Annette Oxenius

Summary

Affiliation: Swiss Federal Institute of Technology
Country: Switzerland

Publications

  1. pmc Emergence of polyfunctional CD8+ T cells after prolonged suppression of human immunodeficiency virus replication by antiretroviral therapy
    Manuela Rehr
    Institute of Microbiology, ETH Hoenggerberg, HCI G401, Wolfgang Pauli Strasse 10, 8093 Zurich, Switzerland
    J Virol 82:3391-404. 2008
  2. pmc Immediate cytotoxicity but not degranulation distinguishes effector and memory subsets of CD8+ T cells
    Petra Wolint
    Institute for Microbiology, Eidgenossische Technische Hochschule Zurich, Schmelzbergstrasse 7, 8092, Switzerland
    J Exp Med 199:925-36. 2004
  3. pmc CD4 T cell responses in latent and chronic viral infections
    Senta Walton
    Department of Microbiology and Immunology, School of Pathology and Laboratory Medicine, University of Western Australia Nedlands, WA, Australia
    Front Immunol 4:105. 2013
  4. ncbi request reprint Structured treatment interruptions in HIV infection: benefit or disappointment?
    Annette Oxenius
    Institute for Microbiology, ETH Zurich, Schmelzbergstrasse 7, 8092 Zürich CH, Switzerland
    Expert Rev Anti Infect Ther 1:129-39. 2003
  5. ncbi request reprint Loss of viral control in early HIV-1 infection is temporally associated with sequential escape from CD8+ T cell responses and decrease in HIV-1-specific CD4+ and CD8+ T cell frequencies
    Annette Oxenius
    Institute for Microbiology, Eidgenossische Technische Hochschule, Zurich, Switzerland
    J Infect Dis 190:713-21. 2004
  6. ncbi request reprint HIV-specific cellular immune response is inversely correlated with disease progression as defined by decline of CD4+ T cells in relation to HIV RNA load
    Annette Oxenius
    Institute for Microbiology, Eidgenossische Technische Hochschule Zurich, Zurich, Switzerland
    J Infect Dis 189:1199-208. 2004
  7. pmc Stimulation of HIV-specific cellular immunity by structured treatment interruption fails to enhance viral control in chronic HIV infection
    Annette Oxenius
    Nuffield Department of Medicine, John Radcliffe Hospital and Peter Medawar Building for Pathogen Research, Oxford OX1 3SY, UK
    Proc Natl Acad Sci U S A 99:13747-52. 2002
  8. doi request reprint Systemic antibody responses to gut commensal bacteria during chronic HIV-1 infection
    Anna Haas
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    Gut 60:1506-19. 2011
  9. ncbi request reprint Residual HIV-specific CD4 and CD8 T cell frequencies after prolonged antiretroviral therapy reflect pretreatment plasma virus load
    Annette Oxenius
    Nuffield Department of Medicine, John Radcliffe Hospital and Peter Medawar Building for Pathogen Research, Oxford, UK
    AIDS 16:2317-22. 2002
  10. doi request reprint Th cells act via two synergistic pathways to promote antiviral CD8+ T cell responses
    Melanie Wiesel
    Institute for Microbiology, Swiss Federal Institute of Technology Zurich ETH Zurich, Zurich, Switzerland
    J Immunol 185:5188-97. 2010

Detail Information

Publications92

  1. pmc Emergence of polyfunctional CD8+ T cells after prolonged suppression of human immunodeficiency virus replication by antiretroviral therapy
    Manuela Rehr
    Institute of Microbiology, ETH Hoenggerberg, HCI G401, Wolfgang Pauli Strasse 10, 8093 Zurich, Switzerland
    J Virol 82:3391-404. 2008
    ..These findings indicate that the level of pVL as a surrogate for antigen load has a dominant influence on the phenotypic and functional profile of virus-specific CD8(+) T cells...
  2. pmc Immediate cytotoxicity but not degranulation distinguishes effector and memory subsets of CD8+ T cells
    Petra Wolint
    Institute for Microbiology, Eidgenossische Technische Hochschule Zurich, Schmelzbergstrasse 7, 8092, Switzerland
    J Exp Med 199:925-36. 2004
    ..Furthermore, these results provide a potential mechanism by which central memory CD8+ T cell-mediated death of antigen-presenting cells within the lymph node is avoided...
  3. pmc CD4 T cell responses in latent and chronic viral infections
    Senta Walton
    Department of Microbiology and Immunology, School of Pathology and Laboratory Medicine, University of Western Australia Nedlands, WA, Australia
    Front Immunol 4:105. 2013
    ....
  4. ncbi request reprint Structured treatment interruptions in HIV infection: benefit or disappointment?
    Annette Oxenius
    Institute for Microbiology, ETH Zurich, Schmelzbergstrasse 7, 8092 Zürich CH, Switzerland
    Expert Rev Anti Infect Ther 1:129-39. 2003
    ..Furthermore, the demonstration of reduced side effects or costs due to structured treatment interruptions awaits the completion of large, comparative studies with a follow-up of several years...
  5. ncbi request reprint Loss of viral control in early HIV-1 infection is temporally associated with sequential escape from CD8+ T cell responses and decrease in HIV-1-specific CD4+ and CD8+ T cell frequencies
    Annette Oxenius
    Institute for Microbiology, Eidgenossische Technische Hochschule, Zurich, Switzerland
    J Infect Dis 190:713-21. 2004
    ..These findings demonstrate the temporal relationship between viral escape from CD8+ T cell activity, decrease in HIV-1-specific T cell frequencies, and loss of control of viral replication...
  6. ncbi request reprint HIV-specific cellular immune response is inversely correlated with disease progression as defined by decline of CD4+ T cells in relation to HIV RNA load
    Annette Oxenius
    Institute for Microbiology, Eidgenossische Technische Hochschule Zurich, Zurich, Switzerland
    J Infect Dis 189:1199-208. 2004
    ..Slower progression was not related to polymorphisms in CCR genes, HLA genotype, or GB virus C coinfection. These data suggest that HIV-specific T cell responses are involved in protecting the host from disease progression...
  7. pmc Stimulation of HIV-specific cellular immunity by structured treatment interruption fails to enhance viral control in chronic HIV infection
    Annette Oxenius
    Nuffield Department of Medicine, John Radcliffe Hospital and Peter Medawar Building for Pathogen Research, Oxford OX1 3SY, UK
    Proc Natl Acad Sci U S A 99:13747-52. 2002
    ....
  8. doi request reprint Systemic antibody responses to gut commensal bacteria during chronic HIV-1 infection
    Anna Haas
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    Gut 60:1506-19. 2011
    ..The mechanisms underlying B cell hyperactivation and the specificities of the resulting hypergammaglobulinaemia are only poorly understood...
  9. ncbi request reprint Residual HIV-specific CD4 and CD8 T cell frequencies after prolonged antiretroviral therapy reflect pretreatment plasma virus load
    Annette Oxenius
    Nuffield Department of Medicine, John Radcliffe Hospital and Peter Medawar Building for Pathogen Research, Oxford, UK
    AIDS 16:2317-22. 2002
    ..This most likely reflects the complex interactions between the virus and these immune effector cells in the absence of treatment...
  10. doi request reprint Th cells act via two synergistic pathways to promote antiviral CD8+ T cell responses
    Melanie Wiesel
    Institute for Microbiology, Swiss Federal Institute of Technology Zurich ETH Zurich, Zurich, Switzerland
    J Immunol 185:5188-97. 2010
    ..Second, Th cells provide CD8(+) T cells with IL-2, thereby enhancing their survival. Thus, Th cells are at the center of an important communication loop with a central role for IL-2/IL-2R and bioactive IL-12...
  11. doi request reprint T-cell help permits memory CD8(+) T-cell inflation during cytomegalovirus latency
    Senta M Walton
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    Eur J Immunol 41:2248-59. 2011
    ..Thus, CD8(+) T-cell inflation during latent CMV infection is strongly dependent on CD4(+) T-cell helper functions, which can partially be compensated by ongoing lytic viral replication in the absence of CD4(+) T cells...
  12. pmc HIV-1 replication activates CD4+ T cells with specificities for persistent herpes viruses
    Anna Haas
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    EMBO Mol Med 2:231-44. 2010
    ..We propose that a large proportion of activated T cells during untreated HIV infection may be specific for herpes viral antigens and identify a novel mechanism contributing to chronic immune activation in untreated HIV-1 infection...
  13. doi request reprint On the role of the inhibitory receptor LAG-3 in acute and chronic LCMV infection
    Kirsten Richter
    Institute of Microbiology, Department of Biology, Wolfgang Pauli Strasse 10, HCI G401, ETH Zurich, 8093 Zurich, Switzerland
    Int Immunol 22:13-23. 2010
    ..These data suggest that even though LAG-3 is continuously up-regulated on LCMV-specific exhausted CD8 T cells, it alone does not significantly contribute to T-cell exhaustion...
  14. pmc IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection
    Iwana Schmitz
    Molecular Biomedicine, Institute of Molecular Health Sciences, Department of Biology, ETH Zurich, Zurich, Switzerland
    PLoS Pathog 9:e1003362. 2013
    ....
  15. doi request reprint Virus-specific CD8 T cells: activation, differentiation and memory formation
    Melanie Wiesel
    Institute of Microbiology, Swiss Federal Institute of Technology, Zurich, Switzerland
    APMIS 117:356-81. 2009
    ....
  16. doi request reprint Type-I IFN drives the differentiation of short-lived effector CD8+ T cells in vivo
    Melanie Wiesel
    Institute for Microbiology, ETH Zurich, Zurich, Switzerland
    Eur J Immunol 42:320-9. 2012
    ..Together, these findings identify type-I IFN as an important factor driving SLEC differentiation and thus instructing the early division between the effector and memory precursor CD8(+) T-cell pool...
  17. ncbi request reprint Kinetic and mechanistic requirements for helping CD8 T cells
    Paola Agnellini
    Swiss Federal Institute of Technology, Institute for Microbiology, Wolfgang Pauli Strasse 10, Zurich, Switzerland
    J Immunol 180:1517-25. 2008
    ....
  18. doi request reprint Type I IFN substitutes for T cell help during viral infections
    Melanie Wiesel
    Institute for Microbiology, Swiss Federal Institute of Technology Zurich, 8093 Zurich, Switzerland
    J Immunol 186:754-63. 2011
    ..Thus, type I IFN can effectively replace the requirement of T cell help by directly promoting CD8(+) T cell survival and differentiation independent of the type I IFN-induced cytokines IL-2 and IL-15...
  19. pmc Immune senescence: relative contributions of age and cytomegalovirus infection
    Andrea Mekker
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Zurich, Switzerland
    PLoS Pathog 8:e1002850. 2012
    ..In summary, our results directly demonstrate in a mouse model that latent CMV-infection impairs immunity in old age and propagates immune senescence...
  20. ncbi request reprint The dynamics of mouse cytomegalovirus-specific CD4 T cell responses during acute and latent infection
    Senta M Walton
    Institute of Microbiology, Swiss Federal Institute of Technology, Zurich, Switzerland
    J Immunol 181:1128-34. 2008
    ..Furthermore, MCMV-specific CD4 T cells displayed a Th1 phenotype, secreting high levels of IFN-gamma and TNF-alpha and to some extent IL-2, cytokines which are involved in protection from CMV disease...
  21. doi request reprint CD8+ T cells are activated in an antigen-independent manner in HIV-infected individuals
    Sonia Bastidas
    Institute of Microbiology, ETH Zurich, 8093 Zurich, Switzerland
    J Immunol 192:1732-44. 2014
    ..These observations explain the higher abundance of activated CD8(+) T cells compared with CD4(+) T cells in untreated HIV-1 infection. ..
  22. doi request reprint Non-neutralizing antibodies protect from chronic LCMV infection independently of activating FcγR or complement
    Kirsten Richter
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    Eur J Immunol 43:2349-60. 2013
    ....
  23. doi request reprint Innate instruction of CD4+ T cell immunity in respiratory bacterial infection
    Gerhard Trunk
    Institute of Microbiology, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    J Immunol 189:616-28. 2012
    ..Collectively, these data illustrate the important role for various pattern recognition receptors triggered by complex pathogens and how they each instruct specific differentiation programs in responding CD4 T cells...
  24. pmc Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8+ T cell functions during chronic viral infection
    Paola Agnellini
    Institute of Microbiology, Eidgenossische Technische Hochschule, Wolfgang Pauli Strasse 10, 8093 Zurich, Switzerland
    Proc Natl Acad Sci U S A 104:4565-70. 2007
    ....
  25. pmc Absence of cross-presenting cells in the salivary gland and viral immune evasion confine cytomegalovirus immune control to effector CD4 T cells
    Senta M Walton
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    PLoS Pathog 7:e1002214. 2011
    ....
  26. pmc IL-10 suppression of NK/DC crosstalk leads to poor priming of MCMV-specific CD4 T cells and prolonged MCMV persistence
    Sanja Mandarić
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    PLoS Pathog 8:e1002846. 2012
    ....
  27. pmc Macrophage and T cell produced IL-10 promotes viral chronicity
    Kirsten Richter
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    PLoS Pathog 9:e1003735. 2013
    ..These data suggest that the decision whether LCMV infection becomes chronic or can be cleared critically depends on early CD4(+) T cell and monocyte/macrophage produced IL-10. ..
  28. doi request reprint T-cell help dependence of memory CD8+ T-cell expansion upon vaccinia virus challenge relies on CD40 signaling
    Gregor Bedenikovic
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    Eur J Immunol 44:115-26. 2014
    ....
  29. doi request reprint Salivary gland resident APCs are Flt3L- and CCR2-independent macrophage-like cells incapable of cross-presentation
    Jenny T Thom
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    Eur J Immunol 44:706-14. 2014
    ..Despite supporting contact formation to CD4(+) and CD8(+) T cells in principle, SG-resident APCs fail to activate the latter due to their inability to cross-present MCMV-derived antigen. ..
  30. doi request reprint Post-translational modification of {alpha}-dystroglycan is not critical for lymphocytic choriomeningitis virus receptor function in vivo
    Mauro Imperiali
    Institute for Microbiology, ETH Zurich, 8093 Zurich, Switzerland
    J Gen Virol 89:2713-22. 2008
    ..However, experiments in animal models showed that this dependence was only very weak in vivo. It is likely that alternative receptors or alternative entry pathways may account for this attenuated in vivo phenotype...
  31. pmc Direct activation of antigen-presenting cells is required for CD8+ T-cell priming and tumor vaccination
    Wolfgang Kratky
    Institute for Microbiology, Eidgenossische Technische Hochschule Zurich, 8093 Zurich, Switzerland
    Proc Natl Acad Sci U S A 108:17414-9. 2011
    ..These findings have important practical implications for vaccine design, indicating that adjuvants must be judiciously chosen to trigger the relevant pattern recognition receptors in APCs...
  32. ncbi request reprint A novel role for neutrophils as critical activators of NK cells
    Roman Spörri
    ETH Zurich, Institute for Microbiology, Zurich, Switzerland
    J Immunol 181:7121-30. 2008
    ..We propose a novel central role for neutrophils as essential IL-18 producers and hence NK cell "helpers" in bacterial infection...
  33. pmc Non-hematopoietic cells in lymph nodes drive memory CD8 T cell inflation during murine cytomegalovirus infection
    Nicole Torti
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    PLoS Pathog 7:e1002313. 2011
    ....
  34. doi request reprint Antigen amount dictates CD8+ T-cell exhaustion during chronic viral infection irrespective of the type of antigen presenting cell
    Kirsten Richter
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    Eur J Immunol 42:2290-304. 2012
    ..Furthermore, exhaustion of virus-specific CD8(+) T cells leads to avoidance of life-threatening immunopathology...
  35. doi request reprint Batf3 transcription factor-dependent DC subsets in murine CMV infection: differential impact on T-cell priming and memory inflation
    Nicole Torti
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    Eur J Immunol 41:2612-8. 2011
    ..These results highlight differential antigen presentation requirements during acute and latent MCMV infection...
  36. doi request reprint Nonhematopoietic cells are key players in innate control of bacterial airway infection
    Salome Leibundgut-Landmann
    Institute of Microbiology, Swiss Federal Institute of Technology Zurich, 8093 Zurich, Switzerland
    J Immunol 186:3130-7. 2011
    ..These data add a new level of complexity to the coordination of the innate immune response to L. pneumophila and illustrate how the cross talk between leukocytes and nonhematopoietic cells contributes to efficient host protection...
  37. pmc Entry and transcription as key determinants of differences in CD4 T-cell permissiveness to human immunodeficiency virus type 1 infection
    Angela Ciuffi
    Institute of Microbiology, University of Lausanne, Switzerland
    J Virol 78:10747-54. 2004
    ..The phenotype of provirus transcription was stable over time, indicating that it represents a genetic trait...
  38. doi request reprint Adoptive transfer of cytomegalovirus-specific effector CD4+ T cells provides antiviral protection from murine CMV infection
    Sanja Mandaric Jeitziner
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    Eur J Immunol 43:2886-95. 2013
    ..Our data reveal a pivotal antiviral role for virus-specific CD4(+) T cells in protection from pathogenic CMV infection and provide evidence for their antiviral therapeutic potential. ..
  39. pmc Impact of antigen specificity on CD4+ T cell activation in chronic HIV-1 infection
    Miranda Z Smith
    Institute of Microbiology, Swiss Federal Institute of Technology ETH Zurich, Zurich, Switzerland
    BMC Infect Dis 13:100. 2013
    ....
  40. doi request reprint Assessment of legionella-specific immunity in mice
    Stefan S Weber
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    Methods Mol Biol 954:505-20. 2013
    ..Furthermore, we describe an immunohistology protocol to analyze lung tissue sections by fluorescence microscopy...
  41. doi request reprint Reversal of chronic to resolved infection by IL-10 blockade is LCMV strain dependent
    Kirsten Richter
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    Eur J Immunol 43:649-54. 2013
    ..These data suggest that the success of IL-10 blockade to control chronic viral infections may critically depend on the virulence of the infecting strain...
  42. doi request reprint From crucial to negligible: functional CD8⁺ T-cell responses and their dependence on CD4⁺ T-cell help
    Melanie Wiesel
    Institute for Microbiology, ETH Zurich, Zurich, Switzerland
    Eur J Immunol 42:1080-8. 2012
    ..Here, we summarize current knowledge about the differential requirement of CD4(+) T-cell help in promoting primary CD8(+) T-cell responses as well as establishing functional memory CD8(+) T cells in various experimental settings...
  43. ncbi request reprint Induction and protective role of antibodies in Legionella pneumophila infection
    Nicole Joller
    Institute for Microbiology, ETH Zurich, Zurich, Switzerland
    Eur J Immunol 37:3414-23. 2007
    ..Actively or passively immunized mice or mice that were infected with opsonized Lpn had 50-100-fold reduced bacterial titers compared to naive animals, clearly demonstrating the capacity of Ab to protect against infection with Lpn...
  44. doi request reprint Identification of protective B cell antigens of Legionella pneumophila
    Stefan S Weber
    Institute of Microbiology, Swiss Federal Institute of Technology, Zurich, CH 8093 Zurich, Switzerland
    J Immunol 189:841-9. 2012
    ..pneumophila Ags. The recognized Ags were indeed conserved across host species, because Abs specific for all three selected Ags could be detected in patient sera, rendering the identified protein Ags potential vaccine candidates...
  45. ncbi request reprint Memory inflation: continuous accumulation of antiviral CD8+ T cells over time
    Urs Karrer
    Nuffield Department of Clinical Medicine, University of Oxford, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK
    J Immunol 170:2022-9. 2003
    ..This may be relevant for understanding the evolution of the large human CMV-specific CD8+ T cell populations seen in humans...
  46. doi request reprint The orientation of HIV-1 gp120 binding to the CD4 receptor differentially modulates CD4+ T cell activation
    Kathrin Zimmermann
    Institute of Microbiology, Swiss Federal Institute of Technology Zurich, 8093 Zurich, Switzerland
    J Immunol 194:637-49. 2015
    ....
  47. doi request reprint Systemic antibody responses to gut microbes in health and disease
    Kathrin Zimmermann
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    Gut Microbes 3:42-7. 2012
    ....
  48. doi request reprint IL-21R on T cells is critical for sustained functionality and control of chronic viral infection
    Anja Fröhlich
    Molecular Biomedicine, Institute of Integrative Biology, ETH Zurich, Switzerland
    Science 324:1576-80. 2009
    ..These data suggest that IL-21R signaling is required for the maintenance of polyfunctional T cells during chronic viral infections and have implications for understanding the immune response to other persisting antigens, such as tumors...
  49. pmc Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor
    Emma Gostick
    Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Eur J Immunol 37:479-86. 2007
    ..This latter effect may provide a fundamental new mechanism with which to enhance T cell immunity to specific antigens...
  50. doi request reprint Gut commensal microbes do not represent a dominant antigenic source for continuous CD4+ T-cell activation during HIV-1 infection
    Kathrin Zimmermann
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    Eur J Immunol 45:3107-13. 2015
    ..We conclude that the increased activation status of circulating CD4(+) T cells in HIV-1 infected individuals is not driven by CD4(+) T cells with specificities for commensal bacterial antigens...
  51. doi request reprint Type I interferons protect T cells against NK cell attack mediated by the activating receptor NCR1
    Josh Crouse
    Institute of Microbiology, ETH Zurich, 8093 Zurich, Switzerland
    Immunity 40:961-73. 2014
    ..Thus, direct sensing of type I IFNs by T cells protects them from NK cell killing by regulating the expression of NCR1 ligands, thereby revealing a mechanism by which T cells can evade the potent cytotoxic activity of NK cells. ..
  52. doi request reprint Immunofluorescence imaging of legionella infection in vitro
    Stefan S Weber
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    Methods Mol Biol 954:265-77. 2013
    ....
  53. pmc Antigen-dependent and -independent mechanisms of T and B cell hyperactivation during chronic HIV-1 infection
    Anna Haas
    Institute of Microbiology, ETH Zurich, Wolfgang Pauli Str 10, HCI G401, 8093 Zurich, Switzerland
    J Virol 85:12102-13. 2011
    ..In this review, we summarized current knowledge about proposed antigen-dependent and -independent mechanisms leading to lymphocyte hyperactivation in the context of HIV-1 infection...
  54. pmc T cell memory in the context of persistent herpes viral infections
    Nicole Torti
    Institute of Microbiology, ETH Zurich, CH 8093 Zurich, Switzerland
    Viruses 4:1116-43. 2012
    ....
  55. pmc Comparison of cytotoxic T lymphocyte efficacy in acute and persistent lymphocytic choriomeningitis virus infection
    Frederik Graw
    Institute of Integrative Biology, ETH Zurich, Universitatstrasse 16, 8092 Zurich, Switzerland
    Proc Biol Sci 278:3395-402. 2011
    ..These results strongly suggest that the in vivo cytotoxicity of CD8(+) T-cell responses in persistent infection is modulated via the number of CTLs rather than their individual functionality...
  56. pmc Antibodies protect against intracellular bacteria by Fc receptor-mediated lysosomal targeting
    Nicole Joller
    Institute for Microbiology, Eidgenössiche Technische Hochschule Zurich, 8093 Zurich, Switzerland
    Proc Natl Acad Sci U S A 107:20441-6. 2010
    ..Based on these findings, we propose a mechanism whereby Abs and FcR engagement subverts the strategies by which intracellular bacterial pathogens evade lysosomal degradation...
  57. doi request reprint How chronic viral infections impact on antigen-specific T-cell responses
    Helge Frebel
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    Eur J Immunol 40:654-63. 2010
    ....
  58. pmc Estimating the In Vivo Killing Efficacy of Cytotoxic T Lymphocytes across Different Peptide-MHC Complex Densities
    Victor Garcia
    Institute of Integrative Biology, ETH Zurich, Universitätstr, Zurich, Switzerland
    PLoS Comput Biol 11:e1004178. 2015
    ..In contrast, peptide load differences can explain at most two orders of magnitude. ..
  59. pmc Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice
    Helge Frebel
    Institute of Microbiology, ETH Zurich, 8093 Zurich, Switzerland
    J Exp Med 209:2485-99. 2012
    ....
  60. ncbi request reprint MyD88-dependent IFN-gamma production by NK cells is key for control of Legionella pneumophila infection
    Roman Spörri
    ETH Zurich, Institute for Microbiology, 8093 Zurich, Switzerland
    J Immunol 176:6162-71. 2006
    ....
  61. doi request reprint Antibody-Fc receptor interactions in protection against intracellular pathogens
    Nicole Joller
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    Eur J Immunol 41:889-97. 2011
    ....
  62. doi request reprint The Salivary Gland Acts as a Sink for Tissue-Resident Memory CD8(+) T Cells, Facilitating Protection from Local Cytomegalovirus Infection
    Jenny Tosca Thom
    Institute of Microbiology, ETH Zurich, 8093 Zurich, Switzerland
    Cell Rep 13:1125-36. 2015
    ..Thus, we unravel a yet-unappreciated role for memory CD8(+) T cells in protecting mucosal tissues against CMV infection...
  63. pmc O Mannosylation of alpha-dystroglycan is essential for lymphocytic choriomeningitis virus receptor function
    Mauro Imperiali
    Institute for Microbiology, ETH Zurich, 8093 Zurich, Switzerland
    J Virol 79:14297-308. 2005
    ....
  64. doi request reprint Regulation of antiviral T cell responses by type I interferons
    Josh Crouse
    Institute of Microbiology, Swiss Federal Institute of Technology ETH Zurich, 8093 Zurich, Switzerland
    Nat Rev Immunol 15:231-42. 2015
    ..This regulation depends, to a large extent, on the timing of type I IFN exposure relative to T cell receptor signalling. Type I IFNs also provide activated T cells with resistance to natural killer cell-mediated elimination. ..
  65. doi request reprint The risks of targeting co-inhibitory pathways to modulate pathogen-directed T cell responses
    Helge Frebel
    Institute of Microbiology, ETH Zurich, Wolfgang Pauli Str 10, 8093 Zurich, Switzerland
    Trends Immunol 34:193-9. 2013
    ..Here, we summarize recent preclinical and clinical interventions that report immune-related adverse events after targeting co-inhibitory pathways...
  66. doi request reprint A novel Th cell epitope of Candida albicans mediates protection from fungal infection
    Eva Bär
    Institute of Microbiology, Swiss Federal Institute of Technology Zurich, 8093 Zurich, Switzerland
    J Immunol 188:5636-43. 2012
    ..Together, these results uncover a new immune determinant of the host response against Candida ssp. that could be exploited for the development of antifungal vaccines and immunotherapies...
  67. pmc Peroxiredoxin 6 is required for blood vessel integrity in wounded skin
    Angelika Kümin
    Institute of Cell Biology, Department of Biology, ETH Zurich, Honggerberg, CH 8093 Zurich, Switzerland
    J Cell Biol 179:747-60. 2007
    ..These results provide insight into the cross-talk between hematopoietic and resident cells at the wound site and the role of reactive oxygen species in this interplay...
  68. pmc Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-gamma c-/- mice
    Stefan Baenziger
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 103:15951-6. 2006
    ....
  69. ncbi request reprint A controlled trial of granulocyte macrophage-colony stimulating factor during interruption of HAART
    Catherine Fagard
    Divisions of Infectious Diseases, University Hospital, Geneva, Geneva, Switzerland
    AIDS 17:1487-92. 2003
    ..To explore the effect of granulocyte macrophage colony stimulating factor (GM-CSF) on viral load and CD4 cell count during interruption of highly active antiretroviral therapy (HAART)...
  70. ncbi request reprint A prospective trial of structured treatment interruptions in human immunodeficiency virus infection
    Catherine Fagard
    Division of Infectious Diseases, Geneva Unmiversity Hospital, 1211 Geneva 14, Switzerland
    Arch Intern Med 163:1220-6. 2003
    ..Many patients who started HAART earlier in their disease course than is currently recommended would like to discontinue, but it is unknown whether it is safe to do so...
  71. pmc Discordant outcomes following failure of antiretroviral therapy are associated with substantial differences in human immunodeficiency virus-specific cellular immunity
    David A Price
    The Peter Medawar Building for Pathogen Research and the Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
    J Virol 77:6041-9. 2003
    ..These correlative data lead to the testable hypothesis that the consequences of viral recrudescence during continuous ART are modulated by the HIV-specific cellular immune response...
  72. ncbi request reprint Virological and immunological effects of short-course antiretroviral therapy in primary HIV infection
    Sarah Fidler
    Wright Fleming Institute, Department of GUM and Communicable Diseases, Faculty of Medicine, Imperial College, St Mary s Hospital, London, UK
    AIDS 16:2049-54. 2002
    ..We sought to investigate whether a short course of antiretroviral therapy (SCART) at PHI was sufficient to preserve HIV-specific cellular immunity...
  73. pmc Human immunodeficiency virus-specific CD8(+) T-cell responses do not predict viral growth and clearance rates during structured intermittent antiretroviral therapy
    Annette Oxenius
    Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J Virol 76:10169-76. 2002
    ..No measure of CTLs was able to predict plateau VLs. Thus, there was no signature in these data of an important contribution to virological control from HIV-specific CD8+ T lymphocytes...
  74. ncbi request reprint T lymphocyte responses against human parvovirus B19: small virus, big response
    Paul Klenerman
    Nuffield Dept of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Pathol Biol (Paris) 50:317-25. 2002
    ....
  75. ncbi request reprint HIV preferentially infects HIV-specific CD4+ T cells
    Daniel C Douek
    Vaccine Research Center, NIAID, NIH, Maryland 20892, USA
    Nature 417:95-8. 2002
    ..Furthermore, the phenomenon of HIV specifically infecting the very cells that respond to it adds a cautionary note to the practice of structured therapy interruption...
  76. ncbi request reprint Differential role of IL-2R signaling for CD8+ T cell responses in acute and chronic viral infections
    Martin F Bachmann
    Cytos Biotechnology AG, Zurich Schlieren, Switzerland
    Eur J Immunol 37:1502-12. 2007
    ..Thus, depending on the chronicity of antigen exposure, IL-2R signaling is either essential or largely dispensable for induction and maintenance of virus-specific CD8+ T cell responses...
  77. pmc HIV-1-specific CD4+ T lymphocyte turnover and activation increase upon viral rebound
    Thomas J Scriba
    Peter Medawar Building for Pathogen Research and Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
    J Clin Invest 115:443-50. 2005
    ..The turnover of these virus-specific cells increased and they adopted an effector phenotype when viremia returned...
  78. ncbi request reprint Humoral immunity to HIV-1: kinetics of antibody responses in chronic infection reflects capacity of immune system to improve viral set point
    Alexandra Trkola
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Ramistrasse 100, 8091 Zurich, Switzerland
    Blood 104:1784-92. 2004
    ..In summary, measuring the kinetics of antibody responses provided a marker to validate the responsiveness and capacities of the immune system of HIV-1-infected individuals and reflected the patients' ability to decrease viral set points...
  79. ncbi request reprint Relevance of HIV-1-specific CD4+ helper T-cell responses during structured treatment interruptions in patients with CD4+ T-cell nadir above 400/mm3
    Montserrat Plana
    Clinic Institute of Infectious Diseases and Immunology, IDIBAPS, Hospital Clinic, Faculty of Medicine, University of Barcelona, Spain
    J Acquir Immune Defic Syndr 36:791-9. 2004
    ..To analyze the dynamics of both HIV-1-specific CD4 and CD8 T-cell responses during structured treatment interruptions (STIs) in chronically HIV-1-infected (CHI) patients and to correlate them with the viral set point achieved...
  80. ncbi request reprint HIV replication elicits little cytopathic effects in vivo: analysis of surrogate markers for virus production, cytotoxic T cell response and infected cell death
    Georg A Funk
    Ecology and Evolution, Clausiusstrasse, ETH Zurich Zentrum, Zurich
    J Med Virol 78:1141-6. 2006
    ..25) cytopathic effect (P < 0.05, N = 36). It is concluded that HIV replication elicits little cytopathic effect in productively infected cells and that CD4(+) T lymphocytes are eroded by other mechanisms...
  81. ncbi request reprint Functional properties and lineage relationship of CD8+ T cell subsets identified by expression of IL-7 receptor alpha and CD62L
    Martin F Bachmann
    Cytos Biotechnology, Zurich Schlieren, Switzerland
    J Immunol 175:4686-96. 2005
    ....
  82. ncbi request reprint Recall proliferation potential of memory CD8+ T cells and antiviral protection
    Martin F Bachmann
    Cytos Biotechnology, Zurich Schlieren, Switzerland
    J Immunol 175:4677-85. 2005
    ..These data indicate that the protective capacity of different subpopulations of memory T cells may vary dependent on the nature and the route of the challenge infection, which must be considered in T cell-based vaccine design...
  83. pmc Low human immunodeficiency virus envelope diversity correlates with low in vitro replication capacity and predicts spontaneous control of plasma viremia after treatment interruptions
    Beda Joos
    University Hospital Zurich, Department of Medicine, Division of Infectious Diseases and Hospital Epidemiology, Ramistrasse 100, CH 8091 Zurich, Switzerland
    J Virol 79:9026-37. 2005
    ....
  84. ncbi request reprint Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies
    Alexandra Trkola
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Ramistrasse 100, 8091 Zurich, Switzerland
    Nat Med 11:615-22. 2005
    ....
  85. ncbi request reprint Defective T helper response of hepatocyte-stimulated CD4 T cells impairs antiviral CD8 response and viral clearance
    Christiane Wiegard
    Department of Medicine I, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Gastroenterology 133:2010-8. 2007
    ..Here, we investigated whether MHC class II-expressing hepatocytes influence in vitro the differentiation of CD4 T cells and in vivo the T-cell response to and control of viral infection...
  86. pmc Quantifiable cytotoxic T lymphocyte responses and HLA-related risk of progression to AIDS
    Almut Scherer
    Zoology Department, Oxford University, South Parks Road, Oxford OX1 3PS, United Kingdom
    Proc Natl Acad Sci U S A 101:12266-70. 2004
    ..These data provide an immunological mechanism to explain HLA-related risk of progression to AIDS and emphasize the central role of viral evolution in the pathogenesis of HIV...
  87. ncbi request reprint Complete mapping of a novel HLA A*6801-restricted HIV-1 Tat epitope directly with a rapid modified enzyme-linked immunospot assay
    Annette Oxenius
    Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK
    AIDS 16:1285-7. 2002
    ....
  88. ncbi request reprint Cutting edge: distinct roles for T help and CD40/CD40 ligand in regulating differentiation of proliferation-competent memory CD8+ T cells
    Martin F Bachmann
    Cytos Biotechnology AG, Zurich Schlieren, Switzerland
    J Immunol 173:2217-21. 2004
    ..Thus, Th cells but not CD40/CD40L are key for the differentiation of proliferation-competent central memory CD8(+) T cells...
  89. ncbi request reprint Long-lived memory CD8+ T cells are programmed by prolonged antigen exposure and low levels of cellular activation
    Martin F Bachmann
    Cytos Biotechnology AG, Zurich Schlieren, Switzerland
    Eur J Immunol 36:842-54. 2006
    ....
  90. ncbi request reprint Differential survival of cytotoxic T cells and memory cell precursors
    Manling Zhang
    Department of Pathology, Ben May Institute for Cancer Research and Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 178:3483-91. 2007
    ..These findings suggest that memory CD8 T cells are derived from progenitors that are refractory to self-inflicted damage, rather than derived from fully differentiated CTLs...
  91. pmc Expansion of protective CD8+ T-cell responses driven by recombinant cytomegaloviruses
    Urs Karrer
    Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom
    J Virol 78:2255-64. 2004
    ....
  92. ncbi request reprint Novel CD8+ T cell antagonists based on beta 2-microglobulin
    Meir Glick
    Department of Chemistry, Central Chemistry Laboratory, University of Oxford, South Parks Road, Oxford, United Kingdom
    J Biol Chem 277:20840-6. 2002
    ..This mutation also significantly reduces CD8alphaalpha binding and is a potent antagonist of CTL activation. These results suggest a novel approach to CTL-specific therapeutic immunosuppression...