Affiliation: Basel Institute for Immunology
- Critical role for mitochondria in B cell receptor-mediated apoptosisA Bouchon
Tumor Immunology Program, German Cancer Research Center DKFZ, Heidelberg, Germany
Eur J Immunol 30:69-77. 2000..Thus, BCR-mediated apoptosis is initiated by the caspase-independent induction of mitochondrial PT resulting in release of cytochrome c and subsequent activation of caspase-9, downstream caspases and apoptosis...
- Tumor necrosis factor-related apoptosis-inducing ligand retains its apoptosis-inducing capacity on Bcl-2- or Bcl-xL-overexpressing chemotherapy-resistant tumor cellsH Walczak
Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany
Cancer Res 60:3051-7. 2000..Thus, TRAIL may still kill tumors that have acquired resistance to chemotherapeutic drugs by overexpression of Bcl-2 or Bcl-xL. These data will influence future treatment strategies involving TRAIL...