Greg Elson

Summary

Affiliation: NovImmune SA
Country: Switzerland

Publications

  1. ncbi request reprint Contribution of Toll-like receptors to the innate immune response to Gram-negative and Gram-positive bacteria
    Greg Elson
    NovImmune SA, Geneva, Switzerland
    Blood 109:1574-83. 2007
  2. ncbi request reprint TLR4/MD-2 monoclonal antibody therapy affords protection in experimental models of septic shock
    Bruno Daubeuf
    NovImmune SA, Geneva, Switzerland
    J Immunol 179:6107-14. 2007
  3. doi request reprint Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation
    Alexandre Garin
    NovImmune SA, 14 Chemin des Aulx, 1228 Plan les Ouates, Switzerland
    Immunity 33:84-95. 2010
  4. ncbi request reprint Pivotal involvement of Fcgamma receptor IIA in the neutralization of lipopolysaccharide signaling via a potent novel anti-TLR4 monoclonal antibody 15C1
    Irene Dunn-Siegrist
    NovImmune SA, 1228 Plan les Ouates, Switzerland
    J Biol Chem 282:34817-27. 2007
  5. pmc A specific anti-citrullinated protein antibody profile identifies a group of rheumatoid arthritis patients with a toll-like receptor 4-mediated disease
    Eric Hatterer
    NovImmune SA, 14 Chemin des Aulx, 1228, Plan les Ouates, Switzerland
    Arthritis Res Ther 18:224. 2016
  6. doi request reprint Enhancement of islet engraftment and achievement of long-term islet allograft survival by Toll-like receptor 4 blockade
    Laurianne Giovannoni
    1 Cell Isolation and Transplantation Center, Department of Surgery, University of Geneva School of Medicine, Geneva, Switzerland 2 Department of Endocrinology Metabolisme and Diabetology Nutrition, Jean Minjoz University Hospital, Besancon, France 3 Division of Transplantation and Visceral Surgery, Department of Surgery, University of Geneva Hospitals, Geneva, Switzerland 4 NovImmune, Plan les Ouates, Switzerland
    Transplantation 99:29-35. 2015
  7. pmc Tlr2 on Bone Marrow and Non-Bone Marrow Derived Cells Regulates Inflammation and Organ Injury in Cooperation with Tlr4 During Resuscitated Hemorrhagic Shock
    Sebastian Korff
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania Department of Trauma Surgery, University of Heidelberg, Heidelberg, Germany Novimmune SA, Geneva, Switzerland Glenmark Pharmaceuticals SA, La Chaux de Fonds, Switzerland
    Shock 46:519-526. 2016
  8. ncbi request reprint Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer
    Stefan Rose-John
    Biochemisches Institut, Christian Albrechts Universitat zu Kiel, Olshausenstr 40, D 24098 Kiel, Germany
    J Leukoc Biol 80:227-36. 2006
  9. ncbi request reprint Gene expression of Toll-like receptor-2, Toll-like receptor-4, and MD2 is differentially regulated in rabbits with Escherichia coli pneumonia
    Osamu Kajikawa
    Pulmonary Research Laboratories at the Seattle Department of Veterans Affairs Medical Center, University of Washington School of Medicine, 151L 1660 South Columbian Way, Seattle, WA 98108, USA
    Gene 344:193-202. 2005
  10. ncbi request reprint Soluble MD-2 is an acute-phase protein and an opsonin for Gram-negative bacteria
    Pierre Tissieres
    Intensive Care, Department of Anesthesiology, Pharmacology and Intensive Care, University Hospitals of Geneva, Switzerland
    Blood 111:2122-31. 2008

Collaborators

  • Jie Fan
  • Iain B McInnes
  • Cem Gabay
  • Carsten J Kirschning
  • Michael Meyer-Hermann
  • Hermann Wagner
  • Marc Thilo Figge
  • Jerome Pugin
  • Marie H Kosco-Vilbois
  • Matthias Gunzer
  • Richard Ulevitch
  • Thierry Berney
  • Bruno Daubeuf
  • Limin Shang
  • Suzanne Herren
  • Sebastian Korff
  • Eric Hatterer
  • Irene Dunn-Siegrist
  • Laurianne Giovannoni
  • Osamu Kajikawa
  • Walter Ferlin
  • Alexandre Garin
  • Lincoln S Smith
  • Pierre Tissieres
  • Thomas R Martin
  • Charles W Frevert
  • Stefan Rose-John
  • David Perret
  • Yi Shan Lee
  • Cristina de Min
  • Susana Salgado Pires
  • James Reilly
  • Melanie Scott
  • Robert Nelson
  • Patricia Loughran
  • Stephanie Teixeira
  • Timothy R Billiar
  • Emmanuel Monnet
  • Changchun Cai
  • Jeremy Sokolove
  • Pierre Simonet
  • Jesse Guardado
  • Philippe Morel
  • Yannick D Muller
  • Sophie Borot
  • Domenico Bosco
  • Christian Toso
  • Raphael P H Meier
  • Vanessa Lavallard
  • Stéphanie Lacotte
  • Geraldine Parnaud
  • Benoît Bédat
  • Kai Michael Toellner
  • Mathias Contie
  • Vanessa Buatois
  • Merry Wick
  • Steve Mongovin
  • Rachel Comte
  • Michela Schappi
  • Vandack Nobre
  • Fabien Dépis
  • John Mathison
  • Stephanie Hugues
  • Olivier Leger
  • Yves Poitevin
  • Yann Dean
  • Stephan Spiller
  • Simon A Jones
  • Jürgen Scheller
  • Kim Ballman
  • Venus Wong
  • Richard B Goodman
  • Steve M Mongovin
  • Shu Min Lin
  • Catherine Guillet
  • Helene Plun-Favreau
  • Hugues Gascan
  • Jean Francois Gauchat
  • Josy Froger
  • Marie Chabbert
  • Francois Rousseau

Detail Information

Publications13

  1. ncbi request reprint Contribution of Toll-like receptors to the innate immune response to Gram-negative and Gram-positive bacteria
    Greg Elson
    NovImmune SA, Geneva, Switzerland
    Blood 109:1574-83. 2007
    ..This study identifies dominant TLRs involved in responses to whole bacteria. It also validates the concept that host cell activation by bacterial pathogens can be therapeutically reduced by anti-TLR4, -TLR2, and -CD14 mAbs...
  2. ncbi request reprint TLR4/MD-2 monoclonal antibody therapy affords protection in experimental models of septic shock
    Bruno Daubeuf
    NovImmune SA, Geneva, Switzerland
    J Immunol 179:6107-14. 2007
    ..These results demonstrate that neutralizing TLR4/MD-2 is highly efficacious in protecting against bacterial infection-induced toxemia and offers TLR4/MD-2 mAb treatment as a potential therapy for numerous clinical indications...
  3. doi request reprint Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation
    Alexandre Garin
    NovImmune SA, 14 Chemin des Aulx, 1228 Plan les Ouates, Switzerland
    Immunity 33:84-95. 2010
    ..Thus, our data place TLR4 in the heart of adaptive humoral immunity, providing further insight into mechanisms driving GCs arising in both health and disease...
  4. ncbi request reprint Pivotal involvement of Fcgamma receptor IIA in the neutralization of lipopolysaccharide signaling via a potent novel anti-TLR4 monoclonal antibody 15C1
    Irene Dunn-Siegrist
    NovImmune SA, 1228 Plan les Ouates, Switzerland
    J Biol Chem 282:34817-27. 2007
    ....
  5. pmc A specific anti-citrullinated protein antibody profile identifies a group of rheumatoid arthritis patients with a toll-like receptor 4-mediated disease
    Eric Hatterer
    NovImmune SA, 14 Chemin des Aulx, 1228, Plan les Ouates, Switzerland
    Arthritis Res Ther 18:224. 2016
    ....
  6. doi request reprint Enhancement of islet engraftment and achievement of long-term islet allograft survival by Toll-like receptor 4 blockade
    Laurianne Giovannoni
    1 Cell Isolation and Transplantation Center, Department of Surgery, University of Geneva School of Medicine, Geneva, Switzerland 2 Department of Endocrinology Metabolisme and Diabetology Nutrition, Jean Minjoz University Hospital, Besancon, France 3 Division of Transplantation and Visceral Surgery, Department of Surgery, University of Geneva Hospitals, Geneva, Switzerland 4 NovImmune, Plan les Ouates, Switzerland
    Transplantation 99:29-35. 2015
    ..The aim of the present study was to assess the role of Toll-like receptor-4 (TLR4) in mediating the inflammatory and immune responses to pancreatic islets, thereby promoting inflammatory destruction and immune rejection of islet grafts...
  7. pmc Tlr2 on Bone Marrow and Non-Bone Marrow Derived Cells Regulates Inflammation and Organ Injury in Cooperation with Tlr4 During Resuscitated Hemorrhagic Shock
    Sebastian Korff
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania Department of Trauma Surgery, University of Heidelberg, Heidelberg, Germany Novimmune SA, Geneva, Switzerland Glenmark Pharmaceuticals SA, La Chaux de Fonds, Switzerland
    Shock 46:519-526. 2016
    ....
  8. ncbi request reprint Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer
    Stefan Rose-John
    Biochemisches Institut, Christian Albrechts Universitat zu Kiel, Olshausenstr 40, D 24098 Kiel, Germany
    J Leukoc Biol 80:227-36. 2006
    ..The pathophysiological mechanisms by which the IL-6/sIL-6R complex regulates the inflammatory state are discussed...
  9. ncbi request reprint Gene expression of Toll-like receptor-2, Toll-like receptor-4, and MD2 is differentially regulated in rabbits with Escherichia coli pneumonia
    Osamu Kajikawa
    Pulmonary Research Laboratories at the Seattle Department of Veterans Affairs Medical Center, University of Washington School of Medicine, 151L 1660 South Columbian Way, Seattle, WA 98108, USA
    Gene 344:193-202. 2005
    ..In contrast, the increased gene expression of TLR2, TLR4, and MD2 in organs distant to the primary site of infection may contribute to the deleterious systemic inflammatory response observed in patients with sepsis...
  10. ncbi request reprint Soluble MD-2 is an acute-phase protein and an opsonin for Gram-negative bacteria
    Pierre Tissieres
    Intensive Care, Department of Anesthesiology, Pharmacology and Intensive Care, University Hospitals of Geneva, Switzerland
    Blood 111:2122-31. 2008
    ..This suggests that sMD-2 plays a key role in the host innate immune response to Gram-negative infections...
  11. doi request reprint Effect of Toll-like receptor 4 blockade on pulmonary inflammation caused by mechanical ventilation and bacterial endotoxin
    Lincoln S Smith
    Division of Pediatric Critical Care, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA
    Exp Lung Res 34:225-43. 2008
    ..In contrast, blockade of CD14 did not significantly decrease the number of neutrophils or the amount of CXCL8. These data show that TLR4 blockade reduces pulmonary inflammation caused by the combination of LPS and Mechanical ventilation...
  12. ncbi request reprint Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock
    Jerome Pugin
    Laboratory of the Division of Intensive Care, Department of Internal Medicine, University Hospital of Geneva, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Blood 104:4071-9. 2004
    ..We therefore propose that soluble MD-2 is an important mediator of organ inflammation during sepsis...
  13. ncbi request reprint Two different contact sites are recruited by cardiotrophin-like cytokine (CLC) to generate the CLC/CLF and CLC/sCNTFRalpha composite cytokines
    David Perret
    INSERM U564, CHU d Angers, 4 rue Larrey, 49033 Angers Cedex 01, France
    J Biol Chem 279:43961-70. 2004
    ..This study establishes the molecular details of the interaction of CLC with CLF, CNTFRalpha, and LIFRbeta and helps to define the precise role of each protein in this functional receptor complex...