Sophie Clement

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi request reprint Expression and function of alpha-smooth muscle actin during embryonic-stem-cell-derived cardiomyocyte differentiation
    Sophie Clement
    Department of Geriatrics, Laboratory of Ageing, Geneva Hospital, Chene Bourg, Geneva, Switzerland
    J Cell Sci 120:229-38. 2007
  2. doi request reprint Role of seipin in lipid droplet morphology and hepatitis C virus life cycle
    Sophie Clement
    Division of Clinical Pathology, University Hospital, University of Geneva School of Medicine, Geneva, Switzerland
    J Gen Virol 94:2208-14. 2013
  3. pmc Hepatitis C Virus Increases Occludin Expression via the Upregulation of Adipose Differentiation-Related Protein
    Emilie Branche
    Department of Immunology and Pathology, Faculty of Medicine, Geneva, Switzerland
    PLoS ONE 11:e0146000. 2016
  4. doi request reprint PTEN protein phosphatase activity regulates hepatitis C virus secretion through modulation of cholesterol metabolism
    Marion Peyrou
    Department of Cellular Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    J Hepatol 59:420-6. 2013
  5. pmc Inflammatory Chemokines MIP-1δ and MIP-3α Are Involved in the Migration of Multipotent Mesenchymal Stromal Cells Induced by Hepatoma Cells
    Esma Lejmi
    1 Surgical Research Unit, University Hospitals of Geneva, Geneva, Switzerland
    Stem Cells Dev 24:1223-35. 2015
  6. doi request reprint Intrahepatic mRNA levels of SOCS1 and SOCS3 are associated with cirrhosis but do not predict virological response to therapy in chronic hepatitis C
    Stéphanie Pascarella
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
    Liver Int 33:94-103. 2013
  7. doi request reprint The hepatitis C virus core protein indirectly induces alpha-smooth muscle actin expression in hepatic stellate cells via interleukin-8
    Sophie Clement
    Division of Clinical Pathology, Geneva University Hospital, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Hepatol 52:635-43. 2010
  8. pmc HCV 3a core protein increases lipid droplet cholesteryl ester content via a mechanism dependent on sphingolipid biosynthesis
    Ursula Loizides-Mangold
    Department of Biochemistry, NCCR Chemical Biology, University of Geneva, Geneva, Switzerland
    PLoS ONE 9:e115309. 2014
  9. ncbi request reprint The hepatitis C virus core protein of genotypes 3a and 1b downregulates insulin receptor substrate 1 through genotype-specific mechanisms
    Valerio Pazienza
    Division of Clinical Pathology, University Hospital, Geneva, Switzerland
    Hepatology 45:1164-71. 2007
  10. ncbi request reprint The N-terminal Ac-EEED sequence plays a role in alpha-smooth-muscle actin incorporation into stress fibers
    Sophie Clement
    Department of Pathology and Immunology, CMU, Geneva, Switzerland
    J Cell Sci 118:1395-404. 2005

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Expression and function of alpha-smooth muscle actin during embryonic-stem-cell-derived cardiomyocyte differentiation
    Sophie Clement
    Department of Geriatrics, Laboratory of Ageing, Geneva Hospital, Chene Bourg, Geneva, Switzerland
    J Cell Sci 120:229-38. 2007
    ..The application of both fusion peptides on beating embryoid bodies impairs frequency. These results suggest specific functional activities for actin isoforms in cardiogenesis and cardiomyocyte contractility...
  2. doi request reprint Role of seipin in lipid droplet morphology and hepatitis C virus life cycle
    Sophie Clement
    Division of Clinical Pathology, University Hospital, University of Geneva School of Medicine, Geneva, Switzerland
    J Gen Virol 94:2208-14. 2013
    ..These results suggest that the available outer surface of lipid droplets is a critical factor for HCV release, independent of the neutral lipid content of the cell. ..
  3. pmc Hepatitis C Virus Increases Occludin Expression via the Upregulation of Adipose Differentiation-Related Protein
    Emilie Branche
    Department of Immunology and Pathology, Faculty of Medicine, Geneva, Switzerland
    PLoS ONE 11:e0146000. 2016
    ..Alltogether, these findings show that HCV induces ADRP, which in turns appears to confer a favorable environment to viral spread. ..
  4. doi request reprint PTEN protein phosphatase activity regulates hepatitis C virus secretion through modulation of cholesterol metabolism
    Marion Peyrou
    Department of Cellular Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    J Hepatol 59:420-6. 2013
    ..We showed that HCV induces steatosis via the downregulation of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN). We here investigated how PTEN may affect HCV production...
  5. pmc Inflammatory Chemokines MIP-1δ and MIP-3α Are Involved in the Migration of Multipotent Mesenchymal Stromal Cells Induced by Hepatoma Cells
    Esma Lejmi
    1 Surgical Research Unit, University Hospitals of Geneva, Geneva, Switzerland
    Stem Cells Dev 24:1223-35. 2015
    ..In conclusion, we report that two inflammatory cytokines, MIP-1δ and MIP-3α, are able to increase MSC migration in vitro. These cytokines might be responsible for migration and evolvement of MSC into myofibroblasts around tumors. ..
  6. doi request reprint Intrahepatic mRNA levels of SOCS1 and SOCS3 are associated with cirrhosis but do not predict virological response to therapy in chronic hepatitis C
    Stéphanie Pascarella
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
    Liver Int 33:94-103. 2013
    ..The suppressor of cytokine signalling (SOCS) family members have been suggested to affect the rate of virological response to therapy, but the published evidence is conflicting...
  7. doi request reprint The hepatitis C virus core protein indirectly induces alpha-smooth muscle actin expression in hepatic stellate cells via interleukin-8
    Sophie Clement
    Division of Clinical Pathology, Geneva University Hospital, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Hepatol 52:635-43. 2010
    ..e., to be mediated by virally-driven inflammation, a direct role of HCV in inducing fibrosis deposition has never been entirely excluded...
  8. pmc HCV 3a core protein increases lipid droplet cholesteryl ester content via a mechanism dependent on sphingolipid biosynthesis
    Ursula Loizides-Mangold
    Department of Biochemistry, NCCR Chemical Biology, University of Geneva, Geneva, Switzerland
    PLoS ONE 9:e115309. 2014
    ..Thus, both sphingolipid and cholesteryl ester biosynthesis are affected by the steatogenic core protein of HCV genotype 3a. These results may explain the peculiar lipid profile of HCV-infected patients with steatosis. ..
  9. ncbi request reprint The hepatitis C virus core protein of genotypes 3a and 1b downregulates insulin receptor substrate 1 through genotype-specific mechanisms
    Valerio Pazienza
    Division of Clinical Pathology, University Hospital, Geneva, Switzerland
    Hepatology 45:1164-71. 2007
    ..We confirmed these findings by using agonists for PPARgamma (rosiglitazone) or short interfering RNAs for SOCS-7...
  10. ncbi request reprint The N-terminal Ac-EEED sequence plays a role in alpha-smooth-muscle actin incorporation into stress fibers
    Sophie Clement
    Department of Pathology and Immunology, CMU, Geneva, Switzerland
    J Cell Sci 118:1395-404. 2005
    ..Here, we propose a new mechanism of how alpha-smooth-muscle actin is incorporated in stress fibers involving the sequence Ac-EEED...
  11. doi request reprint Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets
    Sophie Clement
    Division of Clinical Pathology, University Hospital, Geneva, Switzerland
    Hepatology 54:38-49. 2011
    ..However, IRS1 knockdown per se did not alter the morphology of lipid droplets, and this suggests that other PTEN-dependent mechanisms are involved in this process...
  12. doi request reprint Bile Ducts in Regenerative Liver Nodules of Alagille Patients Are Not the Result of Genetic Mosaicism
    Anne Laure Rougemont
    Department of Pathology, Sainte Justine Hospital, Montreal, Canada Division of Clinical Pathology, Geneva University Hospitals, Geneva, Switzerland Division of Gastroenterology, Hepatology and Nutrition, Sainte Justine Hospital, Montreal, Canada Pediatric Gastroenterology Unit, Geneva University Hospitals, Geneva, Switzerland Génétique Moléculaire, Pharmacogénétique et Hormonologie, Hopital Bicetre, Faculté de Médecine de Bicêtre, Universite Paris Sud, Paris, France Division of Pediatric Surgery, Geneva University Hospitals, Geneva, Switzerland
    J Pediatr Gastroenterol Nutr 61:91-3. 2015
    ..Thus, JAG1 mosaicism and differential haploinsufficiency do not explain the presence of bile ducts in centrally located regenerative nodules...
  13. pmc Fibrogenic potential of human multipotent mesenchymal stromal cells in injured liver
    Reto M Baertschiger
    Surgical Research Unit, Department of Surgery, University Hospital Geneva, Geneva, Switzerland
    PLoS ONE 4:e6657. 2009
    ..These results indicate that MSC in certain circumstances might be harmful due to their fibrogenic potential and this should be considered before potential use of MSC for cell therapy...
  14. doi request reprint Gene expression profile of Huh-7 cells expressing hepatitis C virus genotype 1b or 3a core proteins
    Valerio Pazienza
    Division of Clinical Pathology, University Hospitals and University of Geneva, Geneva, Switzerland
    Liver Int 29:661-9. 2009
    ..The liver disease expression in chronic hepatitis C patients is variable and may partially depend on the sequence of the infecting viral genotype...
  15. doi request reprint Monocyte chemoattractant protein-1 secreted by adipose tissue induces direct lipid accumulation in hepatocytes
    Sophie Clement
    Division of Clinical Pathology, Geneva University Hospital, University of Geneva, Geneva, Switzerland
    Hepatology 48:799-807. 2008
    ..Investigation of the mechanism leading to the triglyceride accumulation showed that both a diminution of apolipoprotein B secretion and an increase in phosphoenolpyruvate carboxykinase messenger RNA may be involved...