Mirjam Christ Crain

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. doi request reprint [Procalcitonin - importance for the diagnosis of bacterial infections]
    Mirjam Christ-Crain
    Bereich Innere Medizin, Universitatsspital Basel
    Ther Umsch 65:559-68. 2008
  2. ncbi request reprint Antibiotic treatment of exacerbations of COPD: a randomized, controlled trial comparing procalcitonin-guidance with standard therapy
    Daiana Stolz
    Clinics of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland
    Chest 131:9-19. 2007
  3. ncbi request reprint Free and total cortisol levels as predictors of severity and outcome in community-acquired pneumonia
    Mirjam Christ-Crain
    Department of Endocrinology, William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, United Kingdom
    Am J Respir Crit Care Med 176:913-20. 2007
  4. ncbi request reprint Serum estradiol after single dose hCG administration correlates with Leydig cell reserve in hypogonadal men: reassessment of the hCG stimulation test
    Christian Meier
    Clinic for Endocrinology, Diabetology and Clinical Nutrition, University Hospital, Basel, Switzerland
    Clin Lab 51:509-15. 2005
  5. pmc Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia
    Beat Muller
    Departments of Internal Medicine, University Hospital, Petersgraben 4, CH 4031, Basel, Switzerland
    BMC Infect Dis 7:10. 2007
  6. ncbi request reprint Changes in plasma copeptin, the c-terminal portion of arginine vasopressin during water deprivation and excess in healthy subjects
    Gabor Szinnai
    Division of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital, CH 4031 Basel, Switzerland
    J Clin Endocrinol Metab 92:3973-8. 2007
  7. ncbi request reprint Somatostatin is expressed and secreted by human adipose tissue upon infection and inflammation
    Dalma Seboek
    Department of Research, University Hospitals, Hebelstrasse 20, CH 4031 Basel, Switzerland
    J Clin Endocrinol Metab 89:4833-9. 2004
  8. ncbi request reprint Biomarkers in the management of pneumonia
    Mirjam Christ Crain
    University Hospitals, Petersgraben 4, CH 4031 Basel, Switzerland
    Expert Rev Respir Med 2:565-72. 2008
  9. pmc Clinical review: the role of biomarkers in the diagnosis and management of community-acquired pneumonia
    Mirjam Christ-Crain
    Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Crit Care 14:203. 2010
  10. doi request reprint Mechanisms of metformin action on glucose transport and metabolism in human adipocytes
    Jean Grisouard
    Department of Biomedicine, Metabolism Group, Div of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, CH 4031 Basel, Switzerland
    Biochem Pharmacol 80:1736-45. 2010

Collaborators

Detail Information

Publications47

  1. doi request reprint [Procalcitonin - importance for the diagnosis of bacterial infections]
    Mirjam Christ-Crain
    Bereich Innere Medizin, Universitatsspital Basel
    Ther Umsch 65:559-68. 2008
    ..Together, Procalcitonin has improved the diagnosis of bacterial infections, however should always be used in context with other laboratory markers, clinical exam and medical history...
  2. ncbi request reprint Antibiotic treatment of exacerbations of COPD: a randomized, controlled trial comparing procalcitonin-guidance with standard therapy
    Daiana Stolz
    Clinics of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland
    Chest 131:9-19. 2007
    ..We evaluated the efficacy and safety of procalcitonin guidance compared to standard therapy with antibiotic prescriptions in patients experiencing exacerbations of COPD...
  3. ncbi request reprint Free and total cortisol levels as predictors of severity and outcome in community-acquired pneumonia
    Mirjam Christ-Crain
    Department of Endocrinology, William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, United Kingdom
    Am J Respir Crit Care Med 176:913-20. 2007
    ..The predictive value of cortisol in pneumonia is unknown. Routinely available assays measure serum total cortisol (TC) and not free cortisol (FC). Whether FC concentrations better reflect outcome is uncertain...
  4. ncbi request reprint Serum estradiol after single dose hCG administration correlates with Leydig cell reserve in hypogonadal men: reassessment of the hCG stimulation test
    Christian Meier
    Clinic for Endocrinology, Diabetology and Clinical Nutrition, University Hospital, Basel, Switzerland
    Clin Lab 51:509-15. 2005
    ..Assessment of E2 increments would render the test procedure more practical, less time-consuming and more cost-effective than assessing peak T levels after 72 hours...
  5. pmc Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia
    Beat Muller
    Departments of Internal Medicine, University Hospital, Petersgraben 4, CH 4031, Basel, Switzerland
    BMC Infect Dis 7:10. 2007
    ..This study aims to evaluate the diagnostic and prognostic accuracy of clinical signs and symptoms and laboratory biomarkers for CAP...
  6. ncbi request reprint Changes in plasma copeptin, the c-terminal portion of arginine vasopressin during water deprivation and excess in healthy subjects
    Gabor Szinnai
    Division of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital, CH 4031 Basel, Switzerland
    J Clin Endocrinol Metab 92:3973-8. 2007
    ..Copeptin is the C-terminal part of provasopressin and has been shown to be a useful tool to indicate AVP concentration in critically ill patients...
  7. ncbi request reprint Somatostatin is expressed and secreted by human adipose tissue upon infection and inflammation
    Dalma Seboek
    Department of Research, University Hospitals, Hebelstrasse 20, CH 4031 Basel, Switzerland
    J Clin Endocrinol Metab 89:4833-9. 2004
    ..It is tempting to speculate that visceral adipose tissue-derived SRIF plays a modulatory role in the immunological and metabolic response to inflammation...
  8. ncbi request reprint Biomarkers in the management of pneumonia
    Mirjam Christ Crain
    University Hospitals, Petersgraben 4, CH 4031 Basel, Switzerland
    Expert Rev Respir Med 2:565-72. 2008
    ..Future studies will show whether an assessment with those novel biomarkers is able to guide prognostic decision-making and improve the allocation of healthcare resources and hospitalization costs...
  9. pmc Clinical review: the role of biomarkers in the diagnosis and management of community-acquired pneumonia
    Mirjam Christ-Crain
    Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Crit Care 14:203. 2010
    ..None should be used on its own; and none is anything more than an aid in the exercise of clinical judgment based upon a synthesis of available clinical, physiologic and laboratory features in each patient...
  10. doi request reprint Mechanisms of metformin action on glucose transport and metabolism in human adipocytes
    Jean Grisouard
    Department of Biomedicine, Metabolism Group, Div of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, CH 4031 Basel, Switzerland
    Biochem Pharmacol 80:1736-45. 2010
    ..In addition, metformin induced glucose oxidation. In conclusion, activation of AMPKα1 without impairment of cell respiration is crucial for metformin-mediated increase in GLUT-4 protein content and glucose uptake in human adipocytes...
  11. pmc Clinical predictors for Legionella in patients presenting with community-acquired pneumonia to the emergency department
    Rico Fiumefreddo
    Department of Internal Medicine, Kantonsspital Aarau, Tellstrasse, CH 5001 Aarau, Switzerland
    BMC Pulm Med 9:4. 2009
    ..Accurate clinical predictors to assess the likelihood of Legionella community-acquired pneumonia (CAP) in patients presenting to the emergency department are lacking...
  12. ncbi request reprint Effect of gastric bypass and gastric banding on proneurotensin levels in morbidly obese patients
    Mirjam Christ-Crain
    Department of Endocrinology, Charterhouse Square, St Bartholomews Hospital, London EC1M 6BQ, United Kingdom
    J Clin Endocrinol Metab 91:3544-7. 2006
    ..Neurotensin is produced mainly in the N cells of the ileum and has a role in appetite regulation; levels are decreased in obese subjects and increase after bariatric surgery. Mature neurotensin is very unstable, with a short half-life...
  13. ncbi request reprint Measurement of serum free cortisol shows discordant responsivity to stress and dynamic evaluation
    Mirjam Christ-Crain
    Department of Endocrinology, Barts and The London, Queen Mary s School of Medicine, University of London, London, United Kingdom
    J Clin Endocrinol Metab 92:1729-35. 2007
    ..However, there are few data on FC levels during surgical stress and in response to standard pharmacological tests...
  14. doi request reprint AMP-activated protein kinase mediates glucocorticoid-induced metabolic changes: a novel mechanism in Cushing's syndrome
    Mirjam Christ-Crain
    Department of Endocrinology, William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine, London EC1M 6BQ, UK
    FASEB J 22:1672-83. 2008
    ..Our data suggest that metformin treatment could be effective in preventing the metabolic complications of chronic glucocorticoid excess...
  15. doi request reprint Assessment of serum-free cortisol levels in patients with adrenocortical carcinoma treated with mitotane: a pilot study
    Krystallenia I Alexandraki
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    Clin Endocrinol (Oxf) 72:305-11. 2010
    ..Mitotane treatment in adrenocortical carcinoma (ACC) results in unreliable measurement of serum total cortisol (TC) levels because of an elevation in corticosteroid-binding globulin (CBG)...
  16. pmc Procalcitonin guided antibiotic therapy and hospitalization in patients with lower respiratory tract infections: a prospective, multicenter, randomized controlled trial
    Philipp Schuetz
    Department of Internal Medicine, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, Basel, Switzerland
    BMC Health Serv Res 7:102. 2007
    ....
  17. ncbi request reprint Biomarkers to improve diagnostic and prognostic accuracy in systemic infections
    Philipp Schuetz
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Curr Opin Crit Care 13:578-85. 2007
    ..We review the advantages and drawbacks of biomarkers in the diagnostic and prognostic assessment of systemic infections...
  18. pmc Circulating precursor levels of endothelin-1 and adrenomedullin, two endothelium-derived, counteracting substances, in sepsis
    Philipp Schuetz
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Endothelium 14:345-51. 2007
    ..The ratio of the two counteracting peptides correlates with mortality and shows a prognostic accuracy to predict adverse outcome comparable to the APACHE II score...
  19. pmc Effect of a 14-day course of systemic corticosteroids on the hypothalamic-pituitary-adrenal-axis in patients with acute exacerbation of chronic obstructive pulmonary disease
    Philipp Schuetz
    Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    BMC Pulm Med 8:1. 2008
    ....
  20. pmc Endothelin-1 precursor peptides correlate with severity of disease and outcome in patients with community acquired pneumonia
    Philipp Schuetz
    Department of Internal Medicine, University Hospital Basel, Switzerland
    BMC Infect Dis 8:22. 2008
    ..The objective of this study was to assess the diagnostic and prognostic value of proET-1 in a prospective cohort of mainly septic patients with community-acquired pneumonia...
  21. doi request reprint Use of B-type natriuretic peptide in the risk stratification of acute exacerbations of COPD
    Daiana Stolz
    Clinic for Pneumology and Respiratory Cell Research, University Hospital Basel, Switzerland
    Chest 133:1088-94. 2008
    ..In patients with COPD, prognosis might be determined at least in part by the extent of cardiac stress induced by hypoxia and pulmonary arterial hypertension...
  22. doi request reprint Calcitonin peptides--the mediators in sepsis or just another fairy tale?
    Mirjam Christ-Crain
    Crit Care Med 36:1684-7. 2008
  23. ncbi request reprint Copeptin, a stable peptide derived from the vasopressin precursor, correlates with the individual stress level
    Mira Katan
    Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
    Neuro Endocrinol Lett 29:341-6. 2008
    ..Copeptin is a more stable peptide stoichiometrically released from the same precursor molecule. The aim of our study was to compare copeptin and cortisol levels in different stress situations...
  24. doi request reprint Procalcitonin-guided antibiotic use vs a standard approach for acute respiratory tract infections in primary care
    Matthias Briel
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Arch Intern Med 168:2000-7; discussion 2007-8. 2008
    ..We consider whether antibiotic therapy guided by procalcitonin reduces the use of antibiotics without increasing the restrictions experienced by patients by more than 1 day...
  25. ncbi request reprint Copeptin, C-reactive protein, and procalcitonin as prognostic biomarkers in acute exacerbation of COPD
    Daiana Stolz
    Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Chest 131:1058-67. 2007
    ....
  26. ncbi request reprint Meta-analysis of procalcitonin for sepsis detection
    Beat Muller
    Lancet Infect Dis 7:498-9; author reply 502-3. 2007
  27. pmc Procalcitonin-guided antibiotic use versus a standard approach for acute respiratory tract infections in primary care: study protocol for a randomised controlled trial and baseline characteristics of participating general practitioners [ISRCTN73182671]
    Matthias Briel
    Basel Institute for Clinical Epidemiology, University Hospital Basel, CH 4031 Basel, Switzerland
    BMC Fam Pract 6:34. 2005
    ..The aim of this trial is to compare a ProCT-guided antibiotic therapy with a standard approach based on evidence-based guidelines for patients with ARTI in primary care...
  28. pmc Pro-atrial natriuretic peptide is a prognostic marker in sepsis, similar to the APACHE II score: an observational study
    Nils G Morgenthaler
    Research Department, BRAHMS AG, Biotechnology Center, Hennigsdorf Berlin, Germany
    Crit Care 9:R37-45. 2005
    ....
  29. ncbi request reprint Procalcitonin in bacterial infections--hype, hope, more or less?
    Mirjam Christ-Crain
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    Swiss Med Wkly 135:451-60. 2005
    ..This review aims to help the clinician to understand the physiopathological basis, to appreciate strengths and weaknesses of this biomarker, and thereby to promote a rational implementation of ProCT in a routine setting...
  30. ncbi request reprint Elevated C-reactive protein and homocysteine values: cardiovascular risk factors in hypothyroidism? A cross-sectional and a double-blind, placebo-controlled trial
    Mirjam Christ-Crain
    Division of Endocrinology, Diabetology, and Clinical Nutrition, University Hospitals, CH 4031 Basel, Switzerland
    Atherosclerosis 166:379-86. 2003
    ..In contrast to overt disease, only CRP, but not tHcy values, are affected in SCH, yet without significant improvement after L-thyroxine therapy...
  31. ncbi request reprint Limits to the use of the procalcitonin level as a diagnostic marker
    Beat Muller
    Clin Infect Dis 39:1867-8. 2004
  32. pmc Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study
    Mirjam Christ-Crain
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Crit Care 9:R816-24. 2005
    ..The aim of the present study was to evaluate the prognostic value of mid-regional pro-adrenomedullin (MR-proADM) levels in a cohort of medical intensive care patients and to compare it with other biomarkers and physiological scores...
  33. ncbi request reprint Procalictonin--you only find what you look for, and you only look for what you know
    Mirjam Christ-Crain
    J Am Geriatr Soc 54:546; author reply 547-8. 2006
  34. ncbi request reprint Procalcitonin guidance of antibiotic therapy in community-acquired pneumonia: a randomized trial
    Mirjam Christ-Crain
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    Am J Respir Crit Care Med 174:84-93. 2006
    ..In patients with community-acquired pneumonia, guidelines recommend antibiotic treatment for 7 to 21 d. Procalcitonin is elevated in bacterial infections, and its dynamics have prognostic implications...
  35. pmc Pro-adrenomedullin to predict severity and outcome in community-acquired pneumonia [ISRCTN04176397]
    Mirjam Christ-Crain
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Crit Care 10:R96. 2006
    ..A major cause of sepsis is community-acquired pneumonia (CAP). The aim of this study was to investigate the value of proADM levels for severity assessment and outcome prediction in CAP...
  36. ncbi request reprint Diagnostic value of signs, symptoms and laboratory values in lower respiratory tract infection
    Daiana Stolz
    Division of Pulmonary Medicine and Cell Research, University of Basel, Basel, Switzerland
    Swiss Med Wkly 136:434-40. 2006
    ..Using the outcome and microbiology findings as gold standard, we determined sensitivity, specificity, positive and negative predictive values of common used signs and symptoms of bacterial LRTI requiring antibiotic therapy...
  37. ncbi request reprint Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial
    Mirjam Christ-Crain
    Division of Pneumology, University Hospitals, Petersgraben 4, CH 4031 Basel, Switzerland
    Lancet 363:600-7. 2004
    ..We aimed to assess a procalcitonin-based therapeutic strategy to reduce antibiotic use in lower respiratory tract infections with a new rapid and sensitive assay...
  38. ncbi request reprint Circulating levels of soluble triggering receptor expressed on myeloid cells (sTREM)-1 in community-acquired pneumonia
    Beat Muller
    Crit Care Med 35:990-1. 2007
  39. ncbi request reprint What cardiologists do need to know about procalcitonin
    Christian Mueller
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Clin Lab 51:1-4. 2005
    ..49 (p < 0.001), as compared to the standard group. Thus, using a sensitive assay, procalcitonin-guidance substantially and safely reduced antibiotic usage in LRTI...
  40. ncbi request reprint Is there a clinical relevance of partial androgen deficiency of the aging male?
    Mirjam Christ-Crain
    Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, University Hospitals, Basel, Switzerland
    J Urol 172:624-7. 2004
    ..We investigate the association between various T measures and clinical and biochemical parameters of the aging male...
  41. ncbi request reprint Restoration of euthyroidism accelerates bone turnover in patients with subclinical hypothyroidism: a randomized controlled trial
    Christian Meier
    Division of Endocrinology, Department of Medicine, University Hospitals, CH 4031, Basel, Switzerland
    Osteoporos Int 15:209-16. 2004
    ..However, long-term studies are needed to confirm this assumption...
  42. doi request reprint Plasma pro-adrenomedullin but not plasma pro-endothelin predicts survival in exacerbations of COPD
    Daiana Stolz
    Clinic of Pneumology, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Chest 134:263-72. 2008
    ..We investigated whether plasma pro-endothelin-1 (proET-1) and/or pro-adrenomedullin (proADM) on admission to the hospital for acute exacerbation predict survival in patients with COPD...
  43. ncbi request reprint Impact of diabetes mellitus and metabolic disorders
    Matthias Turina
    Department of Surgery, Price Institute of Surgical Research, 511 South Floyd Street, MDR Building, Room 312, Louisville, KY 40202, USA
    Surg Clin North Am 85:1153-61, ix. 2005
    ....
  44. ncbi request reprint Human adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagon expressing cells
    Katharina Timper
    Department of Research, University Hospital, Basel, Switzerland
    Biochem Biophys Res Commun 341:1135-40. 2006
    ..Using quantitative PCR a down-regulation of ABCG2 and up-regulation of pancreatic developmental transcription factors Isl-1, Ipf-1, and Ngn3 were observed together with induction of the islet hormones insulin, glucagon, and somatostatin...
  45. ncbi request reprint Anterior and posterior pituitary function testing with simultaneous insulin tolerance test and a novel copeptin assay
    Mira Katan
    Department of Endocrinology, University Hospitals, Petersgraben 4, CH 4031 Basel, Switzerland
    J Clin Endocrinol Metab 92:2640-3. 2007
    ..However, AVP measurement is cumbersome. Copeptin, the stable C-terminal glycopeptide of the AVP prohormone, is stoichiometrically secreted from the posterior pituitary...
  46. ncbi request reprint Copeptin, a stable peptide of the arginine vasopressin precursor, is elevated in hemorrhagic and septic shock
    Nils G Morgenthaler
    Research Department, B R A H M S AG, Biotechnology Centre Hennigsdorf Berlin, Neuendorfstrasse 25, D 16761 Hennigsdorf bei Berlin, Germany
    Shock 28:219-26. 2007
    ..The availability of a reliable assay for the measurement of AVP release can also prove useful for the assessment of fluid and osmosis status in various diseases...
  47. pmc Copeptin: a new and promising diagnostic and prognostic marker
    Mira Katan
    Department of Endocrinology, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Crit Care 12:117. 2008
    ..Furthermore, vasopressin is an important hormone in salt and volume regulation. In this context, copeptin is also a diagnostic marker in patients with diabetes insipidus and in patients with disordered water states...