Fred T Bosman

Summary

Affiliation: Centre Hospitalier Universitaire Vaudois
Country: Switzerland

Publications

  1. pmc Context-dependent interpretation of the prognostic value of BRAF and KRAS mutations in colorectal cancer
    Vlad Popovici
    Institute of Biostatistics and Analyses, Masaryk University, Kotlarska 2, Brno, 611 37, Czech Republic
    BMC Cancer 13:439. 2013
  2. pmc The role of the pathologist in tissue banking: European Consensus Expert Group Report
    Generoso Bevilacqua
    Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa and Pisa University Hospital, Medical School, Via Roma 57, 56126 Pisa, Italy
    Virchows Arch 456:449-54. 2010
  3. ncbi request reprint [Predictive biomarkers in colorectal cancer]
    Fred T Bosman
    Institut universitaire de pathologie CHUV, Lausanne
    Rev Med Suisse 5:1513-8. 2009
  4. ncbi request reprint Tissue biomarker development in a multicentre trial context: a feasibility study on the PETACC3 stage II and III colon cancer adjuvant treatment trial
    Fred T Bosman
    University Institute of Pathology, University of Lausanne Medical Center, Lausanne, Switzerland
    Clin Cancer Res 15:5528-33. 2009
  5. ncbi request reprint Unison or cacophony: postgraduate training in pathology in Europe
    Fred T Bosman
    Institut Universitaire de Pathologie, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 25, 1011, Lausanne CH, Switzerland
    Virchows Arch 454:497-503. 2009
  6. ncbi request reprint Methylation of APC, TIMP3, and TERT: a new predictive marker to distinguish Barrett's oesophagus patients at risk for malignant transformation
    Genevieve Clement
    Institut de Pathologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Pathol 208:100-7. 2006
  7. pmc BORIS/CTCFL-mediated transcriptional regulation of the hTERT telomerase gene in testicular and ovarian tumor cells
    Stéphanie Renaud
    Institute of Pathology, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Nucleic Acids Res 39:862-73. 2011
  8. ncbi request reprint Immunohistochemical localization of hTERT protein in human tissues
    Pu Yan
    Institut de Pathologie, Centre Hospitalier Universitaire Vaudois, Bugnon 25, 1011, Lausanne, Switzerland
    Histochem Cell Biol 121:391-7. 2004
  9. pmc CTCF binds the proximal exonic region of hTERT and inhibits its transcription
    Stéphanie Renaud
    Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Bugnon 25, 1011 Lausanne, Switzerland
    Nucleic Acids Res 33:6850-60. 2005
  10. ncbi request reprint Implication of the exon region in the regulation of the human telomerase reverse transcriptase gene promoter
    Stéphanie Renaud
    Institut de Pathologie, Centre Hospitalier Universitaire Vaudois, Bugnon 25, CH 1011 Lausanne, Switzerland
    Biochem Biophys Res Commun 300:47-54. 2003

Collaborators

  • Pu Yan
  • Eric Van Cutsem
  • Jan G van den Tweel
  • Sabine Tejpar
  • Philip Shaw
  • Roberto Fiocca
  • Marc P Pusztaszeri
  • Hanifa Bouzourene
  • Stéphanie Renaud
  • Jean Benhattar
  • Genevieve Clement
  • Vlad Popovici
  • Generoso Bevilacqua
  • Victor Lobanenkov
  • Dmitri Loukinov
  • Richard Braunschweig
  • Pascale Lachat
  • Isabelle Guilleret
  • Mauro Delorenzi
  • Arnaud D Roth
  • Eva Budinska
  • Yoo Wook Kwon
  • Loredana Alberti
  • Alexander Vostrov
  • Elodie Caboux
  • Heinz Hofler
  • Thibaut Dassesse
  • Denis Larsimont
  • Peter Schirmacher
  • Pierre Hainaut
  • Anne Janin
  • Peter Riegman
  • Rupert Langer
  • Giorgio Stanta
  • Kurt Zatloukal
  • Manuel M Morente
  • Nathalie Pasquier
  • Charlotte Fontolliet
  • Sandra Gebhard
  • Fabienne Grange
  • Pascal Chaubert
  • Nico van Belzen

Detail Information

Publications16

  1. pmc Context-dependent interpretation of the prognostic value of BRAF and KRAS mutations in colorectal cancer
    Vlad Popovici
    Institute of Biostatistics and Analyses, Masaryk University, Kotlarska 2, Brno, 611 37, Czech Republic
    BMC Cancer 13:439. 2013
    ..We investigated the prognostic value of BRAF and KRAS mutations in various contexts defined by stratifications of the patient population...
  2. pmc The role of the pathologist in tissue banking: European Consensus Expert Group Report
    Generoso Bevilacqua
    Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa and Pisa University Hospital, Medical School, Via Roma 57, 56126 Pisa, Italy
    Virchows Arch 456:449-54. 2010
    ....
  3. ncbi request reprint [Predictive biomarkers in colorectal cancer]
    Fred T Bosman
    Institut universitaire de pathologie CHUV, Lausanne
    Rev Med Suisse 5:1513-8. 2009
    ..Pathologists will have to be prepared for a new era: from standard morphology based diagnostic procedures to the prediction of response to therapy using molecular tools...
  4. ncbi request reprint Tissue biomarker development in a multicentre trial context: a feasibility study on the PETACC3 stage II and III colon cancer adjuvant treatment trial
    Fred T Bosman
    University Institute of Pathology, University of Lausanne Medical Center, Lausanne, Switzerland
    Clin Cancer Res 15:5528-33. 2009
    ..We evaluated the feasibility of biomarker development in the context of multicenter clinical trials...
  5. ncbi request reprint Unison or cacophony: postgraduate training in pathology in Europe
    Fred T Bosman
    Institut Universitaire de Pathologie, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 25, 1011, Lausanne CH, Switzerland
    Virchows Arch 454:497-503. 2009
    ..Harmonization might be attained by defining the general and specific competencies at the end of training and subsequent testing them through a test to which all trainees in Europe are subjected...
  6. ncbi request reprint Methylation of APC, TIMP3, and TERT: a new predictive marker to distinguish Barrett's oesophagus patients at risk for malignant transformation
    Genevieve Clement
    Institut de Pathologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Pathol 208:100-7. 2006
    ..Our results suggest that promoter methylation profiling of BE using multiple target genes including APC, TIMP3, and TERT might be used as a predictive marker for increased EAC risk...
  7. pmc BORIS/CTCFL-mediated transcriptional regulation of the hTERT telomerase gene in testicular and ovarian tumor cells
    Stéphanie Renaud
    Institute of Pathology, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Nucleic Acids Res 39:862-73. 2011
    ..These results define an important contribution of BORIS to immortalization during tumorigenesis...
  8. ncbi request reprint Immunohistochemical localization of hTERT protein in human tissues
    Pu Yan
    Institut de Pathologie, Centre Hospitalier Universitaire Vaudois, Bugnon 25, 1011, Lausanne, Switzerland
    Histochem Cell Biol 121:391-7. 2004
    ....
  9. pmc CTCF binds the proximal exonic region of hTERT and inhibits its transcription
    Stéphanie Renaud
    Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Bugnon 25, 1011 Lausanne, Switzerland
    Nucleic Acids Res 33:6850-60. 2005
    ..Our results suggest that CTCF participates in key cellular mechanisms underlying immortality by regulating hTERT gene expression...
  10. ncbi request reprint Implication of the exon region in the regulation of the human telomerase reverse transcriptase gene promoter
    Stéphanie Renaud
    Institut de Pathologie, Centre Hospitalier Universitaire Vaudois, Bugnon 25, CH 1011 Lausanne, Switzerland
    Biochem Biophys Res Commun 300:47-54. 2003
    ..These results provide the first evidence that the first two exons play a major role in the down-regulation of the hTERT promoter in telomerase-positive cells...
  11. ncbi request reprint Monoallelic methylation of the APC promoter is altered in normal gastric mucosa associated with neoplastic lesions
    Genevieve Clement
    Institut de Pathologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Cancer Res 64:6867-73. 2004
    ....
  12. ncbi request reprint Expression of NDRG1, a differentiation-related gene, in human tissues
    Pascale Lachat
    Institut Universitaire de Pathologie, Bugnon 25, 1011 Lausanne, Switzerland
    Histochem Cell Biol 118:399-408. 2002
    ..The multiple localizations of this protein also suggest pleiotropic functions amongst which a functional involvement in the E-cadherin/catenin complex...
  13. ncbi request reprint [How important is the clinical context for a histopathological diagnosis?]
    Fred T Bosman
    Institut Universitaire de Pathologie, Rue du Bugnon 25, 1011 Lausanne
    Rev Med Suisse 1:2779-83. 2005
    ..It is hence preferable for the pathologist to take note of the clinical context only after the microscopic examination has been accomplished...
  14. ncbi request reprint Immunohistochemical expression of endothelial markers CD31, CD34, von Willebrand factor, and Fli-1 in normal human tissues
    Marc P Pusztaszeri
    Institute of Pathology, Rue du Bugnon 25 1011, Lausanne, Switzerland
    J Histochem Cytochem 54:385-95. 2006
    ..The expression of EC markers CD31, CD34, and vWF in the vascular tree is heterogeneous with a specific pattern for individual vessel types and different anatomic compartments of the same organ. D2-40 labels lymphatic EC only...
  15. ncbi request reprint Predictive factors in locally advanced rectal cancer treated with preoperative hyperfractionated and accelerated radiotherapy
    Hanifa Bouzourene
    Institute of Pathology, Lausanne, Switzerland
    Hum Pathol 34:541-8. 2003
    ..We show that patients with advanced pT, positive lymph nodes, vascular invasion, positive RRM, clearance <2 mm, or absence of tumor regression are known to have poor clinical outcome...
  16. ncbi request reprint Hypermethylation of the human telomerase catalytic subunit (hTERT) gene correlates with telomerase activity
    Isabelle Guilleret
    Institut de Pathologie and Institut de Médecine Légale, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Int J Cancer 101:335-41. 2002
    ..To our knowledge, this is the first gene in which methylation of its promoter sequence has been found to be positively correlated with gene expression...