K J Clemetson

Summary

Affiliation: University of Bern
Country: Switzerland

Publications

  1. ncbi request reprint Snake venom C-type lectins as tools in platelet research
    K J Clemetson
    Theodor Kocher Institute, University of Berne, Switzerland
    Platelets 9:165-9. 1998
  2. doi request reprint Platelets and primary haemostasis
    Kenneth J Clemetson
    Department of Haematology, Inselspital, University of Berne, CH 3010 Berne, Switzerland
    Thromb Res 129:220-4. 2012
  3. ncbi request reprint Platelet receptors for adhesion and activation. Variability as a factor in susceptibility to cardiovascular diseases
    K J Clemetson
    Theodor Kocher Institute, University of Berne, Switzerland
    Ital Heart J 2:816-8. 2001
  4. ncbi request reprint Platelet glycoproteins and their role in diseases
    K J Clemetson
    Theodor Kocher Institute, University of Berne, Switzerland
    Transfus Clin Biol 8:155-62. 2001
  5. ncbi request reprint Platelet collagen receptors
    K J Clemetson
    Theodor Kocher Institute, University of Berne, Switzerland
    Thromb Haemost 86:189-97. 2001
  6. ncbi request reprint Platelet receptors and their role in diseases
    Kenneth J Clemetson
    Theodor Kocher Institute, University of Berne, Berne, Switzerland
    Clin Chem Lab Med 41:253-60. 2003
  7. ncbi request reprint The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors
    J M Clemetson
    Theodor Kocher Institute, University of Berne, Freiestrasse 1, CH 3012 Berne, Switzerland
    J Biol Chem 274:29019-24. 1999
  8. ncbi request reprint Platelet collagen receptors: a new target for inhibition?
    K J Clemetson
    Theodor Kocher Institute, University of Berne, Switzerland
    Haemostasis 29:16-26. 1999
  9. ncbi request reprint Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human platelets
    K J Clemetson
    Theodor Kocher Institute, University of Berne, Berne, Switzerland and Serono Pharmaceutical Research Institute SA, Geneva, Switzerland
    Blood 96:4046-54. 2000
  10. ncbi request reprint Integrins and cardiovascular disease
    K J Clemetson
    Theodor Kocher Institute, University of Berne, Switzerland
    Cell Mol Life Sci 54:502-13. 1998

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Snake venom C-type lectins as tools in platelet research
    K J Clemetson
    Theodor Kocher Institute, University of Berne, Switzerland
    Platelets 9:165-9. 1998
    ..M any of these C-type lectins interact with platelet receptors to inhibit or induce platelet activation. The use of these C-type lectins to investigate platelet function is discussed and illustrated with specific examples...
  2. doi request reprint Platelets and primary haemostasis
    Kenneth J Clemetson
    Department of Haematology, Inselspital, University of Berne, CH 3010 Berne, Switzerland
    Thromb Res 129:220-4. 2012
    ..In thrombosis, pathological changes occur that may lead to life-threatening blockage of vessels. Prevention of thrombosis while maintaining haemostasis remains a major goal of medical research...
  3. ncbi request reprint Platelet receptors for adhesion and activation. Variability as a factor in susceptibility to cardiovascular diseases
    K J Clemetson
    Theodor Kocher Institute, University of Berne, Switzerland
    Ital Heart J 2:816-8. 2001
    ..In this review platelet receptor polymorphisms and their role as risk factors are surveyed and their possible relevance discussed...
  4. ncbi request reprint Platelet glycoproteins and their role in diseases
    K J Clemetson
    Theodor Kocher Institute, University of Berne, Switzerland
    Transfus Clin Biol 8:155-62. 2001
    ..Investigation of this area began about five years ago and many findings still remain controversial. The involvement of platelet receptors in other diseases like asthma, diabetes and HIV are only starting to be studied...
  5. ncbi request reprint Platelet collagen receptors
    K J Clemetson
    Theodor Kocher Institute, University of Berne, Switzerland
    Thromb Haemost 86:189-97. 2001
    ..This review discusses how these receptors work separately with specific agonists and proposes possible mechanisms for how they work together to regulate platelet activation by collagen, which remains controversial and poorly understood...
  6. ncbi request reprint Platelet receptors and their role in diseases
    Kenneth J Clemetson
    Theodor Kocher Institute, University of Berne, Berne, Switzerland
    Clin Chem Lab Med 41:253-60. 2003
    ..Recent evidence points to a fundamental role for platelets and their receptors in the origins of atherosclerosis. Studies on the role of platelet receptors in diseases such as asthma, diabetes and HIV are still at an early stage...
  7. ncbi request reprint The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors
    J M Clemetson
    Theodor Kocher Institute, University of Berne, Freiestrasse 1, CH 3012 Berne, Switzerland
    J Biol Chem 274:29019-24. 1999
    ..Dami cells transfected with GPVI cDNA mobilized intracellular Ca(2+) in response to collagen, unlike the nontransfected or mock transfected Dami cells, which do not respond to collagen...
  8. ncbi request reprint Platelet collagen receptors: a new target for inhibition?
    K J Clemetson
    Theodor Kocher Institute, University of Berne, Switzerland
    Haemostasis 29:16-26. 1999
    ..Preliminary studies would seem to suggest that this is indeed the case...
  9. ncbi request reprint Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human platelets
    K J Clemetson
    Theodor Kocher Institute, University of Berne, Berne, Switzerland and Serono Pharmaceutical Research Institute SA, Geneva, Switzerland
    Blood 96:4046-54. 2000
    ..These platelet receptors may be involved in inflammatory or allergic responses or in platelet activation in human immunodeficiency virus infection...
  10. ncbi request reprint Integrins and cardiovascular disease
    K J Clemetson
    Theodor Kocher Institute, University of Berne, Switzerland
    Cell Mol Life Sci 54:502-13. 1998
    ..Both the development of specific inhibitors and of mice with specific integrin subunit genes ablated have contributed to a better understanding of the function of integrins in development of the cardiovascular system...
  11. doi request reprint Snaclecs (snake C-type lectins) that inhibit or activate platelets by binding to receptors
    Kenneth J Clemetson
    Department of Haematology, University of Berne, Inselspital, CH 3010 Berne, Switzerland
    Toxicon 56:1236-46. 2010
    ..This review concentrates on structural and functional properties of venom components of the C-type lectin related class (now named snaclecs) that inhibit or activate platelets by binding to receptors...
  12. doi request reprint Platelet GPIb complex as a target for anti-thrombotic drug development
    Kenneth J Clemetson
    Theodor Kocher Institute, University of Berne, Freiestrasse 1, CH 3012 Berne, Switzerland
    Thromb Haemost 99:473-9. 2008
    ....
  13. ncbi request reprint Collagen receptors as potential targets for novel anti-platelet agents
    Kenneth J Clemetson
    Theodor Kocher Institute, University of Berne, Freiestrasse 1, CH 3012, Berne, Switzerland
    Curr Pharm Des 13:2673-83. 2007
    ..Several thrombosis models and experimental approaches suggest that all three are interesting targets and merit further investigation...
  14. ncbi request reprint Multifunctional snake C-type lectins affecting platelets
    K J Clemetson
    Theodor Kocher Institute, University of Berne, Freiestrasse 1, CH 3012 Berne, Switzerland
    Haemostasis 31:148-54. 2001
    ..e. they had only one receptor per heterodimer. Recent studies show that most of these C-type lectins have binding sites for more than one ligand and have complex mechanisms of action...
  15. ncbi request reprint A short history of platelet glycoprotein Ib complex
    Kenneth J Clemetson
    Theodor Kocher Institute, University of Berne, Freiestrasse 1, CH 3012 Berne, Switzerland
    Thromb Haemost 98:63-8. 2007
  16. ncbi request reprint American Society of Hematology--48th Annual Meeting and Exposition. Updates on therapies. 9-12 December 2006 Orlando, FL, USA
    Kenneth J Clemetson
    University of Berne, Theodor Kocher Institute, Freiestrasse 1, CH 3012 Berne, Switzerland
    IDrugs 10:90-2. 2007
  17. ncbi request reprint Snake venom proteins affecting platelets and their applications to anti-thrombotic research
    Kenneth J Clemetson
    Theodor Kocher Institute, University of Berne, Freiestrasse 1, CH 3012, Berne, Switzerland
    Curr Pharm Des 13:2887-92. 2007
    ..L-amino acid oxidases activate platelets by producing H(2)O(2). Many of these purified components are valuable tools in platelet research, providing new information about receptor function and signaling...
  18. ncbi request reprint Aggretin, a heterodimeric C-type lectin from Calloselasma rhodostoma (malayan pit viper), stimulates platelets by binding to alpha 2beta 1 integrin and glycoprotein Ib, activating Syk and phospholipase Cgamma 2, but does not involve the glycoprotein VI/Fc
    A Navdaev
    Theodor Kocher Institute, University of Berne, Freiestrasse 1, CH-3012 Berne, Switzerland
    J Biol Chem 276:20882-9. 2001
    ..This supports an independent, GPIb- and integrin-based pathway for activation of p72(SYK) not involving the Fcgamma receptor...
  19. ncbi request reprint Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor
    J Polgar
    Theodor Kocher Institute, University of Berne, Freiestrasse 1, CH 3012 Berne, Switzerland
    J Biol Chem 272:13576-83. 1997
    ....
  20. ncbi request reprint Echicetin, a GPIb-binding snake C-type lectin from Echis carinatus, also contains a binding site for IgMkappa responsible for platelet agglutination in plasma and inducing signal transduction
    A Navdaev
    Theodor Kocher Institute, University of Berne, Switzerland
    Blood 97:2333-41. 2001
    ..In vivo, echicetin probably activates platelets rather than inhibits platelet activation, as previously proposed, accounting for the observed induction of thrombocytopenia...
  21. ncbi request reprint Bilinexin, a snake C-type lectin from Agkistrodon bilineatus venom agglutinates platelets via GPIb and alpha2beta1
    X Y Du
    Theodor Kocher Institute, University of Berne, Switzerland
    Thromb Haemost 86:1277-83. 2001
    ..Like alboaggregin B, bilinexin agglutinates platelets, which makes it a good tool to investigate the differences in mechanism between snake C-type lectins causing platelet agglutination and those that induce full activation...
  22. pmc Human group II 14 kDa phospholipase A2 activates human platelets
    J Polgar
    Theodor Kocher Institute, University of Berne, Berne 3012, Switzerland
    Biochem J 327:259-65. 1997
    ....
  23. ncbi request reprint Structure of the human blood platelet membrane glycoprotein Ib alpha gene
    R H Wenger
    Theodor Kocher Institute, University of Berne, Switzerland
    Biochem Biophys Res Commun 156:389-95. 1988
    ..The 3' region contains two repetitive Alu elements, belonging to distinct subfamilies, connected by an oligo(dA) linker...
  24. ncbi request reprint Snake venoms and hemostasis
    Q Lu
    Theodor Kocher Institute, University of Berne, Berne, Switzerland
    J Thromb Haemost 3:1791-9. 2005
    ..Some venom enzymes cleave key basement membrane components and directly affect capillary blood vessels to cause hemorrhaging. L-Amino acid oxidases activate platelets via H2O2 production...
  25. ncbi request reprint Translocation of GPIb and Fc receptor gamma-chain to cytoskeleton in mucetin-activated platelets
    Q Lu
    Theodor Kocher Institute, University of Berne, Freiestrasse 1, Berne, Switzerland
    J Thromb Haemost 3:2065-76. 2005
    ..We propose that cytoskeletal translocation of GPIb is upstream of alphaIIbbeta3 activation and cross-linking of GPIb is sufficient to induce this event in mucetin-activated platelets...
  26. ncbi request reprint Chemokine and chemokine receptor mRNA expression in human platelets
    C A Power
    Glaxo Institute for Molecular Biology, Geneva, Switzerland
    Cytokine 7:479-82. 1995
    ....
  27. ncbi request reprint Platelet glycoprotein Ia* is the processed form of multimerin--isolation and determination of N-terminal sequences of stored and released forms
    J Polgar
    Theodor Kocher Institute, University of Berne, Switzerland
    Thromb Haemost 80:645-8. 1998
    ..This sequence and domain are cleaved off in the p-155 form, described earlier as platelet multimerin, which is probably formed after release from alpha-granules...
  28. ncbi request reprint Variant Bernard-Soulier syndrome associated with a homozygous mutation in the leucine-rich domain of glycoprotein IX
    J M Clemetson
    Theodor Kocher Institute, University of Berne, Switzerland
    Blood 84:1124-31. 1994
    ..This homozygous mutation in GPIX indicates that, among other possible functions, the leucine-rich domains present on all components of GPIb-IX-V may play a role in the assembly and surface expression of the complex...
  29. ncbi request reprint Cloning of cDNA coding for connective tissue activating peptide III from a human platelet-derived lambda gt11 expression library
    R H Wenger
    Theodor Kocher Institute, University of Berne, Switzerland
    Blood 73:1498-503. 1989
    ..8 kb, suggesting that the corresponding cDNA is full length. The cloning of platelet specific CTAP-III provides additional evidence for the platelet specificity of the cDNA library used...
  30. ncbi request reprint Identification of the disulphide bonds in human platelet glycocalicin
    D Hess
    Institute of Biochemistry, University of Berne, Switzerland
    Eur J Biochem 199:389-93. 1991
    ..The position and linkage of these two disulphide bonds are now determined to be 209-248 and 211-264 and the relevance of this double-loop structure for glycoprotein Ib/IX function is discussed...
  31. ncbi request reprint Snake venom C-type lectins interacting with platelet receptors. Structure-function relationships and effects on haemostasis
    Qiumin Lu
    Theodor Kocher Institute, University of Berne, Freiestrasse 1, CH 3012, Berne, Switzerland
    Toxicon 45:1089-98. 2005
    ..The relationship between structure and function in this group of venom proteins will be discussed...
  32. ncbi request reprint Platelet chemokines and their receptors: what is their relevance to platelet storage and transfusion practice?
    F Boehlen
    Theodor Kocher Institute, University of Berne, Freistrasse 1, 3012 Berne, Switzerland
    Transfus Med 11:403-17. 2001
    ....
  33. doi request reprint The role of platelets in defence against pathogens
    K J Clemetson
    Dept of Haematology, University of Bern, Bern, Switzerland
    Hamostaseologie 31:264-8. 2011
    ..Platelets also have receptors for IgE and are implicated via parasitic disorders in development and problems of allergy...
  34. ncbi request reprint The 5' flanking region and chromosomal localization of the gene encoding human platelet membrane glycoprotein Ib alpha
    R H Wenger
    Theodor Kocher Institute, University of Berne, Switzerland
    Gene 85:517-24. 1989
    ..The gpIb alpha gene was found to be located on chromosome 17 in region 17p12-ter, by in situ hybridization...
  35. ncbi request reprint First isolation of actomyosin from a non-muscle cell: first isolated platelet protein
    M Bettex-Galland
    Theodor Kocher Institute, University of Berne, Switzerland
    J Thromb Haemost 3:834-9. 2005
  36. ncbi request reprint All platelets are not equal: COAT platelets
    Lorenzo J Alberio
    Theodor Kocher Institute, University of Berne, Freiestrasse 1, CH 3012 Berne, Switzerland
    Curr Hematol Rep 3:338-43. 2004
    ..More knowledge about how COAT platelets are formed will be important for a better understanding of the physiology and pathology of hemostasis...
  37. ncbi request reprint Glycoprotein Ib cross-linking/ligation on echicetin-coated surfaces or echicetin-IgMkappa in stirred suspension activates platelets by cytoskeleton modulated calcium release
    Alexey Navdaev
    Theodor Kocher Institute, University of Berne, Freiestrasse 1, Berne CH 3012, Switzerland
    J Biol Chem 277:45928-34. 2002
    ..Cross-linking of GPIb complex molecules on platelets, either in suspension or via specific surface attachment, is sufficient to induce platelet activation...
  38. ncbi request reprint Alboluxin, a snake C-type lectin from Trimeresurus albolabris venom is a potent platelet agonist acting via GPIb and GPVI
    - Du Xiao-Yan
    Theodor Kocher Institute, University of Berne, Switzerland
    Thromb Haemost 87:692-8. 2002
    ..The C-type lectin subunits are larger than usual possibly due to post-translational modifications such as glycosylation. Alboluxin is a hexameric (alphabeta)3 snake C-type lectin which activates platelets via both GPIb and GPVI...
  39. ncbi request reprint Snake C-type lectin-like proteins and platelet receptors
    Kenneth J Clemetson
    Theodor Kocher Institute, University of Berne, Berne, Switzerland
    Pathophysiol Haemost Thromb 34:150-5. 2005
    ..Structure-activity studies show that these proteins are quite complex despite similar backbone folding. Snake C-type lectin-like proteins often interact with more than one platelet receptor and have complex mechanisms of action...
  40. ncbi request reprint Ophioluxin, a convulxin-like C-type lectin from Ophiophagus hannah (King cobra) is a powerful platelet activator via glycoprotein VI
    Xiao Yan Du
    Theodor Kocher Institute, University of Berne, CH 3012 Berne, Switzerland
    J Biol Chem 277:35124-32. 2002
    ..Ophioluxin is the first multiheterodimeric, convulxin-like snake C-type lectin, as well as the first platelet agonist, to be described from the Elapidae snake family...
  41. ncbi request reprint GPIb is involved in platelet aggregation induced by mucetin, a snake C-type lectin protein from Chinese habu (Trimeresurus mucrosquamatus) venom
    Qiumin Lu
    Theodor Kocher Institute, University of Bern, Switzerland
    Thromb Haemost 91:1168-76. 2004
    ..Sequence and structural comparison with closely related members of this protein family point to features that may be responsible for the functional differences...
  42. ncbi request reprint Snake venom L-amino acid oxidases
    Xiao Yan Du
    Theodor Kocher Institute, University of Berne, Freiestrasse 1, CH 3012 Berne, Switzerland
    Toxicon 40:659-65. 2002
    ..In addition, the putative mechanisms of SV-LAAO-induced platelet aggregation and apoptosis of cells are discussed in more detail...
  43. ncbi request reprint Platelet receptor signalling
    Kenneth J Clemetson
    University of Bern, Bern, Switzerland
    Hematol J 5:S159-63. 2004
  44. ncbi request reprint Platelet activation induces metalloproteinase-dependent GP VI cleavage to down-regulate platelet reactivity to collagen
    Gillian Stephens
    Portola Pharmaceuticals Inc, San Francisco, CA 94080, USA
    Blood 105:186-91. 2005
    ..Induction of GP VI cleavage caused specific down-regulation of collagen-induced platelet aggregation, providing a mechanism for the modulation of platelet responsiveness to this important platelet agonist...
  45. ncbi request reprint Stejnulxin, a novel snake C-type lectin-like protein from Trimeresurus stejnegeri venom is a potent platelet agonist acting specifically via GPVI
    Wen Hui Lee
    Department of Animal Toxinology, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, Yunnan, PR China
    Thromb Haemost 90:662-71. 2003
    ..In addition, stejnulxin induced a tyrosine phosphorylation profile in platelets that resembled that produced by convulxin. Biotinylated stejnulxin bound specifically to platelet membrane GPVI...
  46. ncbi request reprint Crystal structure of the platelet glycoprotein Ib(alpha) N-terminal domain reveals an unmasking mechanism for receptor activation
    Sarah Uff
    Department of Biochemistry, University of Leicester, Leicester LE1 7RH, United Kingdom
    J Biol Chem 277:35657-63. 2002
    ..Using molecular docking of the GPIb and vWF-A1 crystal structures, we were also able to model the GPIb.vWF-A1 complex...
  47. ncbi request reprint High molecular weight kininogen regulates platelet-leukocyte interactions by bridging Mac-1 and glycoprotein Ib
    Triantafyllos Chavakis
    Department of Internal Medicine I, University Heidelberg, D 69115 Heidelberg, Germany
    J Biol Chem 278:45375-81. 2003
    ..These distinct molecular interactions of HK with leukocytes and platelets contribute to the regulation of the adhesive behavior of vascular cells and provide novel molecular targets for reducing atherothrombotic pathologies...
  48. ncbi request reprint Stimulated platelets use serotonin to enhance their retention of procoagulant proteins on the cell surface
    George L Dale
    W K Warren Medical Research Institute and Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Nature 415:175-9. 2002
    ..These data indicate that COAT-platelets use serotonin conjugation to augment the retention of procoagulant proteins on their cell surface through an as yet unidentified serotonin receptor...
  49. ncbi request reprint Thrombospondin-1 mediates platelet adhesion at high shear via glycoprotein Ib (GPIb): an alternative/backup mechanism to von Willebrand factor
    Kerstin Jurk
    Department of Anaesthesiology and Intensive Care, Experimental and Clinical Haemostasis, University Hospital Munster, Mendelstr 11, 48149 Munster, Germany
    FASEB J 17:1490-2. 2003
    ....
  50. doi request reprint The crystal structure of the platelet activator aggretin reveals a novel (alphabeta)2 dimeric structure
    Elizabeth Hooley
    Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, UK
    Biochemistry 47:7831-7. 2008
    ....
  51. ncbi request reprint Profiling of alterations in platelet proteins during storage of platelet concentrates
    Thomas Thiele
    Institute for Immunology and Transfusion Medicine, Ernst Moritz Arndt University, Greifswald, Germany
    Transfusion 47:1221-33. 2007
    ..In contrast, proteomic technologies provide a comprehensive overview of the PLT proteome. High interassay variability, however, limits meaningful assessment of samples taken from the same product over time or before and after processing...
  52. ncbi request reprint A common ancestral glycoprotein (GP) 9 1828A>G (Asn45Ser) gene mutation occurring in European families from Australia and Northern Europe with Bernard-Soulier Syndrome (BSS)
    Hai Po Helena Liang
    Northern Blood Research Centre, Department of Haematology and Transfusion Medicine, Royal North Shore Hospital, St Leonards, Australia
    Thromb Haemost 94:599-605. 2005
    ..Additional members from these 'atypical' lineages would need to be screened to resolve this question...
  53. ncbi request reprint L-amino acid oxidase from Naja atra venom activates and binds to human platelets
    Rui Li
    Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
    Acta Biochim Biophys Sin (Shanghai) 40:19-26. 2008
    ....