Affiliation: St. Gallen
- Interferon-gamma inducible exchanges of 20S proteasome active site subunits: why?M Groettrup
Research Department, Cantonal Hospital St Gall, 9007, St Gallen, Switzerland
Biochimie 83:367-72. 2001..This difference in epitope generation may serve to better stimulate T cells in the sites of an ongoing immune response and to avoid autoimmunity in uninflamed tissues...
- Structural plasticity of the proteasome and its function in antigen processingM Groettrup
Research Department, Cantonal Hospital St Gallen, Switzerland
Crit Rev Immunol 21:339-58. 2001..Moreover, we review the latest data on how the ubiquitin pathway targets protein antigens for peptide processing and discuss the potential of proteasome inhibitors for the modulation of antigen presentation...
- Immunoproteasomes largely replace constitutive proteasomes during an antiviral and antibacterial immune response in the liverS Khan
Research Department and Institute for Pathology, Cantonal Hospital St Gallen, St Gallen, Switzerland
J Immunol 167:6859-68. 2001....
- The selective proteasome inhibitors lactacystin and epoxomicin can be used to either up- or down-regulate antigen presentation at nontoxic dosesK Schwarz
Research Department, Cantonal Hospital St Gall, St Gallen, Switzerland
J Immunol 164:6147-57. 2000....