Genomes and Genes
Affiliation: University of Bern
- How do fibroblasts translate mechanical signals into changes in extracellular matrix production?Matthias Chiquet
ITI Research Institute for Dental and Skeletal Biology, University of Bern, P O Box 54, Switzerland
Matrix Biol 22:73-80. 2003..In the case of the tenascin-C gene, different promoter elements might be involved in induction by cyclic stretch. Thus, different mechanical signals seem to regulate distinct ECM genes in complex ways...
- Gene regulation by mechanotransduction in fibroblastsMatthias Chiquet
ITI Research Institute for Dental and Skeletal Biology, University of Bern, Murtenstrasse 35, CH 3010 Bern, Switzerland
Appl Physiol Nutr Metab 32:967-73. 2007..Thus, RhoA/ROCK-controlled actin dynamics are required for the induction of specific ECM genes by mechanical stress. These findings have implications for the understanding of regeneration and for tissue engineering...
- Induction of tenascin-C by cyclic tensile strain versus growth factors: distinct contributions by Rho/ROCK and MAPK signaling pathwaysMatthias Chiquet
ITI Research Institute for Dental and Skeletal Biology, University of Bern, Murtenstrasse 35, P O Box 54, CH 3010 Bern, Switzerland
Biochim Biophys Acta 1693:193-204. 2004..The data suggest that regulation of tenascin-C in fibroblasts by cyclic strain occurs independently from soluble mediators and MAPK pathways; however, it requires Rho/ROCK signaling...
- Role of RhoA/ROCK-dependent actin contractility in the induction of tenascin-C by cyclic tensile strainAna Sarasa-Renedo
ITI Research Institute for Dental and Skeletal Biology, University of Bern, Murtenstrasse 35, P O Box 54, Switzerland
Exp Cell Res 312:1361-70. 2006..Previous RhoA/ROCK activation, either by chemical or mechanical signals, might render fibroblasts more sensitive to external tensile stress, e.g., during wound healing...
- Cleavage of extracellular matrix in periodontitis: gingipains differentially affect cell adhesion activities of fibronectin and tenascin-CSabrina Ruggiero
Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Switzerland
Biochim Biophys Acta 1832:517-26. 2013..We conclude that cleavage by gingipains directly affects the biological activity of both fibronectin and tenascin-C in a manner that might lead to increased cell detachment and loss during periodontal disease...
- Tensile stress-dependent collagen XII and fibronectin production by fibroblasts requires separate pathwaysMartin Fluck
M E Müller Institute for Biomechanics, University of Bern, Bern, Switzerland
Biochim Biophys Acta 1593:239-48. 2003....
- From mechanotransduction to extracellular matrix gene expression in fibroblastsMatthias Chiquet
Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, CH 4058, Basel, Switzerland
Biochim Biophys Acta 1793:911-20. 2009..As assembly lines for diverse signaling pathways, matrix adhesion contacts are now recognized as the major sites of crosstalk between mechanical and chemical stimuli, with important consequences for cell growth and differentiation...
- Electron microscopy of high pressure frozen samples: bridging the gap between cellular ultrastructure and atomic resolutionDaniel Studer
Institute for Anatomy, University of Bern, Baltzerstr 2, 3000, Bern 9, Switzerland
Histochem Cell Biol 130:877-89. 2008..High pressure freezing of tissue is the base which may lead to precise models of macromolecular assemblies in situ, and thus to a better understanding of the function of complex cellular structures...
- Transient induction of cyclin A in loaded chicken skeletal muscleMartin Fluck
Dept of Anatomy, Univ of Bern, Buhlstrasse 26, 3000 Bern 9, Switzerland
J Appl Physiol (1985) 95:1664-71. 2003....
- Cell shape-dependent early responses of fibroblasts to cyclic strainNeha Gadhari
Department of Orthodontics and Dentofacial Orthopaedics, University of Bern, Switzerland
Biochim Biophys Acta 1833:3415-25. 2013..We conclude that integrin-mediated responses to external mechanical strain are differentially modulated in cells that have the same spreading area but different geometries, and do not only depend on mere cell size. ..
- Tenascin-C and matrix metalloproteinase-9 levels in crevicular fluid of teeth and implantsCeyda Ozçakir-Tomruk
Department of Prosthodontics, School of Dentistry, University of Bern, Bern, Switzerland
Clin Implant Dent Relat Res 14:672-81. 2012..The role of and interaction between bacterial infection and biomechanical impact in the development of peri-implant inflammatory processes is not clear...
- Identification of a fibronectin interaction site in the extracellular matrix protein ameloblastinMichael Beyeler
Department of Clinical Research, University of Bern, Bern, Switzerland
Exp Cell Res 316:1202-12. 2010..The recruited fibronectin should then promote cell adhesion on the implant surface, thereby accelerating osseointegration of the implant...
- Reloading of atrophied rat soleus muscle induces tenascin-C expression around damaged muscle fibersMartin Fluck
M E Müller Institute for Biomechanics, Department of Anatomy, University of Bern, 3000 Bern 9, Switzerland
Am J Physiol Regul Integr Comp Physiol 284:R792-801. 2003..The observations demonstrate that an unaccustomed increase of rat soleus muscle loading causes modification of the basement membrane of damaged muscle fibers through ectopic endomysial expression of tenascin-C...
- Tenascin-C induction by cyclic strain requires integrin-linked kinaseSilke Maier
Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, CH 4058 Basel, Switzerland
Biochim Biophys Acta 1783:1150-62. 2008..Our results indicate that ILK is selectively required for the induction of specific genes by mechanical stimulation via RhoA-mediated pathways...
- Ectopic expression of tenascin-CMatthias Chiquet
J Cell Sci 116:3851; author reply 3851-3; discussion 3853. 2003
- Tenascins: regulation and putative functions during pathological stressRuth Chiquet-Ehrismann
Friedrich Miescher Institute, Novartis Research Foundation, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
J Pathol 200:488-99. 2003....
- Collagen XII interacts with avian tenascin-X through its NC3 domainGuido Veit
Center for Biochemistry, Department of Dermatology, Medical Faculty, University of Cologne, D 50931 Cologne, Germany, and Shriners Hospital for Children Research Center, Portland, Oregon 97239, USA
J Biol Chem 281:27461-70. 2006..On the ultrastructural level, detection of collagen XII and tenascin-X by immunogold labeling confirmed this finding...