Affiliation: Centre Hospitalier Universitaire Vaudois
- Synaptic plasticity impairment and hypofunction of NMDA receptors induced by glutathione deficit: relevance to schizophreniaP Steullet
Center for Psychiatric Neurosciences, Department of Adult Psychiatry, University Medical Center, University of Lausanne, 1008 Prilly, Switzerland
Neuroscience 137:807-19. 2006..Thus, glutathione deficit could be one causal factor for the hypofunction of NMDA receptors in schizophrenia...
- A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neuronsPascal Steullet
Center for Psychiatric Neurosciences, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Prilly Lausanne, Switzerland
Free Radic Biol Med 44:1042-54. 2008..This represents a mechanism by which dopaminergic systems could be dysfunctional under conditions of impaired glutathione synthesis as in schizophrenia...
- Impaired glutathione synthesis in schizophrenia: convergent genetic and functional evidenceRene Gysin
Center for Psychiatric Neuroscience, Department of Psychiatry, University Hospital Center and University of Lausanne, 1008 Prilly Lausanne, Switzerland
Proc Natl Acad Sci U S A 104:16621-6. 2007..Taken together, the study provides genetic and functional evidence that an impaired capacity to synthesize GSH under conditions of oxidative stress is a vulnerability factor for schizophrenia...
- Redox dysregulation, neurodevelopment, and schizophreniaKim Q Do
Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Site de Cery, CH 1008 Prilly Lausanne, Switzerland
Curr Opin Neurobiol 19:220-30. 2009..Novel interventions based on these mechanisms if applied in early phases of the disease hold great therapeutic promise...
- Redox dysregulation affects the ventral but not dorsal hippocampus: impairment of parvalbumin neurons, gamma oscillations, and related behaviorsPascal Steullet
Department of Psychiatry, Center for Psychiatric Neuroscience, Centre Hospitalier Universitaire Vaudois and University of Lausanne, 1008 Prilly Lausanne, Switzerland
J Neurosci 30:2547-58. 2010..Thus, a GSH deficit affects PV-IR interneuron's integrity and neuronal synchrony in a region- and time-specific manner, leading to behavioral phenotypes related to psychiatric disorders...
- TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticityKrisztián A Kovács
Center for Psychiatric Neuroscience and Service of Child and Adolescent Psychiatry, Department of Psychiatry, University Medical Center, University of Lausanne, CH 1008 Prilly Lausanne, Switzerland
Proc Natl Acad Sci U S A 104:4700-5. 2007..We provide evidence that TORC1 is involved in L-LTP maintenance at the Schaffer collateral-CA1 synapses in the hippocampus...
- Dual antennular chemosensory pathways mediate odor-associative learning and odor discrimination in the Caribbean spiny lobster Panulirus argusPascal Steullet
Department of Biology and Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA 30303, USA
J Exp Biol 205:851-67. 2002..This study presents the first evidence for a role of non-aesthetasc chemosensory neurons in complex odor-mediated behaviors such as learning and discrimination...