Wolfgang Langhans

Summary

Affiliation: Swiss Federal Institute of Technology
Country: Switzerland

Publications

  1. pmc Ovariectomy and overeating palatable, energy-dense food increase subcutaneous adipose tissue more than intra-abdominal adipose tissue in rats
    Viktoria Gloy
    Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, Switzerland
    Biol Sex Differ 2:6. 2011
  2. doi request reprint Fatty acid oxidation in the energostatic control of eating--a new idea
    Wolfgang Langhans
    Physiology and Behaviour Group, Institute of Animal Sciences, ETH Zurich, Schorenstrasse 16, Schwerzenbach, Switzerland
    Appetite 51:446-51. 2008
  3. doi request reprint The enterocyte as an energy flow sensor in the control of eating
    Wolfgang Langhans
    Physiology and Behaviour Group, Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland
    Forum Nutr 63:75-84. 2010
  4. ncbi request reprint Signals generating anorexia during acute illness
    Wolfgang Langhans
    Physiology and Behaviour Group, Institute of Animal Sciences, ETH Zurich, Schwerzenbach, Switzerland
    Proc Nutr Soc 66:321-30. 2007
  5. doi request reprint Dietary fat sensing via fatty acid oxidation in enterocytes: possible role in the control of eating
    Wolfgang Langhans
    Physiology and Behaviour Laboratory, Institute of Food Nutrition and Health, Zurich, Schwerzenbach, Switzerland
    Am J Physiol Regul Integr Comp Physiol 300:R554-65. 2011
  6. doi request reprint Combined deficiency of iron and (n-3) fatty acids in male rats disrupts brain monoamine metabolism and produces greater memory deficits than iron deficiency or (n-3) fatty acid deficiency alone
    Jeannine Baumgartner
    Laboratory of Human Nutrition, ETH, Zurich, Switzerland
    J Nutr 142:1463-71. 2012
  7. ncbi request reprint Role for nerve growth factor in the in vivo regulation of glutathione in response to LPS in mice
    Denis Arsenijevic
    Institute of Animal Sciences, ETH Zurich, Schwerzenbach, Switzerland
    Eur Cytokine Netw 18:93-101. 2007
  8. ncbi request reprint Vagal afferents mediate the feeding response to mercaptoacetate but not to the beta (3) adrenergic receptor agonist CL 316,243
    Karsten Brandt
    Institute of Animal Sciences, ETH Zurich, Schorenstrasse 16, CH 8603 Schwerzenbach, Switzerland
    Neurosci Lett 411:104-7. 2007
  9. ncbi request reprint Mercaptoacetate fails to block the feeding-inhibitory effect of the beta3-adrenergic receptor agonist CGP 12177A
    Karsten Brandt
    Institute of Animal Sciences, ETH Zurich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
    Physiol Behav 89:128-32. 2006
  10. doi request reprint Reduced insulin sensitivity as a marker for acute mountain sickness?
    Kerstin Spliethoff
    1 Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
    High Alt Med Biol 14:240-50. 2013

Detail Information

Publications80

  1. pmc Ovariectomy and overeating palatable, energy-dense food increase subcutaneous adipose tissue more than intra-abdominal adipose tissue in rats
    Viktoria Gloy
    Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, Switzerland
    Biol Sex Differ 2:6. 2011
    ..Therefore, we used micro-computed tomography (microCT) to investigate this question in both chow-fed and dietary-obese rats...
  2. doi request reprint Fatty acid oxidation in the energostatic control of eating--a new idea
    Wolfgang Langhans
    Physiology and Behaviour Group, Institute of Animal Sciences, ETH Zurich, Schorenstrasse 16, Schwerzenbach, Switzerland
    Appetite 51:446-51. 2008
    ..Here I propose that MA may stimulate eating by inhibiting FAO in enterocytes and present some evidence supporting the idea that changes in enterocyte FAO can affect eating...
  3. doi request reprint The enterocyte as an energy flow sensor in the control of eating
    Wolfgang Langhans
    Physiology and Behaviour Group, Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland
    Forum Nutr 63:75-84. 2010
    ..These recent developments are discussed here and an outline is given of the challenges of this promising new concept...
  4. ncbi request reprint Signals generating anorexia during acute illness
    Wolfgang Langhans
    Physiology and Behaviour Group, Institute of Animal Sciences, ETH Zurich, Schwerzenbach, Switzerland
    Proc Nutr Soc 66:321-30. 2007
    ..In summary, the immune signalling pathways of LPS-induced, and presumably acute illness-induced, anorexia converge on central neural signalling systems that control food intake and energy balance in healthy individuals...
  5. doi request reprint Dietary fat sensing via fatty acid oxidation in enterocytes: possible role in the control of eating
    Wolfgang Langhans
    Physiology and Behaviour Laboratory, Institute of Food Nutrition and Health, Zurich, Schwerzenbach, Switzerland
    Am J Physiol Regul Integr Comp Physiol 300:R554-65. 2011
    ..Further studies are necessary to identify the link between enterocyte FAO and vagal afferents and to examine the specificity and potential physiological relevance of such a mechanism...
  6. doi request reprint Combined deficiency of iron and (n-3) fatty acids in male rats disrupts brain monoamine metabolism and produces greater memory deficits than iron deficiency or (n-3) fatty acid deficiency alone
    Jeannine Baumgartner
    Laboratory of Human Nutrition, ETH, Zurich, Switzerland
    J Nutr 142:1463-71. 2012
    ..42; P = 0.018). These results suggest that the combined deficiencies of Fe and (n-3) FA disrupt brain monoamine metabolism and produce greater deficits in reference memory than ID or (n-3)FAD alone...
  7. ncbi request reprint Role for nerve growth factor in the in vivo regulation of glutathione in response to LPS in mice
    Denis Arsenijevic
    Institute of Animal Sciences, ETH Zurich, Schwerzenbach, Switzerland
    Eur Cytokine Netw 18:93-101. 2007
    ....
  8. ncbi request reprint Vagal afferents mediate the feeding response to mercaptoacetate but not to the beta (3) adrenergic receptor agonist CL 316,243
    Karsten Brandt
    Institute of Animal Sciences, ETH Zurich, Schorenstrasse 16, CH 8603 Schwerzenbach, Switzerland
    Neurosci Lett 411:104-7. 2007
    ....
  9. ncbi request reprint Mercaptoacetate fails to block the feeding-inhibitory effect of the beta3-adrenergic receptor agonist CGP 12177A
    Karsten Brandt
    Institute of Animal Sciences, ETH Zurich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
    Physiol Behav 89:128-32. 2006
    ..Although the beta3-AR agonist CGP reduced saccharin intake in a one-bottle condition taste aversion test, it seems unlikely that the hypophagic effect of CGP is elicited by malaise...
  10. doi request reprint Reduced insulin sensitivity as a marker for acute mountain sickness?
    Kerstin Spliethoff
    1 Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
    High Alt Med Biol 14:240-50. 2013
    ..Reduced CCK may contribute to the beneficial effect of dexamethasone on high altitude anorexia. However, reduced insulin sensitivity questions the widespread use of dexamethasone to prevent/treat AMS...
  11. doi request reprint Dissociation of mercaptoacetate's effects on feeding and fat metabolism by dietary medium- and long-chain triacylglycerols in rats
    Abdelhak Mansouri
    Physiology and Behaviour Group, Institute of Animal Sciences, ETH Zurich, Schwerzenbach, Switzerland
    Nutrition 24:360-5. 2008
    ....
  12. doi request reprint Circulating glucagon-like peptide-1 (GLP-1) inhibits eating in male rats by acting in the hindbrain and without inducing avoidance
    Mukesh Punjabi
    Physiology and Behavior Laboratory, Institute of Food, Nutrition, and Health, Swiss Federal Institute of Technology Zurich ETH Zurich, 8603 Schwerzenbach, Switzerland
    Endocrinology 155:1690-9. 2014
    ....
  13. ncbi request reprint Beta-adrenergic-mediated inhibition of feeding by mercaptoacetate in food-deprived rats
    Karsten Brandt
    Institute of Animal Sciences, ETH Zurich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
    Pharmacol Biochem Behav 85:722-7. 2006
    ..These results suggest that the FAO inhibitor MA elicits a feeding-inhibitory effect in fasted rats that is mediated by a different mechanism than its feeding-stimulatory effect...
  14. ncbi request reprint Hepatic-portal oleic acid inhibits feeding more potently than hepatic-portal caprylic acid in rats
    Ulrike L Jambor de Sousa
    Institute of Animal Sciences, ETH Zurich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
    Physiol Behav 89:329-34. 2006
    ....
  15. ncbi request reprint Role for glutathione in the hyposensitivity of LPS-pretreated mice to LPS anorexia
    Noemi Hernadfalvi
    Institute of Animal Sciences, ETH Zurich, Schwerzenbach, Switzerland
    Eur Cytokine Netw 18:86-92. 2007
    ..Together, these findings suggest a prominent role for GSH and its intracellular repartition in LPS anorexia...
  16. pmc Intraperitoneal injections of low doses of C75 elicit a behaviorally specific and vagal afferent-independent inhibition of eating in rats
    Abdelhak Mansouri
    Physiology and Behaviour Group, Institute of Animal Sciences, ETH Zurich, Schwerzenbach, Switzerland
    Am J Physiol Regul Integr Comp Physiol 295:R799-805. 2008
    ..We conclude that intraperitoneal injections of low doses of C75 inhibit eating in a behaviorally specific manner and that this effect does not require abdominal vagal afferents...
  17. doi request reprint Diet-genotype interactions in the early development of obesity and insulin resistance in mice with a genetic deficiency in tumor necrosis factor-alpha
    Brenda Bouter
    Institute of Food, Nutrition and Health, Physiology and Behavior Group, ETH Zurich, Schwerzenbach, Switzerland
    Metabolism 59:1065-73. 2010
    ..The efficacy of therapeutic measures designed to counteract the effects of TNF-alpha may be increased during the early stages of obesity and insulin resistance...
  18. ncbi request reprint Pharmacological, but not genetic, disruptions in 5-HT(2C) receptor function attenuate LPS anorexia in mice
    Lori Asarian
    Institute of Animal Science, ETH Zurich, Schorentstr 16, 8603, Schwerzenbach, Switzerland
    Pharmacol Biochem Behav 86:493-8. 2007
    ..Our genetic data, in contrast, suggest that 5-HT(2C)R is not a necessary part of LPS anorexia...
  19. doi request reprint Iron from nanocompounds containing iron and zinc is highly bioavailable in rats without tissue accumulation
    Florentine M Hilty
    Human Nutrition Laboratory, Institute of Food, Nutrition and Health, ETH Zurich, Schmelzbergstrasse 7, Zurich, Switzerland
    Nat Nanotechnol 5:374-80. 2010
    ..Nanosizing of poorly water-soluble Fe compounds sharply increases their absorption and nutritional value...
  20. doi request reprint Beneficial effects on glucose metabolism of chronic feeding of isomaltulose versus sucrose in rats
    Doreen Häberer
    Physiology and Behavior Group, Institute of Animal Sciences, ETH Zurich, Schwerzenbach, Switzerland
    Ann Nutr Metab 54:75-82. 2009
    ..Because this sugar's metabolic effects are poorly characterized, we compared the effects of chronic ad libitum access to high-isomaltulose and high-sucrose diets on glucose metabolism in rats...
  21. doi request reprint Serotonin 2C receptor signaling in a diffuse neuronal network is necessary for LPS anorexia
    Brigitte S Kopf
    Physiology and Behaviour Group, ETH Zurich, Schorenstr 16, 8603, Schwerzenbach, Switzerland
    Brain Res 1306:77-84. 2010
    ....
  22. ncbi request reprint Effect of intraperitoneal CCK-8 on food intake and brain orexin-A after 48 h of fasting in the rat
    Eva Gallmann
    Physiology and Animal Husbandry, Institute of Animal Sciences Swiss Federal Institute of Technology, Schwerzenbach, Switzerland
    Regul Pept 133:139-46. 2006
    ....
  23. ncbi request reprint Caprylic acid infusion acts in the liver to decrease food intake in rats
    Ulrike L Jambor de Sousa
    Institute of Animal Sciences, ETH Zurich, 8603 Schwerzenbach, Switzerland
    Physiol Behav 87:388-95. 2006
    ..These data indicate that CA acts in the liver to produce a signal that inhibits feeding and that this inhibitory effect may be related to increases in hepatic fatty acid oxidation rather than be the result of aversion or toxicity...
  24. pmc Intrameal hepatic portal and intraperitoneal infusions of glucagon-like peptide-1 reduce spontaneous meal size in the rat via different mechanisms
    Elisabeth B Rüttimann
    Physiology and Behaviour Group, Institute of Animal Sciences, ETH Zurich, 8603 Schwerzenbach, Switzerland
    Endocrinology 150:1174-81. 2009
    ..The findings suggest that iv GLP-1 infusions do not inhibit eating via hepatic portal or hepatic GLP-1 receptors but may act directly on the brain...
  25. doi request reprint Basal plasma levels of insulin, leptin, ghrelin, and amylin do not signal adiposity in rats recovering from forced overweight
    Viktoria L Gloy
    Physiology and Behavior Laboratory, Institute of Food, Nutrition, and Health, ETH Zurich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
    Endocrinology 151:4280-8. 2010
    ..These data indicate that basal insulin, leptin, ghrelin, and amylin do not encode AT mass in rats dynamically regulating BW and adiposity during recovery from OW...
  26. doi request reprint Evidence that PGE2 in the dorsal and median raphe nuclei is involved in LPS-induced anorexia in rats
    Brigitte S Kopf
    Physiology and Behaviour Laboratory, Institute of Food, Nutrition and Health, ETH Zurich, Switzerland
    Pharmacol Biochem Behav 99:437-43. 2011
    ..Because the DRN and MnR are sources of major serotonergic projections to the forebrain, these data suggest that serotonergic neurons originating in the midbrain raphe play an important role in acute-phase response anorexia...
  27. doi request reprint Intragastric infusion of pea-protein hydrolysate reduces test-meal size in rats more than pea protein
    Doreen Häberer
    Physiology and Behaviour Laboratory, Institute of Food, Nutrition and Health, ETH Zurich, 8603 Schwerzenbach, Switzerland
    Physiol Behav 104:1041-7. 2011
    ..g., CCK and glucagon) do not play crucial roles. Thus, PPH reduced short-term food intake more than PP under our conditions, but the mechanism(s) involved remain unclear...
  28. ncbi request reprint Vitamin A repletion in rats with concurrent vitamin A and iodine deficiency affects pituitary TSHbeta gene expression and reduces thyroid hyperstimulation and thyroid size
    Ralf Biebinger
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, ETH Zurich, Switzerland
    J Nutr 137:573-7. 2007
    ..In concurrent VAD and ID, VAS, independent of iodine repletion, reduces thyroid hyperstimulation and size, an effect likely mediated through the effects of VA on pituitary TSHbeta gene expression...
  29. ncbi request reprint Fatty acid oxidation and control of food intake
    Monika Leonhardt
    Institute of Animal Sciences, Swiss Federal Institute of Technology, Schorenstr 16, CH 8603 Schwerzenbach, Switzerland
    Physiol Behav 83:645-51. 2004
    ..The generation of rats with inducible, liver-specific overexpression of CPT 1alpha should permit to critically examine the putative contribution of hepatic fatty acid oxidation to the control of food intake...
  30. pmc Possible role of intestinal fatty acid oxidation in the eating-inhibitory effect of the PPAR-α agonist Wy-14643 in high-fat diet fed rats
    Elnaz Karimian Azari
    Physiology and Behavior Laboratory, ETH Zurich, Schwerzenbach, Switzerland
    PLoS ONE 8:e74869. 2013
    ....
  31. pmc Diacylglycerol acyltransferase-1 inhibition enhances intestinal fatty acid oxidation and reduces energy intake in rats
    Gudrun Schober
    Physiology and Behavior Laboratory, Institute of Food, Nutrition, and Health, Swiss Federal Institute of Technology, Zurich, Switzerland
    J Lipid Res 54:1369-84. 2013
    ..3494) and HuTu80 (EC50 = 0.00762) cells. Thus, pharmacological DGAT-1 inhibition leads to an increase in intestinal FAO and ketogenesis when dietary fat is available. This may contribute to the observed eating-inhibitory effect...
  32. doi request reprint Disturbed eating at high altitude: influence of food preferences, acute mountain sickness and satiation hormones
    Isabelle Aeberli
    Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Zurich, Zurich, Switzerland
    Eur J Nutr 52:625-35. 2013
    ..The aim was therefore to assess changes in eating after rapid ascent to 4,559 m and to investigate to what extent hypoxia, acute mountain sickness (AMS), food preferences and satiation hormones influence eating behavior...
  33. doi request reprint Effects of anesthesia and blood sampling techniques on plasma metabolites and corticosterone in the rat
    Myrtha Arnold
    Physiology and Behaviour Laboratory, Institute of Food, Nutrition and Health, ETH Zurich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
    Physiol Behav 99:592-8. 2010
    ..This must be considered for the design and interpretation of blood sampling experiments in laboratory animals...
  34. ncbi request reprint Effect of concurrent vitamin A and iodine deficiencies on the thyroid-pituitary axis in rats
    Ralf Biebinger
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, ETH Zurich, Switzerland
    Thyroid 16:961-5. 2006
    ..Vitamin A deficiency (VAD) may adversely affect thyroid metabolism. The study aim was to investigate the effects of concurrent vitamin A and iodine deficiencies on the thyroid-pituitary axis in rats...
  35. pmc Administration of the Y2 receptor agonist PYY3-36 in mice induces multiple behavioral changes relevant to schizophrenia
    Ulrike Stadlbauer
    Physiology and Behavior Laboratory, Swiss Federal Institute of Technology ETH Zurich, Schwerzenbach, Switzerland
    Neuropsychopharmacology 38:2446-55. 2013
    ..At least some of the behavioral deficits induced by augmentation of Y2 receptor signaling may involve increased dopaminergic activity...
  36. doi request reprint In male rats with concurrent iron and (n-3) fatty acid deficiency, provision of either iron or (n-3) fatty acids alone alters monoamine metabolism and exacerbates the cognitive deficits associated with combined deficiency
    Jeannine Baumgartner
    Laboratory of Human Nutrition, ETH Zurich, Zurich, Switzerland
    J Nutr 142:1472-8. 2012
    ....
  37. ncbi request reprint Synthesis, characterization, and bioavailability in rats of ferric phosphate nanoparticles
    Fabian Rohner
    Institute of Food Science and Nutrition, ETH Zurich, Switzerland
    J Nutr 137:614-9. 2007
    ..In conclusion, nanoparticles of FePO(4) have a solubility and RBV not significantly different from FeSO(4). Reducing poorly soluble Fe compounds to nanoscale may increase their value for human nutrition...
  38. doi request reprint GLP-1 antagonism with exendin (9-39) fails to increase spontaneous meal size in rats
    Elisabeth B Rüttimann
    Physiology and Behaviour Laboratory, Institute of Food, Nutrition and Health, ETH Zurich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
    Physiol Behav 100:291-6. 2010
    ..The situations in which GLP-1 is of physiological relevance for satiation require further research...
  39. ncbi request reprint Subdiaphragmatic vagal deafferentation affects body weight gain and glucose metabolism in obese male Zucker (fa/fa) rats
    Bettina Ferrari
    Swiss Federal Institute of Technology, Institute of Animal Sciences, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
    Am J Physiol Regul Integr Comp Physiol 289:R1027-34. 2005
    ..These results suggest that elimination of vagal afferent signals from the upper gut reduces food intake and body weight gain without affecting the insulin sensitivity index measured by minimal modeling in obese Zucker rats...
  40. ncbi request reprint Increased infarct size and lack of hyperphagic response after focal cerebral ischemia in peroxisome proliferator-activated receptor beta-deficient mice
    Denis Arsenijevic
    Institute of Animal Sciences, ETHZ, Zurich, Switzerland
    J Cereb Blood Flow Metab 26:433-45. 2006
    ....
  41. ncbi request reprint CPT1alpha over-expression increases long-chain fatty acid oxidation and reduces cell viability with incremental palmitic acid concentration in 293T cells
    Ulrike L Jambor de Sousa
    Institute of Animal Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland
    Biochem Biophys Res Commun 338:757-61. 2005
    ..This inducible expression system should be well suited to study the roles of CPT1 and fatty acid oxidation in lipotoxicity and metabolism in vivo...
  42. ncbi request reprint Gut vagal afferents are not necessary for the eating-stimulatory effect of intraperitoneally injected ghrelin in the rat
    Myrtha Arnold
    Institute of Animal Sciences, Swiss Federal Institute of Technology Zurich, Schwerzenbach 8603, Switzerland
    J Neurosci 26:11052-60. 2006
    ....
  43. ncbi request reprint Evidence for a role of the 5-HT2C receptor in central lipopolysaccharide-, interleukin-1 beta-, and leptin-induced anorexia
    Claudia von Meyenburg
    Department of Physiology and Animal Husbandry, Institute of Animal Sciences, Swiss Federal Institute of Technology, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
    Pharmacol Biochem Behav 74:1025-31. 2003
    ..Our results also suggest that the midbrain raphe nuclei play a role in mediating the anorectic response to peripheral LPS and IL-1 beta...
  44. pmc Regulation of adipocyte formation by GLP-1/GLP-1R signaling
    Tenagne Delessa Challa
    Swiss Federal Institute of Technology, ETH Zurich, Institute of Food Nutrition and Health, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
    J Biol Chem 287:6421-30. 2012
    ....
  45. ncbi request reprint Effect of hydroxycitrate on respiratory quotient, energy expenditure, and glucose tolerance in male rats after a period of restrictive feeding
    Monika Leonhardt
    Institute of Animal Sciences, Swiss Federal Institute of Technology, Schwerzenbach, Switzerland
    Nutrition 20:911-5. 2004
    ..However, it is not known whether HCA also affects the respiration quotient (RQ), energy expenditure (EE), and glucose tolerance in this animal model...
  46. ncbi request reprint Current perspectives on behavioural and cellular mechanisms of illness anorexia
    Lori Asarian
    Swiss Federal Institute of Technology, Institute of Animal Sciences, Schwerzenbach, Switzerland
    Int Rev Psychiatry 17:451-9. 2005
    ..Understanding the behavioural and molecular mechanisms of LPS-anorexia may even provide useful leads for identifying mechanisms of eating disorders in humans...
  47. pmc Limiting glucocorticoid secretion increases the anorexigenic property of Exendin-4
    Shin J Lee
    Physiology and Behavior Laboratory, ETH Zurich, 8603 Schwerzenbach, Switzerland
    Mol Metab 5:552-65. 2016
    ..Peripheral administration of the GLP-1R agonist Exendin-4 (Ex-4) also increases glucocorticoid secretion in rodents and humans, but whether the released glucocorticoids interact with Ex-4's anorexigenic effect remains unclear...
  48. doi request reprint Metabolic Adaptation of the Small Intestine to Short- and Medium-Term High-Fat Diet Exposure
    Rosmarie Clara
    Physiology and Behavior Laboratory, ETH Zurich, Switzerland
    J Cell Physiol 232:167-75. 2017
    ..This highlights the importance of the small intestine in the adaptation of the body to the metabolic changes induced by HFD exposure. J. Cell. Physiol. 232: 167-175, 2017. © 2016 Wiley Periodicals, Inc. ..
  49. pmc Enhancing hepatic mitochondrial fatty acid oxidation stimulates eating in food-deprived mice
    Abdelhak Mansouri
    Physiology and Behavior Laboratory, Institute of Food, Nutrition, and Health, ETH Zurich, Switzerland
    Am J Physiol Regul Integr Comp Physiol 308:R131-7. 2015
    ..Rather, it may even stimulate eating after prolonged food deprivation. These data do not support the hypothesis that an increase in hepatic FAO decreases food intake. ..
  50. pmc Priming of metabolic dysfunctions by prenatal immune activation in mice: relevance to schizophrenia
    Gustavo Pacheco-López
    Physiology and Behavior Laboratory, Swiss Federal Institute of Technology Zurich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
    Schizophr Bull 39:319-29. 2013
    ....
  51. doi request reprint Meal-contingent intestinal lymph sampling from awake, unrestrained rats
    Myrtha Arnold
    Physiology and Behavior Laboratory, Institute of Food, Nutrition and Health, ETH Zurich, Schorenstr 16, 8603 Schwerzenbach, Switzerland
    Am J Physiol Regul Integr Comp Physiol 302:R1365-71. 2012
    ..Furthermore, the advantage of this system is that the animal can act as its own control when the effect of different experimental protocols is tested...
  52. doi request reprint Peripheral glucagon-like peptide-1 (GLP-1) and satiation
    Mukesh Punjabi
    Physiology and Behaviour Laboratory, Institute of Food, Nutrition and Health, ETH Zurich, 8603 Schwerzenbach, Switzerland
    Physiol Behav 105:71-6. 2011
    ..Therefore, further studies should examine whether a local paracrine action of GLP-1 in the intestine or and endocrine action in the hepatic-portal area is physiologically relevant for satiation...
  53. pmc Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma
    Bettina Meissburger
    ETH Zurich, Institute of Food Nutrition and Health, Schwerzenbach, Switzerland
    EMBO Mol Med 3:637-51. 2011
    ..RORγ might therefore serve as a novel pharmaceutical target to treat obesity-associated insulin resistance...
  54. doi request reprint Validation of computed tomographic estimates of intra-abdominal and subcutaneous adipose tissue in rats and mice
    Jacquelien J G Hillebrand
    Physiology and Behaviour Group, ETH Zurich, Schwerzenbach, Switzerland
    Obesity (Silver Spring) 18:848-53. 2010
    ..80). Coefficients of variance (CVs) of duplicate scans were <5%. We conclude that CT is a valid tool for studies of AT weight in rats and mice, especially when rapid throughput or longitudinal measures are desired...
  55. ncbi request reprint Enterostatin decreases postprandial pancreatic UCP2 mRNA levels and increases plasma insulin and amylin
    Denis Arsenijevic
    Institute of Animal Sciences, Eidegnossische Technische Hochschule Zurich, Schwerzenbach, Switzerland
    Am J Physiol Endocrinol Metab 289:E40-5. 2005
    ..This implies that enterostatin changes lipid and carbohydrate metabolic pathways in addition to its effects on food intake and energy expenditure...
  56. ncbi request reprint Subdiaphragmatic vagal deafferentation fails to block the anorectic effect of hydroxycitrate
    Monika Leonhardt
    Institute of Animal Sciences, Swiss Federal Institute of Technology, Schorenstr 16, CH 8603 Schwerzenbach
    Physiol Behav 82:263-8. 2004
    ..Vagal afferents, however, appear to play a role in the control of intake when a high-glucose diet is consumed after a period of restrictive feeding...
  57. ncbi request reprint Estradiol-mediated increases in the anorexia induced by intraperitoneal injection of bacterial lipopolysaccharide in female rats
    Nori Geary
    EW Bourne Laboratory, Weill Medical College, Cornell University, White Plains, NY, USA
    Physiol Behav 82:251-61. 2004
    ..The mechanism of the pathophysiological effect of estradiol on meal frequency appears to be different from the physiological effect of estradiol on food intake because the latter is expressed solely as a change in meal size...
  58. ncbi request reprint Peripheral mechanisms involved with catabolism
    Wolfgang Langhans
    Institute of Animal Sciences, Swiss Federal Institute of Technology ETH, Zurich, Switzerland
    Curr Opin Clin Nutr Metab Care 5:419-26. 2002
    ..Current knowledge on the hypermetabolism which often contributes to cachexia is also considered...
  59. ncbi request reprint Carbohydrate to protein ratio in food and cognitive performance in the morning
    Karina Fischer
    INW Nutrition Biology, Department of Agriculture and Food Science, Swiss Federal Institute of Technology Zurich, ETH Zentrum LFW A 58, CH 8092, Zurich, Switzerland
    Physiol Behav 75:411-23. 2002
    ....
  60. doi request reprint The Y2 receptor agonist PYY(3-36) increases the behavioural response to novelty and acute dopaminergic drug challenge in mice
    Ulrike Stadlbauer
    Physiology and Behaviour Laboratory, Swiss Federal Institute of Technology ETH Zurich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
    Int J Neuropsychopharmacol 17:407-19. 2014
    ..These effects do not seem to involve direct activation of midbrain dopamine cells but instead are associated with neuronal activation in the major input areas of the mesoaccumbal and nigrostriatal pathways...
  61. doi request reprint Possible mechanisms of circulating PYY-induced satiation in male rats
    Ulrike Stadlbauer
    Swiss Federal Institute of Technology Zurich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
    Endocrinology 154:193-204. 2013
    ..Endogenous PYY may induce satiation by acting directly in the brain, but further studies should examine whether PYY(3-36) administrations that mimic the meal-induced increase in plasma PYY are sufficient to inhibit eating...
  62. ncbi request reprint Hydroxycitrate has long-term effects on feeding behavior, body weight regain and metabolism after body weight loss in male rats
    Monika Leonhardt
    Institute of Animal Sciences, Swiss Federal Institute of Technology, CH 8603 Schwerzenbach, Switzerland
    J Nutr 132:1977-82. 2002
    ..The fact that HCA did not change plasma BHB concentration does not support a role for increased hepatic fatty acid oxidation in the anorectic effect of HCA...
  63. doi request reprint A new look on brain mechanisms of acute illness anorexia
    Lori Asarian
    Institute of Food, Nutrition and Health, ETH Zurich, 8603, Schwerzenbach, Switzerland
    Physiol Behav 100:464-71. 2010
    ..The paper represents an invited review by a symposium, award winner or keynote speaker at the Society for the Study of Ingestive Behavior [SSIB] Annual Meeting in Portland, July 2009...
  64. ncbi request reprint The effect of etomoxir on 24-h substrate oxidation and satiety in humans
    Vera B Hinderling
    Institute of Animal Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 76:141-7. 2002
    ..The carnitine O-palmitoyltransferase I (EC 2.3.1.21) inhibitor etomoxir inhibits fatty acid oxidation, and hepatic fatty acid oxidation has been suggested to be a metabolic satiety signal in subjects who consume high-fat diets...
  65. ncbi request reprint Particle size reduction and encapsulation affect the bioavailability of ferric pyrophosphate in rats
    Rita Wegmüller
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, Institute of Animal Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland
    J Nutr 134:3301-4. 2004
    ..Encapsulation of FePP with hydrogenated palm oil at a capsule:substrate ratio of 60:40 decreased RBV. Particle size reduction increases the RBV of FePP and may make this compound more useful for food fortification...
  66. ncbi request reprint Effect of CCK-8 on insulin-induced hyperphagia and hypothalamic orexigenic neuropeptide expression in the rat
    Eva Gallmann
    Physiology and Animal Husbandry, Institute of Animal Sciences, Swiss Federal Institute of Technology, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
    Peptides 26:437-45. 2005
    ..Signals triggered by peripheral CCK-8 act to decrease the expression of orexin and melanin-concentrating hormone. This may be associated with a reduction in hyperphagia...
  67. doi request reprint Anorexia-cachexia syndrome in hepatoma tumour-bearing rats requires the area postrema but not vagal afferents and is paralleled by increased MIC-1/GDF15
    Tito Borner
    Vetsuisse Faculty, Institute of Veterinary Physiology, University of Zurich, Zurich, Switzerland
    J Cachexia Sarcopenia Muscle . 2016
    ..Recently, the tumour-derived macrophage inhibitory cytokine-1 (MIC-1) emerged as a possible mediator of cancer anorexia because lesions of these brainstem areas attenuated the anorectic effect of exogenous MIC-1 in mice...
  68. doi request reprint Vagal mediation of GLP-1's effects on food intake and glycemia
    Jean Philippe Krieger
    Physiology and Behavior Laboratory, Institute of Food, Nutrition, and Health, ETH Zurich, Switzerland Electronic address
    Physiol Behav 152:372-80. 2015
    ..Finally, lesion-based approaches are limited and new technical approaches are discussed to improve the understanding of vagal GLP-1R functions in maintaining normal energy balance and its relevance in pharmacological interventions...
  69. doi request reprint Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice
    Marie A Labouesse
    Physiology and Behavior Laboratory, ETH Zurich, Schorenstrasse 16, 8603, Schwerzenbach, Switzerland
    Psychopharmacology (Berl) 232:2981-94. 2015
    ..However, the relative contribution of different estrogen-receptor (ER) isoforms in these associations still awaits examination...
  70. ncbi request reprint Evidence that the anorexia induced by lipopolysaccharide is mediated by the 5-HT2C receptor
    Claudia von Meyenburg
    Department of Physiology and Animal Husbandry, Institute of Animal Sciences, Swiss Federal Institute of Technology, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
    Pharmacol Biochem Behav 74:505-12. 2003
    ..01). Our results suggest that at least part of the anorexia following peripheral LPS administration is mediated through an enhanced 5-HT-ergic activity and the 5-HT(2C) receptor...
  71. doi request reprint Long-term pathological consequences of prenatal infection: beyond brain disorders
    Marie A Labouesse
    Physiology and Behavior Laboratory, ETH Zurich, Switzerland
    Am J Physiol Regul Integr Comp Physiol 309:R1-R12. 2015
    ..Targeting peripheral abnormalities may thus represent a valuable strategy to improve the wide spectrum of behavioral abnormalities that can emerge in subjects with prenatal infection histories. ..
  72. ncbi request reprint Iron deficiency anemia reduces thyroid peroxidase activity in rats
    Sonja Y Hess
    Laboratory for Human Nutrition, Institute of Food Science, Swiss Federal Institute of Technology, Zurich, Switzerland
    J Nutr 132:1951-5. 2002
    ..05). These data indicate that Fe deficiency sharply reduces TPO activity and suggest that decreased TPO activity contributes to the adverse effects of IDA on thyroid metabolism...
  73. ncbi request reprint Role of the liver in the control of glucose-lipid utilization and body weight
    Wolfgang Langhans
    Physiology and Animal Husbandry, Institute of Animal Sciences, Schwerzenbach, Switzerland
    Curr Opin Clin Nutr Metab Care 6:449-55. 2003
    ..The mechanisms involved have implications for the pathogenesis of obesity and type II diabetes...
  74. ncbi request reprint Lack of TNF alpha supports persistence of a plasmid encoding the bovine leukaemia virus in TNF(-/-) mice
    Catherine Muller
    Institute of Animal Sciences, ETH Zurich, Schornenstrasse 16, CH 8603 Schwerzenbach, Switzerland
    Vet Immunol Immunopathol 92:15-22. 2003
    ....
  75. ncbi request reprint Inhibitory effects of lipopolysaccharide on hypothalamic nuclei implicated in the control of food intake
    Csilla Becskei
    Institute of Veterinary Physiology and Zurich Centre of Human Integrative Physiology, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland
    Brain Behav Immun 22:56-64. 2008
    ..Thus, physiological satiety signals released during refeeding and anorexia during bacterial infection seem to engage similar neuronal substrates...
  76. ncbi request reprint Effects of obestatin on energy balance and growth hormone secretion in rodents
    Ruben Nogueiras
    Department of Pharmacology, German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    Endocrinology 148:21-6. 2007
    ..Therefore, the results presented here do not support a role of the obestatin/GPR-39 system in the regulation of energy balance...
  77. pmc Pancreatic signals controlling food intake; insulin, glucagon and amylin
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati, OH 45237 USA
    Philos Trans R Soc Lond B Biol Sci 361:1219-35. 2006
    ..Finally, their actions include gastrointestinal and metabolic as well as behavioural effects...
  78. ncbi request reprint Etomoxir-induced increase in UCP3 supports a role of uncoupling protein 3 as a mitochondrial fatty acid anion exporter
    Patrick Schrauwen
    Nutrition and Toxicology Research Institute Maastricht, Department of Human Biology, Maastricht University, 6200 MD Maastricht, The Netherlands
    FASEB J 16:1688-90. 2002
    ..In addition our data show that up-regulation of uncoupling protein-3 can be beneficial in the treatment of type 2 diabetes...
  79. ncbi request reprint Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels
    Fabienne de Bilbao
    Department of Psychiatry, University Hospitals Geneva, Geneva, Switzerland
    J Neurochem 89:1283-92. 2004
    ..Moreover, our data imply that UCP2 is not directly involved in the regulation of ROS production but acts by regulating mitochondrial GSH levels in microglia...
  80. ncbi request reprint Effect of sainfoin (Onobrychis viciifolia) silage and hay on established populations of Haemonchus contortus and Cooperia curticei in lambs
    Felix Heckendorn
    Department of Veterinary Parasitology, Research Institute of Organic Agriculture, Ackerstrasse, CH 5070 Frick, Switzerland
    Vet Parasitol 142:293-300. 2006
    ..For both, hay and silage, an antiparasitic effect could be shown, offering promising perspectives for the use of conserved tanniferous fodder as a complementary control approach against GIN...