Henri Bounameaux

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi The challenge of diagnosing pulmonary embolism in elderly patients: influence of age on commonly used diagnostic tests and strategies
    Marc Righini
    Division of Angiology and Hemostasis, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
    J Am Geriatr Soc 53:1039-45. 2005
  2. doi The novel anticoagulants: entering a new era
    H Bounameaux
    Division of Angiology and Hemostasis, Department of Internal Medicine, University Hospitals of Geneva and Faculty of Medicine, Geneva, Switzerland
    Swiss Med Wkly 139:60-4. 2009
  3. ncbi Is laboratory monitoring of low-molecular-weight heparin therapy necessary? No
    H Bounameaux
    Division of Angiology and Hemostasis, Department of Internal Medicine, University Hospital of Geneva, Geneva, Switzerland
    J Thromb Haemost 2:551-4. 2004
  4. ncbi Diagnosis of pulmonary embolism: in transition
    Henri Bounameaux
    Division of Angiology and Hemostasis, Department of Internal Medicine, University Hospital of Geneva, CH 1211 Geneva 14, Switzerland
    Curr Opin Hematol 13:344-50. 2006
  5. ncbi Diagnostic approaches to suspected deep vein thrombosis and pulmonary embolism
    Henri Bounameaux
    Division of Angiology and Hemostasis, Department of Internal Medicine, University Hospital of Geneva, Geneva, Switzerland
    Hematol J 4:97-103. 2003
  6. ncbi Fondaparinux: a new synthetic pentasaccharide for thrombosis prevention
    Henri Bounameaux
    Division of Angiology and Haemostasis, Department of Internal Medicine and Institute for Social and Preventive Medicine, University Hospitals of Geneva, 1211 Geneva 14, Switzerland
    Lancet 359:1710-1. 2002
  7. doi Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study
    Marc Righini
    Division of Angiology and Hemostasis, Geneva University Hospital, Geneva, Switzerland
    JAMA 311:1117-24. 2014
  8. ncbi Comparison of four strategies for diagnosing deep vein thrombosis: a cost-effectiveness analysis
    N Perone
    Medical Clinic 2 (NP, Department of Medicine, Geneva University Hospital, Geneva, Switzerland
    Am J Med 110:33-40. 2001
  9. doi Diagnosis of pulmonary embolism by multidetector CT alone or combined with venous ultrasonography of the leg: a randomised non-inferiority trial
    Marc Righini
    Division of Angiology and Hemostasis, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
    Lancet 371:1343-52. 2008
  10. ncbi Clinical usefulness of D-dimer testing in cancer patients with suspected pulmonary embolism
    Marc Righini
    Division of Angiology and Hemostasis, Department of Internal Medicine, Geneva University Hospital and Faculty of Medicine, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
    Thromb Haemost 95:715-9. 2006

Collaborators

Detail Information

Publications111 found, 100 shown here

  1. ncbi The challenge of diagnosing pulmonary embolism in elderly patients: influence of age on commonly used diagnostic tests and strategies
    Marc Righini
    Division of Angiology and Hemostasis, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
    J Am Geriatr Soc 53:1039-45. 2005
    ..Therefore, a rational diagnostic approach to PE in older people should rest mainly on the sequential use of those tests that have demonstrated strong diagnostic yield, accuracy, and safety in this population...
  2. doi The novel anticoagulants: entering a new era
    H Bounameaux
    Division of Angiology and Hemostasis, Department of Internal Medicine, University Hospitals of Geneva and Faculty of Medicine, Geneva, Switzerland
    Swiss Med Wkly 139:60-4. 2009
    ....
  3. ncbi Is laboratory monitoring of low-molecular-weight heparin therapy necessary? No
    H Bounameaux
    Division of Angiology and Hemostasis, Department of Internal Medicine, University Hospital of Geneva, Geneva, Switzerland
    J Thromb Haemost 2:551-4. 2004
  4. ncbi Diagnosis of pulmonary embolism: in transition
    Henri Bounameaux
    Division of Angiology and Hemostasis, Department of Internal Medicine, University Hospital of Geneva, CH 1211 Geneva 14, Switzerland
    Curr Opin Hematol 13:344-50. 2006
    ..To discuss reports published in 2005 on the diagnosis of clinically suspected nonmassive pulmonary embolism...
  5. ncbi Diagnostic approaches to suspected deep vein thrombosis and pulmonary embolism
    Henri Bounameaux
    Division of Angiology and Hemostasis, Department of Internal Medicine, University Hospital of Geneva, Geneva, Switzerland
    Hematol J 4:97-103. 2003
    ....
  6. ncbi Fondaparinux: a new synthetic pentasaccharide for thrombosis prevention
    Henri Bounameaux
    Division of Angiology and Haemostasis, Department of Internal Medicine and Institute for Social and Preventive Medicine, University Hospitals of Geneva, 1211 Geneva 14, Switzerland
    Lancet 359:1710-1. 2002
  7. doi Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study
    Marc Righini
    Division of Angiology and Hemostasis, Geneva University Hospital, Geneva, Switzerland
    JAMA 311:1117-24. 2014
    ..D-dimer measurement is an important step in the diagnostic strategy of clinically suspected acute pulmonary embolism (PE), but its clinical usefulness is limited in elderly patients...
  8. ncbi Comparison of four strategies for diagnosing deep vein thrombosis: a cost-effectiveness analysis
    N Perone
    Medical Clinic 2 (NP, Department of Medicine, Geneva University Hospital, Geneva, Switzerland
    Am J Med 110:33-40. 2001
    ..Serial ultrasonography is less cost-effective...
  9. doi Diagnosis of pulmonary embolism by multidetector CT alone or combined with venous ultrasonography of the leg: a randomised non-inferiority trial
    Marc Righini
    Division of Angiology and Hemostasis, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
    Lancet 371:1343-52. 2008
    ..We compared this combination with a strategy in which both a negative venous ultrasonography of the leg and MSCT were needed to exclude pulmonary embolism...
  10. ncbi Clinical usefulness of D-dimer testing in cancer patients with suspected pulmonary embolism
    Marc Righini
    Division of Angiology and Hemostasis, Department of Internal Medicine, Geneva University Hospital and Faculty of Medicine, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
    Thromb Haemost 95:715-9. 2006
    ..Increasing the cut-off value of D-dimer in cancer patients might increase the test's clinical usefulness...
  11. doi Diagnosis of venous thromboembolism: an update
    Henri Bounameaux
    Division of Angiology and Hemostasis, Department of Internal Medicine, University Hospitals of Geneva and Faculty of Medicine, Geneva, Switzerland
    Vasc Med 15:399-406. 2010
    ..This review gives a critical appraisal of the sequential steps of the diagnostic work-up in suspected DVT or PE...
  12. doi Prognostic value of the Geneva prediction rule in patients with pulmonary embolism
    Laurent Bertoletti
    Division of Angiology and Haemostasis, Department of Internal Medicine, Geneva Faculty of Medicine, University of Geneva, CH 1211 Geneva, Switzerland
    Thromb Res 132:32-6. 2013
    ..Some items of the Geneva prediction rule may have a prognostic value. We analyzed whether the initial probability assessed by the Geneva rule was associated with the outcome of patients with PE...
  13. ncbi Clinical usefulness of D-dimer depending on clinical probability and cutoff value in outpatients with suspected pulmonary embolism
    Marc Righini
    Division of Angiology and Hemostasis, Geneva University Hospital, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Arch Intern Med 164:2483-7. 2004
    ....
  14. ncbi Multidetector-row computed tomography in suspected pulmonary embolism
    Arnaud Perrier
    Service of General Internal Medicine, Geneva Faculty of Medicine and Geneva University Hospital, Geneva, Switzerland
    N Engl J Med 352:1760-8. 2005
    ..We evaluated whether the use of D-dimer measurement and multidetector-row CT, without lower-limb ultrasonography, might safely rule out pulmonary embolism...
  15. ncbi Validation of a risk score identifying patients with acute pulmonary embolism, who are at low risk of clinical adverse outcome
    Mathieu R Nendaz
    Medical Clinic 1, Department of Internal Medicine, Geneva University Hospitals, Switzerland
    Thromb Haemost 91:1232-6. 2004
    ..Whether this score remains accurate and useful in clinical practice should be determined in a prospective multicentre validation study...
  16. ncbi Diagnostic strategies for suspected pulmonary embolism among outpatients
    H Bounameaux
    Division of Angiology and Hemostasis, University Hospital of Geneva, Geneva, Switzerland
    Semin Vasc Med 1:189-94. 2001
    ..The results indicate that they should now be implemented in daily practice taking into account local facilities and expertise. The exact place of helical computed tomography in such sequential algorithms remains to be established...
  17. ncbi Influence of specific alternative diagnoses on the probability of pulmonary embolism
    Ariane Testuz
    Division of Angiology and Hemostasis, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
    Thromb Haemost 95:958-62. 2006
    ....
  18. doi Swiss results from a global observational study of venous thromboembolism risk and prophylaxis use in the acute care hospital setting: analysis from the ENDORSE study
    Pierre Chopard
    Hopitaux Universitaires de Geneve, Geneva, Switzerland
    Swiss Med Wkly 139:630-5. 2009
    ....
  19. doi Differences in clinical presentation of pulmonary embolism in women and men
    H Robert-Ebadi
    Division of Angiology and Hemostasis, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
    J Thromb Haemost 8:693-8. 2010
    ..The risk of recurrence of pulmonary embolism (PE) is higher in men than in women. Differences in clinical presentation of deep vein thrombosis (DVT) have been reported between the two genders but comparative data on PE are lacking...
  20. ncbi A new rapid point-of-care D-dimer enzyme-linked immunosorbent assay (Stratus CS D-dimer) for the exclusion of venous thromboembolism
    Guido Reber
    Division of Angiology and Haemostasis, Geneva University Hospital, Switzerland
    Blood Coagul Fibrinolysis 15:435-8. 2004
    ..At 400 ng/ml, three results were false-negative, one with both devices and two with the Stratus D-dimer only. Stratus D-dimer appears to be suitable for the exclusion of venous thromboembolism in the emergency room setting...
  21. ncbi Clinical relevance of distal deep vein thrombosis. Review of literature data
    Marc Righini
    Division of Angiology and Hemostasis, Geneva University Hospital, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Thromb Haemost 95:56-64. 2006
    ..There is an urgent need for randomised trials assessing the usefulness of anticoagulant treatment in distal DVT...
  22. doi Impending paradoxical embolism: systematic review of prognostic factors and treatment
    Patrick O Myers
    Division of Cardiovascular Surgery, Geneva University Hospitals and Geneva University School of Medicine, 4, rue Gabrielle Perret Gentil, 1211 Geneva 14, Switzerland
    Chest 137:164-70. 2010
    ..Our aim was to review observational studies on this subject to identify prognostic factors and to compare mortality and systemic embolism between treatments...
  23. ncbi Portal vein thrombosis following a primary cytomegalovirus infection in an immunocompetent adult
    Salah Gueddi
    Division of Angiology and Haemostasis, University Hospital of Geneva, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Thromb Haemost 95:199-201. 2006
  24. doi Clinical relevance of distal deep vein thrombosis
    Marc Righini
    Division of Angiology and Hemostasis, Geneva University Hospital, Geneva, Switzerland
    Curr Opin Pulm Med 14:408-13. 2008
    ..To discuss pros and cons of anticoagulant treatment in the presence of symptomatic distal deep vein thrombosis...
  25. ncbi Venous thrombosis: risk factors and management
    Marc Righini
    Division of Angiology and Hemostasis, Geneva University Hospital, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Herz 32:27-34. 2007
    ....
  26. ncbi Performances of a new, automated latex assay for the exclusion of venous thromboembolism
    G Reber
    Division of Angiology and Haemostasis, Geneva University Hospital, Switzerland
    Blood Coagul Fibrinolysis 12:217-20. 2001
    ..6-99.4). This new assay is fast and fully automated, and its performance is suitable to exclude venous thromboembolism. Management studies should be performed to assess its utility...
  27. ncbi Management of severe ischemia of the hand following intra-arterial injection
    Marc Righini
    Division of Angiology and Hemostasis, Geneva University Hospital, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Thromb Haemost 94:219-21. 2005
  28. ncbi Comparison of two clinical prediction rules and implicit assessment among patients with suspected pulmonary embolism
    Isabelle Chagnon
    Division of Angiology and Hemostasis, Geneva University Hospital, Geneva, Switzerland
    Am J Med 113:269-75. 2002
    ..We compared the predictive accuracy and the concordance of the two methods, as well as the Geneva score overridden by implicit clinical judgment...
  29. ncbi Cost-effectiveness analysis of diagnostic strategies for suspected pulmonary embolism including helical computed tomography
    Arnaud Perrier
    Medical Clinic 1, Geneva University Hospital, Geneva, Switzerland
    Am J Respir Crit Care Med 167:39-44. 2003
    ..In summary, including helical CT in diagnostic strategies for pulmonary embolism is cost-effective provided that it is combined with DD and US. In contrast, helical CT as a single test is not cost-effective...
  30. ncbi Effect of age on the performance of single detector helical computed tomography in suspected pulmonary embolism
    Marc Righini
    Division of Angiology and Hemostasis, Geneva University Hospital, Geneva, Switzerland
    Thromb Haemost 91:296-9. 2004
    ..Our data suggest that age does not have a marked influence on the diagnostic performances of hCT in clinically suspected pulmonary embolism...
  31. ncbi Treatment strategies for acute pulmonary embolism
    Marc Blondon
    Division of General Internal Medicine, Department of Internal Medicine, Geneva University Hospital and Faculty of Medicine, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
    Expert Opin Pharmacother 10:1159-71. 2009
    ..Acute pulmonary embolism (PE) is a life-threatening condition that has been treated with anticoagulation for almost 50 years...
  32. ncbi Images in cardiovascular medicine. An unusual cause of hand cellulitis
    Marc Righini
    Division of Angiology and Hemostasis, Geneva University Hospital, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Circulation 115:e65-6. 2007
  33. ncbi Evaluation of advanced D-dimer assay for the exclusion of venous thromboembolism
    Guido Reber
    Division of Angiology and Haemostasis, Geneva University Hospital, Geneva 14, Switzerland
    Thromb Res 107:197-200. 2002
    ..5% (88.9, 98.8) and 47.8% (40.8, 54.9) at a cutt-off value of 1.1 microg/ml. This assay appears promising and should be validated in clinical practise to assess its place in the work-up schemes of thromboembolism...
  34. ncbi Pulmonary cement embolism after vertebroplasty
    Marc Righini
    Division of Angiology and Hemostasis, Geneva University Hospital, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Thromb Haemost 95:388-9. 2006
  35. ncbi Human tibia bone marrow: defining a model for the study of haemodynamics as a function of age by near infrared spectroscopy
    Tiziano Binzoni
    Department of Radiology, Geneva University Hospital, Switzerland
    J Physiol Anthropol Appl Human Sci 22:211-8. 2003
    ..The human tibia bone marrow model presented here and the related measurement technique should enable access to new areas of physiological research...
  36. ncbi [Multidisciplinary management of angiomas]
    Henri Bounameaux
    Departement de Medecine Interne, HUG, Geneve
    Rev Med Suisse 6:287-8, 290-1. 2010
    ..The present paper summarizes contemporary classification of angiomas and presents some principles of multidisciplinary approach as it is applied for the past fifteen years at the University Hospitals of Geneva...
  37. ncbi [Pulmonary embolism: role of the diagnostic and prognostic scores]
    Henri Bounameaux
    Departement de Medecine Interne, HUG, Geneve
    Rev Med Suisse 6:282, 284-6. 2010
    ..Prognostic scores have also been developed in order to stratify patients for the different therapeutic options: outpatient or inpatient treatment, anticoagulant treatment or thrombolysis or surgical or endovascular mechanical treatment...
  38. doi Contemporary management of pulmonary embolism: the answers to ten questions
    H Bounameaux
    Division of Angiology and Hemostasis, Department of Internal Medicine, University Hospitals of Geneva and Faculty of Medicine, Geneva, Switzerland
    J Intern Med 268:218-31. 2010
    ..A critical appraisal of the contemporary management of suspected PE is given in this overview with the discussion of 10 practical questions...
  39. ncbi Validation of helical computed tomography for suspected pulmonary embolism: a near miss?
    A Perrier
    Division of General Internal Medicine, Department of Internal Medicine, Geneva Faculty of Medicine and Geneva University Hospital, Geneva, Switerland
    J Thromb Haemost 3:14-6. 2005
  40. ncbi Influence of age on the cost-effectiveness of diagnostic strategies for suspected pulmonary embolism
    M Righini
    Division of Angiology and Haemostasis, Department of Internal Medicine, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
    J Thromb Haemost 5:1869-77. 2007
    ....
  41. ncbi Ten years after
    A Perrier
    Department of Internal Medicine, Division of General Internal Medicine, Geneva University Hospital and Geneva Faculty of Medicine, Geneva, Switzerland
    J Thromb Haemost 4:732-3. 2006
  42. doi Venous thromboembolism: contemporary diagnostic and therapeutic aspects
    H Bounameaux
    Division of Angiology and Hemostasis, Department of Internal Medicine, University Hospitals of Geneva and Faculty of Medicine, Geneva, Switzerland
    Vasa 37:211-26. 2008
    ..5-2) after an initial full-intensity treatment (INR 2-3) period of 3 to 12 months, and the emergence of new anticoagulant drugs such as direct oral synthetic inhibitors of thrombin or factor Xa...
  43. doi Cardiac biomarkers for risk stratification in non-massive pulmonary embolism: a multicenter prospective study
    N Vuilleumier
    Division of Laboratory Medicine, Department of Genetics and Laboratory Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
    J Thromb Haemost 7:391-8. 2009
    ..Troponins (cTnI and cTnT), N-terminal pro-Brain Natriuretic Peptide (NT-proBNP), myoglobin, heart-type fatty acid-binding protein (H-FABP) and fibrin D-Dimer are emergent candidates for risk stratification in pulmonary embolism (PE)...
  44. ncbi LMWH contra LMWH: superior, equivalent or non-inferior?
    H Bounameaux
    Division of Angiology and Hemostasis and Medical Clinic, Department of Internal Medicine, University Hospital of Geneva, Geneva, Switzerland
    J Thromb Haemost 1:414-5. 2003
  45. ncbi Cost-effective diagnosis of deep vein thrombosis and pulmonary embolism
    A Perrier
    Medical Clinic 1, Department of Internal Medicine, Geneva University Hospital, Switzerland
    Thromb Haemost 86:475-87. 2001
    ..This paper reviews the performance of clinical evaluation and diagnostic tests for venous thromboembolism, and recently validated diagnostic schemes...
  46. ncbi Measurement of plasma D-dimer is not useful in the prediction or diagnosis of postoperative deep vein thrombosis in patients undergoing total knee arthroplasty
    H Bounameaux
    Division of Angiology and Hemostasis, University Hospital of Geneva, Switzerland
    Blood Coagul Fibrinolysis 9:749-52. 1998
    ..In conclusion, the results of the present study suggest that plasma measurement of D-dimer concentration is of no value for predicting, diagnosing or ruling out DVT in patients undergoing total knee arthroplasty...
  47. ncbi Cost-effectiveness of noninvasive diagnostic aids in suspected pulmonary embolism
    A Perrier
    Medical Clinic 1, Geneva University Hospital, Switzerland
    Arch Intern Med 157:2309-16. 1997
    ....
  48. ncbi Non-invasive diagnosis of venous thromboembolism in outpatients
    A Perrier
    Medical Clinic 1, Geneva University Hospital, Switzerland
    Lancet 353:190-5. 1999
    ....
  49. ncbi Human tibia bone marrow blood perfusion by non-invasive near infrared spectroscopy: a new tool for studies on microgravity
    T Binzoni
    Department of Radiology, Geneva University Hospital, Switzerland
    J Gravit Physiol 9:P183-4. 2002
    ..The results define a "normal" baseline and demonstrate the sensitivity of the method to PI changes. The present technique should allow one to investigate physio-pathological effects induced by microgravity on tibia BM blood perfusion...
  50. ncbi [Drug treatment strategies for peripheral obliterative arteriopathy]
    H Bounameaux
    Departement de Medecine Interne, Hopitaux Universitaires de Geneve, Suisse
    Drugs 56:17-23. 1998
    ....
  51. ncbi An exploratory trial of two dosages of a novel synthetic thrombin inhibitor (napsagatran, Ro 46-6240) compared with unfractionated heparin for treatment of proximal deep-vein thrombosis -- results of the European multicenter ADVENT trial
    H Bounameaux
    Department of Internal Medicine, Hopital Cantonal Universitaire, Geneva, Switzerland
    Thromb Haemost 78:997-1002. 1997
    ..These results suggest that synthetic direct thrombin inhibitors are a promising class of antithrombotic agents which deserves further development in this field...
  52. ncbi Performance of helical computed tomography in unselected outpatients with suspected pulmonary embolism
    A Perrier
    Medical Clinic 1, Department of Internal Medicine, Geneva University Hospital, Rue Micheli du Crest 24, CH 1211 Geneva 14, Switzerland
    Ann Intern Med 135:88-97. 2001
    ..Helical computed tomography (CT) is commonly used to diagnose pulmonary embolism, although its operating characteristics have been insufficiently evaluated...
  53. ncbi Optimal duration of oral anticoagulant therapy following deep vein thrombosis of lower limbs
    H Bounameaux
    Division of Angiology and Haemostasis, University Hospital of Geneva, Switzerland
    Blood Coagul Fibrinolysis 7:507-14. 1996
    ..g. idiopathic proximal vein thrombosis in a patient with inherited thrombophilia or malignancy)...
  54. ncbi Differential inhibition of thrombin activity and thrombin generation by a synthetic direct thrombin inhibitor (napsagatran, Ro 46-6240) and unfractionated heparin in patients with deep vein thrombosis. ADVENT Investigators
    H Bounameaux
    Division of Angiology and Hemostasis, University Hospital of Geneva, Switzerland
    Thromb Haemost 81:498-501. 1999
    ..Direct thrombin inhibitors belong to a new class of antithrombotic drugs whose effects on blood coagulation in vivo in patients suffering from acute thrombotic conditions have not yet been fully explored...
  55. ncbi Using clinical evaluation and lung scan to rule out suspected pulmonary embolism: Is it a valid option in patients with normal results of lower-limb venous compression ultrasonography?
    A Perrier
    Medical Clinic 1, Geneva University Hospital, Switzerland
    Arch Intern Med 160:512-6. 2000
    ..In patients with a low clinical probability of pulmonary embolism (PE) and a nondiagnostic lung scan, the prevalence of PE is theoretically very low. We assessed the safety and usefulness of this association for ruling out PE...
  56. doi AngioJet rheolytic thrombectomy in patients presenting with high-risk pulmonary embolism and cardiogenic shock: a feasibility pilot study
    Robert F Bonvini
    Cardiology Division, University Hospital, Geneva, Switzerland
    EuroIntervention 8:1419-27. 2013
    ..While intravenous thrombolysis is considered the therapy of choice, percutaneous mechanical thrombectomy may represent an alternative treatment...
  57. doi Symptoms and clinical relevance: a dilemma for clinical trials on prevention of venous thromboembolism
    Henri Bounameaux
    Prof H Bounameaux, Division of Angiology and Hemostasis, University Hospitals of Geneva HUG and Faculty of Medicine, CH 1211 Geneva 14, Switzerland
    Thromb Haemost 109:585-8. 2013
    ..In particular, the case is made that asymptomatic events may be clinically relevant and that asymptomatic venographically detected thrombosis is a clinically relevant surrogate outcome for fatal pulmonary embolism...
  58. doi Antiplatelet drug response status does not predict recurrent ischemic events in stable cardiovascular patients: results of the Antiplatelet Drug Resistances and Ischemic Events study
    Jean Luc Reny
    Division of General Internal Medicine, University Hospitals of Geneva, 4, rue Gabrielle Perret Gentil, CH 1211 Geneva 14, Switzerland
    Circulation 125:3201-10. 2012
    ....
  59. doi Contrast-enhanced sonographic diagnosis of unsuspected internal iliac vein thrombosis
    Thomas de Perrot
    Department of Radiology, Geneva University Hospitals, Geneva, Switzerland
    J Clin Ultrasound 39:553-5. 2011
    ..Contrast-enhanced ultrasound confirmed the diagnosis, by displaying a well-defined filling defect...
  60. ncbi An evaluation of thromboembolism prophylaxis in acutely ill medical patients
    Patricia Chmelik
    Division of Angiology and Hemostasis, Department of Internal Medicine, Geneva University Hospital, Switzerland
    Swiss Med Wkly 132:513-6. 2002
    ..To examine the frequency and adequacy of thromboprophylaxis in acutely ill medical patients hospitalised in a primary-tertiary care hospital...
  61. doi The potential role of new oral anticoagulants in the prevention and treatment of thromboembolism
    Thomas Mavrakanas
    Department of Internal Medicine, Division of Angiology and Haemostasis, University Hospitals of Geneva, CH 1211 Geneva 14, Switzerland
    Pharmacol Ther 130:46-58. 2011
    ..Because these new oral agents have a rapid onset of action and can be given at fixed doses without the need for routine coagulation monitoring, they may simplify treatment paradigms and are expected to improve overall clinical outcome...
  62. ncbi External validation and comparison of recently described prediction rules for suspected pulmonary embolism
    Marc Righini
    Division of Angiology and Hemostasis, Geneva University Hospitals, Geneva, Switzerland
    Curr Opin Pulm Med 10:345-9. 2004
    ..Therefore, the purpose of this review is to discuss the external validation of these rules, because this particular point has been only recently achieved...
  63. ncbi Clinical and laboratory diagnosis of deep vein thrombosis: new cost-effective strategies
    H Bounameaux
    Division of Angiology and Hemostasis, Medical Clinic, University Hospital of Geneva, Geneva, Switzerland
    Semin Vasc Med 1:39-42. 2001
    ..The results indicate that they should now be implemented in daily practice, taking into account local facilities and expertise...
  64. ncbi Venous thromboembolism prophylaxis in acutely ill medical patients: definite need for improvement
    P Chopard
    Faculty of Medicine, University Hospitals, Geneva, Switzerland
    J Intern Med 257:352-7. 2005
    ..To examine the frequency and adequacy of thromboprophylaxis in acutely ill medical patients hospitalized in eight Swiss medical hospitals...
  65. doi Complete venous ultrasound in outpatients with suspected pulmonary embolism
    M Righini
    Division of Angiology and Haemostasis, Department of Internal Medicine, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
    J Thromb Haemost 7:406-12. 2009
    ..Recent studies suggested a limited yield of proximal US when multislice computed tomography (MSCT) was used...
  66. ncbi Assessing clinical probability of pulmonary embolism in the emergency ward: a simple score
    J Wicki
    Medical Clinic 1, Department of Internal Medicine, Geneva University Hospital, 24 rue Micheli-du-Crest, CH-1211 Geneva 14, Switzerland
    Arch Intern Med 161:92-7. 2001
    ..Applying this score to emergency ward patients suspected of having PE could allow a more effective diagnostic process...
  67. ncbi Suspicion of pulmonary embolism in outpatients: nonspecific chest pain is the most frequent alternative diagnosis
    S Bernard Bagattini
    Division of Angiology and Hemostasis, Geneva University Hospital, Geneva, Switzerland
    J Intern Med 256:153-60. 2004
    ..Our aim was to evaluate whether clinical characteristics would allow predicting alternative diagnoses other than pulmonary embolism thereby ruling out venous thromboembolism...
  68. ncbi Inability of serial fibrin monomer measurements to predict or exclude deep venous thrombosis in asymptomatic patients undergoing total knee arthroplasty
    G Reber
    Division of Angiology and Haemostasis, Geneva University Hospital, Switzerland
    Blood Coagul Fibrinolysis 11:305-8. 2000
    ..Therefore, despite differences between patients with or without DVT, serial FM determinations are of no value for predicting or ruling out DVT in individual patients undergoing total knee arthroplasty...
  69. pmc Comparison of Cardiac and Non-Cardiac Biomarkers for Risk Stratification in Elderly Patients with Non-Massive Pulmonary Embolism
    Nicolas Vuilleumier
    Division of Laboratory Medicine, Department of Genetics and Laboratory Medicine, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
    PLoS ONE 11:e0155973. 2016
    ..In elderly NMPE patients, cardiac biomarkers appear to be valuable prognostic to identify very low-risk individuals...
  70. doi Venous thromboembolism diagnosis: unresolved issues
    Marc Righini
    Marc Righini, MD, Division of Angiology and Hemostasis, Department of Medical Specialties, Geneva University Hospital and Faculty of Medicine, 4, rue Gabrielle Perret Gentil, CH 1211 Geneva 14, Switzerland, Tel 41 22 372 92 94, Fax 41 22 372 92 99, E mail
    Thromb Haemost 113:1184-92. 2015
    ....
  71. ncbi Integrated diagnostic approach to suspected deep vein thrombosis and pulmonary embolism
    Henri Bounameaux
    Division of Angiology and Hemostasis, Department of Internal Medicine, University Hospital of Geneva, Geneva, Switzerland
    Vasa 31:15-21. 2002
    ..They should now be implemented in daily practice according to cost-effectiveness analyses as well as local facilities and expertise...
  72. ncbi Prevalence of factor V Leiden and prothrombin G20210A mutations in unselected patients with venous thromboembolism
    P de Moerloose
    Division of Angiology and Haemostasis, Unit, University Hospital of Geneva, Switzerland
    Br J Haematol 110:125-9. 2000
    ..No statistically significant differences were observed between patients and controls for the prothrombin G20210A mutation...
  73. ncbi D-dimer testing and venous thromboembolism: four view points
    P de Moerloose
    Division of Angiology and Haemostasis Unit, University Hospital Geneva and Geneva Faculty of Medicine, Geneva, Switzerland
    J Thromb Haemost 3:380-2. 2005
  74. ncbi Cost-effectiveness of new antiplatelet regimens used as secondary prevention of stroke or transient ischemic attack
    F P Sarasin
    Department of Internal Medicine, Hopital Cantonal, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Arch Intern Med 160:2773-8. 2000
    ..However, their cost-effectiveness ratios relative to aspirin alone have not been estimated...
  75. ncbi Diagnosing pulmonary embolism: running after the decreasing prevalence of cases among suspected patients
    G Le Gal
    Division of Angiology and Hemostasis, Department of Internal Medicine, Geneva University Hospitals, Geneva, Switzerland
    J Thromb Haemost 2:1244-6. 2004
  76. ncbi Prediction of pulmonary embolism extent by clinical findings, D-dimer level and deep vein thrombosis shown by ultrasound
    C Galle
    Division of Angiology and Hemostasis, Geneva University Hospital, Switzerland
    Thromb Haemost 86:1156-60. 2001
    ....
  77. doi Duration of anticoagulation therapy for venous thromboembolism
    Henri Bounameaux
    Department of Medicine, University Hospitals of Geneva, Faculty of Medicine, Geneva, Switzerland
    Hematology Am Soc Hematol Educ Program . 2008
    ..These features might modify the risk-benefit balance of extending anticoagulant therapy beyond the usual, limited duration...
  78. doi Clinical prognosis of non-massive central and non-central pulmonary embolism: a registry-based cohort study
    Bobby Gouin
    Division of Angiology and Hemostasis, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland Division of General Internal Medicine, Universite de Sherbrooke, Sherbrooke, Canada on leave Electronic address
    Chest . 2016
    ..Our aim is to characterize associations of non-massive PE localization with risks of recurrent venous thromboembolism (VTE), major bleeding and mortality during and after anticoagulation...
  79. doi Direct oral anticoagulants: a guide for daily practice
    Pierre Fontana
    Division of Angiology and Haemostasis, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
    Swiss Med Wkly 146:w14286. 2016
    ....
  80. doi Life-threatening pulmonary embolism associated with a thrombus straddling a patent foramen ovale: report of a case
    Patrick O Myers
    Division of Cardiovascular Surgery, Geneva University Hospital, Geneva, Switzerland
    J Card Surg 23:376-8. 2008
    ..A biatrial thrombus straddling a patent foramen ovale (PFO) is rare. The optimal management is controversial. This report offers an additional report and brief review of the literature...
  81. doi Prospective randomized trial comparing endovenous laser ablation and surgery for treatment of primary great saphenous varicose veins with a 2-year follow-up
    Jan T Christenson
    Division of Cardiovascular Surgery, Venous Centre, University Hospital of Geneva and Faculty of Medicine, Geneva University, Geneva, Switzerland
    J Vasc Surg 52:1234-41. 2010
    ..Only a few randomized trials have reported early results. This prospective randomized trial compared EVLT (980 nm) and HL/S results at 1 and 2 years after the intervention...
  82. doi Clinical prediction rules for pulmonary embolism: a systematic review and meta-analysis
    E Ceriani
    Division of Angiology and Hemostasis, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
    J Thromb Haemost 8:957-70. 2010
    ..Pretest probability assessment is necessary to identify patients in whom pulmonary embolism (PE) can be safely ruled out by a negative D-dimer without further investigations...
  83. doi D-Dimer for venous thromboembolism diagnosis: 20 years later
    M Righini
    Division of Angiology and Hemostasis, Department of Internal Medicine, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
    J Thromb Haemost 6:1059-71. 2008
    ....
  84. ncbi Severe ischemia of the hand following intra-arterial promazine injection: effects of vasodilation, anticoagulation, and local thrombolysis with tissue-type plasminogen activator
    H Bounameaux
    Department of Medicine, University Hospital of Geneva, Switzerland
    Vasa 19:68-71. 1990
    ..The outcome was favourable and amputation could be avoided...
  85. doi Adequacy of venous thromboprophylaxis in acutely ill medical patients (IMPART): multisite comparison of different clinical decision support systems
    M R Nendaz
    Service of General Internal Medicine, University Hospitals, Geneva, Switzerland
    J Thromb Haemost 8:1230-4. 2010
    ..The adequacy of thromboprophylaxis prescriptions in acutely ill hospitalized medical patients needs improvement...
  86. ncbi Diagnosis of pulmonary embolism in outpatients by sequential noninvasive tools
    A Perrier
    Division of Angiology and Hemostasis, University Hospital, Geneva, Switzerland
    Semin Thromb Hemost 27:25-32. 2001
    ..Finally, spiral computed tomography (CT) seems promising and might modify the diagnostic work-up of PE in the near future. However, it is insufficiently validated, and its place in a rational diagnostic algorithm is not defined...
  87. ncbi Deep venous thrombosis and thrombophilia: indications for testing and clinical implications
    P de Moerloose
    Division of Angiology and Haemostasis, University Hospital Geneva, Geneva, Switzerland
    Semin Vasc Med 1:89-96. 2001
    ..This article provides answers to some of these issues. These answers should, however, be considered as tentative and provisional because new findings and study results will certainly modify them in the near future...
  88. ncbi Helical computed tomography as a test for pulmonary embolism
    Arnaud Perrier
    Ann Intern Med 139:955-6; author reply 956. 2003
  89. ncbi Uptake of new treatment strategies for deep vein thrombosis: an international audit
    Drahomir A Aujesky
    University of Lausanne
    Int J Qual Health Care 16:193-200. 2004
    ....
  90. ncbi D-dimer for the diagnosis of pulmonary embolism: a call for sticking to evidence
    Gregoire Le Gal
    Intensive Care Med 31:1-2. 2005
  91. ncbi Ximelagatran vs low-molecular-weight heparin and warfarin for the treatment of deep vein thrombosis: a randomized trial
    Jean Noel Fiessinger
    Department of Vascular Medicine, Hopital Europeen Georges Pompidou, Paris, France
    JAMA 293:681-9. 2005
    ..Ximelagatran, an oral direct thrombin inhibitor with a rapid onset of action and predictable antithrombotic effect, has the potential to be a simple therapeutic alternative to current standard treatment of acute venous thromboembolism...
  92. ncbi Diagnosing pulmonary embolism in outpatients with clinical assessment, D-dimer measurement, venous ultrasound, and helical computed tomography: a multicenter management study
    Arnaud Perrier
    Medical Clinic 1, Geneva University Hospital, Switzerland
    Am J Med 116:291-9. 2004
    ..To evaluate a diagnostic strategy for pulmonary embolism that combined clinical assessment, plasma D-dimer measurement, lower limb venous ultrasonography, and helical computed tomography (CT)...
  93. ncbi Fondaparinux and prevention of venous thromboembolism after orthopaedic surgery
    Henri Bounameaux
    Lancet 362:1581; author reply 1582. 2003
  94. ncbi D-dimer and venous thromboembolism
    Gregoire Le Gal
    Ann Intern Med 141:481-2; author reply 483. 2004
  95. ncbi Treating patients with venous thromboembolism: initial strategies and long-term secondary prevention
    Menno V Huisman
    Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Semin Vasc Med 5:276-84. 2005
    ....
  96. ncbi Value of D-dimer testing for the exclusion of pulmonary embolism in patients with previous venous thromboembolism
    Gregoire Le Gal
    Department of Internal Medicine and Chest Diseases, Brest University Hospital, Brest, France
    Arch Intern Med 166:176-80. 2006
    ....
  97. doi Challenges in the diagnosis of acute pulmonary embolism
    Paul D Stein
    Department of Research, St Joseph Mercy Oakland Hospital, Pontiac, Mich, USA
    Am J Med 121:565-71. 2008
    ..A patient-specific approach to the diagnosis of pulmonary embolism can be taken safely in hemodynamically stable patients to increase efficiency and decrease cost and exposure to radiation...
  98. ncbi Accuracy or outcome in suspected pulmonary embolism
    Arnaud Perrier
    N Engl J Med 354:2383-5. 2006
  99. ncbi A rebuttal: withholding anticoagulation in patients with suspected pulmonary embolism and a low probability ventilation perfusion scan: an unacceptable risk
    Arnaud Perrier
    Thromb Haemost 88:702. 2002
  100. ncbi A positive compression ultrasonography of the lower limb veins is highly predictive of pulmonary embolism on computed tomography in suspected patients
    Gregoire Le Gal
    EA 3878, département de médecine interne et de pneumologie, CHU de la Cavale Blanche, 29609 Brest Cedex, France
    Thromb Haemost 95:963-6. 2006
    ..It allows ruling in the diagnosis of PE without further invasive and/or expensive testing in suspected patients...
  101. ncbi Out of hospital antithrombotic prophylaxis after total hip replacement: low-molecular-weight heparin, warfarin, aspirin or nothing? A cost-effectiveness analysis
    Francois P Sarasin
    Medical Clinics 1 and 2, and Department of Internal Medicine, Hĵpital Cantonal, University of Geneva Medical School, Switzerland
    Thromb Haemost 87:586-92. 2002
    ..Extending prophylaxis up to 6 weeks is more risky in patients at high bleeding risk, and generates additional costs...