S Werner

Summary

Affiliation: Swiss Federal Institute of Technology
Country: Switzerland

Publications

  1. pmc Regulation of liver regeneration by growth factors and cytokines
    Friederike Böhm
    Department of Biology, Institute of Cell Biology, ETH Zurich, Zurich, Switzerland
    EMBO Mol Med 2:294-305. 2010
  2. pmc Peroxiredoxin 6 is required for blood vessel integrity in wounded skin
    Angelika Kümin
    Institute of Cell Biology, Department of Biology, ETH Zurich, Honggerberg, CH 8093 Zurich, Switzerland
    J Cell Biol 179:747-60. 2007
  3. pmc Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis
    Jingxuan Yang
    Department of Biology, Institute of Cell Biology, Eidgenossische Technische Hochschule Zurich, 8093 Zurich, Switzerland
    J Cell Biol 188:935-52. 2010
  4. pmc Nrf2 links epidermal barrier function with antioxidant defense
    Matthias Schafer
    Department of Biology, Institute of Cell Biology, ETH Zurich, Zurich, Switzerland
    EMBO Mol Med 4:364-79. 2012
  5. pmc Activin enhances skin tumourigenesis and malignant progression by inducing a pro-tumourigenic immune cell response
    Maria Antsiferova
    Department of Biology, Institute of Cell Biology, ETH Zurich, 8093 Zurich, Switzerland
    Nat Commun 2:576. 2011
  6. ncbi request reprint Paracrine regulation of keratinocyte proliferation and differentiation
    S Werner
    Institute of Cell Biology, Swiss Federal Institute of Technology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Trends Cell Biol 11:143-6. 2001
  7. ncbi request reprint Roles of activin in tissue repair, fibrosis, and inflammatory disease
    Sabine Werner
    Institute of Cell Biology, Department of Biology, ETH Zurich, Honggerberg, CH 8093 Zurich, Switzerland
    Cytokine Growth Factor Rev 17:157-71. 2006
  8. ncbi request reprint Regulation of wound healing by growth factors and cytokines
    Sabine Werner
    Institute of Cell Biology, ETH Zurich, Honggerberg, HPM D42, CH 8093 Zurich, Switzerland
    Physiol Rev 83:835-70. 2003
  9. ncbi request reprint The Mad1 transcription factor is a novel target of activin and TGF-beta action in keratinocytes: possible role of Mad1 in wound repair and psoriasis
    S Werner
    Institute of Cell Biology, , , Switzerland
    Oncogene 20:7494-504. 2001
  10. ncbi request reprint The activin binding proteins follistatin and follistatin-related protein are differentially regulated in vitro and during cutaneous wound repair
    M Wankell
    Institute of Cell Biology, ETH Zurich, Honggerberg, HPM D42, CH 8093 Zurich, Switzerland
    J Endocrinol 171:385-95. 2001

Collaborators

Detail Information

Publications88

  1. pmc Regulation of liver regeneration by growth factors and cytokines
    Friederike Böhm
    Department of Biology, Institute of Cell Biology, ETH Zurich, Zurich, Switzerland
    EMBO Mol Med 2:294-305. 2010
    ..This review summarizes the results obtained by functional studies that have addressed the roles and mechanisms of action of growth factors and cytokines in liver regeneration after acute injury to this organ...
  2. pmc Peroxiredoxin 6 is required for blood vessel integrity in wounded skin
    Angelika Kümin
    Institute of Cell Biology, Department of Biology, ETH Zurich, Honggerberg, CH 8093 Zurich, Switzerland
    J Cell Biol 179:747-60. 2007
    ..These results provide insight into the cross-talk between hematopoietic and resident cells at the wound site and the role of reactive oxygen species in this interplay...
  3. pmc Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis
    Jingxuan Yang
    Department of Biology, Institute of Cell Biology, Eidgenossische Technische Hochschule Zurich, 8093 Zurich, Switzerland
    J Cell Biol 188:935-52. 2010
    ..Our results identify essential roles for FGFs in the regulation of the epidermal barrier and in the prevention of cutaneous inflammation, and highlight the importance of stromal-epithelial interactions in skin homeostasis and disease...
  4. pmc Nrf2 links epidermal barrier function with antioxidant defense
    Matthias Schafer
    Department of Biology, Institute of Cell Biology, ETH Zurich, Zurich, Switzerland
    EMBO Mol Med 4:364-79. 2012
    ..These results identify an unexpected role of Nrf2 in epidermal barrier function, which needs to be considered for pharmacological use of Nrf2 activators...
  5. pmc Activin enhances skin tumourigenesis and malignant progression by inducing a pro-tumourigenic immune cell response
    Maria Antsiferova
    Department of Biology, Institute of Cell Biology, ETH Zurich, 8093 Zurich, Switzerland
    Nat Commun 2:576. 2011
    ..These findings highlight the parallels between wound healing and cancer, and suggest inhibition of activin action as a promising strategy for the treatment of cancers overexpressing this factor...
  6. ncbi request reprint Paracrine regulation of keratinocyte proliferation and differentiation
    S Werner
    Institute of Cell Biology, Swiss Federal Institute of Technology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Trends Cell Biol 11:143-6. 2001
    ....
  7. ncbi request reprint Roles of activin in tissue repair, fibrosis, and inflammatory disease
    Sabine Werner
    Institute of Cell Biology, Department of Biology, ETH Zurich, Honggerberg, CH 8093 Zurich, Switzerland
    Cytokine Growth Factor Rev 17:157-71. 2006
    ..In this review we highlight recent data regarding the expression and function of activins in tissue repair, fibrosis, and inflammation...
  8. ncbi request reprint Regulation of wound healing by growth factors and cytokines
    Sabine Werner
    Institute of Cell Biology, ETH Zurich, Honggerberg, HPM D42, CH 8093 Zurich, Switzerland
    Physiol Rev 83:835-70. 2003
    ..Most importantly, we also report on genetic studies addressing the functions of endogenous growth factors in the wound repair process...
  9. ncbi request reprint The Mad1 transcription factor is a novel target of activin and TGF-beta action in keratinocytes: possible role of Mad1 in wound repair and psoriasis
    S Werner
    Institute of Cell Biology, , , Switzerland
    Oncogene 20:7494-504. 2001
    ....
  10. ncbi request reprint The activin binding proteins follistatin and follistatin-related protein are differentially regulated in vitro and during cutaneous wound repair
    M Wankell
    Institute of Cell Biology, ETH Zurich, Honggerberg, HPM D42, CH 8093 Zurich, Switzerland
    J Endocrinol 171:385-95. 2001
    ..The different expression pattern of FLRG and follistatin and their differential regulation suggest different functions of these activin-binding proteins in vivo...
  11. pmc Impaired wound healing in transgenic mice overexpressing the activin antagonist follistatin in the epidermis
    M Wankell
    Institute of Cell Biology, ETH Zurich, Honggerberg, CH 8093 Zurich, Switzerland
    EMBO J 20:5361-72. 2001
    ..The wounds, however, finally healed, and the resulting scar area was smaller than in control animals. These results implicate an important function of endogenous activin in the control of wound repair and scar formation...
  12. ncbi request reprint Novel roles of NM23 proteins in skin homeostasis, repair and disease
    S Braun
    Institute of Cell Biology, ETH Zurich, Honggerberg, Zurich, Switzerland
    Oncogene 26:532-42. 2007
    ..These findings suggest that epidermal homeostasis depends on a tight regulation of the levels of NM23 isoforms...
  13. pmc Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound
    Susanne Braun
    Institute of Cell Biology, Department of Biology, ETH Zurich, Honggerberg, CH 8093 Zurich, Switzerland
    Mol Cell Biol 22:5492-505. 2002
    ..Taken together, our results reveal novel roles of the KGF-regulated transcription factors Nrf2 and possibly Nrf3 in the control of gene expression and inflammation during cutaneous wound repair...
  14. ncbi request reprint Expression and function of keratinocyte growth factor and activin in skin morphogenesis and cutaneous wound repair
    H D Beer
    Institute of Cell Biology, Swiss Federal Institute of Technology, Zurich
    J Investig Dermatol Symp Proc 5:34-9. 2000
    ..Most importantly, overexpression of activin strongly enhanced the process of granulation tissue formation, demonstrating a novel and important role of activin in cutaneous wound repair...
  15. ncbi request reprint Id proteins: novel targets of activin action, which regulate epidermal homeostasis
    D Rotzer
    Institute of Cell Biology, Department of Biology, ETH Zurich, Honggerberg, Zurich, Switzerland
    Oncogene 25:2070-81. 2006
    ..These results identify an important function of Id1 in the regulation of epidermal homeostasis...
  16. pmc Loss of serum response factor in keratinocytes results in hyperproliferative skin disease in mice
    Heidi Koegel
    Institute of Cell Biology, Department of Biology, ETH Zurich, Zurich, Switzerland
    J Clin Invest 119:899-910. 2009
    ..These results reveal that loss of SRF disrupts epidermal homeostasis and strongly suggest its involvement in the pathogenesis of hyperproliferative skin diseases, including psoriasis...
  17. pmc Peroxiredoxin 6 is a potent cytoprotective enzyme in the epidermis
    Angelika Kümin
    Department of Biology, Institute of Cell Biology, ETH Zurich, Honggerberg, HPM D42, CH 8093 Zurich, Switzerland
    Am J Pathol 169:1194-205. 2006
    ....
  18. ncbi request reprint Roles and mechanisms of action of the Nrf2 transcription factor in skin morphogenesis, wound repair and skin cancer
    T A Beyer
    Department of Biology, Institute of Cell Biology, ETH Zurich, Zurich, Switzerland
    Cell Death Differ 14:1250-4. 2007
  19. ncbi request reprint The Ca2+-binding proteins S100A8 and S100A9 are encoded by novel injury-regulated genes
    I S Thorey
    Institute of Cell Biology, , , , Switzerland
    J Biol Chem 276:35818-25. 2001
    ....
  20. pmc Activities of the matrix metalloproteinase stromelysin-2 (MMP-10) in matrix degradation and keratinocyte organization in wounded skin
    Monika Krampert
    Department of Biology, Institute of Cell Biology, Eidgenössishe Technische Hochschule Zurich, 8093 Zurich, Switzerland
    Mol Biol Cell 15:5242-54. 2004
    ..These results suggest that a tightly regulated expression level of stromelysin-2 is required for limited matrix degradation at the wound site, thereby controlling keratinocyte migration...
  21. ncbi request reprint Electrophilic chemicals but not UV irradiation or reactive oxygen species activate Nrf2 in keratinocytes in vitro and in vivo
    Moritz Durchdewald
    Department of Biology, Institute of Cell Biology, ETH Zurich, Zurich, Switzerland
    J Invest Dermatol 127:646-53. 2007
    ..Electrophiles but not UVB activated the reporter in an Nrf2-dependent manner. These results provide the basis for the identification of novel Nrf2 activators in keratinocytes with therapeutic potential for skin tumor prevention...
  22. ncbi request reprint Fibroblast growth factor 22 and its potential role during skin development and repair
    Tobias A Beyer
    Institute of Cell Biology, ETH Zurich, Honggerberg, CH 8093 Zurich, Switzerland
    Exp Cell Res 287:228-36. 2003
    ..5 embryos, as well as in adult skin and keratinocytes of the hyperthickened wound epithelium. This expression pattern suggests a potential role for FGF-22 in cutaneous development and repair...
  23. ncbi request reprint The roles of activin in cytoprotection and tissue repair
    Miriam Wankell
    Institute of Cell Biology, ETH Zurich, Honggerberg, CH 8093 Zurich, Switzerland
    Ann N Y Acad Sci 995:48-58. 2003
    ..Our own results have provided evidence for an important function of activin in cutaneous wound repair as well as in neuroprotection, and these data will be summarized and discussed in this chapter...
  24. ncbi request reprint The chemokine receptor CCR1 is strongly up-regulated after skin injury but dispensable for wound healing
    Susanne Kaesler
    Institute of Cell Biology, Department of Biology, ETH Zurich, Zurich, Switzerland
    Wound Repair Regen 12:193-204. 2004
    ..These results show that CCR1 is dispensable for wound healing, most likely due to redundancy in chemokine/chemokine receptor signaling...
  25. pmc Activin controls skin morphogenesis and wound repair predominantly via stromal cells and in a concentration-dependent manner via keratinocytes
    Casimir Bamberger
    Department of Biology, Institute of Cell Biology, Swiss Federal Institute of Technology ETH Zurich, Zurich, Switzerland
    Am J Pathol 167:733-47. 2005
    ..These results demonstrate that activin affects both stromal cells and keratinocytes in normal and wounded skin and that the effect on keratinocytes is dose-dependent in vivo...
  26. pmc Haem oxygenase-1: a novel player in cutaneous wound repair and psoriasis?
    C Hanselmann
    Institute of Cell Biology, Swiss Federal Institute of Technology, Honggerberg, CH 8093 Zurich, Switzerland
    Biochem J 353:459-66. 2001
    ..Our findings suggest a novel role for HO in wound healing and inflammatory skin disease, where it might be involved in haem degradation and in the protection of cells from the toxic effects of ROS...
  27. ncbi request reprint Regulation of epidermal homeostasis and repair by phosphoinositide 3-kinase
    Sandra Pankow
    Institute of Cell Biology, Department of Biology, ETH Zurich, CH 8093 Zurich, Switzerland
    J Cell Sci 119:4033-46. 2006
    ..These results identify PI3K as an important intracellular regulator of epidermal homeostasis and repair...
  28. ncbi request reprint Cell cycle inhibitors p21 and p16 are required for the regulation of Schwann cell proliferation
    Suzana Atanasoski
    Department of Biology, Institute of Cell Biology, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich, Switzerland
    Glia 53:147-57. 2006
    ..Different mechanisms appear to underlie the inhibitory function, depending on whether p21 is cytoplasmic or nuclear...
  29. ncbi request reprint Expression of different p63 variants in healing skin wounds suggests a role of p63 in reepithelialization and muscle repair
    Casimir Bamberger
    Institute of Cell Biology, Department of Biology, ETH Zurich, Zurich, Switzerland
    Wound Repair Regen 13:41-50. 2005
    ..These findings suggest splice-variant specific functions of p63 in reepithelialization and muscle repair...
  30. ncbi request reprint The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair
    Hans Dietmar Beer
    Department of Biology, Institute of Cell Biology, ETH Zurich, Honggerberg, CH 8093 Zurich, Switzerland
    Oncogene 24:5269-77. 2005
    ....
  31. ncbi request reprint Reactive oxygen species and their detoxification in healing skin wounds
    Ulrich auf dem Keller
    Department of Biology, Institute of Cell Biology, ETH Zurich, Honggerberg, Zurich, Switzerland
    J Investig Dermatol Symp Proc 11:106-11. 2006
    ..In this review, we summarize the results on the expression of cytoprotective genes in wounded skin, and we discuss their possible roles in the wound-healing process...
  32. ncbi request reprint The estrogen-responsive B box protein: a novel regulator of keratinocyte differentiation
    Hans Dietmar Beer
    Institute of Cell Biology, Department of Biology, ETH Zurich, CH 8093 Zurich, Switzerland
    J Biol Chem 277:20740-9. 2002
    ....
  33. pmc Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis
    Matthias Schafer
    Department of Biology, Institute of Cell Biology, ETH Zurich, Zurich, Switzerland
    Genes Dev 24:1045-58. 2010
    ..Taken together, our results identify Nrf2 as a key regulator in the UV response of the skin...
  34. pmc Keratinocyte-derived follistatin regulates epidermal homeostasis and wound repair
    Maria Antsiferova
    Department of Biology, Institute of Cell Biology, ETH Zurich, Honggerberg, Zurich, Switzerland
    Lab Invest 89:131-41. 2009
    ..However, granulation tissue formation and scarring were not affected. These results demonstrate that selective activation of activin in the epidermis enhances reepithelialization without affecting the quality of the healed wound...
  35. ncbi request reprint Transcriptional control of wound repair
    Matthias Schafer
    Institute of Cell Biology, Department of Biology, ETH Zurich, Zurich, Switzerland
    Annu Rev Cell Dev Biol 23:69-92. 2007
    ..This review summarizes recent data on the expression of transcription factors in skin wounds and their functions in the repair process...
  36. ncbi request reprint Creatine kinase and creatine transporter in normal, wounded, and diseased skin
    Uwe Schlattner
    Institute of Cell Biology, Swiss Federal Institute of Technology, Hönggerberg HPM, Zurich, Switzerland
    J Invest Dermatol 118:416-23. 2002
    ....
  37. ncbi request reprint Keratinocyte growth factor protects epidermis and hair follicles from cell death induced by UV irradiation, chemotherapeutic or cytotoxic agents
    Susanne Braun
    Institute of Cell Biology, Department of Biology, ETH Zurich, Honggerberg, 8093 Zurich, Switzerland
    J Cell Sci 119:4841-9. 2006
    ..Taken together, our results encourage the use of KGF for skin protection from chemical and physical insults...
  38. ncbi request reprint A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair
    Richard Grose
    Institute of Cell Biology, Department of Biology, ETH Zurich, 8093 Zurich, Switzerland
    Development 129:2303-15. 2002
    ..These findings demonstrate a crucial role of beta 1 integrins in keratinocyte migration and wound re-epithelialisation. Movies available on-line..
  39. pmc FGF receptors 1 and 2 control chemically induced injury and compound detoxification in regenerating livers of mice
    Friederike Böhm
    Department of Biology, Institute of Cell Biology, ETH Zurich, Switzerland
    Gastroenterology 139:1385-96. 2010
    ..We investigated the functions and mechanisms of action of these receptors in liver homeostasis, regeneration, and fibrosis...
  40. pmc Fibroblast growth factors in epithelial repair and cytoprotection
    Susanne Braun
    Institute of Cell Biology, Department of Biology, ETH Zurich, Honggerberg, CH 8093 Zurich, Switzerland
    Philos Trans R Soc Lond B Biol Sci 359:753-7. 2004
    ..Most interestingly, several genes were identified that are likely to mediate the cytoprotective effect of FGF-7 for epithelial cells in vitro and possibly also in injured and diseased tissues in vivo...
  41. ncbi request reprint Suppression of keratin 15 expression by transforming growth factor beta in vitro and by cutaneous injury in vivo
    S Werner
    Institute of Cell Biology, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich, CH 8093, Switzerland
    Exp Cell Res 254:80-90. 2000
    ..These data demonstrate that K15 is excluded from the activated keratinocytes of the hyperthickened wound epidermis, possibly as a result of increased growth factor expression in injured skin...
  42. ncbi request reprint The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion
    C Munding
    Department of Biology, Institute of Cell Biology, ETH Zurich, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Cell Death Differ 13:1938-49. 2006
    ..Vice versa, endogenous and overerexpressed EBBP increased IL-1beta secretion. These results provide evidence for a role of EBBP in innate immunity by enhancing the alternative secretion pathway of IL-1beta...
  43. ncbi request reprint The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes
    Laurence Feldmeyer
    Institute of Cell Biology, Department of Biology, ETH Zurich, Zurich, Switzerland
    Curr Biol 17:1140-5. 2007
    ..This supports the concept that keratinocytes are important immuno-competent cells under physiological and pathological conditions [5]...
  44. ncbi request reprint Transgenic mice reveal novel activities of growth hormone in wound repair, angiogenesis, and myofibroblast differentiation
    Irmgard S Thorey
    Institute of Cell Biology, Department of Biology, ETH Zurich, Honggerberg, CH 8093 Zurich, Switzerland
    J Biol Chem 279:26674-84. 2004
    ..Furthermore, our data suggested that systemic GH treatment is detrimental for wound healing in healthy individuals...
  45. ncbi request reprint Transgenic mice expressing dominant-negative activin receptor IB in forebrain neurons reveal novel functions of activin at glutamatergic synapses
    Mischa Roland Müller
    Institute of Cell Biology, Department of Biology, ETH Zurich, CH 8093 Zurich, Switzerland
    J Biol Chem 281:29076-84. 2006
    ..This is the first demonstration that activin receptor signaling is essential to optimize the performance of neuronal circuits in the mature brain under physiological conditions...
  46. ncbi request reprint ADAMTS1 proteinase is up-regulated in wounded skin and regulates migration of fibroblasts and endothelial cells
    Monika Krampert
    Department of Biology, Institute of Cell Biology, Eidgenossische Technische Hochschule Zurich, Hönggerberg CH 8093, Switzerland
    J Biol Chem 280:23844-52. 2005
    ..Similar effects were also observed with endothelial cells. Taken together, our results suggest a role of ADAMTS1 in keratinocyte differentiation and migration of fibroblasts and endothelial cells in healing skin wounds...
  47. pmc Nrf transcription factors in keratinocytes are essential for skin tumor prevention but not for wound healing
    Ulrich auf dem Keller
    Institute of Cell Biology, Department of Biology, ETH Zurich, Honggerberg, HPM D42, CH 8093 Zurich, Switzerland
    Mol Cell Biol 26:3773-84. 2006
    ....
  48. doi request reprint Cancer as an overhealing wound: an old hypothesis revisited
    Matthias Schafer
    Institute of Cell Biology, ETH Zurich, Schafmattstrasse 18, 8093 Zurich, Switzerland
    Nat Rev Mol Cell Biol 9:628-38. 2008
    ..However, a few crucial differences were also observed, which could account for the altered metabolism, impaired differentiation capacity and invasive growth of malignant tumours...
  49. ncbi request reprint Activin: an important regulator of wound repair, fibrosis, and neuroprotection
    Silke Sulyok
    Institute of Cell Biology, ETH Zurich, Honggerberg, CH 8093 Zurich, Switzerland
    Mol Cell Endocrinol 225:127-32. 2004
    ..Together with results from other laboratories, these findings suggest that activin is an important player in inflammation, repair and cytoprotection in various organs...
  50. ncbi request reprint Fibroblast growth factors: key players in epithelial morphogenesis, repair and cytoprotection
    Heike Steiling
    Institute of Cell Biology, Department of Biology, ETH Zurich, Honggerberg, CH 8093 Zurich, Switzerland
    Curr Opin Biotechnol 14:533-7. 2003
    ..Indeed, the first successful clinical trials using FGFs for the treatment of radiation- and chemotherapy-induced mucosal epithelial damage have been announced...
  51. ncbi request reprint Meeting report: growth factors in development, repair and disease
    Susanne Braun
    Institute of Cell Biology, ETH Zurich, Department of Biology, Switzerland
    Eur J Cell Biol 81:375-82. 2002
  52. ncbi request reprint Keratinocyte growth factor: effects on keratinocytes and mechanisms of action
    Ulrich auf demKeller
    Institute of Cell Biology, Department of Biology, ETH Zurich, Zurich, Switzerland
    Eur J Cell Biol 83:607-12. 2004
    ..In this review we summarize the current knowledge on the role of KGF in tissue repair and cytoprotection, and we report on its mechanisms of action in keratinocytes...
  53. ncbi request reprint Upregulation and activation of the Nrf-1 transcription factor in the lesioned hippocampus
    Moritz Hertel
    Institute of Cell Biology, Department of Biology, ETH Zurich, Honggerberg, Switzerland
    Eur J Neurosci 15:1707-11. 2002
    ..Because Nrf-1 and Nrf-2 are potent inducers of various cytoprotective proteins, our data suggest a role of Nrf-1 and Nrf-2 in neuronal survival after acute brain injury...
  54. ncbi request reprint The healing skin wound: a novel site of action of the chemokine C10
    Susanne Kaesler
    Institute of Cell Biology, ETH Zurich, Honggerberg, CH 8093 Zurich, Switzerland
    Cytokine 17:157-63. 2002
    ..Since C10 is a potent chemoattractant for macrophages, our results suggest that this chemokine contributes to the strong macrophage influx observed in the healing skin wound...
  55. doi request reprint Oxidative stress in normal and impaired wound repair
    Matthias Schafer
    ETH Zurich, Institute of Cell Biology, Schafmattstr 18, HPM D42, CH 8093 Zurich, Switzerland
    Pharmacol Res 58:165-71. 2008
    ....
  56. ncbi request reprint Fibroblast growth factor (FGF) receptor 1-IIIb is a naturally occurring functional receptor for FGFs that is preferentially expressed in the skin and the brain
    H D Beer
    Institute of Cell Biology, Swiss Federal Institute of Technology, CH 8093 Zurich, Switzerland
    J Biol Chem 275:16091-7. 2000
    ....
  57. ncbi request reprint Keratinocyte-fibroblast interactions in wound healing
    Sabine Werner
    Institute of Cell Biology, Eidgenossische Technische Hochschule Zurich, Honggerberg, Zurich, Switzerland
    J Invest Dermatol 127:998-1008. 2007
    ..As the phenotype of fibroblasts from different tissues or body sites becomes better defined, we may understand their individual contribution in wound healing in more detail and possibly explain different clinical outcomes...
  58. ncbi request reprint Molecular and cellular mechanisms of tissue repair
    Sabine Werner
    Institute of Cell Biology, ETH Zurich, Honggerberg, 8093 Zurich, Switzerland
    Exp Dermatol 14:786-7. 2005
  59. doi request reprint Active caspase-1 is a regulator of unconventional protein secretion
    Martin Keller
    Institute of Cell Biology, Department of Biology, ETH Zurich, CH 8093 Zurich, Switzerland
    Cell 132:818-31. 2008
    ..By this mechanism, stress-induced activation of caspase-1 directly links inflammation to cytoprotection, cell survival, and regenerative processes...
  60. pmc A role for endogenous glucocorticoids in wound repair
    Richard Grose
    Institute of Cell Biology, Department of Biology, ETH Zurich, CH 8093 Zurich, Switzerland
    EMBO Rep 3:575-82. 2002
    ..These results demonstrate an as yet unidentified role of endogenous glucocorticoids in the regulation of wound repair...
  61. doi request reprint The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis
    Weihua Xu
    Department of Biology, Institute of Cell Biology, ETH Zurich, Switzerland
    Lab Invest 88:1068-78. 2008
    ..These results suggest that activation of Nrf2 may be a novel strategy to prevent or ameliorate toxin-induced liver injury and fibrosis...
  62. pmc Activated hepatic stellate cells express keratinocyte growth factor in chronic liver disease
    Heike Steiling
    Department of Biology, Institute of Cell Biology, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Pathol 165:1233-41. 2004
    ..Based on the known effects of KGF on hepatocytes in vitro, our findings suggest that HSC/myofibroblast-derived KGF may enhance liver regeneration and/or hepatocyte survival in patients with chronic liver disease...
  63. ncbi request reprint Fibroblast growth factor receptor signalling is crucial for liver homeostasis and regeneration
    Heike Steiling
    Institute of Cell Biology, ETH Zurich, Honggerberg, CH 8093 Zurich, Switzerland
    Oncogene 22:4380-8. 2003
    ..These data demonstrate a key role of FGFR signalling in repair after liver injury...
  64. pmc Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance
    Tobias A Beyer
    Department of Biology, Institute of Cell Biology, ETH Zurich, Zurich, Switzerland
    EMBO J 27:212-23. 2008
    ..These findings may provide the basis for the development of new strategies to improve regeneration in patients with acute or chronic liver damage...
  65. ncbi request reprint Chemical and biological investigations of beta-oligoarginines
    Dieter Seebach
    Laboratorium fur Organische Chemie, ETH Zurich, ETH Honggerberg, HCI, CH 8093 Zurich
    Chem Biodivers 1:65-97. 2004
    ..Thus, the mechanisms of cell and GUV-model penetration appear to be different. Finally, the possible applications and implications of the 'protein transduction' by beta-oligoarginines are discussed...
  66. ncbi request reprint An aPPARently protective mechanism for keratinocytes in wounded skin
    Richard Grose
    Trends Mol Med 8:149-51. 2002
  67. ncbi request reprint Wound-healing studies in transgenic and knockout mice
    Richard Grose
    London Research Institute Lab 214, Cancer Research UK, 61 Lincoln s Inn Fields, London WC2A 3PX, UK
    Mol Biotechnol 28:147-66. 2004
    ..For a regularly updated web archive of studies, we have constructed a Compendium of Published Wound Healing Studies on Genetically Modified Mice which is avaialble at http://icbxs.ethz.ch/members/grose/woundtransgenic/home.html...
  68. ncbi request reprint Expression and potential function of beta-amyloid precursor proteins during cutaneous wound repair
    Christiane Kummer
    Institute of Cell Biology, University of Bonn, Ulrich Haberland Strasse 61a, 53121, Bonn, Germany
    Exp Cell Res 280:222-32. 2002
    ....
  69. pmc Overexpression of mIGF-1 in keratinocytes improves wound healing and accelerates hair follicle formation and cycling in mice
    Ekaterina Semenova
    European Molecular Biology Laboratory EMBL Mouse Biology Unit, Campus A Buzzati Traverso, Monterotondo Scalo, Roma, Italy
    Am J Pathol 173:1295-310. 2008
    ..Our analysis supports the use of mIGF-1 for skin and hair regeneration and describes a potential cell type-restricted action...
  70. ncbi request reprint Endostatin down-regulates soluble guanylate cyclase (sGC) in endothelial cells in vivo: influence of endostatin on vascular endothelial growth factor (VEGF) signaling
    Annette Schmidt
    Department of Molecular and Cellular Sport Medicine, German Sport University, Cologne, Germany
    Endothelium 12:251-7. 2005
    ..The authors conclude that endostatin affects VEGF signaling in endothelial cells by a post-transcriptional PP2A-dependent down-regulation of sGC protein levels...
  71. ncbi request reprint Increased keratinocyte proliferation by JUN-dependent expression of PTN and SDF-1 in fibroblasts
    Lore Florin
    Division of Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Cell Sci 118:1981-9. 2005
    ....
  72. pmc Accelerated wound closure in mice deficient for interleukin-10
    Sabine A Eming
    Department of Dermatology, University of Cologne, Joseph Stelzmann Str 9, 50931 Koln, Germany
    Am J Pathol 170:188-202. 2007
    ..These results show for the first time that IL-10 can impede wound repair...
  73. ncbi request reprint Identification of novel AP-1 target genes in fibroblasts regulated during cutaneous wound healing
    Lore Florin
    Division of Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg D 69120, Germany
    Oncogene 23:7005-17. 2004
    ..The identification of novel Jun target genes should provide a basis for understanding the molecular mechanisms underlying mesenchymal-epithelial interactions and the critical contribution of AP-1 to tissue homeostasis and repair...
  74. ncbi request reprint Betacellulin regulates hair follicle development and hair cycle induction and enhances angiogenesis in wounded skin
    Marlon R Schneider
    Institute of Molecular Animal Breeding and Biotechnology, Gene Center, University of Munich, Munich, Germany
    J Invest Dermatol 128:1256-65. 2008
    ..These results provide evidence for a role of BTC in the regulation of epidermal homeostasis, hair follicle morphogenesis and cycling, and wound angiogenesis...
  75. ncbi request reprint Isoform-specific downregulation of peroxiredoxin in human failing myocardium
    Klara Brixius
    Department of Molecular and Cellular Sport Medicine, Institute of Cardiology and Sport Medicine, German Sport University, Germany
    Life Sci 81:823-31. 2007
    ..The selective downregulation of peroxiredoxin 3-6 isoforms may point towards a subcellular specific dysregulation of the antioxidative defence during the development of DCM...
  76. ncbi request reprint Fibroblast growth factor receptor 1-IIIb is dispensable for skin morphogenesis and wound healing
    Hongbing Zhang
    Five Prime Therapeutics Inc, South San Francisco, CA, USA
    Eur J Cell Biol 83:3-11. 2004
    ..Finally, several genes that encode key players in wound repair were normally expressed in these animals. These data demonstrate that FGFR1-IIIb is dispensable for skin development and wound repair...
  77. ncbi request reprint Regulation of NF-kappaB activity and keratinocyte differentiation by the RIP4 protein: implications for cutaneous wound repair
    Stephanie Adams
    Institute of Physiology, Charite University Medicine Berlin, Berlin, Germany
    J Invest Dermatol 127:538-44. 2007
    ..These data suggest important and unique functions of different RIP proteins in keratinocytes of normal and wounded skin...
  78. ncbi request reprint Wound healing studies in transgenic and knockout mice. A review
    Richard Grose
    Cancer Research UK, London Research Institute, Viral Carcinogenesis, London, UK
    Methods Mol Med 78:191-216. 2003
  79. ncbi request reprint Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation
    Xiu Ping Wang
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, PO Box 56, University of Helsinki, FIN 00014 Helsinki, Finland
    Dev Cell 7:719-30. 2004
    ....
  80. ncbi request reprint A novel regulator of telomerase. S100A8 mediates differentiation-dependent and calcium-induced inhibition of telomerase activity in the human epidermal keratinocyte line HaCaT
    Sabine Rosenberger
    Genetics of Skin Carcinogenesis, German Cancer Research Center Heidelberg, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Biol Chem 282:6126-35. 2007
    ..We hypothesize that calcium binds to S100A8/S100A9 complexes and alters their composition, thus enabling S100A8 to interact with the telomerase complex and inhibit its activity...
  81. pmc c-Met is essential for wound healing in the skin
    Jolanta Chmielowiec
    Department of Cancer Biology, Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany
    J Cell Biol 177:151-62. 2007
    ....
  82. ncbi request reprint Targeted expression of a dominant-negative fibroblast growth factor (FGF) receptor in gonadotropin-releasing hormone (GnRH) neurons reduces FGF responsiveness and the size of GnRH neuronal population
    Pei San Tsai
    Department of Integrative Physiology and the Center for Neuroscience, University of Colorado, 114 Clare Small, Boulder, Colorado 80309 0354, USA
    Mol Endocrinol 19:225-36. 2005
    ..Overall, our results are the first to show, at the level of the organism, that FGFs are one of the important components involved in the formation and maintenance of the GnRH system...
  83. ncbi request reprint Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin
    Motonobu Nakamura
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
    FASEB J 17:497-9. 2003
    ..These observations suggest that follistatin and activin interaction plays an important role in both HF development and cycling, possibly in part by regulating expression of BMP-2 and its antagonist...
  84. ncbi request reprint Fibroblast growth factors and neuroprotection
    Christian Alzheimer
    Institute of Physiology, University of Munich, Pettenkoferstr 12, D 80336 Munich, Germany
    Adv Exp Med Biol 513:335-51. 2002
    ..As the molecular targets of FGF2 are going to be unraveled over the next years, new therapeutic strategies will hopefully emerge that enable us to influence the various protective mechanisms of FGF2 in a more specific fashion...
  85. ncbi request reprint Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans
    Armelle Logie
    UMR 144, Centre National de la Recherche Scientifique, Section de Recherche, Institut Curie, Paris, France
    Hum Mol Genet 14:1153-60. 2005
    ..Our findings directly implicate FGFR3 activation as a major cause of benign epidermal tumors in humans...
  86. ncbi request reprint Endostatin influences endothelial morphology via the activated ERK1/2-kinase endothelial morphology and signal transduction
    Annette Schmidt
    Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Germany
    Microvasc Res 71:152-62. 2006
    ..These findings provide new insight into a key signaling pathway of vascular remodeling evoked by a matrix-derived factor...
  87. doi request reprint Wound repair and regeneration
    Geoffrey C Gurtner
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 257 Campus Drive, Stanford, California 94305 5148, USA
    Nature 453:314-21. 2008
    ..Knowledge gained from studying such organisms might help to unlock latent regenerative pathways in humans, which would change medical practice as much as the introduction of antibiotics did in the twentieth century...
  88. ncbi request reprint Modulation of activin/bone morphogenetic protein signaling by follistatin is required for the morphogenesis of mouse molar teeth
    Xiu Ping Wang
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Dev Dyn 231:98-108. 2004
    ..We propose that finely tuned antagonistic effects between follistatin and TGF beta superfamily signals are critical for enamel knot formation and function, as well as for patterning of tooth cusps...