- Mechanism of irradiation-induced mammary cancer metastasis: A role for SAP-dependent Mkl1 signalingMaria B Asparuhova
Friedrich Miescher Institute for Biomedical Research, Affiliated with the Novartis Institutes for Biomedical Research and the University of Basel, Maulbeerstrasse 66, 4058 Basel, Switzerland Electronic address
Mol Oncol 9:1510-27. 2015..Thus, we identified SAP-dependent Mkl1 signaling as a previously unrecognized mediator of aggressive progression of mammary tumors locally relapsing after radiotherapy, and provide a novel signaling pathway for therapeutic intervention. ..
- SAP domain-dependent Mkl1 signaling stimulates proliferation and cell migration by induction of a distinct gene set indicative of poor prognosis in breast cancer patientsIrem Gurbuz
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel CH 4058, Switzerland
Mol Cancer 13:22. 2014..Tenascin-C is known to be expressed in metastatic niches, is highly induced in cancer stroma and promotes breast cancer metastasis to the lung...
- Role of the actin cytoskeleton in tuning cellular responses to external mechanical stressM B Asparuhova
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Scand J Med Sci Sports 19:490-9. 2009..We describe examples of genes that are regulated by mechanical stress in a manner depending on actin dynamics, among them the ECM protein, tenascin-C...