Genomes and Genes
University of Geneva
Organization: University of Geneva
- The nuclear pore complex: bridging nuclear transport and gene regulationCaterina Strambio-de-Castillia
Department of Microbiology and Molecular Medicine, University of Geneva, 1 rue Michel Servet, CH 1211 Geneva, Switzerland
Nat Rev Mol Cell Biol 11:490-501. 2010....
- [Vaccinology update for 2008: what's new in Switzerland?]C A Siegrist
Centre de vaccinologie et d immunologie néonatale, CMU, 1211 Geneve
Rev Med Suisse 4:72-5. 2008..A source of information to be recommended without hesitation!..
- An automated system for intracellular and intranuclear injectionRon C Hogg
Department of Neurosciences Fondamentales, Medical Faculty, University of Geneva, Switzerland
J Neurosci Methods 169:65-75. 2008..Moreover, we demonstrate that this method can also be successfully applied to inject zebrafish embryos and could be extended to other cell types...
- Aging and lexical inhibition: the effect of orthographic neighborhood frequency in young and older adultsChristelle Robert
Department of Psychology, Universite Bordeaux 2, France
J Gerontol B Psychol Sci Soc Sci 62:P340-2. 2007..These data are consistent with the assumption of an age-related decline in lexical inhibition and activation. The findings are discussed in the framework of visual word recognition and aging...
- Long-term sealing ability of Pulp Canal Sealer, AH-Plus, GuttaFlow and EpiphanyS Bouillaguet
Department of Cariology and Endodontology, University of Geneva, Geneva, Switzerland
Int Endod J 41:219-26. 2008..To evaluate the long-term sealing ability of four contemporary endodontic sealers [Pulp Canal Sealer (PCS), AH-Plus, GuttaFlow and Epiphany] using a fluid filtration technique...
- The influence of action perception on object recognition: a developmental studyPierre Mounoud
Department of Psychology, Universite de Geneve, Geneva, Switzerland
Dev Sci 10:836-52. 2007..Implications of these results for the organization and development of conceptual knowledge are discussed...
- Role of histone and DNA methylation in gene regulationIsabelle Vaillant
Laboratory of Plant Genetics, University of Geneva, Sciences III, 30 Quai Ernest Ansermet, CH 1211 Geneva 4, Switzerland
Curr Opin Plant Biol 10:528-33. 2007..Recent studies have refined our understanding of the biological significance of and the molecular mechanisms involved in the interplay between DNA and histone H3 methylation...
- Gene-environment interactions in the skeletal response to nutrition and exercise during growthJean Philippe Bonjour
Division of Bone Diseases, WHO Collaborating Centre for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, University Hospitals of Geneva, Geneva 14, Switzerland
Med Sport Sci 51:64-80. 2007..Identifying the functionally implicated genes interacting with mechanical loading and/or specific nutrients represents a formidable but hopefully not intractable challenge...
- The impact of pharmaceutical company funding on results of randomized trials of nicotine replacement therapy for smoking cessation: a meta-analysisJean Francois Etter
Institute of Social and Preventive Medicine, University of Geneva, Switzerland
Addiction 102:815-22. 2007..To assess whether source of funding affected the results of trials of nicotine replacement therapy (NRT) for smoking cessation...
- Anatomical modelling of the musculoskeletal system from MRIBenjamin Gilles
MIRALab, University of Geneva, CH 1211 Geneva, Switzerland
Med Image Comput Comput Assist Interv 9:289-96. 2006..We validate our methods for the hip joint and the thigh (20 muscles, 4 bones) on 4 datasets: average error = 1.5 mm, computation time = 15 min...
- Cell growth control: little eukaryotes make big contributionsC De Virgilio
Département de Microbiologie et Médecine Moléculaire, Universite de Geneve, CMU, Geneva, Switzerland
Oncogene 25:6392-415. 2006..Given the unsurpassed resources available to yeast researchers, this simple eukaryote continues to contribute to our understanding of eukaryotic cell growth in general and TOR function in particular...
- Dynamics of composite polymerization mediates the development of cuspal strainS Bouillaguet
Division of Cariology and Endodontology, School of Dental Medicine, University of Geneva, 19 Rue BarthElemy Menn, 1205 Geneva, Switzerland
Dent Mater 22:896-902. 2006..Our hypothesis was that composites with higher polymerization shrinkage should cause more cuspal strain as measured by ESPI...
- Deciphering the human nucleolar proteomeYohann Coute
Biomedical Proteomics Research Group, Département de biologie structurale et bioinformatique, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 14, Switzerland
Mass Spectrom Rev 25:215-34. 2006....
- The effects of beta1-adrenergic blockade on cardiovascular oxygen flow in normoxic and hypoxic humans at exerciseGuido Ferretti
Departement de Physiologie, Centre Medical Universitaire, Geneva, Switzerland
Eur J Appl Physiol 95:250-9. 2005..The two observed relationships between QvO(2) and SaO(2) apply to conditions of predominant sympathetic or vagal activation, respectively. Moving from one line to the other implies resetting of the cardiovascular regulation...
- [Diagnosis and management of mild bleeding disorders]P Fontana
Service d angiologie et d hémostase, Departement de Medecine Interne, HUG, 1211 Geneve
Rev Med Suisse 4:122-6. 2008..Several pharmacological agents are available; however, before prophylactic administration of such drugs, a trade-off between their thrombotic risks and excessive bleeding should be made...
- Conscious emotional experience emerges as a function of multilevel, appraisal-driven response synchronizationDidier Grandjean
Swiss Center for Affective Sciences, University of Geneva, 7 rue des Battoirs, CH 1205 Geneva, Switzerland
Conscious Cogn 17:484-95. 2008..Third, we review recent neuroscience evidence that bolsters our claim of the central importance of the synchronization of neuronal assemblies at different levels of processing...
- [Medicine and the social sciences: a creative alliance]M de Coulon
Rev Med Suisse 4:1062-5. 2008
- Relationships between structural dynamics and functional kinetics in oligomeric membrane receptorsStuart J Edelstein
European Molecular Biology Laboratory European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK
Biophys J 98:2045-52. 2010..Concerning published varphi(F) values underlying the conformational wave hypothesis for nicotinic receptors, we note that interpretations may be complicated by variations in the width of harmonic energy profiles...
- [Vaccine update 2009: questions around the safety of the influenza A (H1N1) vaccine]Claire Anne Siegrist
Centre de vaccinologie et d immunologie néonatale, HUG et Faculté de médecine, 1211 Geneve 14
Rev Med Suisse 6:67-70. 2010..The huge number of questions sent by professionals to InfoVac experts (www.infovac.ch), and the expressed gratitude, allows for some hope...
- Short-term change in self-reported COPD symptoms after smoking cessation in an internet sampleJ F Etter
Institute of Social and Preventive Medicine, University of Geneva, CMU, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
Eur Respir J 35:1249-55. 2010..COPD is largely underdiagnosed and undertreated. Internet screening is reliable and may allow for the early detection of COPD symptoms at a large scale, in patients who may otherwise have no access to COPD case-finding efforts...
- Attentional networks efficiency in preterm childrenR Pizzo
Child Clinical Neuropsychology Unit, University of Geneva, Geneva, Switzerland
J Int Neuropsychol Soc 16:130-7. 2010..We also observed a significantly higher correlation between the orienting and executive control networks in the preterm group, suggesting less differentiation of these two networks in this population...
- Detection of genomic variation by selection of a 9 mb DNA region and high throughput sequencingSergey I Nikolaev
Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
PLoS ONE 4:e6659. 2009....
- Full-mouth adhesive rehabilitation of a severely eroded dentition: the three-step technique. Part 2Francesca Vailati
Dept of Fixed Prosthodontics and Occlusion, School of Dental Medicine, University of Geneva, Switzerland
Eur J Esthet Dent 3:128-46. 2008..A brief summary of the first step is also included...
- Inhibition of basal p38 or JNK activity enhances epithelial barrier function through differential modulation of claudin expressionFabio Carrozzino
Dept of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Am J Physiol Cell Physiol 297:C775-87. 2009....
- Endocytosis, asymmetric cell division, stem cells and cancer: unus pro omnibus, omnes pro unoMaximilian Fürthauer
Department of Biochemistry, University of Geneva, Sciences II, CH 1211 Geneva 4, Switzerland
Mol Oncol 3:339-53. 2009..We review recent findings suggesting that an understanding of the relationship between endocytosis, asymmetric cell division, stem cells and cancer will be crucial to unravel the cell biological basis of tumourigenesis...
- Persistence and growth of faecal culturable bacterial indicators in water column and sediments of Vidy Bay, Lake Geneva, SwitzerlandJohn Pote
University of Geneva, E A Forel Institute, 10 route de Suisse, 1290 Versoix, Switzerland
J Environ Sci (China) 21:62-9. 2009....
- Compromised stability of DNA methylation and transposon immobilization in mosaic Arabidopsis epigenomesJon Reinders
Department of Plant Biology, University of Geneva, Sciences III, Geneva, Switzerland
Genes Dev 23:939-50. 2009..Such persistently "unstable" epigenetic states complicate linkage-based epigenomic mapping. Thus, future epigenomic analyses should consider possible genetic instabilities and alternative mapping strategies...
- Untangling the phylogeny of amoeboid protistsJan Pawlowski
Department of Zoology and Animal Biology, University of Geneva, Geneva, Switzerland
J Eukaryot Microbiol 56:16-25. 2009..Finally, we highlight the interest of Amoebozoa and Rhizaria for understanding eukaryotic evolution and suggest that resolving their phylogenies will be among the main challenges for future phylogenomic analyses...
- Divergence in prevalence of mesiocclusion caused by different diagnostic criteriaChristine Bettina Staudt
Division of Orthodontics, Section de Médecine Dentaire, Faculte de Medecine, University of Geneva, Geneva, Switzerland
Am J Orthod Dentofacial Orthop 135:323-7. 2009..In addition to differences in ethnic background, sex, and age, inconsistency in diagnostic criteria might be important. Our aim was to investigate the prevalence of mesiocclusion in the same group by modifying the diagnostic criteria...
- Historical record of mercury contamination in sediments from the Babeni Reservoir in the Olt River, RomaniaAndrea Garcia Bravo
Institut F A Forel, University of Geneva, Versoix, Switzerland
Environ Sci Pollut Res Int 16:S66-75. 2009..Preliminary analyses (unpublished) showed high Hg concentrations in the surface sediment of the Babeni Reservoir. One core was taken in the upstream Valcea Reservoir to provide a local background level of Hg concentrations in sediments...
- Ego involvement and effort: cardiovascular, electrodermal, and performance effectsGuido H E Gendolla
Department of Psychology, University of Geneva, Geneva, Switzerland
Psychophysiology 42:595-603. 2005....
- Internet-based smoking cessation programsJean Francois Etter
Institute of Social and Preventive Medicine, University of Geneva, CMU, Case Postale, CH 1211 Geneva 4, Switzerland
Int J Med Inform 75:110-6. 2006..To present a smoking cessation website and a reflection on the use of the Internet as a smoking cessation tool...
- Carbohydrate moieties in human secretory componentG J Hughes
Department of Medical Biochemistry at the Medical Center, Faculty of Medicine, University of Geneva, 1 rue Michel Servet, CH 1211, Geneva, Switzerland
Biochim Biophys Acta 1434:86-93. 1999..Three of these oligosaccharides are the major carbohydrate moieties in human lactoferrin. A possible biological role of the secretory component glycans in the protection of mucosal surfaces is discussed...
- Expression of alpha-1 proteinase inhibitor in human islet microvascular endothelial cellsJ Lou
Department of Surgery, University Hospital, University of Geneva, Switzerland
Diabetes 48:1773-8. 1999..These results indicate that HI-MVEC exhibit some specific morphological and functional characteristics that differ from MVEC derived from other organs...
- Acetylcholine synthesis and quantal release reconstituted by transfection of mediatophore and choline acetyltranferase cDNAsA Bloc
Pharmacologie, Centre Medical Universitaire, Geneve, Switzerland
Eur J Neurosci 11:1523-34. 1999....
- Anatomy teaching for medical undergraduates: general practice as a guideline? The brainJ H Fasel
Department of Morphology, University Medical Center, Geneva, Switzerland
Clin Anat 12:115-9. 1999..We also hope that this approach may serve as a model for the teaching of other basic sciences...
- Differential usage of two 5' splice sites in a complex exon generates additional protein sequence complexity in chicken CLIP-170 isoformsL Griparic
Molecular Biophysics Program and Department of Biological Science, Florida State University, Tallahassee, FL, USA
Biochim Biophys Acta 1449:119-24. 1999..Differential usage of the 5'-splice junctions in this complex exon appears to be tissue- rather than isoform-specific...
- von Willebrand factor (vWf) as a plasma marker of endothelial activation in diabetes: improved reliability with parallel determination of the vWf propeptide (vWf:AgII)U M Vischer
Department of Internal Medicine, HCU, Geneva, Switzerland
Thromb Haemost 80:1002-7. 1998....
- Influence of maternal antibodies on vaccine responses: inhibition of antibody but not T cell responses allows successful early prime-boost strategies in miceC A Siegrist
W H O Collaborating Center for Neonatal Vaccinology, Department of Pathology, University of Geneva Medical School, Switzerland
Eur J Immunol 28:4138-48. 1998..It suggests that effective vaccine responses may be obtained earlier in presence of maternal antibodies through the use of appropriate immunization strategies using conventional or novel vaccines for early priming...
- Differential reactivity of brain microvascular endothelial cells to TNF reflects the genetic susceptibility to cerebral malariaJ Lou
Department of Anesthesiology, Pharmacology and Surgical Intensive Care, University Hospital, Geneva, Switzerland
Eur J Immunol 28:3989-4000. 1998..These results indicate that brain MVEC purified from CM-S and CM-R mice exhibit distinctive sensitivity to TNF This difference may be partly due to a differential regulation of TNF receptors and via distinct protein kinase pathways...
- Selective vulnerability of neocortical association areas in Alzheimer's diseaseP Giannakopoulos
Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Switzerland
Microsc Res Tech 43:16-23. 1998..Moreover, recent data on pathological correlates of apraxia in AD are examined in the light of the hypothesis of global corticocortical disconnection in this disorder...
- Cerebral cortex pathology in aging and Alzheimer's disease: a quantitative survey of large hospital-based geriatric and psychiatric cohortsP Giannakopoulos
Department of Psychiatry, HUG Belle Idée, University of Geneva School of Medicine, Switzerland
Brain Res Brain Res Rev 25:217-45. 1997..These observations are discussed in the light of the hypothesis of global corticocortical disconnection and with respect to the notion of selective neuronal vulnerability in Alzheimer's disease...
- Haptic processing by the left hemisphere in a split-brain patientM Badan
Faculty of Psychology and Educational Sciences, University of Geneva, Switzerland
Neuropsychologia 35:1275-87. 1997....
- The secalosides, novel tumor cell growth inhibitory glycosides from a pollen extractJ C Jaton
Department of Medical Biochemistry, University of Geneva, Switzerland
J Nat Prod 60:356-60. 1997..IC50 values obtained were about 5 micrograms/mouse for the secalosides and 1 microgram/mouse for 3 and 4...
- Haemostatic properties of human pulmonary and cerebral microvascular endothelial cellsG E Grau
Department of Anaesthesiology, University Hospital, Geneva, Switzerland
Thromb Haemost 77:585-90. 1997..It is concluded that MVEC display different haemostatic features depending on the tissue they come from and that lung MVEC from ARDS patients present a procoagulant profile when compared with those from controls...
- Post-stripping sclerodermiform dermatitisL E French
Department Hospitalo Universitaire Romand de Dermatologie Geneva Lausanne, Geneva, Switzerland
Arch Dermatol 135:1387-91. 1999....
- Human calf microvascular compliance measured by near-infrared spectroscopyT Binzoni
Departments of Physiology and Radiology, Faculty of Medicine, University of Geneva, 1211 Geneva 4, Switzerland
J Appl Physiol (1985) 88:369-72. 2000..However, by following the changes in oxy- and deoxyhemoglobin in the P range -16 to 100 mmHg, it appears to be possible to assess the characteristics of the vasomotor response of the arteriolar system...
- The parting of the endothelium: miracle, or simply a junctional affair?C Johnson-Leger
Department of Pathology, Centre Medical Universitaire, Switzerland
J Cell Sci 113:921-33. 2000..Passage of the leukocyte across the endothelium appears to require delocalization of certain endothelial cell molecules and proteolytic degradation of junctional complexes...
- Mislocalization of flashes during smooth pursuit hardly depends on the lighting conditionsDirk Kerzel
Faculte de Psychologie et des Sciences de l Education, Universite de Geneve, 40 bd du Pont d Arve, CH 1205 Geneve, Switzerland
Vision Res 46:1145-54. 2006..We conclude that although the lighting conditions do influence the localization errors under some circumstances, it is certainly not so that such errors are absent whenever the experiment is conducted in the dark...
- Nitric oxide production within rat urothelial cellsD Mastrangelo
Urology Clinic, Department of Surgery, Geneva University Hospital, Switzerland
J Urol 170:1409-14. 2003..We investigated endogenous NO production in the proximal half of the rat ureter, localized its cellular source, characterized the NOS isoforms involved and assessed the impact of NO on ureteral motility...
- Cell biology. Apoptosis--the calcium connectionNicolas Demaurex
Department of Physiology, University of Geneva Medical Center, Geneva, Switzerland
Science 300:65-7. 2003
- The Q motif: a newly identified motif in DEAD box helicases may regulate ATP binding and hydrolysisN Kyle Tanner
Departement de Biochimie Medicale, Centre Medical Universitaire, 1, rue Michel Servet, 1211 Geneva 4, Switzerland
Mol Cell 11:127-38. 2003..These results are consistent with computer studies of the solved crystal structures...
- Retinoids induce lumen morphogenesis in mammary epithelial cellsRoberto Montesano
Department of Morphology, University of Geneva Medical Center, CH 1211 Geneva 4, Switzerland
J Cell Sci 115:4419-31. 2002..Collectively, our results provide evidence that RA promotes lumen formation by mammary epithelial cells in vitro and suggest that it plays a similar role during mammary gland development in vivo...
- Physicochemical aspects of lead bioaccumulation by Chlorella vulgarisVera I Slaveykova
Analytical and Biophysical Environmental Chemistry, University of Geneva, Switzerland
Environ Sci Technol 36:969-75. 2002..67) M(-1) at pH 6. Results were discussed within the perspective of the free ion activity and biotic ligand models...
- The use of digital dermoscopy for the follow-up of congenital nevi: a pilot studyR P Braun
Pigmented Skin Lesion Unit, Department of Dermatology, University Hospital Geneva, Geneva, Switzerland
Pediatr Dermatol 18:277-81. 2001..We showed the feasibility of follow-up of congenital nevi using digital dermoscopy. Furthermore, we identified three different patterns as well as some typical structures seen in congenital nevi by DD...
- Coexistence in a predator-prey systemM Droz
Département de Physique Théorique, Universite de Geneve, quai E Ansermet 24, 1211 Geneve 4, Switzerland
Phys Rev E Stat Nonlin Soft Matter Phys 63:051909. 2001..We demonstrate that the probability of arriving at one of the above states depends on the initial densities of the prey and predator populations, the amount of cover, and the way it is spatially distributed...
- Raft membrane domains: from a liquid-ordered membrane phase to a site of pathogen attackF G van der Goot
Department of Biochemistry, University of Geneva, 1211 Geneva, 30 quai E Ansermet, Switzerland
Semin Immunol 13:89-97. 2001..Elucidation of these interactions requires a detailed understanding raft structure and dynamics...
- Raft-partitioning of the ubiquitin ligases Cbl and Nedd4 upon IgE-triggered cell signalingF Lafont
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 110, D 01307 Dresden, Germany
Proc Natl Acad Sci U S A 98:3180-4. 2001..Because Cbl is known to interact with the FcepsilonRI signaling complex, ubiquitination is likely to be an important parameter regulating IgE-triggered signaling occurring in rafts...
- [Respiratory sleep disorders in the elderly]J P Janssens
Departement de Geriatrie, Hopitaux Universitaires de Geneve
Rev Med Suisse Romande 120:869-79. 2000..SRBD should be considered as a possible cause of "reversible dementia" and sought for in the presence of daytime somnolence, delirium, or unexplained right-sided heart failure in older patients...
- Human and Xenopus cingulin share a modular organization of the coiled-coil rod domain: predictions for intra- and intermolecular assemblyS Citi
Department of Molecular Biology, University of Geneva, Geneva, 1205, Switzerland
J Struct Biol 131:135-45. 2000..Cingulin mRNA ( approximately 5.2 kb) was detected by Northern blotting in epithelial tissues. A human cingulin EST was mapped to chromosome 1q21 using the UniGene database...
- Vasopressin-induced von Willebrand factor secretion from endothelial cells involves V2 receptors and cAMPJ E Kaufmann
Division of Clinical Biochemistry, Geneva, Switzerland Research Institute for Molecular Pharmacology, Berlin, Germany
J Clin Invest 106:107-16. 2000..They also demonstrate functional expression of V2R in endothelial cells, and provide a cellular mechanism for the hemostatic effects of DDAVP...
- Dynamic changes in nuclear architecture during mitosis: on the role of protein phosphorylation in spindle assembly and chromosome segregationE A Nigg
Department of Molecular Biology, Sciences II, University of Geneva, 30, Quai Ernest Ansermet, Geneva 4, CH 1211, Switzerland
Exp Cell Res 229:174-80. 1996..This observation hints at the existence of a checkpoint linking Cdc2 activation to the presence of functional centrosomes...
- ROLE OF GLIL IN BASAL CELL CARCINOMA DEVELOPMENTAriel Ruiz i Altaba; Fiscal Year: 2002..In addition, understanding how deregulation of the Shh signaling pathway and Gli1 function lead to BCC formation, will shed light into the normal role of this gene in follicle development. ..
- FUNCTION OF THE GLI GENES IN SONIC SIGNALINGAriel Ruiz i Altaba; Fiscal Year: 2002....
- FUNCTION OF THE GLI GENES IN SONIC HEDGEHOG SIGNALINGAriel Ruiz i Altaba; Fiscal Year: 2007..In addition, the knowledge of how the SHH-GLI pathway affects brain precursors will help our understanding of how brain tumors arise, an area of research covered under a different, yet related, project in the laboratory. ..
- Anthrax toxin-host cell interactionsFRANCOISE VAN DER GOOT; Fiscal Year: 2004..abstract_text> ..
- Gag and Cyclophillin in HIV-1 ReplicationJeremy Luban; Fiscal Year: 2006..These immunologic abnormalities would be expected to contribute to HIV-1 replication and pathogenesis. ..
- Cyclophilin A Function in the Immune SystemJeremy Luban; Fiscal Year: 2006..New information concerning these basic biological processes will help understand the etiology of such diseases as asthma and AIDS, and, therefore, is critical for the development of much-needed medical therapies. ..
- Cyclophilin A Function in the Immune SystemJeremy Luban; Fiscal Year: 2009..New information concerning these basic biological processes will help understand the etiology of such diseases as asthma and AIDS, and, therefore, is critical for the development of much-needed medical therapies. ..
- GAG AND CYCLOPHILIN IN HIV1 REPLICATIONJeremy Luban; Fiscal Year: 2003..4) To gain biochemical evidence for the function of CyPA for HIV-1 replication, including a test of the hypothesis that this cellular protein acts by destabilizing HIV-1 cores, thereby promoting disassembly in the newly infected cell. ..
- MOLECULAR DESCRIPTION OF HIV1 GAG ASSEMBLYJeremy Luban; Fiscal Year: 2000..The role of viral RNA in Gag multimerization will also be studied. Finally, a selection of techniques will be used to assess how mutations affecting Gag multimerization impact upon HIV-1 infectivity in vitro. ..
- Molecular Description of HIV-1 GAG AssemblyJeremy Luban; Fiscal Year: 2003..Experiments proposed here will promote understanding of HIV-1 replication mechanisms and may contribute to development of new antiviral agents. ..