Psychiatric University Hospital

Summary

Organization: Psychiatric University Hospital
Country: Switzerland

Top Publications

  1. ncbi Trends in psychiatric hospitalisation of people with schizophrenia: a register-based investigation over the last three decades
    Barbara Lay
    Psychiatric University Hospital Zurich, Research Unit for Clinical and Social Psychiatry, Zurich, Switzerland
    Schizophr Res 97:68-78. 2007
  2. doi Low-threshold methadone treatment, heroin price, police activity and incidence of heroin use: the Zurich experience
    Carlos Nordt
    Psychiatric University Hospital, Zurich, Switzerland
    Int J Drug Policy 20:497-501. 2009
  3. pmc Estimating incidence trends in regular heroin use in 26 regions of Switzerland using methadone treatment data
    Carlos Nordt
    Research Group on Substance Use Disorders, Psychiatric University Hospital, Zurich, Switzerland
    Subst Abuse Treat Prev Policy 4:14. 2009
  4. pmc Sensorimotor gating depends on polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase, but not on neuregulin-1 Arg38Gln genotype: a replication study
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Germany
    Biol Psychiatry 66:614-20. 2009
  5. doi Combinatory electrical and pharmacological neuroprosthetic interfaces to regain motor function after spinal cord injury
    Pavel Musienko
    Experimental Neurorehabilitation Laboratory, Department of Neurology, University of Zurich, CH 8006 Zurich, Switzerland
    IEEE Trans Biomed Eng 56:2707-11. 2009
  6. doi [The German version of the Inventory of Stigmatizing Experiences (ISE)--a new tool for assessing the prevalence and impact of "felt stigma"]
    Beate Schulze
    Universitat Zurich, Forschungsbereich Klinische und Soziale Psychiatrie, Fachzentrum für Katastrophen und Wehrpsychiatrie
    Psychiatr Prax 36:e19-27. 2009
  7. pmc Transformation of nonfunctional spinal circuits into functional states after the loss of brain input
    Gregoire Courtine
    Neurology Department, University of Zurich, Zurich, Switzerland
    Nat Neurosci 12:1333-42. 2009
  8. pmc Flotillins are involved in the polarization of primitive and mature hematopoietic cells
    Lawrence Rajendran
    Systems and Cell Biology of Neurodegeneration, Department of Psychiatry Research, University of Zurich, Zurich, Switzerland
    PLoS ONE 4:e8290. 2009
  9. doi Subcellular targeting strategies for drug design and delivery
    Lawrence Rajendran
    Systems and Cell Biology of Neurodegeneration, Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Nat Rev Drug Discov 9:29-42. 2010
  10. doi Subjective distress predicts treatment seeking for depression, bipolar, anxiety, panic, neurasthenia and insomnia severity spectra
    J Angst
    Zurich University Psychiatric Hospital, Switzerland
    Acta Psychiatr Scand 122:488-98. 2010

Detail Information

Publications29

  1. ncbi Trends in psychiatric hospitalisation of people with schizophrenia: a register-based investigation over the last three decades
    Barbara Lay
    Psychiatric University Hospital Zurich, Research Unit for Clinical and Social Psychiatry, Zurich, Switzerland
    Schizophr Res 97:68-78. 2007
    ..The considerable decrease in inpatient treatment for people with schizophrenia emphasizes the need to further investigate the current state of coverage for and the appropriateness of health care available to this patient group...
  2. doi Low-threshold methadone treatment, heroin price, police activity and incidence of heroin use: the Zurich experience
    Carlos Nordt
    Psychiatric University Hospital, Zurich, Switzerland
    Int J Drug Policy 20:497-501. 2009
    ..And finally, the intensity of police activity in the drug field may also affect prices for street heroin...
  3. pmc Estimating incidence trends in regular heroin use in 26 regions of Switzerland using methadone treatment data
    Carlos Nordt
    Research Group on Substance Use Disorders, Psychiatric University Hospital, Zurich, Switzerland
    Subst Abuse Treat Prev Policy 4:14. 2009
    ..Regional incidence trends in regular heroin use are important for assessing the effectiveness of drug policies and for forecasting potential future epidemics...
  4. pmc Sensorimotor gating depends on polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase, but not on neuregulin-1 Arg38Gln genotype: a replication study
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Germany
    Biol Psychiatry 66:614-20. 2009
    ..Therefore, we aimed to replicate these results and investigated the impact of the related polymorphisms on PPI in healthy human volunteers...
  5. doi Combinatory electrical and pharmacological neuroprosthetic interfaces to regain motor function after spinal cord injury
    Pavel Musienko
    Experimental Neurorehabilitation Laboratory, Department of Neurology, University of Zurich, CH 8006 Zurich, Switzerland
    IEEE Trans Biomed Eng 56:2707-11. 2009
    ..Such novel biomedical technologies may offer unparalleled potential to induce multiple and flexible locomotor states in paralyzed subjects...
  6. doi [The German version of the Inventory of Stigmatizing Experiences (ISE)--a new tool for assessing the prevalence and impact of "felt stigma"]
    Beate Schulze
    Universitat Zurich, Forschungsbereich Klinische und Soziale Psychiatrie, Fachzentrum für Katastrophen und Wehrpsychiatrie
    Psychiatr Prax 36:e19-27. 2009
    ..The present study aims at field-testing the German version of the Inventory of Stigmatizing Experiences (ISE) , developed to investigate the epidemiology of "felt stigma"...
  7. pmc Transformation of nonfunctional spinal circuits into functional states after the loss of brain input
    Gregoire Courtine
    Neurology Department, University of Zurich, Zurich, Switzerland
    Nat Neurosci 12:1333-42. 2009
    ..These findings provide a strategy by which individuals with spinal cord injuries could regain substantial levels of motor control...
  8. pmc Flotillins are involved in the polarization of primitive and mature hematopoietic cells
    Lawrence Rajendran
    Systems and Cell Biology of Neurodegeneration, Department of Psychiatry Research, University of Zurich, Zurich, Switzerland
    PLoS ONE 4:e8290. 2009
    ..Many molecules implicated in migratory polarity show uniform cellular distribution under non-activated conditions, but acquire a polarized localization upon exposure to migratory cues...
  9. doi Subcellular targeting strategies for drug design and delivery
    Lawrence Rajendran
    Systems and Cell Biology of Neurodegeneration, Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Nat Rev Drug Discov 9:29-42. 2010
    ..In this Review, we explore the fundamentals of membrane trafficking and subcellular organization, as well as strategies used by pathogens to appropriate these mechanisms and the implications for drug design and delivery...
  10. doi Subjective distress predicts treatment seeking for depression, bipolar, anxiety, panic, neurasthenia and insomnia severity spectra
    J Angst
    Zurich University Psychiatric Hospital, Switzerland
    Acta Psychiatr Scand 122:488-98. 2010
    ..To examine correlates of mental health treatment seeking such as gender, diagnosis, impairment, distress and mastery...
  11. doi The neurobiology of psychedelic drugs: implications for the treatment of mood disorders
    Franz X Vollenweider
    Neuropsychopharmacology and Brain Imaging Research Unit, University Hospital of Psychiatry, Zurich, Switzerland
    Nat Rev Neurosci 11:642-51. 2010
    ..These findings raise the possibility that research into psychedelics might identify novel therapeutic mechanisms and approaches that are based on glutamate-driven neuroplasticity...
  12. pmc Psychometric evaluation of the altered states of consciousness rating scale (OAV)
    Erich Studerus
    Neuropsychopharmacology and Brain Imaging and Heffter Research Center, University Hospital of Psychiatry Zurich, Zurich, Switzerland
    PLoS ONE 5:e12412. 2010
    ....
  13. doi Alzheimer's disease: a general introduction and pathomechanism
    Verena H Finder
    University of Zurich, Switzerland
    J Alzheimers Dis 22:5-19. 2010
    ....
  14. doi Relationship between neuroleptic extrapyramidal syndromes and patients' all-cause mortality
    J Modestin
    University of Zurich, Department of Psychiatry, Burghölzli Hospital, Zurich, Switzerland
    Pharmacopsychiatry 42:57-60. 2009
    ..The objective of this study was to test whether the occurrence of neuroleptic-induced extrapyramidal syndromes (EPS) including tardive dyskinesia (TD) is associated with an increased patients' all-cause mortality...
  15. doi GMP-compliant radiosynthesis of [18F]altanserin and human plasma metabolite studies
    F Hasler
    University Hospital of Psychiatry, Heffter Research Center, Zurich, Switzerland
    Appl Radiat Isot 67:598-601. 2009
    ..We conclude that metabolite analysis for correction of individual plasma input functions used in tracer modeling is not necessary for [(18)F]altanserin studies involving psilocybin or dexfenfluramine treatment...
  16. doi Does psychomotor agitation in major depressive episodes indicate bipolarity? Evidence from the Zurich Study
    Jules Angst
    Psychiatric Hospital, Zurich University, Lenggstrasse 31, P O Box 1931, 8032 Zurich, Switzerland
    Eur Arch Psychiatry Clin Neurosci 259:55-63. 2009
    ..This paper tested whether, how, and to what extent both psychomotor symptoms, agitation and retardation in depression are related to bipolarity and anxiety...
  17. pmc Impaired prepulse inhibition and prepulse-elicited reactivity but intact reflex circuit excitability in unmedicated schizophrenia patients: a comparison with healthy subjects and medicated schizophrenia patients
    Philipp A Csomor
    University Hospital of Psychiatry, Zurich Switzerland
    Schizophr Bull 35:244-55. 2009
    ..The extent to which PPER may or may not be causally associated with sensorimotor gating in schizophrenia has to be further investigated in human and animal studies...
  18. doi Estimating heroin epidemics with data of patients in methadone maintenance treatment, collected during a single treatment day
    Carlos Nordt
    Psychiatric University Hospital, Zurich, Switzerland
    Addiction 103:591-7. 2008
    ..We aimed to develop a simple method to estimate these dynamics with data that can be gathered from patients in substitution treatment within a single day...
  19. doi Sensorimotor gating and attentional set-shifting are improved by the mu-opioid receptor agonist morphine in healthy human volunteers
    Boris B Quednow
    University Hospital of Psychiatry, Experimental Psychopathology and Brain Imaging, University of Zurich, Switzerland
    Int J Neuropsychopharmacol 11:655-69. 2008
    ....
  20. pmc Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories
    Uwe Konietzko
    Division of Psychiatry Research, University of Zurich, August Forel Street 1, 8008 Zurich, Switzerland
    Neurobiol Aging 31:58-73. 2010
    ..Fe65 and Tip60 also co-localized with APP in the neurites of primary neurons. Pre-assembled AFT complexes may serve to assist fast nuclear signaling upon endoproteolytic APP cleavage...
  21. doi Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphisms
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Germany
    Biol Psychiatry 64:434-7. 2008
    ..Moreover, both schizophrenia and PPI are thought to be inheritable. We investigated the impact of three 5-HT(2A)R polymorphisms (A-1438G, T102C, H452Y) on PPI in schizophrenia patients...
  22. doi Impaired sensorimotor gating of the acoustic startle response in the prodrome of schizophrenia
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Biol Psychiatry 64:766-73. 2008
    ..To test this assumption, we investigated PPI of ASR in individuals with prodromal symptoms of schizophrenia and patients with first-episode schizophrenia...
  23. doi Diagnosis and course of affective psychoses: was Kraepelin right?
    Jules Angst
    Psychiatrische Universitatsklinik, Lenggstrasse 31, Postfach 1931, 8032, Zurich, Switzerland
    Eur Arch Psychiatry Clin Neurosci 258:107-10. 2008
    ..In contrast to Kraepelin's unitarian view the long-term prognosis of subgroups of mood disorders varies considerably. Overall it is nevertheless astonishing how much of Kraepelin's legacy has survived...
  24. doi Targeting beta-amyloid pathology in Alzheimer's disease with Abeta immunotherapy
    Roger M Nitsch
    Division of Psychiatry Research, University of Zurich, Switzerland
    Neurotherapeutics 5:415-20. 2008
    ....
  25. pmc Sensorimotor gating of schizophrenia patients depends on Catechol O-methyltransferase Val158Met polymorphism
    Boris B Quednow
    University Hospital of Psychiatry, University of Zurich, Lenggstrasse31, CH 8032 Zurich, Switzerland
    Schizophr Bull 36:341-6. 2010
    ..These preliminary results imply that PPI is influenced by COMT Val(158)Met genotype in schizophrenia as well. In concert with other findings, our data suggest that PPI is a polygenic trait...
  26. doi Investigation of serotonin-1A receptor function in the human psychopharmacology of MDMA
    F Hasler
    Department of Clinical Research, Heffter Research Center, University Hospital of Psychiatry, Zurich, Switzerland
    J Psychopharmacol 23:923-35. 2009
    ..Our findings suggest that MDMA differentially affects higher cognitive functions, but does not support the hypothesis from animal studies, that some of the MDMA effects are causally mediated through action at the 5-HT1A receptor system...
  27. pmc Bipolar disorder--methodological problems and future perspectives
    Jules Angst
    Zurich University, Psychiatric Hospital, Research Department, Zurich, Switzerland
    Dialogues Clin Neurosci 10:129-39. 2008
    ..Early and timely diagnosis of BPD is necessary to enable prompt intervention and secondary prevention of the disorder. The paper describes the current status and future directions of developing clinical concepts of bipolarity...
  28. doi On the influence of baseline startle reactivity on the indexation of prepulse inhibition
    Philipp A Csomor
    Psychiatric University Hospital Zurich, Zurich, Switzerland
    Behav Neurosci 122:885-900. 2008
    ....
  29. doi Combined effects of law enforcement and substitution treatment on heroin mortality
    Carlos Nordt
    Psychiatric University Hospital, Zurich, Switzerland
    Drug Alcohol Rev 29:540-5. 2010
    ..To explore the combined effects of street-level law enforcement and substitution treatment programs on drug-related mortality, taking into account prevalence of heroin use and changes in injecting behaviour...