T Miyazaki

Summary

Affiliation: Basel Institute for Immunology
Country: Switzerland

Publications

  1. pmc Two distinct steps during thymocyte maturation from CD4-CD8- to CD4+CD8+ distinguished in the early growth response (Egr)-1 transgenic mice with a recombinase-activating gene-deficient background
    T Miyazaki
    Basel Institute for Immunology, Postfach CH 4005, Basel, Switzerland
    J Exp Med 186:877-85. 1997
  2. pmc Increased susceptibility of thymocytes to apoptosis in mice lacking AIM, a novel murine macrophage-derived soluble factor belonging to the scavenger receptor cysteine-rich domain superfamily
    T Miyazaki
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 189:413-22. 1999
  3. pmc Modulation of thymic selection by expression of an immediate-early gene, early growth response 1 (Egr-1)
    T Miyazaki
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 188:715-23. 1998
  4. pmc Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81
    T Miyazaki
    Basel Institute for Immunology, Switzerland
    EMBO J 16:4217-25. 1997
  5. ncbi Function of RNH-1/14-3-3 beta gene in cellular differentiation and proliferation
    R Takai
    Department of Biological Science and Technology, Science University of Tokyo, Noda
    J Biochem 118:1045-53. 1995
  6. ncbi A new protein containing an SH2 domain that inhibits JAK kinases
    T A Endo
    Institute of Life Science, Kurume University, Aikawamachi, Japan
    Nature 387:921-4. 1997
  7. ncbi Selection of a broad repertoire of CD4+ T cells in H-2Ma0/0 mice
    S Tourne
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale, Strasbourg, France
    Immunity 7:187-95. 1997
  8. ncbi Evidence for involvement of p59fyn in fasting-induced thymic involution
    H Nishio
    Department of Legal Medicine, Osaka Medical College, Takatsuki, Japan
    Scand J Immunol 62:103-7. 2005
  9. pmc Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway
    T Miyazaki
    Department of Immunology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, 113, Japan
    Genes Dev 12:770-5. 1998
  10. ncbi Lambda5 is required for rearrangement of the Ig kappa light chain gene in pro-B cell lines
    T Miyazaki
    Department of Life Science, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama 226 8501, Japan
    Int Immunol 11:1195-202. 1999

Collaborators

Detail Information

Publications50

  1. pmc Two distinct steps during thymocyte maturation from CD4-CD8- to CD4+CD8+ distinguished in the early growth response (Egr)-1 transgenic mice with a recombinase-activating gene-deficient background
    T Miyazaki
    Basel Institute for Immunology, Postfach CH 4005, Basel, Switzerland
    J Exp Med 186:877-85. 1997
    ..The first step, from the CD25+CD44- DN to the ISP stage, can be entirely promoted by overexpression of Egr-1...
  2. pmc Increased susceptibility of thymocytes to apoptosis in mice lacking AIM, a novel murine macrophage-derived soluble factor belonging to the scavenger receptor cysteine-rich domain superfamily
    T Miyazaki
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 189:413-22. 1999
    ..These results indicate that in the thymus, AIM functions in trans to induce resistance to apoptosis within DP cells, and thus supports the viability of DP thymocytes before thymic selection...
  3. pmc Modulation of thymic selection by expression of an immediate-early gene, early growth response 1 (Egr-1)
    T Miyazaki
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 188:715-23. 1998
    ..These results suggest that expression of Egr-1 and/or its target gene(s) may directly influence the thresholds required for thymocyte selection...
  4. pmc Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81
    T Miyazaki
    Basel Institute for Immunology, Switzerland
    EMBO J 16:4217-25. 1997
    ....
  5. ncbi Function of RNH-1/14-3-3 beta gene in cellular differentiation and proliferation
    R Takai
    Department of Biological Science and Technology, Science University of Tokyo, Noda
    J Biochem 118:1045-53. 1995
    ..These results provide additional evidence that RNH-1/14-3-3 beta protein participates in cellular differentiation, proliferation and transformation through the signal transduction pathways of various growth factors...
  6. ncbi A new protein containing an SH2 domain that inhibits JAK kinases
    T A Endo
    Institute of Life Science, Kurume University, Aikawamachi, Japan
    Nature 387:921-4. 1997
    ..JAB and CIS appear to function as negative regulators in the JAK signalling pathway...
  7. ncbi Selection of a broad repertoire of CD4+ T cells in H-2Ma0/0 mice
    S Tourne
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale, Strasbourg, France
    Immunity 7:187-95. 1997
    ....
  8. ncbi Evidence for involvement of p59fyn in fasting-induced thymic involution
    H Nishio
    Department of Legal Medicine, Osaka Medical College, Takatsuki, Japan
    Scand J Immunol 62:103-7. 2005
    ....
  9. pmc Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway
    T Miyazaki
    Department of Immunology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, 113, Japan
    Genes Dev 12:770-5. 1998
    ..Collectively, these results suggest that Pyk2 is a newly identified component of the Jak-mediated IL-2 signaling pathway...
  10. ncbi Lambda5 is required for rearrangement of the Ig kappa light chain gene in pro-B cell lines
    T Miyazaki
    Department of Life Science, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama 226 8501, Japan
    Int Immunol 11:1195-202. 1999
    ..The results demonstrate that formation of a complete surrogate L chain, consisting of both lambda5 and V(pre-B), stimulates efficient rearrangement of the kappa L chain genes...
  11. ncbi Association of AIM, a novel apoptosis inhibitory factor, with hepatitis via supporting macrophage survival and enhancing phagocytotic function of macrophages
    I Haruta
    Institute of Gastroenterology and Department of Pathology, Tokyo Women's Medical University, 8-1 Kawata-cho, Shinjuku-ku, Tokyo 162-8666, Japan
    J Biol Chem 276:22910-4. 2001
    ....
  12. ncbi LAG-3 is not responsible for selecting T helper cells in CD4-deficient mice
    T Miyazaki
    Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, Strasbourg, France
    Int Immunol 8:725-9. 1996
    ..LAG-3 thus does not explain class II-restricted lymphocyte selection and function in the absence of CD4, strengthening the idea that these phenomena can occur independently of co-receptor signalling...
  13. ncbi Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway
    Y Minami
    Institute for Molecular and Cellular Biology Osaka University, Japan
    Immunity 2:89-100. 1995
    ..Thus, Syk PTK may be a critical integral member of the signaling molecules engaged by the IL-2R...
  14. ncbi In vivo cytokine gene expression in various T cell subsets of the autoimmune MRL/Mp-lpr/lpr mouse
    K Mori
    Section of Immunopathogenesis, School of Medicine, Hokkaido University, Sapporo, Japan
    Autoimmunity 17:49-57. 1994
    ..We also demonstrated that CD4+ T cells infiltrating into kidney tissues of MRL/lpr mice expressed various cytokine genes such as IL-1, IL-5, IL-6, IFN-gamma, TNF-alpha, TNF-beta and TGF-beta...
  15. ncbi Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation
    T Miyazaki
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Cell 81:223-31. 1995
    ..These studies demonstrate a novel approach to dissecting signaling pathways regulating cellular proliferation...
  16. ncbi Cadherin-11 expressed in association with mesenchymal morphogenesis in the head, somite, and limb bud of early mouse embryos
    Y Kimura
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Dev Biol 169:347-58. 1995
    ..These results suggest that cad-11 is involved in specific associations of subsets of mesenchymal cells and also of some neural cells during early embryogenesis...
  17. ncbi Molecular cloning of a novel thyroid hormone-responsive gene, ZAKI-4, in human skin fibroblasts
    T Miyazaki
    Department of Endocrinology and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464 01, Japan
    J Biol Chem 271:14567-71. 1996
    ..No homologous protein sequence was found in a data base. Elucidation of the function of ZAKI-4 gene product will provide new insights into an important role of T3 in various organs...
  18. pmc The integrity of the conserved 'WS motif' common to IL-2 and other cytokine receptors is essential for ligand binding and signal transduction
    T Miyazaki
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    EMBO J 10:3191-7. 1991
    ..Our results indicate the critical role of the two Trp residues in the proper folding of the IL-2R beta extracellular domain and point to the general functional importance of the WS motif in the new cytokine receptor family...
  19. ncbi Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway
    T Miyazaki
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Universite Louis Pasteur, France
    Cell 84:531-41. 1996
    ..Peripheral T cells reacted strongly to splenocytes from syngeneic wild-type mice, no doubt reflecting the unique peptide complement carried by class II molecules in mutant animals...
  20. ncbi Independent modes of natural killing distinguished in mice lacking Lag3
    T Miyazaki
    Institut de Génétique et de Biologie Moléculaire et Cellulaire Inserm, CNRS, ULP, Strasbourg, France
    Science 272:405-8. 1996
    ..It appears that LAG3 is a receptor or coreceptor that defines different modes of natural killing...
  21. pmc A novel autoimmune pancreatitis model in MRL mice treated with polyinosinic:polycytidylic acid
    W M Qu
    Department of Pathology, Ehime University School of Medicine, Japan
    Clin Exp Immunol 129:27-34. 2002
    ..These findings suggest that an MRL strain of mice treated with poly I:C might be a good model for developing new approaches to the study of the pathogenesis of autoimmune pancreatitis...
  22. ncbi Recombinant forms of glycophorin C as a tool for characterization of epitopes for new murine monoclonal antibodies with anti-glycophorin C specificity
    E Jaskiewicz
    Department of Immunochemistry, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
    Transfus Med 12:141-9. 2002
    ....
  23. ncbi c-Ets1 is a promising marker in epithelial ovarian cancer
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Oita 879 5593, Japan
    Int J Mol Med 9:287-92. 2002
    ..05). Our results demonstrate that c-Ets1 expression in epithelial ovarian cancer correlates to the malignant potential of the tumor...
  24. pmc An adult Japanese Sanfilippo A patient with novel compound heterozygous S347F and D444G mutations in the sulphamidase gene
    T Miyazaki
    J Neurol Neurosurg Psychiatry 73:777-8. 2002
  25. pmc Reduced expression of Axin correlates with tumour progression of oesophageal squamous cell carcinoma
    M Nakajima
    Department of Surgery I, Gunma University Faculty of Medicine, 3 39 22 Showa machi, Maebashi, Japan
    Br J Cancer 88:1734-9. 2003
    ..However, additional studies will be necessary to elucidate the mechanism responsible for loss of Axin expression in tumour cells...
  26. ncbi Delayed neuronal damage related to microglia proliferation after mild spinal cord compression injury
    T Morino
    Department of Orthopaedic Surgery, Ehime University School of Medicine, Shigenobu, 791 0295, Ehime, Japan
    Neurosci Res 46:309-18. 2003
    ..These results suggest that our mild-compression spinal cord injury model showed late-onset or delayed neuronal damage that may be related to pathological microglia proliferation...
  27. pmc FAK overexpression is correlated with tumour invasiveness and lymph node metastasis in oesophageal squamous cell carcinoma
    T Miyazaki
    Department of Surgery I, Gunma University Faculty of Medicine, 3 39 22, Showa machi, Maebashi, Gunma 371 8511, Japan
    Br J Cancer 89:140-5. 2003
    ..In conclusion, FAK overexpression of ESCC was related to cell differentiation, tumour invasiveness, and lymph node metastasis. Consequently, patients with ESCC who had FAK overexpression had a poor prognosis...
  28. ncbi Antibacterial titanium plate anodized by being discharged in NaCl solution exhibits cell compatibility
    Y Shibata
    Department of Oral Biomaterials and Technology, Showa University School of Dentistry, 1 5 8 Hatanodai, Shinagawa ku, Tokyo, 142 8555, Japan
    J Dent Res 83:115-9. 2004
    ..These findings suggest that antibacterial titanium is a promising material for use in dental implant systems...
  29. ncbi Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits
    T Miyazaki
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Science 266:1045-7. 1994
    ..Furthermore, Jak3-negative fibroblasts expressing reconstituted IL-2R became responsive to IL-2 after the additional expression of Jak3 complementary DNA. Thus, activation of Jak1 and Jak3 may be a key event in IL-2 signaling...
  30. ncbi Identification of a novel allele HLA-A*1113 in a Japanese donor
    D Takahashi
    Hokkaido Red Cross Blood Center, Sapporo, Japan
    Tissue Antigens 64:81-3. 2004
    ....
  31. pmc An epistatic effect of the female specific loci on the development of autoimmune vasculitis and antinuclear autoantibody in murine lupus
    M C Zhang
    Department of Pathology, Tohoku University Graduate School of Medicine, 2 1 Seiryo, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Ann Rheum Dis 65:495-500. 2006
    ..To identify the genetic loci regulating the incidence and severity of renal autoimmune vasculitis developed in murine lupus...
  32. ncbi Anticancer effects of gallic acid isolated from Indonesian herbal medicine, Phaleria macrocarpa (Scheff.) Boerl, on human cancer cell lines
    A Faried
    Department of General Surgical Science Surgery I, Gunma University, Maebashi, Gunma 371 8511, Japan
    Int J Oncol 30:605-13. 2007
    ..Our results suggest that GA might be a potential anticancer compound. However, in depth in vivo studies are needed to elucidate the exact mechanism...
  33. ncbi A genetic locus controlling aging-sensitive regression of B lymphopoiesis in an autoimmune-prone MRL/lpr strain of mice
    K Nakatani
    First Department of Internal Medicine, Nara Medical University, Kashihara, Japan
    Scand J Immunol 66:654-61. 2007
    ..This is first evidence for the presence of a genetic locus that affects B lymphopoiesis in an aging-sensitive manner...
  34. ncbi Chicken erythrocyte pyrimidine 5'-nucleotidase: purification and characterization of the subclass I enzyme
    S Hokari
    Department of Biochemistry, Junior College, Saitama Medical School, Moroyama-machi, Iruma-gun, Japan
    Biol Chem 382:919-24. 2001
    ..These findings indicate that P5N subclass I may have an important function in chicken erythropoiesis...
  35. ncbi Fatal propionic acidemia in mice lacking propionyl-CoA carboxylase and its rescue by postnatal, liver-specific supplementation via a transgene
    T Miyazaki
    Center for Immunology, The University of Texas Southwestern Medical Center, Dallas Texas 75390 9093, USA
    J Biol Chem 276:35995-9. 2001
    ....
  36. ncbi A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins
    T Miyazaki
    The Burnham Institute, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Nat Immunol 2:493-500. 2001
    ..Elucidation of this mechanism suggests GTP-binding proteins as potential targets for pharmacological intervention in TRAIL-induced apoptosis...
  37. pmc Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction
    N Kobayashi
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Proc Natl Acad Sci U S A 90:4201-5. 1993
    ..Taken together with previous results, our current study suggests that different src-PTKs, each of which is expressed in a cell-type-specific manner, can participate in the IL-2 signal transduction...
  38. ncbi The IL-2 receptor complex: its structure, function, and target genes
    Y Minami
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Annu Rev Immunol 11:245-68. 1993
    ..Another pathway leads to c-myc gene induction by an as yet unknown mechanism. We discuss the complex signalling machinery that links the cell surface receptor to the nuclear events...
  39. pmc Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexes
    S Tourne
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, University Louis Pasteur 1, Strasbourg, France
    Proc Natl Acad Sci U S A 94:9255-60. 1997
    ....
  40. ncbi Charged collagen structure mediates the recognition of negatively charged macromolecules by macrophage scavenger receptors
    T Doi
    Faculty of Pharmaceutical Sciences, Osaka University, Japan
    J Biol Chem 268:2126-33. 1993
    ..Based on computational modeling of this domain, we propose that a "charged collagen" structure containing a lysine cluster forms a positively charged groove which specifically interacts with negatively charged ligands...
  41. ncbi The phenotype of H-2M-deficient mice is dependent on the MHC class II molecules expressed
    P R Wolf
    Department of Pathology, Harvard Medical School, Boston 02115, USA
    Eur J Immunol 28:2605-18. 1998
    ..Some of these findings in vivo contrast significantly with findings from in vitro studies on murine MHC class II molecules in human DM-deficient cell lines...
  42. ncbi Dissociation of bovine cytochrome c1 subcomplex and the status of cysteine residues in the subunits
    K Mukai
    J Biochem 98:1417-25. 1985
    ..The conformation of the hinge protein was predicted to be composed largely of either two-alpha-helical or four-alpha-helical conformation with the amino (N)-terminal 20 residues being in a random structure...
  43. ncbi c-Myb acetylation at the carboxyl-terminal conserved domain by transcriptional co-activator p300
    A Tomita
    First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Oncogene 19:444-51. 2000
    ..We present a new manner of post-translational modification of the c-Myb protein and the potential significance of the acetylation in c-Myb...
  44. ncbi Genetic dissection of vasculitis in MRL/lpr lupus mice: a novel susceptibility locus involving the CD72c allele
    W M Qu
    Department of Pathology, Ehime University School of Medicine, Japan
    Eur J Immunol 30:2027-37. 2000
    ....
  45. ncbi Identification of XAF1 as an antagonist of XIAP anti-Caspase activity
    P Liston
    Cancer Research Group, Ottawa Regional Cancer Center, 501 Smyth Road, Ottawa, K1H 8L6, Canada
    Nat Cell Biol 3:128-33. 2001
    ..Loss of control over apoptotic signalling is now recognized as a critical event in the development of cancer. Our results indicate that XAF1 may be important in mediating the apoptosis resistance of cancer cells...
  46. ncbi Polo-like kinase expression in normal human endometrium during the menstrual cycle
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Japan
    Reprod Fertil Dev 12:59-67. 2000
    ....
  47. pmc Detection of serum thermolabile beta-2 macroglycoprotein (Hakata antigen) by enzyme-linked immunosorbent assay using polysaccharide produced by Aerococcus viridans
    M Tsujimura
    Fukuoka Red Cross Blood Center, 1-2-1 Kamikoga, Chikushino, Fukuoka 818-8588, Japan
    Clin Diagn Lab Immunol 8:454-9. 2001
    ..These observations indicate that PSA is a useful adsorbent to TMG and can be used to develop appropriate methods for tracing the functions of TMG...
  48. ncbi Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice
    A Naito
    Department of Oncology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Genes Cells 4:353-62. 1999
    ..However, the functions of TRAF6 in vivo remain unidentified...
  49. ncbi Involvement of protein kinase C-epsilon in signal transduction of thrombopoietin in enhancement of interleukin-3-dependent proliferation of primitive hematopoietic progenitors
    N Shiroshita
    Third Department of Internal Medicine, Hokkaido University School of Medicine, Japan
    J Pharmacol Exp Ther 297:868-75. 2001
    ..These data taken together suggest that TPO has a direct effect on primitive progenitors and enhances IL-3-dependent colony formation, at least partly through the activation of PKC-epsilon...
  50. ncbi Therapeutic effect of CXCR3-expressing regulatory T cells on liver, lung and intestinal damages in a murine acute GVHD model
    H Hasegawa
    Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Ehime, Japan
    Gene Ther 15:171-82. 2008
    ..This method may provide a new therapeutic approach for organ damage in acute GVHD...