Thierry Berney

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi Serum profiles of interleukin-6, interleukin-8, and interleukin-10 in patients with severe and mild acute pancreatitis
    T Berney
    Clinic of Digestive Surgery, Geneva University Hospital, Switzerland
    Pancreas 18:371-7. 1999
  2. ncbi Immunosuppression for pancreatic islet transplantation
    T Berney
    Division of Visceral and Transplantation Surgery, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    Transplant Proc 36:362S-366S. 2004
  3. ncbi Five-year follow-up after pediatric living related small bowel transplantation between two monozygotic twins
    T Berney
    Department of Visceral and Transplantation Surgery, Geneva University Hospitals, Geneva, Switzerland
    Transplant Proc 36:316-8. 2004
  4. ncbi Islet of Langerhans allogeneic transplantation at the University of Geneva in the steroid free era in islet after kidney and simultaneous islet-kidney transplantations
    T Berney
    Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    Transplant Proc 36:1121-2. 2004
  5. ncbi Islet autotransplantation for the prevention of surgical diabetes after extended pancreatectomy for the resection of benign tumors of the pancreas
    T Berney
    Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    Transplant Proc 36:1123-4. 2004
  6. ncbi Islet transplantation: steeple chase and the next hurdle
    Thierry Berney
    Division of Visceral and Transplantation Surgery, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    Transplantation 80:1658-9. 2005
  7. ncbi Detection of insulin mRNA in the peripheral blood after human islet transplantion predicts deterioration of metabolic control
    T Berney
    Division of Visceral and Transplant Surgery, Geneva University Hospitals, Geneva, Switzerland
    Am J Transplant 6:1704-11. 2006
  8. ncbi Monitoring of the islet graft
    T Berney
    Cell Isolation and Transplantation Center, Division of Visceral and Transplant Surgery, Geneva University Hospitals, Geneva, Switzerland
    Diabetes Metab 32:503-12. 2006
  9. doi Rapamycin in islet transplantation: friend or foe?
    Thierry Berney
    Division of Transplantation and Visceral Surgery, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    Transpl Int 22:153-61. 2009
  10. doi Long-term insulin-independence after allogeneic islet transplantation for type 1 diabetes: over the 10-year mark
    T Berney
    Division of Visceral Transplant Surgery, Geneva University Hospitals, Geneva, Switzerland
    Am J Transplant 9:419-23. 2009

Research Grants

Detail Information

Publications124 found, 100 shown here

  1. ncbi Serum profiles of interleukin-6, interleukin-8, and interleukin-10 in patients with severe and mild acute pancreatitis
    T Berney
    Clinic of Digestive Surgery, Geneva University Hospital, Switzerland
    Pancreas 18:371-7. 1999
    ..These findings provide new evidence on the role of mediators of the inflammatory/antiinflammatory balance in acute pancreatitis. These molecules appear to be valuable early markers of severity...
  2. ncbi Immunosuppression for pancreatic islet transplantation
    T Berney
    Division of Visceral and Transplantation Surgery, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    Transplant Proc 36:362S-366S. 2004
    ....
  3. ncbi Five-year follow-up after pediatric living related small bowel transplantation between two monozygotic twins
    T Berney
    Department of Visceral and Transplantation Surgery, Geneva University Hospitals, Geneva, Switzerland
    Transplant Proc 36:316-8. 2004
    ..d-Xylose absorption in the recipient remained lower than that in the donor. Within 6 months fecal fat excretion normalized in the recipient. d-Xylose absorption and fecal fat excretion were always within a normal range in the donor...
  4. ncbi Islet of Langerhans allogeneic transplantation at the University of Geneva in the steroid free era in islet after kidney and simultaneous islet-kidney transplantations
    T Berney
    Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    Transplant Proc 36:1121-2. 2004
    ..We report a single-center experience of islet allogeneic transplantation in islet after kidney (IAK) and simultaneous islet-kidney (SIK) type 1 diabetic recipients using a steroid-free immunosuppressive regimen...
  5. ncbi Islet autotransplantation for the prevention of surgical diabetes after extended pancreatectomy for the resection of benign tumors of the pancreas
    T Berney
    Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    Transplant Proc 36:1123-4. 2004
    ..The objective of this article is to report a single-center experience with islet autotransplantation after extensive pancreatic resection for benign tumors of the pancreas...
  6. ncbi Islet transplantation: steeple chase and the next hurdle
    Thierry Berney
    Division of Visceral and Transplantation Surgery, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    Transplantation 80:1658-9. 2005
  7. ncbi Detection of insulin mRNA in the peripheral blood after human islet transplantion predicts deterioration of metabolic control
    T Berney
    Division of Visceral and Transplant Surgery, Geneva University Hospitals, Geneva, Switzerland
    Am J Transplant 6:1704-11. 2006
    ..These data suggest that insulin mRNA detection in the peripheral blood is a promising method for the prediction of islet graft damage...
  8. ncbi Monitoring of the islet graft
    T Berney
    Cell Isolation and Transplantation Center, Division of Visceral and Transplant Surgery, Geneva University Hospitals, Geneva, Switzerland
    Diabetes Metab 32:503-12. 2006
    ..Progress is likely to arise in the fields of immune monitoring, molecular monitoring and islet imaging, notably thanks to magnetic resonance (MR) or positron emission tomography (PET) technologies...
  9. doi Rapamycin in islet transplantation: friend or foe?
    Thierry Berney
    Division of Transplantation and Visceral Surgery, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    Transpl Int 22:153-61. 2009
    ..This paper reviews the sometimes contradictory evidence on the impact of rapamycin in islet transplantation...
  10. doi Long-term insulin-independence after allogeneic islet transplantation for type 1 diabetes: over the 10-year mark
    T Berney
    Division of Visceral Transplant Surgery, Geneva University Hospitals, Geneva, Switzerland
    Am J Transplant 9:419-23. 2009
    ..This observation is so far an exceptional case, but clearly demonstrates the validity of the concept that long-term insulin independence after allogeneic islet transplantation is an achievable target...
  11. doi Donor pancreata: evolving approaches to organ allocation for whole pancreas versus islet transplantation
    Thierry Berney
    Department of Surgery, Cell Isolation and Transplantation Center, Geneva University Hospitals and University of Geneva School of Medicine, Geneva, Switzerland
    Transplantation 90:238-43. 2010
    ..In this overview, we show that transplanted islet mass does not necessarily correlate with graft function and make the case that donor selection criteria for islet transplantation, and hence allocation rules, may need to be redefined...
  12. doi Comparative impact on islet isolation and transplant outcome of the preservation solutions Institut Georges Lopez-1, University of Wisconsin, and Celsior
    Nadja Niclauss
    Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
    Transplantation 93:703-8. 2012
    ..In this study, we assessed the impact of IGL-1, UW, and Celsior (CS) solutions on islet isolation and transplant outcome...
  13. ncbi Transplantation of discordant xenogeneic islets using repeated therapy with anti-CD154
    Pascal Bucher
    Surgical Research Unit, Department of Surgery, University Hospital Geneva, 1211 Geneva, Switzerland
    Transplantation 79:1545-52. 2005
    ..Costimulatory blockade has been shown to allow long-term survival of xenogeneic islets. The aim of the present study was to analyze the possibility of xenogeneic islet retransplantation using costimulatory blockade...
  14. ncbi Anti-CD154 mAb treatment but not recipient CD154 deficiency leads to long-term survival of xenogeneic islet grafts
    Gang Mai
    Surgical Research Unit, Department of Surgery, University Hospital Geneva, Switzerland
    Am J Transplant 5:1021-31. 2005
    ..Rejection of xenografts and strong MLR responses in Groups 3 and 4 are possible through efficient activation of alternate pathways of costimulation...
  15. ncbi Impairment of renal function after islet transplant alone or islet-after-kidney transplantation using a sirolimus/tacrolimus-based immunosuppressive regimen
    Axel Andres
    Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    Transpl Int 18:1226-30. 2005
    ..Although a specific etiology was not identified, some subsets of patients presented a higher risk for decline of kidney function. Low creatinin clearance, albuminuria and long-established kidney graft were associated with poorer outcome...
  16. doi A model for dropout assessment of candidates with or without hepatocellular carcinoma on a common liver transplant waiting list
    Christian Toso
    Division of Transplant, Department of Surgery, University of Geneva Hospitals, Geneva, Switzerland
    Hepatology 56:149-56. 2012
    ..Because this model and MELD did not share compatible scales, a correlation between both models was computed according to the predicted risk of dropout, and drop-out equivalent MELD (deMELD) points were calculated...
  17. pmc Immunomodulation by blockade of the TRANCE co-stimulatory pathway in murine allogeneic islet transplantation
    Anne Wojtusciszyn
    Cell Isolation and Transplantation Center, University of Geneva School of Medicine, Geneva, Switzerland
    Transpl Int 22:931-9. 2009
    ..TRANCE-targeting may be an effective strategy for the prolongation of allogeneic islet graft survival, thanks to its inhibitory effects on co-stimulatory signals and macrophage recruitment...
  18. doi Macrophage migration inhibitory factor deficiency leads to age-dependent impairment of glucose homeostasis in mice
    Veronique Serre-Beinier
    Surgical Research Unit, Department of Surgery Department of Surgery, Cell Isolation and Transplantation Center, Geneva University Hospitals and University of Geneva, 1211 Geneva 4, Switzerland
    J Endocrinol 206:297-306. 2010
    ..In conclusion, this mouse model provides evidence for the role of MIF in the control of glucose homeostasis...
  19. doi Quantification of islet loss and graft functionality during immune rejection by 3-tesla MRI in a rat model
    Sophie Borot
    Cell Isolation and Transplant Center, Department of Surgery, University of Geneva and Geneva University Hospitals, Geneva, Switzerland
    Transplantation 96:438-44. 2013
    ..However, the relation between graft functionality assessed by glycemia, and MRI signal remains unclear...
  20. ncbi Influence of donor age on islet isolation and transplantation outcome
    Nadja Niclauss
    Department of Surgery, Cell Isolation and Transplantation Center, Geneva, Switzerland
    Transplantation 91:360-6. 2011
    ..It has been suggested that the age of human organ donors might influence islet isolation and transplantation outcome in a negative way due to a decrease of in vivo function in islets isolated from older donors...
  21. doi Impact of the number of infusions on 2-year results of islet-after-kidney transplantation in the GRAGIL network
    Sophie Borot
    Department of Surgery, Islet Isolation and Transplantation Center, Geneva University Hospitals, Geneva, Switzerland
    Transplantation 92:1031-8. 2011
    ..However, single infusion would increase the number of recipients. Our aim was to evaluate the results of islet-after-kidney transplantation according to the number of infusions...
  22. doi Posttransplant cellular immune reactivity against donor antigen correlates with clinical islet transplantation outcome: towards a better posttransplant monitoring
    Stéphanie Lacotte
    Department of Surgery, Geneva University Hospitals, Faculty of Medicine, University of Geneva, Rue Gabrielle Perret Gentil 4, Geneva, Switzerland
    Cell Transplant 21:2339-50. 2012
    ..Cellular immune reactivity against donor cells correlates with posttransplant islet function. The tested assays have the potential to be of substantial help in the management of islet graft recipients and deserve prospective validation...
  23. doi Islet autotransplantation after extended pancreatectomy for focal benign disease of the pancreas
    Frederic Ris
    Division of Visceral and Transplantation Surgery, Geneva University Hospitals and University of Geneva School of Medicine, Geneva, Switzerland
    Transplantation 91:895-901. 2011
    ..The aim of the present study is to demonstrate the safety and efficiency of islet autotransplantation after extended left pancreatectomy for benign disease...
  24. doi A score predicting survival after liver retransplantation for hepatitis C virus cirrhosis
    Axel Andres
    Abdominal and Transplantation Surgery, Department of Surgery, University Hospital Geneva, Switzerland
    Transplantation 93:717-22. 2012
    ..Although the relisting decision can be difficult in these patients, a score could help in selection of candidates with the best potential outcomes...
  25. ncbi Microbial surveillance during human pancreatic islet isolation
    Pascal Bucher
    Laboratory for Cell Isolation and Transplantation, Clinic for Visceral and Transplant Surgery, Geneva University Hospital, Geneva, Switzerland
    Transpl Int 18:584-9. 2005
    ..Most microorganisms are eliminated during islet isolation, and de novo contaminations during islet isolation are rare. Pancreas decontamination reduces the risk of infection of the final islet preparation...
  26. doi Computer-assisted digital image analysis to quantify the mass and purity of isolated human islets before transplantation
    Nadja Niclauss
    Department of Surgery, Cell Isolation and Transplantation Center, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
    Transplantation 86:1603-9. 2008
    ..Therefore, we developed a computerized approach aimed at evaluating more objectively the number and purity of isolated human islets...
  27. doi Regulated laminin-332 expression in human islets of Langerhans
    Mathieu Armanet
    Department of Surgery, Cell Isolation and Transplantation Center, Geneva University Hospitals and University of Geneva, 1211 Geneva 4, Switzerland
    FASEB J 23:4046-55. 2009
    ..These results show that LN-332, known to have some beneficial effect on beta cells in vitro, is produced and secreted by endocrine islet cells and is up-regulated by stressing conditions such as culture and IL-1beta-exposure...
  28. pmc Factors predicting survival after post-transplant hepatocellular carcinoma recurrence
    Christian Toso
    Divisions of Transplant and Abdominal Surgery, Department of Surgery, University of Geneva Hospitals, rue Gabrielle Perret Gentil, 1211, Geneva, Switzerland
    J Hepatobiliary Pancreat Sci 20:342-7. 2013
    ..Although factors associated with an increased risk of recurrence after liver transplantation for hepatocellular carcinoma (HCC) have been extensively studied, the history of patients with a post-transplant recurrence is poorly known...
  29. ncbi Impact of HLA matching on the outcome of simultaneous pancreas-kidney transplantation
    Thierry Berney
    Division of Visceral and Transplantation Surgery, Geneva University Hospitals, Switzerland
    Nephrol Dial Transplant 20:ii48-53, ii62. 2005
    ..The current analysis examined the impact of human leukocyte antigen (HLA) matching on graft outcome following SPK transplantation. The study population was obtained from patients enrolled in the Euro-SPK 001 study...
  30. ncbi Macrophage depletion prolongs discordant but not concordant islet xenograft survival
    Axel Andres
    Surgical Research Unit, Department of Surgery, University Hospital Geneva, Geneva, Switzerland
    Transplantation 79:543-9. 2005
    ..In vivo, we analyzed the effect of macrophage depletion on concordant and discordant islet xenograft survival to assess in which combination this strategy can be used as therapeutic tool...
  31. doi Low risk of anti-human leukocyte antigen antibody sensitization after combined kidney and islet transplantation
    Sylvie Ferrari-Lacraz
    Transplantation Immunology Unit, Service of Immunology and Allergy and Service of Laboratory Medicine, Geneva University Hospital and Medical School, Geneva, Switzerland
    Transplantation 86:357-9. 2008
    ..8% that is comparable with the risk of immunization after kidney transplantation alone. Multiple islet infusions do not represent a specific risk for the development of anti-HLA antibodies after combined kidney-islets transplantation...
  32. doi Detecting rejection after mouse Islet transplantation utilizing islet protein-stimulated ELISPOT
    Christian Toso
    Transplant Unit, Department of Surgery, University of Geneva Hospitals, Switzerland
    Cell Transplant 20:955-62. 2011
    ..Overall, allogeneic rejection was associated to a transient increase in the reactivity of splenocytes against islet proteins. Such a strategy has the potential to improve islet graft monitoring in human and should be further explored...
  33. doi Rapamycin impairs proliferation of transplanted islet β cells
    Nadja Niclauss
    Department of Surgery, Cell Isolation and Transplantation Center, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
    Transplantation 91:714-22. 2011
    ..In this study, we examined the effect of rapamycin, a key component of the immunosuppressive regimen, on β-cell replication of transplanted islets...
  34. doi The impact of wait list body mass index changes on the outcome after liver transplantation
    Lorenzo A Orci
    Divisions of visceral and transplantation surgery, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    Transpl Int 26:170-6. 2013
    ..5 kg/m(2) . Obesity does not constitute an absolute contraindication to liver transplantation...
  35. doi Assessment of human islet labeling with clinical grade iron nanoparticles prior to transplantation for graft monitoring by MRI
    Frederic Ris
    Cell Isolation and Transplantation Center, Geneva University Hospitals and University of Geneva, School of Medicine, 4 rue Gabrielle Perret Gentil, Geneva 14, Switzerland
    Cell Transplant 19:1573-85. 2010
    ..A rapid signal decrease was observed in rejecting xenogeneic islets. According to the present data, ferucarbotran is the most appropriate of available clinical grade SPIOs for human islet imaging...
  36. ncbi Sequential kidney/islet transplantation: efficacy and safety assessment of a steroid-free immunosuppression protocol
    C Toso
    Cell Isolation and Transplantation Center, Division of Visceral and Transplant Surgery, Geneva University Hospitals, Geneva, Switzerland
    Am J Transplant 6:1049-58. 2006
    ..The net harm versus benefit has not yet been established and will require further studies with larger numbers of enrolled subjects...
  37. doi Cell rearrangement in transplanted human islets
    Vanessa Lavallard
    Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland Cell Therapy Unit, Hopital Saint Louis, Assistance Publique Hopitaux de Paris, and University Paris 7, Paris, France and Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche Scientifique 1138, Centre de Recherches des Cordeliers, Paris, France
    FASEB J 30:748-60. 2016
    ..These results indicate that the maintenance of islet cell arrangement is dependent on in vivo features such as extracellular matrix but independent of vascularization...
  38. pmc Systematic review and meta-analysis of fibrin sealants for patients undergoing pancreatic resection
    Lorenzo A Orci
    Division of Visceral and Transplantation Surgery, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    HPB (Oxford) 16:3-11. 2014
    ..The role of fibrin sealants in decreasing the risk of POPF remains debatable. The aim of this study was to evaluate the literature regarding the effectiveness of fibrin sealants in pancreatic surgery...
  39. doi Assessment of sexual function and conjugal satisfaction prior to and after liver transplantation
    Jacques Klein
    Division of Urologic Surgery, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    Ann Transplant 18:136-45. 2013
    ..The aims of this study were to assess sexual function and conjugal satisfaction in patients prior to and after liver transplantation, and in comparison to healthy individuals...
  40. ncbi Treatment of fulminant liver failure by transplantation of microencapsulated primary or immortalized xenogeneic hepatocytes
    Gang Mai
    Surgical Research Unit, Department of Surgery, University Hospital Geneva, Switzerland
    Xenotransplantation 12:457-64. 2005
    ..The aim of this study was to evaluate in vitro and in vivo functions of isolated hepatocytes after immortalization, cryopreservation, encapsulation and xenotransplantation into mice with fulminant liver failure (FLF)...
  41. doi Cadherin engagement protects human β-cells from apoptosis
    Geraldine Parnaud
    Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, 1211 Geneva 4, Switzerland
    Endocrinology 152:4601-9. 2011
    ..Our results show that at least E- and N-cadherins are expressed at the surface of human β-cells and that these adhesion molecules are involved in the maintenance of β-cell viability...
  42. pmc Improved liver function after portal vein embolization and an elective right hepatectomy
    Raphael P H Meier
    Hepato Pancreato Biliary Centre, Visceral and Transplantation Surgery, Department of Surgery, University Hospitals of Geneva and Faculty of Medicine, Geneva, Switzerland
    HPB (Oxford) 17:1009-18. 2015
    ..6% of the patient's weight). The objective was to determine whether pre-operative PVE impacts on post-operative liver function independently from the increase in liver volume...
  43. doi Cadherin engagement improves insulin secretion of single human β-cells
    Geraldine Parnaud
    Department of Surgery, Cell Isolation and Transplantation Center, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
    Diabetes 64:887-96. 2015
    ..Our results demonstrate that adhesion of β-cells to E- and N-cadherins is regulated by insulin secretagogues and that E- and N-cadherin engagement promotes stimulated insulin secretion. ..
  44. doi Islet of Langerhans isolation from pediatric and juvenile donor pancreases
    Raphael P H Meier
    Department of Surgery, Cell Isolation and Transplantation Center, University of Geneva Hospitals and School of Medicine, Geneva, Switzerland
    Transpl Int 27:949-55. 2014
    ..Efforts should be directed at improving islet extraction in these donors to realize their full potential for islet transplantation. ..
  45. doi Enhancement of islet engraftment and achievement of long-term islet allograft survival by Toll-like receptor 4 blockade
    Laurianne Giovannoni
    1 Cell Isolation and Transplantation Center, Department of Surgery, University of Geneva School of Medicine, Geneva, Switzerland 2 Department of Endocrinology Metabolisme and Diabetology Nutrition, Jean Minjoz University Hospital, Besancon, France 3 Division of Transplantation and Visceral Surgery, Department of Surgery, University of Geneva Hospitals, Geneva, Switzerland 4 NovImmune, Plan les Ouates, Switzerland
    Transplantation 99:29-35. 2015
    ..The aim of the present study was to assess the role of Toll-like receptor-4 (TLR4) in mediating the inflammatory and immune responses to pancreatic islets, thereby promoting inflammatory destruction and immune rejection of islet grafts...
  46. doi Initial cholecystectomy vs sequential common duct endoscopic assessment and subsequent cholecystectomy for suspected gallstone migration: a randomized clinical trial
    Pouya Iranmanesh
    Division of Digestive Surgery, Department of Surgery, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland2Division of Transplant Surgery, Department of Surgery, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland3He
    JAMA 312:137-44. 2014
    ..Many stones migrate spontaneously into the duodenum, making preoperative common duct investigations unnecessary...
  47. doi Outcome of treated and untreated asymptomatic bacteriuria in renal transplant recipients
    Emmanuelle Boffi El Amari
    Department of Medical Specialities, University Hospital Geneva, Geneva, Switzerland
    Nephrol Dial Transplant 26:4109-14. 2011
    ..Because of scarce clinical symptoms and fear of complications, such episodes are frequently treated based on subjective criteria without clear clinical benefit, with the risk of selecting resistant pathogens...
  48. doi Demographics and outcomes of severe herpes simplex virus hepatitis: a registry-based study
    Bogdan Moldovan
    Transplantation Division, Department of Surgery, Geneva, Switzerland
    J Hepatol 55:1222-6. 2011
    ..The present study was based on the SRTR registry, and included all listed patients for liver transplantation from 1985 to 2009 with a diagnosis of HSV hepatitis...
  49. pmc Unique arrangement of alpha- and beta-cells in human islets of Langerhans
    Domenico Bosco
    Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
    Diabetes 59:1202-10. 2010
    ..However, a clear description of human islet architecture has not yet been reported. The aim of this work was to describe our observations on the arrangement of human islet cells...
  50. ncbi Impact of a sirolimus/tacrolimus-based immunosuppressive regimen on kidney function after islet transplantation
    A Andres
    Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    Transplant Proc 37:1326-7. 2005
    ..Herein, we analyze the impact of the sirolimus/low-dose tacrolimus-based protocol on kidney function...
  51. ncbi Assessment of a novel two-component enzyme preparation for human islet isolation and transplantation
    Pascal Bucher
    Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospital, Geneva, Switzerland
    Transplantation 79:91-7. 2005
    ..In this study, we have evaluated a new enzyme preparation in which highly purified collagenase can be blended with separately supplied neutral protease in a predetermined ratio...
  52. ncbi Logistics and transplant coordination activity in the GRAGIL Swiss-French multicenter network of islet transplantation
    Marie Claude Kempf
    Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    Transplantation 79:1200-5. 2005
    ..Some institutions have elected to associate in multicenter networks, such as the Swiss-French GRAGIL (Groupe Rhin-Rhône-Alpes-Genève pour la Transplantation d'Ilots de Langerhans) consortium...
  53. ncbi Expression and secretion of alpha1-proteinase inhibitor are regulated by proinflammatory cytokines in human pancreatic islet cells
    Domenico Bosco
    Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals, Switzerland
    Diabetologia 48:1523-33. 2005
    ..The aims of this study were to assess the islet cell types that produce alpha1-PI, to determine whether alpha1-PI is actually secreted by islet cells, and to assess how its production and/or secretion are regulated...
  54. doi Mesenchymal stem cells derived from human exocrine pancreas express transcription factors implicated in beta-cell development
    Reto M Baertschiger
    Department of Surgery, Surgical Research Unit, University Hospital Geneva, Geneva, Switzerland
    Pancreas 37:75-84. 2008
    ..The aim of this study was to isolate, expand, and characterize cells from human exocrine pancreas and analyze their potential to differentiate into beta cells...
  55. pmc Bimodal effect on pancreatic β-cells of secretory products from normal or insulin-resistant human skeletal muscle
    Karim Bouzakri
    Department of Genetic Medicine and Development, University Medical Center, University of Geneva, Geneva, Switzerland
    Diabetes 60:1111-21. 2011
    ..Type 2 diabetes is characterized by insulin resistance with a relative deficiency in insulin secretion. This study explored the potential communication between insulin-resistant human skeletal muscle and primary (human and rat) β-cells...
  56. doi Asymmetrical distribution of δ and PP cells in human pancreatic islets
    Charlotte Barbieux
    Department of SurgeryCell Isolation and Transplantation Center, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
    J Endocrinol 229:123-32. 2016
    ..In conclusion, the distribution of δ cells differs from that of PP cells in human islets, suggesting that vessels at the periphery and at the centre of islets drain different hormonal cocktails. ..
  57. doi Impact of graft implantation order on graft survival in simultaneous pancreas-kidney transplantation
    Nadja Niclauss
    Divisions of visceral and transplantation surgery, Department of Surgery, University of Geneva Hospitals and School of Medicine, Geneva, Switzerland
    Transpl Int 29:627-35. 2016
    ..Graft implantation order had no impact on kidney graft survival. In summary, although observed differences are small, pancreas graft implantation first increases short-term pancreas graft survival and reduces rates of technical failure. ..
  58. pmc A meta-analysis of extended versus standard lymphadenectomy in patients undergoing pancreatoduodenectomy for pancreatic adenocarcinoma
    Lorenzo A Orci
    Division of Abdominal Surgery, Department of Surgery, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    HPB (Oxford) 17:565-72. 2015
    ..This systematic review and meta-analysis examines the outcomes of extended versus standard lymphadenectomy in the published literature...
  59. doi Impact of recipient body mass index on short-term and long-term survival of pancreatic grafts
    Benoît Bédat
    1 Division of Visceral and Transplantation Surgery, Department of Surgery, University of Geneva Hospitals and School of Medicine, Geneve, Switzerland 2 Division of Clinical Epidemiology, University of Geneva Hospitals and School of Medicine, Geneve, Switzerland
    Transplantation 99:94-9. 2015
    ..The impact of recipient body mass index on graft and patient survival after pancreas transplantation is not well known...
  60. doi Pre-retrieval reperfusion decreases cancer recurrence after rat ischemic liver graft transplantation
    Graziano Oldani
    Divisions of Transplant and Abdominal Surgery, Department of Surgery, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland Department of Surgery, University of Pavia, Italy
    J Hepatol 61:278-85. 2014
    ..Graft reperfusion prior to retrieval (as for extracorporeal membrane oxygenation--ECMO) can prevent I/R lesions. The impact of I/R on the risk of cancer recurrence was assessed on a syngeneic Fischer-rat liver transplantation model...
  61. doi Validation of a dropout assessment model of candidates with/without hepatocellular carcinoma on a common liver transplant waiting list
    Christian Toso
    Divisions of Transplant and Abdominal Surgery, Department of Surgery, University of Geneva Hospitals, Geneva, Switzerland Hepato Pancreato Biliary Centre, University of Geneva Hospitals, Geneva, Switzerland
    Transpl Int 27:686-95. 2014
    ..2-73.7% vs. 52.7-56.6%). In addition, the model shows a similar distribution as MELD for patients with non-HCC, and both scores could be used in parallel for the management of waiting-list patients with and without HCC...
  62. pmc Soluble CD40 ligand in prediction of acute severe pancreatitis
    Jean Louis Frossard
    Division of Gastroenterology, Geneva University Hospital, 1211 Geneve 14, Switzerland
    World J Gastroenterol 12:1613-6. 2006
    ..To assess the early predictability of the soluble CD40L (sCD40L) in pancreatitis severity...
  63. doi Responses of solid organ transplant recipients to the AS03-adjuvanted pandemic influenza vaccine
    Claire Anne Siegrist
    Center for Vaccinology, Geneva University Hospitals, Geneva, Switzerland
    Antivir Ther 17:893-903. 2012
    ..Solid organ transplant (SOT) recipients are a priority group for influenza vaccination and strategies enhancing immunogenicity are needed...
  64. pmc Epidural anaesthesia restores pancreatic microcirculation and decreases the severity of acute pancreatitis
    Alp Demirag
    Surgical Research Unit, Department of Surgery, University Hospital Geneva, 24, Rue Micheli du Crest, 1211, Geneva 14, Switzerland
    World J Gastroenterol 12:915-20. 2006
    ..To investigate the effect of epidural anaesthesia (EA) on pancreatic microcirculation during acute pancreatitis (AP)...
  65. pmc Cx36 makes channels coupling human pancreatic beta-cells, and correlates with insulin expression
    Veronique Serre-Beinier
    Surgical Research Unit, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    Hum Mol Genet 18:428-39. 2009
    ..The data show that Cx36 is a native protein of human pancreatic islets, which mediates the coupling of the insulin-producing beta-cells, and contributes to control beta-cell function by modulating gene expression...
  66. pmc Survival of free and encapsulated human and rat islet xenografts transplanted into the mouse bone marrow
    Raphael P H Meier
    Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
    PLoS ONE 9:e91268. 2014
    ..Although there was no evidence for immune-privilege, the bone marrow may represent a feasible site for encapsulated xenogeneic islet transplantation. ..
  67. doi Association between lymphoepithelial cysts of the pancreas and HIV infection
    Benoît Bédat
    Department of Surgery, Division of Visceral Surgery, Geneva University Hospitals, rue Gabrielle Perret Gentil, 4, 1211 Geneva 14, Switzerland
    Pancreatology 12:61-4. 2012
    ..To report the association of lymphoepithelial cysts (LEC) of the pancreas with Human Immunodeficiency Virus (HIV) infection. An association between LEC and HIV infection is already established in the parotid gland (PG)...
  68. ncbi Positron-emission tomography imaging of early events after transplantation of islets of Langerhans
    Christian Toso
    Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    Transplantation 79:353-5. 2005
    ..Ex vivo labeling of islets and imaging of posttransplant early events were feasible. Islets engrafted exclusively in the liver. No islet loss could be demonstrated 6 hours after transplantation...
  69. doi Organ preservation in pancreas and islet transplantation
    Reto M Baertschiger
    Islet Isolation and Transplantation Center, Department of Surgery, University Hospital Geneva, Geneva, Switzerland
    Curr Opin Organ Transplant 13:59-66. 2008
    ..With the chronic lack of organs for transplantation, marginal donors are more and more frequently used in Western countries. New challenges, therefore, have to be met in organ preservation...
  70. ncbi Effect of microcapsule composition and short-term immunosuppression on intraportal biocompatibility
    Christian Toso
    Centre d isolement et de transplantation cellulaire, Service de Chirurgie Viscerale, Hopital Universitaire, 4, Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
    Cell Transplant 14:159-67. 2005
    ..Biocompatibility after intraportal infusion was best for barium-alginate microbeads and poorest for polycation-containing microcapsules. Short- and long-term overgrowth could be significantly reduced by short-term immunosuppression...
  71. pmc Management of hepatocellular adenoma: solitary-uncomplicated, multiple and ruptured tumors
    Christian Toso
    Abdominal and Transplant Surgery, University Hospital, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    World J Gastroenterol 11:5691-5. 2005
    ..While hepatocellular adenomas (HAs) have often been studied as a unique entity, we aimed to better define current management of the various forms of HAs...
  72. doi The role of macrophage migration inhibitory factor in mouse islet transplantation
    Christian Toso
    Islet Transplant Program, Alberta Diabetes Institute, University of Alberta, Edmonton AB, Canada
    Transplantation 86:1361-9. 2008
    ..Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine produced by many tissues including pancreatic beta-cells...
  73. ncbi Crohn's disease as a risk factor for the outcome of pregnancy
    M Morales
    Department of Obstetrics and Gynecology, Geneva University Hospital, Geneva, Switzerland
    Hepatogastroenterology 47:1595-8. 2000
    ..To study the effects of Crohn's disease on the course of pregnancy and the influence of pregnancy on the activity of Crohn's disease...
  74. ncbi Islet of Langerhans transplantation for the treatment of type 1 diabetes
    P Bucher
    Clinic of Visceral and Transplantation Surgery, Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospital, Geneva, Switzerland
    Swiss Surg 9:242-6. 2003
    ..Twenty-one patients have been transplanted in Geneva since 2002. They were five solitary islet transplants, 14 islet after kidney transplants and two simultaneous islet-kidney (SIK) recipients. Insulin independence was achieved in 67%...
  75. ncbi Short-term immunosuppression reduces fibrotic cellular infiltration around barium-M-alginate microbeads injected intraportally
    Z Mathe
    Cell Isolation and Transplantation Center, Geneva University Hospitals, Geneva, Switzerland
    Transplant Proc 36:1199-200. 2004
    ..One of the major barriers affecting the viability of encapsulated islets is pericapsular fibrotic infiltration (PFI). This study aimed to design strategies to reduce PFI around intraportally injected alginate microbeads...
  76. ncbi [Diabetes Type I therapy through transplantation]
    P Bucher
    Departement de Chirurgie, Service de chirurgie viscérale et de transplantation, Hopitaux Universitaires de Geneve, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Ann Chir 130:374-83. 2005
    ..It could be done either through pancreas or islet of Langerhans transplantation. In this paper, we review actual knowledge regarding these two types of transplantations...
  77. ncbi Prospective study of 310 patients: can early CT predict the severity of acute pancreatitis?
    A S Knoepfli
    Department of Radiology, Geneva University Hospital, Geneva, Switzerland
    Abdom Imaging 32:111-5. 2007
    ..This study was designed to determine the most important early CT parameters predictive of acute pancreatitis severity...
  78. ncbi Assessment of 18F-FDG-leukocyte imaging to monitor rejection after pancreatic islet transplantation
    C Toso
    Cell Isolation and Transplantation Center, Clinic for Visceral and Transplant Surgery, University Hospital, Geneva, Switzerland
    Transplant Proc 38:3033-4. 2006
    ..We sought to investigate the feasibility of 18F-FDG-leukocyte imaging to detect islet rejection...
  79. doi Clinical magnetic resonance imaging of pancreatic islet grafts after iron nanoparticle labeling
    C Toso
    Cell Isolation and Transplantation Center, Geneva University Hospitals, Geneva, Switzerland
    Am J Transplant 8:701-6. 2008
    ..Altogether, this study demonstrates the feasibility and safety of MRI-based islet graft monitoring in clinical practice. Iron overload (spontaneous or induced) represents the major obstacle to the technique...
  80. ncbi [Acute pancreatitis or the need of anticipation]
    F Schwenter
    Service de Chirurgie Viscerale, Departement de Chirurgie, HUG, 1211 Geneve
    Rev Med Suisse 5:1425-30. 2009
    ..In summary, the anticipation in diagnosis, etiology, classification of the severity and early reanimation are needed for an optimal treatment of this complex disease...
  81. ncbi Kidney-pancreas transplantation in a long-term non-progressor HIV-infected recipient
    Christian Toso
    Transplantation Unit, Visceral and Transplant Surgery, University Hospitals, Geneva, Switzerland
    Am J Transplant 3:631-3. 2003
    ..HAART is not required, thus sparing drug interactions and their unique immunological features, such as CCR5 mutation, might prevent rejection. This subgroup of HIV patients should be offered less restricted access to transplantation...
  82. pmc Signaling pathways implicated in the stimulation of beta-cell proliferation by extracellular matrix
    Geraldine Parnaud
    Department of Genetic Medicine and Development, University of Geneva University Medical Center, Geneva, Switzerland
    Mol Endocrinol 23:1264-71. 2009
    ..Conversely, inhibition of the MAPK pathway increased beta-cell proliferation, indicating a counterregulatory restraining role for this signaling pathway...
  83. doi Immune monitoring of pancreatic islet graft: towards a better understanding, detection and treatment of harmful events
    Stéphanie Lacotte
    University of Geneva, Department of Surgery, Rue Gabrielle Perret Gentil 4, 1211 Geneva 14, Switzerland
    Expert Opin Biol Ther 11:55-66. 2011
    ..An accurate monitoring strategy could allow for the detection and treatment of harmful immune events, potentially resulting in higher rates of insulin-independence...
  84. ncbi Transplantation of islets of Langerhans: new developments
    T Berney
    Department of Surgery, University Hospital of Geneva, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
    Swiss Med Wkly 131:671-80. 2001
    ....
  85. pmc Four year nutritional follow up after living related small bowel transplantation between monozygotic twins
    L Genton
    Department of Nutrition, Geneva University Hospital, Switzerland
    Gut 52:659-62. 2003
    ..SBTX improved the nutritional state and growth of the graft recipient although body composition, femoral bone mineral densities, and intestinal absorption had not completely normalised after four years...
  86. ncbi Optimization of neutral protease to collagenase activity ratio for islet of Langerhans isolation
    P Bucher
    Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    Transplant Proc 36:1145-6. 2004
    ..The optimal neutral protease to collagenase activity ratio has not been determined for islet isolation. We evaluated a new highly purified collagenase that can be blended with predetermined amounts of neutral protease (NP)...
  87. ncbi Phylogenetic disparity influences the predominance of direct over indirect pathway of antigen presentation in islet xenotransplantation
    A Andres
    Surgical Research Unit, Department of Surgery, University Hospital Geneva, Geneva, Switzerland
    Transplant Proc 37:463-5. 2005
    ..The aim of this study was to analyze in vitro the predominance of direct or indirect presentation, and in vivo the effect of macrophage depletion on concordant and discordant islet xenograft survival...
  88. ncbi Invasive zygomycosis in transplant recipients
    Ilker Uckay
    Service of Infectious Diseases, University Hospital of Geneva, Geneva, Switzerland
    Clin Transplant 21:577-82. 2007
    ..In transplant recipients cumulating risk factors for zygomycosis, a high index of suspicion is required. Early diagnosis and combining surgery with systemic amphotericin-B are mandatory to improve survival rates...
  89. ncbi Renal transplantation in the elderly: a long-term, single-centre experience
    P Saudan
    Division of Nephrology, Department of Medicine, University Hospital, Geneva, Switzerland
    Nephrol Dial Transplant 16:824-8. 2001
    ..Although these patients have a shorter life expectancy, they benefit from renal transplantation similarly to younger kidney transplant recipients...
  90. ncbi Renal transplantation with donors aged over 50: a long-term, single centre experience
    P Saudan
    Division of Nephrology, Department of Medicine, University Hospital, Geneva, Switzerland
    Swiss Med Wkly 131:117-21. 2001
    ..Overall, donor age was not a predictive factor for graft survival, as shown by multiple logistic regression. CONCLUSIONS: Kidneys obtained from donors > 50 years are suitable for renal transplantation and yield acceptable graft survival...
  91. ncbi Morbidity associated with intraportal islet transplantation
    P Bucher
    Department of Surgery, Cell Isolation and Transplantation Center, Geneva University Hospital, Geneva, Switzerland
    Transplant Proc 36:1119-20. 2004
    ..Complications associated with intraportal islet infusion have been reported. In this study, we analyzed the relationship between occurrence of complications and islet preparation characteristics/infusion technique...
  92. ncbi Role of CD40-CD154 pathway in the rejection of concordant and discordant xenogeneic islets
    G Mai
    Surgical Research Unit, Department of Surgery, University Hospital Geneva, Geneva, Switzerland
    Transplant Proc 37:460-2. 2005
    ..The aim of the present study was to evaluate the role of recipient CD40 and CD154 in the rejection process of concordant and discordant islet xenotransplantation (Tx)...
  93. doi Insulin secretion from human beta cells is heterogeneous and dependent on cell-to-cell contacts
    A Wojtusciszyn
    Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals, 1 rue Michel Servet, Geneve 4, Switzerland
    Diabetologia 51:1843-52. 2008
    ..We assessed the heterogeneity of insulin secretion from human isolated beta cells and its regulation by cell-to-cell contacts...
  94. ncbi Serva collagenase NB1: a new enzyme preparation for human islet isolation
    P Bucher
    Department of Surgery, Cell Isolation and Transplantation Center, Geneva University Hospital, Geneva, Switzerland
    Transplant Proc 36:1143-4. 2004
    ..In this study we evaluated a new enzyme preparation composed of a highly purified collagenase that can be reproducibly blended with predetermined amounts of separately packaged neutral protease...
  95. ncbi Microbial surveillance during human pancreatic islet isolation
    P Bucher
    Cell Isolation and Transplantation Center, Geneva University Hospitals, Geneva, Switzerland
    Transplant Proc 36:1147-8. 2004
    ..The study aim was to investigate the microbiological safety of islet isolation and transplantation...
  96. ncbi Treatment of fulminant liver failure by transplantation of microencapsulated primary or immortalized xenogeneic hepatocytes
    G Mai
    Department of Surgery, Surgical Research Unit, University Hospital Geneva, Geneva, Switzerland
    Transplant Proc 37:527-9. 2005
    ..The aim of this study was to evaluate the in vitro and in vivo function of hepatocytes after immortalization, cryopreservation, encapsulation, and xenotransplantation into mice with fulminant liver failure (FLF)...
  97. ncbi Risk factors for early failure of native arteriovenous fistulas
    T Ernandez
    Division of Nephrology, University Hospitals of Geneva, Geneva, Switzerland
    Nephron Clin Pract 101:c39-44. 2005
    ..However, this kind of vascular access has a high rate of early failure (early thrombosis or non-maturation). Our aim was to examine whether clear risk factors for early AVF failure could be identified in our patients...
  98. ncbi Neonatal porcine pancreatic cell clusters as a potential source for transplantation in humans: characterization of proliferation, apoptosis, xenoantigen expression and gene delivery with recombinant AAV
    Caterina Vizzardelli
    Diabetes Research Institute, Cell Transplant Center, University of Miami School of Medicine, FL 33136, USA
    Xenotransplantation 9:14-24. 2002
    ..This characterization might be helpful in the definition of the potential use of neonatal porcine islets for human transplantation...
  99. ncbi Portal versus systemic drainage of small bowel allografts: comparative assessment of survival, function, rejection, and bacterial translocation
    Thierry Berney
    Liver Gastrointestinal Transplantation, Department of Surgery, University of Miami School of Medicine, Miami, FL 33136, USA
    J Am Coll Surg 195:804-13. 2002
    ..Comparisons in animal models have not demonstrated a clear advantage of one technique over the other, but clinical data are lacking...
  100. ncbi Prolonged islet allograft survival in diabetic NOD mice by targeting CD45RB and CD154
    R Damaris Molano
    Cell Transplant Center, Diabetes Research Institute, University of Miami School of Medicine, Miami, Florida, USA
    Diabetes 52:957-64. 2003
    ..These data show that nondiabetogenic regimens of immunomodulation can lead to prolonged islet allograft survival in the challenging NOD mouse model...
  101. ncbi A retrospective review of sirolimus (Rapamune) therapy in orthotopic liver transplant recipients diagnosed with chronic rejection
    Guy W Neff
    University of Miami, Department of Medicine, Miami, FL 33136, USA
    Liver Transpl 9:477-83. 2003
    ..Recombinant erythropoietin was started in 5 of 21 patients. Sirolimus serum levels were found to be greater than 20 ng/dL in 12 patients. Sirolimus was discontinued in 9 patients,..

Research Grants1

  1. ISLET OF LANGERHANS GRAFT MONITORING BY MAGNETIC RESONANCE IMAGING
    Thierry Berney; Fiscal Year: 2008
    ..unreadable] [unreadable]..