 2002
    ..Asthma is an inflammatory airway disease associated with an infiltration of T cells and eosinophils, increased levels of pro-inflammatory cytokines, and shedding of bronchial epithelial cells (ECs)...
  74. ncbi Regulation of the IgE response at the molecular level: impact on the development of systemic anti IgE therapeutic strategies
    Gernot Achatz
    Department of Molecular Biology, University of Salzburg, Salzburg, Austria
    Chem Immunol Allergy 91:204-17. 2006
    ....
  75. ncbi Direct selection of cDNAs from filamentous phage surface display libraries: potential and limitations
    Claudio Rhyner
    Swiss Institute of Allergy and Asthma Research SIAF, Davos
    Curr Pharm Biotechnol 3:13-21. 2002
    ..Here we discuss recent progress in construction and screening of cDNA libraries displayed on phage surface and emerging concepts allowing fast identification of virtually all different clones present in enriched libraries...
  76. pmc Phage display of human antibodies from a patient suffering from coeliac disease and selection of isotype-specific scFv against gliadin
    Claudio Rhyner
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    Immunology 110:269-74. 2003
    ..The VH and VL chains from samples of these monoclonal isotype-specific phage were sequenced to identify the most common variable regions used by the immune system to elicit antibody responses against gliadin...
  77. ncbi High-throughput isolation of recombinant antibodies against recombinant allergens
    Claudio Rhyner
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    Biotechniques 35:672-4. 2003
  78. ncbi Correlation-associated peptide networks of human cerebrospinal fluid
    Jens Lamerz
    Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology ETH, Zurich, Switzerland
    Proteomics 5:2789-98. 2005
    ..Our results indicate that CAN is a powerful bioinformatic tool for the systematic analysis and interpretation of large peptidomics and proteomics data and helps to discover novel bioactive and diagnostic peptides...
  79. ncbi Peptide sequence prediction supported by correlation-associated networks in human cerebrospinal fluid
    Jens Lamerz
    Department of Bioinformatics, BioVisioN AG, Feodor Lynen Str 5, D 30625 Hannover, Germany
    Comb Chem High Throughput Screen 8:789-99. 2005
    ..On the basis of this approach, identification of peptide coordinates can be prioritized, and a rapid overview of the peptide content of a novel sample source can be obtained...
  80. ncbi Datamining methodology for LC-MALDI-MS based peptide profiling
    Hans Dieter Zucht
    BioVisioN AG, Feodor Lynen Str 5, D 30625 Hannover, Germany
    Comb Chem High Throughput Screen 8:717-23. 2005
    ..Mass spectrometric experiments in peptidomics raise numerous questions in the fields of signal processing, statistics, experimental design and discriminant analysis...
  81. pmc Association between the MHC gene region and variation of serum IgE levels against specific mould allergens in the horse
    Ino Curik
    Animal Science Department, Faculty of Agriculture, University of Zagreb, Svetosimunska 25, 10000 Zagreb, Croatia
    Genet Sel Evol 35:S177-90. 2003
    ..However, although the strongest associations were found with DQA and UM-011, this study did not distinguish if the observed effects were due to the MHC itself or to other tightly linked genes...
  82. ncbi Allergic bronchopulmonary aspergillosis in cystic fibrosis--state of the art: Cystic Fibrosis Foundation Consensus Conference
    David A Stevens
    Department of Medicine, Santa Clara Valley Medical Center, Stanford University Medical School, San Jose, California 95128 2699, USA
    Clin Infect Dis 37:S225-64. 2003
    ..Diagnostic criteria that could provide a framework for monitoring were adopted, and helpful imaging features were identified. New possibilities in therapy produced plans for managing diverse clinical presentations...
  83. pmc GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells
    Pierre Yves Mantel
    Swiss Institute of Allergy and Asthma Research Davos SIAF, Davos Platz, Switzerland
    PLoS Biol 5:e329. 2007
    ....