Mirjam Christ-Crain

Summary

Affiliation: University of Basel
Country: Switzerland

Publications

  1. pmc Hyponatremia and anti-diuretic hormone in Legionnaires' disease
    Philipp Schuetz
    Medical University Clinic, Kantonsspital Aarau, Aarau, Switzerland
    BMC Infect Dis 13:585. 2013
  2. pmc Pre-analytic factors and initial biomarker levels in community-acquired pneumonia patients
    Alexander Kutz
    University Department of Medicine, Tellstrasse, CH 5001 Kantonsspital Aarau, Switzerland
    BMC Anesthesiol 14:102. 2014
  3. pmc Copeptin is associated with mortality and outcome in patients with acute intracerebral hemorrhage
    Christian Zweifel
    Department of Neurosurgery, University Hospital of Basel, Spitalstrasse 21, 4031 Basel, Switzerland
    BMC Neurol 10:34. 2010
  4. pmc Enhancement of CURB65 score with proadrenomedullin (CURB65-A) for outcome prediction in lower respiratory tract infections: derivation of a clinical algorithm
    Werner C Albrich
    Medical University Department of the University of Basel, Kantonsspital Aarau, Switzerland
    BMC Infect Dis 11:112. 2011
  5. ncbi request reprint Biomarkers in the management of pneumonia
    Mirjam Christ Crain
    University Hospitals, Petersgraben 4, CH 4031 Basel, Switzerland
    Expert Rev Respir Med 2:565-72. 2008
  6. pmc Clinical review: the role of biomarkers in the diagnosis and management of community-acquired pneumonia
    Mirjam Christ-Crain
    Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Crit Care 14:203. 2010
  7. pmc Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia
    Beat Muller
    Departments of Internal Medicine, University Hospital, Petersgraben 4, CH 4031, Basel, Switzerland
    BMC Infect Dis 7:10. 2007
  8. ncbi request reprint Copeptin, C-reactive protein, and procalcitonin as prognostic biomarkers in acute exacerbation of COPD
    Daiana Stolz
    Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Chest 131:1058-67. 2007
  9. pmc Procalcitonin-guided antibiotic use versus a standard approach for acute respiratory tract infections in primary care: study protocol for a randomised controlled trial and baseline characteristics of participating general practitioners [ISRCTN73182671]
    Matthias Briel
    Basel Institute for Clinical Epidemiology, University Hospital Basel, CH 4031 Basel, Switzerland
    BMC Fam Pract 6:34. 2005
  10. pmc Pro-adrenomedullin to predict severity and outcome in community-acquired pneumonia [ISRCTN04176397]
    Mirjam Christ-Crain
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Crit Care 10:R96. 2006

Detail Information

Publications75

  1. pmc Hyponatremia and anti-diuretic hormone in Legionnaires' disease
    Philipp Schuetz
    Medical University Clinic, Kantonsspital Aarau, Aarau, Switzerland
    BMC Infect Dis 13:585. 2013
    ..We tested the hypothesis whether hyponatremia in patients with Legionnaires' disease would be caused by increased CT-ProVasopressin...
  2. pmc Pre-analytic factors and initial biomarker levels in community-acquired pneumonia patients
    Alexander Kutz
    University Department of Medicine, Tellstrasse, CH 5001 Kantonsspital Aarau, Switzerland
    BMC Anesthesiol 14:102. 2014
    ..How pre-analytic factors affect these markers' initial levels in this population is unknown...
  3. pmc Copeptin is associated with mortality and outcome in patients with acute intracerebral hemorrhage
    Christian Zweifel
    Department of Neurosurgery, University Hospital of Basel, Spitalstrasse 21, 4031 Basel, Switzerland
    BMC Neurol 10:34. 2010
    ..Copeptin, the C-terminal part of provasopressin, has emerged as a new prognostic marker in a variety of diseases, but its prognostic value in ICH is unknown...
  4. pmc Enhancement of CURB65 score with proadrenomedullin (CURB65-A) for outcome prediction in lower respiratory tract infections: derivation of a clinical algorithm
    Werner C Albrich
    Medical University Department of the University of Basel, Kantonsspital Aarau, Switzerland
    BMC Infect Dis 11:112. 2011
    ..We aimed to derive a practical algorithm combining the CURB65 score with ProADM-levels in patients with community-acquired pneumonia (CAP) and non-CAP-LRTI...
  5. ncbi request reprint Biomarkers in the management of pneumonia
    Mirjam Christ Crain
    University Hospitals, Petersgraben 4, CH 4031 Basel, Switzerland
    Expert Rev Respir Med 2:565-72. 2008
    ..Future studies will show whether an assessment with those novel biomarkers is able to guide prognostic decision-making and improve the allocation of healthcare resources and hospitalization costs...
  6. pmc Clinical review: the role of biomarkers in the diagnosis and management of community-acquired pneumonia
    Mirjam Christ-Crain
    Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Crit Care 14:203. 2010
    ..None should be used on its own; and none is anything more than an aid in the exercise of clinical judgment based upon a synthesis of available clinical, physiologic and laboratory features in each patient...
  7. pmc Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia
    Beat Muller
    Departments of Internal Medicine, University Hospital, Petersgraben 4, CH 4031, Basel, Switzerland
    BMC Infect Dis 7:10. 2007
    ..This study aims to evaluate the diagnostic and prognostic accuracy of clinical signs and symptoms and laboratory biomarkers for CAP...
  8. ncbi request reprint Copeptin, C-reactive protein, and procalcitonin as prognostic biomarkers in acute exacerbation of COPD
    Daiana Stolz
    Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Chest 131:1058-67. 2007
    ....
  9. pmc Procalcitonin-guided antibiotic use versus a standard approach for acute respiratory tract infections in primary care: study protocol for a randomised controlled trial and baseline characteristics of participating general practitioners [ISRCTN73182671]
    Matthias Briel
    Basel Institute for Clinical Epidemiology, University Hospital Basel, CH 4031 Basel, Switzerland
    BMC Fam Pract 6:34. 2005
    ..The aim of this trial is to compare a ProCT-guided antibiotic therapy with a standard approach based on evidence-based guidelines for patients with ARTI in primary care...
  10. pmc Pro-adrenomedullin to predict severity and outcome in community-acquired pneumonia [ISRCTN04176397]
    Mirjam Christ-Crain
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Crit Care 10:R96. 2006
    ..A major cause of sepsis is community-acquired pneumonia (CAP). The aim of this study was to investigate the value of proADM levels for severity assessment and outcome prediction in CAP...
  11. pmc Endothelin-1 precursor peptides correlate with severity of disease and outcome in patients with community acquired pneumonia
    Philipp Schuetz
    Department of Internal Medicine, University Hospital Basel, Switzerland
    BMC Infect Dis 8:22. 2008
    ..The objective of this study was to assess the diagnostic and prognostic value of proET-1 in a prospective cohort of mainly septic patients with community-acquired pneumonia...
  12. ncbi request reprint Antibiotic treatment of exacerbations of COPD: a randomized, controlled trial comparing procalcitonin-guidance with standard therapy
    Daiana Stolz
    Clinics of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland
    Chest 131:9-19. 2007
    ..We evaluated the efficacy and safety of procalcitonin guidance compared to standard therapy with antibiotic prescriptions in patients experiencing exacerbations of COPD...
  13. pmc Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections
    Philipp Schuetz
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Crit Care 14:R106. 2010
    ..Measurement of prohormones representing different pathophysiological pathways could enhance risk stratification in patients with community-acquired pneumonia (CAP) and other lower respiratory tract infections (LRTI)...
  14. ncbi request reprint Elevated C-reactive protein and homocysteine values: cardiovascular risk factors in hypothyroidism? A cross-sectional and a double-blind, placebo-controlled trial
    Mirjam Christ-Crain
    Division of Endocrinology, Diabetology, and Clinical Nutrition, University Hospitals, CH 4031 Basel, Switzerland
    Atherosclerosis 166:379-86. 2003
    ..In contrast to overt disease, only CRP, but not tHcy values, are affected in SCH, yet without significant improvement after L-thyroxine therapy...
  15. doi request reprint Procalcitonin levels predict bacteremia in patients with community-acquired pneumonia: a prospective cohort trial
    Fabian Müller
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
    Chest 138:121-9. 2010
    ..However, the yield of true-positive results is low. We investigated the benefit of procalcitonin (PCT) on hospital admission to predict blood culture positivity in CAP...
  16. doi request reprint Use of B-type natriuretic peptide in the risk stratification of acute exacerbations of COPD
    Daiana Stolz
    Clinic for Pneumology and Respiratory Cell Research, University Hospital Basel, Switzerland
    Chest 133:1088-94. 2008
    ..In patients with COPD, prognosis might be determined at least in part by the extent of cardiac stress induced by hypoxia and pulmonary arterial hypertension...
  17. doi request reprint Both inflammatory and classical lipolytic pathways are involved in lipopolysaccharide-induced lipolysis in human adipocytes
    Jean Grisouard
    Department of Biomedicine, Metabolism Group, University Hospital Basel, Basel, Switzerland
    Innate Immun 18:25-34. 2012
    ..In turn, LPS-induced lipolysis reinforces the expression of pro-inflammatory cytokines and, thereby, triggers its own lipolytic activity...
  18. doi request reprint Midregional proatrial natriuretic peptide predicts survival in exacerbations of COPD
    Maurizio Bernasconi
    Clinic of Pulmonary Medicine and Respiratory Cell Research, University Hospital Basel, Basel, Switzerland
    Chest 140:91-9. 2011
    ..We investigated whether midregional proatrial natriuretic peptide (MR-proANP) predicts survival in patients with COPD when they are admitted to the hospital for exacerbation...
  19. pmc Prognostic value of dehydroepiandrosterone-sulfate and other parameters of adrenal function in acute ischemic stroke
    Claudine A Blum
    Department of Endocrinology, Medical University Clinic, Cantonal Hospital, Aarau, Switzerland
    PLoS ONE 8:e63224. 2013
    ..Acute stroke has a high morbidity and mortality. We evaluated the predictive value of adrenal function testing in acute ischemic stroke...
  20. doi request reprint Guidance of antibiotic therapy with procalcitonin in lower respiratory tract infections: insights into the ProHOSP study
    Philipp Schuetz
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
    Virulence 1:88-92. 2010
    ..In lower respiratory tract infections, PCT guidance had a differential effect on antibiotic exposure depending on the underlying type and severity of respiratory tract infection...
  21. pmc Circulating precursor levels of endothelin-1 and adrenomedullin, two endothelium-derived, counteracting substances, in sepsis
    Philipp Schuetz
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Endothelium 14:345-51. 2007
    ..The ratio of the two counteracting peptides correlates with mortality and shows a prognostic accuracy to predict adverse outcome comparable to the APACHE II score...
  22. doi request reprint Glucose-dependent insulinotropic polypeptide induces cytokine expression, lipolysis, and insulin resistance in human adipocytes
    Katharina Timper
    Department of Biomedicine, University Hospital Basel, Basel, Switzerland
    Am J Physiol Endocrinol Metab 304:E1-13. 2013
    ..In conclusion, GIP induces an inflammatory and prolipolytic response via the PKA -NF-κB-IL-1 pathway and impairs insulin sensitivity of glucose uptake in human adipocytes...
  23. pmc Copeptin, procalcitonin and routine inflammatory markers-predictors of infection after stroke
    Felix Fluri
    Department of Neurology, University Hospital Basel, Basel, Switzerland
    PLoS ONE 7:e48309. 2012
    ..Early predictors for the development of stroke-associated infection may identify patients at high risk and reduce post-stroke infection and mortality...
  24. doi request reprint The use of copeptin, the stable peptide of the vasopressin precursor, in the differential diagnosis of sodium imbalance in patients with acute diseases
    Nicole Nigro
    Department of Endocrinology, University Hospital Basel, Basel, CH, Switzerland
    Swiss Med Wkly 141:w13270. 2011
    ..This study assessed copeptin concentrations in sick patients with serum sodium imbalance of different aetiology on admission to the emergency department...
  25. doi request reprint Midregional pro-atrial natriuretic peptide and outcome in patients with acute ischemic stroke
    Mira Katan
    Department of Endocrinology, University Hospital Basel, Basel, Switzerland
    J Am Coll Cardiol 56:1045-53. 2010
    ..The purpose of this study was to examine the prognostic value of midregional pro-atrial natriuretic peptide (MR-proANP) in patients with acute ischemic stroke...
  26. ncbi request reprint What cardiologists do need to know about procalcitonin
    Christian Mueller
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Clin Lab 51:1-4. 2005
    ..49 (p < 0.001), as compared to the standard group. Thus, using a sensitive assay, procalcitonin-guidance substantially and safely reduced antibiotic usage in LRTI...
  27. ncbi request reprint Prolactin dysregulation in women with subclinical hypothyroidism: effect of levothyroxine replacement therapy
    Christian Meier
    Division of Endocrinology, Diabetology, and Clinical Nutrition, Department of Internal Medicine, University Hospitals, Basel, Switzerland
    Thyroid 13:979-85. 2003
    ....
  28. pmc Association of adrenal function and disease severity in community-acquired pneumonia
    Cornelia Mueller
    Department of Endocrinology, Diabetology and Metabolism, UniversityHospital, Basel, Switzerland
    PLoS ONE 9:e99518. 2014
    ..We herein validated the prognostic value of the adrenal hormones DHEA, DHEA-Sulfate (DHEAS), cortisol/DHEA-, cortisol/DHEAS- and DHEA/DHEAS-ratios in patients with CAP...
  29. pmc Predictors for length of hospital stay in patients with community-acquired pneumonia: results from a Swiss multicenter study
    Isabelle Suter-Widmer
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland
    BMC Pulm Med 12:21. 2012
    ..Accurate estimation of LOS on admission and during follow-up may result in earlier and more efficient discharge strategies...
  30. ncbi request reprint Pancreatic stone protein predicts positive sputum bacteriology in exacerbations of COPD
    Andreas Scherr
    Clinic of Pulmonary Medicine and Respiratory Cell Research, Diabetes and Clinical Nutrition, University Hospital, Basel, Switzerland
    Chest 143:379-87. 2013
    ..Pancreatic stone protein/regenerating protein (PSP/reg) serum levels are supposed to be increased in bacterial inflammation. PSP/reg levels also might be useful, therefore, as a predictor of bacterial infection in COPD...
  31. pmc Mannose-binding lectin deficiency is associated with smaller infarction size and favorable outcome in ischemic stroke patients
    Michael Osthoff
    Laboratory of Clinical Immunology, Department of Biomedicine and Clinic for Internal Medicine, University Hospital Basel, Basel, Switzerland
    PLoS ONE 6:e21338. 2011
    ....
  32. doi request reprint Role of calcium in lipopolysaccharide-induced calcitonin gene expression in human adipocytes
    Tanja M Radimerski
    Department of Biomedicine, University Hospital Basel, Basel, Switzerland
    Innate Immun 17:403-13. 2011
    ....
  33. pmc Procalcitonin guided antibiotic therapy and hospitalization in patients with lower respiratory tract infections: a prospective, multicenter, randomized controlled trial
    Philipp Schuetz
    Department of Internal Medicine, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, Basel, Switzerland
    BMC Health Serv Res 7:102. 2007
    ....
  34. doi request reprint Copeptin: a novel, independent prognostic marker in patients with ischemic stroke
    Mira Katan
    Department of Endocrinology, University Hospital Basel, Switzerland
    Ann Neurol 66:799-808. 2009
    ..Vasopressin is a stress hormone. Its production rate is mirrored in circulating levels of copeptin, a fragment of provasopressin. We evaluated the prognostic value of copeptin in acute stroke patients...
  35. doi request reprint Glucose-dependent insulinotropic polypeptide (GIP) induces calcitonin gene-related peptide (CGRP)-I and procalcitonin (Pro-CT) production in human adipocytes
    Katharina Timper
    University Hospital Basel, Department of Biomedicine, Metabolism Group, Hebelstrasse 20, CH 4031 Basel, Switzerland
    J Clin Endocrinol Metab 96:E297-303. 2011
    ..Adipocytes express functional GIP receptors and the CT peptides Pro-CT and CGRP-I. However, a link between GIP and CT peptides has not been studied yet...
  36. pmc Which patients with lower respiratory tract infections need inpatient treatment? Perceptions of physicians, nurses, patients and relatives
    Claudia Baehni
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    BMC Pulm Med 10:12. 2010
    ..This survey analyzed perceptions of physicians, nurses, patients and relatives about feasibility of outpatient management and required duration of hospital stay...
  37. doi request reprint Low triiodothyronine syndrome: a prognostic marker for outcome in sepsis?
    Stefanie Meyer
    Department of Internal Medicine, Division of Endocrinology Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
    Endocrine 39:167-74. 2011
    ..04 and P = 0.02). T3 and fT4 levels on admission were not prognostic in this cohort of critically ill patients. A decrease in fT4 levels in the course of disease, however, may point to adverse outcome...
  38. doi request reprint Dexamethasone suppression test predicts later development of an impaired adrenal function after a 14-day course of prednisone in healthy volunteers
    Stefanie Neidert
    Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Eur J Endocrinol 162:943-9. 2010
    ..Identification of patients at risk is of clinical importance. We hypothesized that the dexamethasone suppression test predicts the development of corticosteroid-induced impaired adrenal function...
  39. doi request reprint Adjunct prednisone therapy for patients with community-acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial
    Claudine Angela Blum
    Endocrinology, Diabetology and Metabolism, Department of Internal Medicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland Medical University Clinic, Departments of Internal and Emergency Medicine and Department of Endocrinology, Diabetology and Clinical Nutrition, Kantonsspital Aarau, Aarau, Switzerland
    Lancet 385:1511-8. 2015
    ..We assessed whether short-term corticosteroid treatment reduces time to clinical stability in patients admitted to hospital for community-acquired pneumonia...
  40. doi request reprint MR-pro-atrial natriuretic peptide (MR-proANP) predicts short- and long-term outcomes in respiratory tract infections: a prospective validation study
    Miriam Vazquez
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Switzerland
    Int J Cardiol 156:16-23. 2012
    ..This study aims to validate these findings and describe patterns of MR-proANP in a large cohort of patients with lower respiratory tract infections...
  41. pmc Effect of a 14-day course of systemic corticosteroids on the hypothalamic-pituitary-adrenal-axis in patients with acute exacerbation of chronic obstructive pulmonary disease
    Philipp Schuetz
    Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    BMC Pulm Med 8:1. 2008
    ....
  42. doi request reprint Long-term stability of procalcitonin in frozen samples and comparison of Kryptor and VIDAS automated immunoassays
    Philipp Schuetz
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Clin Biochem 43:341-4. 2010
    ..To assess long-term stability of PCT in deep-frozen samples and assess whether Kryptor procalcitonin cutoff ranges can be transferred on the bioMérieux VIDAS system...
  43. pmc Corticosteroid treatment for community-acquired pneumonia--the STEP trial: study protocol for a randomized controlled trial
    Claudine A Blum
    Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Trials 15:257. 2014
    ..Available studies show controversial results, and the question about benefits and harms of adjunct corticosteroid therapy has not been conclusively resolved, particularly in the non-critical care setting...
  44. pmc BNP but Not s-cTnln is associated with cardioembolic aetiology and predicts short and long term prognosis after cerebrovascular events
    Nicole Nigro
    Department of Endocrinology, University Hospital Basel, Basel, Switzerland Department of Clinical Research, University Hospital Basel, Basel, Switzerland
    PLoS ONE 9:e102704. 2014
    ..We analyzed the prognostic value of b-type natriuretic peptide (BNP) and sensitive cardiac Troponin (s-cTnI) in patients with ischemic stroke or transient ischemic attack (TIA) and their significance in predicting stroke aetiology...
  45. ncbi request reprint Anterior and posterior pituitary function testing with simultaneous insulin tolerance test and a novel copeptin assay
    Mira Katan
    Department of Endocrinology, University Hospitals, Petersgraben 4, CH 4031 Basel, Switzerland
    J Clin Endocrinol Metab 92:2640-3. 2007
    ..However, AVP measurement is cumbersome. Copeptin, the stable C-terminal glycopeptide of the AVP prohormone, is stoichiometrically secreted from the posterior pituitary...
  46. ncbi request reprint Outcome of radioiodine therapy without, on or 3 days off carbimazole: a prospective interventional three-group comparison
    Martin A Walter
    Institute of Nuclear Medicine, University Hospital, Petersgraben 4, 4031, Basel, Switzerland
    Eur J Nucl Med Mol Imaging 33:730-7. 2006
    ..By generating three groups with comparable radioiodine uptake, we also investigated whether the effect of carbimazole depends on the radioiodine uptake...
  47. doi request reprint Direct comparison of three natriuretic peptides for prediction of short- and long-term mortality in patients with community-acquired pneumonia
    Albina Nowak
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Chest 141:974-82. 2012
    ..Early and accurate risk stratification for patients with community-acquired pneumonia (CAP) is an unmet clinical need...
  48. doi request reprint Symptoms and characteristics of individuals with profound hyponatremia: a prospective multicenter observational study
    Nicole Nigro
    Clinic of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland Department of Clinical Research, University Hospital Basel, Basel, Switzerland
    J Am Geriatr Soc 63:470-5. 2015
    ..To assess symptoms and characteristics of hyponatremia, the most common electrolyte disturbance in hospitalized individuals and a condition that is associated with substantial morbidity and mortality...
  49. pmc Copeptin: a new and promising diagnostic and prognostic marker
    Mira Katan
    Department of Endocrinology, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Crit Care 12:117. 2008
    ..Furthermore, vasopressin is an important hormone in salt and volume regulation. In this context, copeptin is also a diagnostic marker in patients with diabetes insipidus and in patients with disordered water states...
  50. ncbi request reprint Biomarkers to improve diagnostic and prognostic accuracy in systemic infections
    Philipp Schuetz
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Curr Opin Crit Care 13:578-85. 2007
    ..We review the advantages and drawbacks of biomarkers in the diagnostic and prognostic assessment of systemic infections...
  51. ncbi request reprint Changes in plasma copeptin, the c-terminal portion of arginine vasopressin during water deprivation and excess in healthy subjects
    Gabor Szinnai
    Division of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital, CH 4031 Basel, Switzerland
    J Clin Endocrinol Metab 92:3973-8. 2007
    ..Copeptin is the C-terminal part of provasopressin and has been shown to be a useful tool to indicate AVP concentration in critically ill patients...
  52. pmc Copeptin levels remain unchanged during the menstrual cycle
    Claudine A Blum
    Endocrinology, Medical University Clinic, Kantonsspital Aarau, Aarau, Switzerland Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
    PLoS ONE 9:e98240. 2014
    ..We investigated copeptin during the menstrual cycle and its relationship to sex hormones, markers of subclinical inflammation and estimates of body fluid...
  53. pmc Isolated insular strokes and plasma MR-proANP levels are associated with newly diagnosed atrial fibrillation: a pilot study
    Karl Frontzek
    Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland Department of Neurology, University Hospital Basel, Basel, Switzerland
    PLoS ONE 9:e92421. 2014
    ..In this study, we assessed the relationship of insular strokes and plasma MR-proANP levels with newly diagnosed atrial fibrillation (NDAF)...
  54. pmc Targeting AMP-activated protein kinase in adipocytes to modulate obesity-related adipokine production associated with insulin resistance and breast cancer cell proliferation
    Jean Grisouard
    Department of Biomedicine, University Hospital Basel, Basel, CH 4031, Switzerland
    Diabetol Metab Syndr 3:16. 2011
    ..abstract:..
  55. ncbi request reprint Restoration of euthyroidism accelerates bone turnover in patients with subclinical hypothyroidism: a randomized controlled trial
    Christian Meier
    Division of Endocrinology, Department of Medicine, University Hospitals, CH 4031, Basel, Switzerland
    Osteoporos Int 15:209-16. 2004
    ..However, long-term studies are needed to confirm this assumption...
  56. ncbi request reprint Serum estradiol after single dose hCG administration correlates with Leydig cell reserve in hypogonadal men: reassessment of the hCG stimulation test
    Christian Meier
    Clinic for Endocrinology, Diabetology and Clinical Nutrition, University Hospital, Basel, Switzerland
    Clin Lab 51:509-15. 2005
    ..Assessment of E2 increments would render the test procedure more practical, less time-consuming and more cost-effective than assessing peak T levels after 72 hours...
  57. ncbi request reprint Free and total cortisol levels as predictors of severity and outcome in community-acquired pneumonia
    Mirjam Christ-Crain
    Department of Endocrinology, William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, United Kingdom
    Am J Respir Crit Care Med 176:913-20. 2007
    ..The predictive value of cortisol in pneumonia is unknown. Routinely available assays measure serum total cortisol (TC) and not free cortisol (FC). Whether FC concentrations better reflect outcome is uncertain...
  58. pmc Clinical predictors for Legionella in patients presenting with community-acquired pneumonia to the emergency department
    Rico Fiumefreddo
    Department of Internal Medicine, Kantonsspital Aarau, Tellstrasse, CH 5001 Aarau, Switzerland
    BMC Pulm Med 9:4. 2009
    ..Accurate clinical predictors to assess the likelihood of Legionella community-acquired pneumonia (CAP) in patients presenting to the emergency department are lacking...
  59. doi request reprint Diagnostic Accuracy of Copeptin in the Differential Diagnosis of the Polyuria-polydipsia Syndrome: A Prospective Multicenter Study
    Katharina Timper
    Clinic of Endocrinology, Diabetes and Metabolism, Department of Clinical Research K T, N F, M C C, University Hospital Basel, CH 4031 Basel, Switzerland Integrated Research and Treatment Center for Adiposity Diseases W F, Leipzig University Medical Center, 04103 Leipzig, Germany Division of Endocrinology, Diabetes and Clinical Nutrition F K, C S, University Hospital Bern Inselspital, CH 3010 Bern, Switzerland Department of Internal Medicine B Ar, Spital Rheinfelden, CH 4310 Rheinfelden, Switzerland University Clinic of Internal Medicine J R, Kantonsspital Baselland, CH 4101 Binningen, Switzerland Division of Endocrinology, Metabolism and Molecular Medicine and Center for Genetic Medicine P K, Northwestern University, Chicago, Illinois 60611 Department of Internal Medicine I, Endocrine and Diabetes Unit B Al, University Hospital Wurzburg, 97080 Wurzburg, Germany Division of Endocrinology, Diabetology and Metabolism, Medical University Clinic B M, Kantonsspital Aarau, CH 5001 Aarau, Switzerland and Department of Neurology M K, Department of Molecular Biology
    J Clin Endocrinol Metab 100:2268-74. 2015
    ..The diagnostic "gold standard" is the water deprivation test with assessment of arginine vasopressin (AVP) activity. However, test interpretation and AVP measurement are challenging...
  60. doi request reprint Copeptin concentrations during psychological stress: the PsyCo study
    Judith Siegenthaler
    Clinic of EndocrinologyDiabetology, and Metabolism, University Hospital Basel, Petersgraben 4, Basel CH 4031, SwitzerlandDepartment of Internal MedicineKantonsspital Aarau, Tellstrasse, Aaraun CH 5001, Switzerland
    Eur J Endocrinol 171:737-42. 2014
    ..Whether copeptin concentration increases upon psychological stress is unknown. We investigated psychological stress effects on copeptin secretion in healthy volunteers and patients with central diabetes insipidus (DI)...
  61. doi request reprint Plasma pro-adrenomedullin but not plasma pro-endothelin predicts survival in exacerbations of COPD
    Daiana Stolz
    Clinic of Pneumology, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Chest 134:263-72. 2008
    ..We investigated whether plasma pro-endothelin-1 (proET-1) and/or pro-adrenomedullin (proADM) on admission to the hospital for acute exacerbation predict survival in patients with COPD...
  62. pmc Concentrations of the stress hormone copeptin increase upon hypoglycaemia in patients with type 1 diabetes dependent of hypoglycaemia awareness
    Eleonora Seelig
    Department of Diabetology, Endocrinology and Metabolism, University Hospital Basel, Basel, Switzerland
    PLoS ONE 8:e72876. 2013
    ..The aim of this study was to investigate whether copeptin increases upon hypoglycaemia in patients with type 1 diabetes mellitus and is associated with the degree of hypoglycaemia awareness...
  63. pmc Effects of antithyroid drugs on radioiodine treatment: systematic review and meta-analysis of randomised controlled trials
    Martin A Walter
    Institute of Nuclear Medicine, University Hospital Basel, Switzerland
    BMJ 334:514. 2007
    ..To determine the effect of adjunctive antithyroid drugs on the risk of treatment failure, hypothyroidism, and adverse events after radioiodine treatment...
  64. ncbi request reprint Somatostatin is expressed and secreted by human adipose tissue upon infection and inflammation
    Dalma Seboek
    Department of Research, University Hospitals, Hebelstrasse 20, CH 4031 Basel, Switzerland
    J Clin Endocrinol Metab 89:4833-9. 2004
    ..It is tempting to speculate that visceral adipose tissue-derived SRIF plays a modulatory role in the immunological and metabolic response to inflammation...
  65. ncbi request reprint Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial
    Mirjam Christ-Crain
    Division of Pneumology, University Hospitals, Petersgraben 4, CH 4031 Basel, Switzerland
    Lancet 363:600-7. 2004
    ..We aimed to assess a procalcitonin-based therapeutic strategy to reduce antibiotic use in lower respiratory tract infections with a new rapid and sensitive assay...
  66. doi request reprint Copeptin as a stress marker prior and after a written examination--the CoEXAM study
    Sandrine A Urwyler
    Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
    Stress 18:134-7. 2015
    ..Higher cortisol levels, but not copeptin, correlated with a better academic performance in this cohort of students...
  67. ncbi request reprint Copeptin, a stable peptide derived from the vasopressin precursor, correlates with the individual stress level
    Mira Katan
    Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
    Neuro Endocrinol Lett 29:341-6. 2008
    ..Copeptin is a more stable peptide stoichiometrically released from the same precursor molecule. The aim of our study was to compare copeptin and cortisol levels in different stress situations...
  68. doi request reprint Circulating levels of GH predict mortality and complement prognostic scores in critically ill medical patients
    Philipp Schuetz
    Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Internal Medicine, Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland
    Eur J Endocrinol 160:157-63. 2009
    ..We assessed the prognostic implications of GH on admission and during follow-up in critically ill adult patients admitted to a medical intensive care unit...
  69. ncbi request reprint Is there a clinical relevance of partial androgen deficiency of the aging male?
    Mirjam Christ-Crain
    Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, University Hospitals, Basel, Switzerland
    J Urol 172:624-7. 2004
    ..We investigate the association between various T measures and clinical and biochemical parameters of the aging male...
  70. doi request reprint Copeptin in the diagnosis of vasopressin-dependent disorders of fluid homeostasis
    Mirjam Christ-Crain
    Department of Endocrinology, University Hospital Basel, University of Basel, Petersgraben 4, Basel CH 4031, Switzerland
    Nat Rev Endocrinol 12:168-76. 2016
    ....
  71. doi request reprint Copeptin levels are independent of ingested nutrient type after standardised meal administration--the CoMEAL study
    Carla Walti
    Division of Endocrinology, Diabetology, and Metabolism, University Hospital, Basel, Switzerland
    Biomarkers 19:557-62. 2014
    ..To clarify ambiguous published data, we determined whether standardized nutrient intake influences serum copeptin concentrations...
  72. doi request reprint Potential role of blood biomarkers in the management of nontraumatic intracerebral hemorrhage
    Rebecca Senn
    Department of Endocrinology, University Hospital Basel, Basel, Switzerland
    Cerebrovasc Dis 38:395-409. 2014
    ..This paper provides an overview on the most promising blood biomarkers and their potential role in the diagnosis and management of spontaneous ICH...
  73. doi request reprint Procalcitonin-guided antibiotic use vs a standard approach for acute respiratory tract infections in primary care
    Matthias Briel
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Arch Intern Med 168:2000-7; discussion 2007-8. 2008
    ..We consider whether antibiotic therapy guided by procalcitonin reduces the use of antibiotics without increasing the restrictions experienced by patients by more than 1 day...
  74. pmc Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study
    Mirjam Christ-Crain
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Crit Care 9:R816-24. 2005
    ..The aim of the present study was to evaluate the prognostic value of mid-regional pro-adrenomedullin (MR-proADM) levels in a cohort of medical intensive care patients and to compare it with other biomarkers and physiological scores...
  75. doi request reprint Mechanisms of metformin action on glucose transport and metabolism in human adipocytes
    Jean Grisouard
    Department of Biomedicine, Metabolism Group, Div of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, CH 4031 Basel, Switzerland
    Biochem Pharmacol 80:1736-45. 2010
    ..In addition, metformin induced glucose oxidation. In conclusion, activation of AMPKα1 without impairment of cell respiration is crucial for metformin-mediated increase in GLUT-4 protein content and glucose uptake in human adipocytes...