Hanifa Bouzourene

Summary

Affiliation: Centre Hospitalier Universitaire Vaudois
Country: Switzerland

Publications

  1. ncbi p53 and Ki-ras as prognostic factors for Dukes' stage B colorectal cancer
    H Bouzourene
    Institute of Pathology, Lausanne, Switzerland
    Eur J Cancer 36:1008-15. 2000
  2. ncbi Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy
    Hanifa Bouzourene
    Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Cancer 94:1121-30. 2002
  3. ncbi Role of metallothioneins in irradiated human rectal carcinoma
    Hanifa Bouzourene
    Institute of Pathology, Lausanne, Switzerland
    Cancer 95:1003-8. 2002
  4. ncbi Predictive factors in locally advanced rectal cancer treated with preoperative hyperfractionated and accelerated radiotherapy
    Hanifa Bouzourene
    Institute of Pathology, Lausanne, Switzerland
    Hum Pathol 34:541-8. 2003
  5. ncbi Immunogenicity of the carcinoembryonic antigen derived peptide 694 in HLA-A2 healthy donors and colorectal carcinoma patients
    Pedro M S Alves
    Division of Clinical Onco Immunology, Ludwig Institute for Cancer Research, Hopital Orthopedique, HO 05, rue Pierre Decker, 4, 1005, Lausanne, Switzerland
    Cancer Immunol Immunother 56:1795-805. 2007
  6. doi PAR2 promotes vaccine-induced protection against Helicobacter infection in mice
    Dominique Velin
    Service of Gastroenterology and Hepatology, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Gastroenterology 141:1273-82, 1282.e1. 2011
  7. doi The role of COX-2 in rectal cancer treated with preoperative radiotherapy
    Hanifa Bouzourene
    Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Bugnon 25, CH 1011 Lausanne, Switzerland
    Virchows Arch 452:499-505. 2008
  8. ncbi A cost-effective algorithm for hereditary nonpolyposis colorectal cancer detection
    Hanifa Bouzourene
    Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Am J Clin Pathol 125:823-31. 2006
  9. doi Reduction of Helicobacter infection in IL-10-/- mice is dependent on CD4+ T cells but not on mast cells
    Dominique Velin
    Service de gastro entérologie et d hépatologie, Centre Hospitalier Uniersitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Helicobacter 13:361-9. 2008
  10. doi Serrated polyps of the large intestine: a molecular study comparing sessile serrated adenomas and hyperplastic polyps
    Dominique Sandmeier
    Institute of Pathology, CHUV, Lausanne CH 1011, Switzerland
    Histopathology 55:206-13. 2009

Collaborators

Detail Information

Publications33

  1. ncbi p53 and Ki-ras as prognostic factors for Dukes' stage B colorectal cancer
    H Bouzourene
    Institute of Pathology, Lausanne, Switzerland
    Eur J Cancer 36:1008-15. 2000
    ..12-4.11, P = 0.02). Assessment of p53 protein expression is more discriminative than TP53 mutation to predict the outcome of Dukes' stage B tumours and could be a useful tool to identify patients who might benefit from adjuvant therapy...
  2. ncbi Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy
    Hanifa Bouzourene
    Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Cancer 94:1121-30. 2002
    ..Nevertheless, to the authors' knowledge few data are available regarding the histopathologic response to radiotherapy as assessed on surgical specimens as a potential predictive factor for outcome...
  3. ncbi Role of metallothioneins in irradiated human rectal carcinoma
    Hanifa Bouzourene
    Institute of Pathology, Lausanne, Switzerland
    Cancer 95:1003-8. 2002
    ..This is the first study that investigates whether MT expression is involved in the radioresistance of rectal carcinoma...
  4. ncbi Predictive factors in locally advanced rectal cancer treated with preoperative hyperfractionated and accelerated radiotherapy
    Hanifa Bouzourene
    Institute of Pathology, Lausanne, Switzerland
    Hum Pathol 34:541-8. 2003
    ..We show that patients with advanced pT, positive lymph nodes, vascular invasion, positive RRM, clearance <2 mm, or absence of tumor regression are known to have poor clinical outcome...
  5. ncbi Immunogenicity of the carcinoembryonic antigen derived peptide 694 in HLA-A2 healthy donors and colorectal carcinoma patients
    Pedro M S Alves
    Division of Clinical Onco Immunology, Ludwig Institute for Cancer Research, Hopital Orthopedique, HO 05, rue Pierre Decker, 4, 1005, Lausanne, Switzerland
    Cancer Immunol Immunother 56:1795-805. 2007
    ..However, the low avidity of the specific CTLs generated from cancer patients as well as the high-antigen expression levels required for CTL recognition pose serious concerns for the use of CEA694-702 in cancer immunotherapy...
  6. doi PAR2 promotes vaccine-induced protection against Helicobacter infection in mice
    Dominique Velin
    Service of Gastroenterology and Hepatology, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Gastroenterology 141:1273-82, 1282.e1. 2011
    ..Protease-activated receptor 2 (PAR2) signaling is believed to regulate immune and inflammatory responses. We investigated the role of PAR2 in vaccine-induced immunity against Helicobacter infection...
  7. doi The role of COX-2 in rectal cancer treated with preoperative radiotherapy
    Hanifa Bouzourene
    Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Bugnon 25, CH 1011 Lausanne, Switzerland
    Virchows Arch 452:499-505. 2008
    ..We conclude that COX-2 expression is overexpressed in the majority of rectal cancers treated with radiotherapy and likely plays a role in local relapse...
  8. ncbi A cost-effective algorithm for hereditary nonpolyposis colorectal cancer detection
    Hanifa Bouzourene
    Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Am J Clin Pathol 125:823-31. 2006
    ..Absence of hMLH1 promoter methylation in MSI-H colorectal cancer could be predictive of hereditary colorectal cancer, and, hence, methylation analysis might constitute the second step in the identification of patients with HNPCC...
  9. doi Reduction of Helicobacter infection in IL-10-/- mice is dependent on CD4+ T cells but not on mast cells
    Dominique Velin
    Service de gastro entérologie et d hépatologie, Centre Hospitalier Uniersitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Helicobacter 13:361-9. 2008
    ..In contrast to wild type, interleukin-10-deficient (IL-10(-/-)) mice are able to clear Helicobacter infection. In this study, we investigated the immune response of IL-10(-/-) mice leading to the reduction of Helicobacter infection...
  10. doi Serrated polyps of the large intestine: a molecular study comparing sessile serrated adenomas and hyperplastic polyps
    Dominique Sandmeier
    Institute of Pathology, CHUV, Lausanne CH 1011, Switzerland
    Histopathology 55:206-13. 2009
    ....
  11. pmc An unusual case of metastatic melanoma sensitive to chemotherapy and immunotherapy, with late immune escape in the brain
    Verena Voelter
    Multidisciplinary Oncology Center, University of Lausanne Hospitals CHUV, Lausanne, Switzerland
    Cancer Immun 8:6. 2008
  12. pmc Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization
    Lukas Baitsch
    Clinical Tumor Biology and Immunotherapy Unit, Ludwig Center, University of Lausanne, Lausanne, Switzerland
    PLoS ONE 7:e30852. 2012
    ..Blocking multiple inhibitory receptors simultaneously or sequentially may improve T-cell based therapies, but further studies are necessary to clarify the role of each receptor-ligand pair...
  13. ncbi Preoperative hyperfractionated accelerated radiotherapy (HART) and concomitant CPT-11 in locally advanced rectal carcinoma: a phase I study
    Verena Voelter
    Multidisciplinary Oncology Center, University Hospital CHUV, Lausanne, Switzerland
    Int J Radiat Oncol Biol Phys 56:1288-94. 2003
    ..In this Phase I trial, we aimed at introducing chemotherapy early in the treatment course with both intrinsic antitumor activity and a radiosensitizer effect...
  14. doi Selection of patients with germline MLH1 mutated Lynch syndrome by determination of MLH1 methylation and BRAF mutation
    Hanifa Bouzourene
    Institute of Pathology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Bugnon 25, 1011, Lausanne, Switzerland
    Fam Cancer 9:167-72. 2010
    ..These potentially Lynch syndrome patients should be offered genetic counselling before searching for MLH1 gene mutations...
  15. doi Enrichment of human CD4+ V(alpha)24/Vbeta11 invariant NKT cells in intrahepatic malignant tumors
    Gabriel Bricard
    Division of Clinical Onco Immunology, Ludwig Institute for Cancer Research, Lausanne Branch, Lausanne, Switzerland
    J Immunol 182:5140-51. 2009
    ....
  16. doi Nodal staging in colorectal cancer: should distant lymph nodes be recovered in surgical specimens?
    Marc Pusztaszeri
    Department of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Hum Pathol 40:552-7. 2009
    ..In the rectum, systematic sampling of close and distant lymph nodes is mandatory because in rare cases, metastases are detected only in distant lymph nodes, particularly in patients who have undergone neoadjuvant radiotherapy...
  17. pmc Exhaustion of tumor-specific CD8⁺ T cells in metastases from melanoma patients
    Lukas Baitsch
    Clinical Tumor Immune Biology Unit, Ludwig Institute for Cancer Research, Lausanne, Switzerland
    J Clin Invest 121:2350-60. 2011
    ..Functional T cell impairment is mediated by inhibitory receptors and further molecular pathways, which represent potential targets for cancer therapy...
  18. ncbi Serrated polyps of the colorectum: is sessile serrated adenoma distinguishable from hyperplastic polyp in a daily practice?
    Dominique Sandmeier
    Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Bugnon 25, CH 1011 Lausanne, Switzerland
    Virchows Arch 450:613-8. 2007
    ..One SSA of our series showed low-grade dysplasia supporting the concept that this lesion might be a precursor of serrated adenocarcinoma...
  19. ncbi Comparison of microsatellite instability and chromosomal instability in predicting survival of patients with T3N0 colorectal cancer
    Pascal Gervaz
    Department of Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Surgery 131:190-7. 2002
    ..Their respective roles in predicting clinical outcomes of patients with T3N0 colorectal cancer remain unknown...
  20. ncbi Mast cells are critical mediators of vaccine-induced Helicobacter clearance in the mouse model
    Dominique Velin
    Service de gastro entérologie et d hépatologie, CHUV, Lausanne, Switzerland
    Gastroenterology 129:142-55. 2005
    ..Despite the proven ability of immunization to prevent Helicobacter infection in mouse models, the precise mechanism of protection has remained elusive...
  21. ncbi The role of interval nodes in sentinel lymph node mapping and dissection for melanoma patients
    Maurice Matter
    Department of Visceral Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Nucl Med 48:1607-13. 2007
    ..As shown in previous reports, these interval SNs seem to be at the same metastatic risk as are SNs in the usual, classic areas. This study aimed to review the incidence, lymphatic anatomy, and metastatic risk of interval SNs...
  22. ncbi Naturally acquired MAGE-A10- and SSX-2-specific CD8+ T cell responses in patients with hepatocellular carcinoma
    Gabriel Bricard
    Division of Clinical Onco Immunology, Ludwig Institute for Cancer Research, Lausanne, Switzerland
    J Immunol 174:1709-16. 2005
    ....
  23. doi Diffuse minute clear cell proliferation in kidney: case report and review of literature
    Marc Pusztaszeri
    Department of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Urology 73:443.e9-11. 2009
    ..The benign or malignant nature of those clear cell microtumors was investigated by immunohistochemistry and fluorescent in situ hybridization analysis of chromosome 3p...
  24. ncbi Malakoplakia and colonic adenoma: a rare association
    Elena Rizzo
    Institute of Pathology and Surgical Department, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Ann Diagn Pathol 8:364-6. 2004
    ..Our observation confirms the isolated association of malakoplakia and colonic adenomas and the rarity of this association...
  25. ncbi Primary clear cell sarcoma of the ileum: an uncommon and misleading site
    Lorenzo Taminelli
    Department of Pathology, University Hospital, Lausanne, Switzerland
    Virchows Arch 447:772-7. 2005
    ..This case demonstrates that the gastrointestinal tract is a potential site for primary clear cell sarcoma of soft tissues, and, furthermore, that cytogenetics and/or molecular techniques play a central role in the diagnosis...
  26. pmc Role of Inflammatory Monocytes in Vaccine-Induced Reduction of Helicobacter felis Infection
    Mati Moyat
    Service of Gastroenterology and Hepatology, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland
    Infect Immun 83:4217-28. 2015
    ..pylori in an iNOS-dependent manner. Collectively, these data show that inflammatory monocytes play a direct role in the immunization-induced reduction of H. felis infection from the gastric mucosa. ..
  27. doi Interleukin-17 is a critical mediator of vaccine-induced reduction of Helicobacter infection in the mouse model
    Dominique Velin
    Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Gastroenterology 136:2237-2246.e1. 2009
    ..This study explores the possibility that interleukin (IL)-17 plays a role in the reduction of Helicobacter infection following vaccination of wild-type animals or in spontaneous reduction of bacterial infection in IL-10-deficient mice...
  28. ncbi Preoperative hyper-fractionated accelerated radiotherapy (HART) in locally advanced rectal cancer (LARC) immediately followed by surgery. A prospective phase II trial
    Philippe A Coucke
    Department of Radiation Oncology, Hopital Maisonneuve Rosemont, Montreal, Quebec, Canada
    Radiother Oncol 79:52-8. 2006
    ..This fractionation schedule was designed to keep the overall treatment time (OTT) as short as possible...
  29. ncbi Inflammatory gene profiles in gastric mucosa during Helicobacter pylori infection in humans
    Sicheng Wen
    Department of Laboratory Medicine, Karolinska Institute at Huddinge Hospital, Stockholm, Sweden
    J Immunol 172:2595-606. 2004
    ..The expression data of the array hybridization was confirmed by quantitative real-time PCR assays. Future studies may help identify gene expression patterns predictive of complications of the infection...
  30. ncbi Effect of timing of surgery on survival after preoperative hyperfractionated accelerated radiotherapy (HART) for locally advanced rectal cancer (LARC): is it a matter of days?
    Philippe A Coucke
    Department of Radiation Oncology, Centre Hospitalier Universitaire Liège, Belgique
    Acta Oncol 45:1086-93. 2006
    ..Gap duration predicts survival outcome but not local control. The patients submitted to surgery after a median delay of more than 5 days had a significantly better outcome...
  31. doi [Sessile serrated polyps of the colorectum: how to distinguish a sessile serrated adenoma from a hyperplastic polyp in a daily practice?]
    Dominique Sandmeier
    Institut de Pathologie, Centre Hospitalier Universitaire Vaudois, Bugnon 25, CH 1011 Lausanne, Suisse
    Ann Pathol 28:79-84. 2008
    ..However, it is important for the pathologist to identify SSA because recent data show that they might be the precursors of serrated adenocarcinomas which are probably involved in the serrated pathway...
  32. pmc Identification of tumor-associated antigens by large-scale analysis of genes expressed in human colorectal cancer
    Pedro M S Alves
    National Center of Competence in Research, Molecular Oncology, ISREC, Ch des Boveresses 155, 1066 Epalinges, Switzerland
    Cancer Immun 8:11. 2008
    ..Our data suggest that this sequence should be considered as a target of immunological interventions against colorectal cancer...
  33. ncbi Human achaete-scute homologue (hASH1) mRNA level as a diagnostic marker to distinguish esthesioneuroblastoma from poorly differentiated tumors arising in the sinonasal tract
    Paulette Mhawech
    Department of Clinical Pathology, Geneva University Hospital, Switzerland
    Am J Clin Pathol 122:100-5. 2004
    ..The hASH1 mRNA level might represent a useful tool for distinguishing esthesioneuroblastoma from poorly differentiated tumors of the sinonasal region...