Johan Auwerx

Summary

Country: Switzerland

Publications

  1. pmc Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis
    Pablo J Fernandez-Marcos
    Laboratory of Integrative and Systems Physiology LISP NCEM, School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
    Sci Rep 2:425. 2012
  2. pmc The metabolic footprint of aging in mice
    Riekelt H Houtkooper
    Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fe de rale de Lausanne EPFL, 1015 Lausanne, Switzerland
    Sci Rep 1:134. 2011
  3. pmc Mitonuclear protein imbalance as a conserved longevity mechanism
    Riekelt H Houtkooper
    Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Nature 497:451-7. 2013
  4. pmc Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics
    Hana Koutnikova
    Institut Clinique de la Souris, Illkirch, France
    PLoS Genet 5:e1000591. 2009
  5. pmc Ppargamma2 is a key driver of longevity in the mouse
    Carmen Argmann
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Illkirch, France
    PLoS Genet 5:e1000752. 2009
  6. pmc Interference between PARPs and SIRT1: a novel approach to healthy ageing?
    Carles Canto
    Ecole Polytechnique Federale de Lausanne, Switzerland
    Aging (Albany NY) 3:543-7. 2011
  7. pmc Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?
    Carles Canto
    Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Pharmacol Rev 64:166-87. 2012
  8. pmc The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}
    Agnes Coste
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, 67404 Illkirch, France
    Proc Natl Acad Sci U S A 105:17187-92. 2008
  9. pmc Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice
    Lluis Fajas
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, Illkirch, France
    J Clin Invest 113:1288-95. 2004
  10. doi request reprint The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface
    Sami Heikkinen
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, 67404 Illkirch, France
    Cell Metab 9:88-98. 2009

Collaborators

Detail Information

Publications66

  1. pmc Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis
    Pablo J Fernandez-Marcos
    Laboratory of Integrative and Systems Physiology LISP NCEM, School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
    Sci Rep 2:425. 2012
    ....
  2. pmc The metabolic footprint of aging in mice
    Riekelt H Houtkooper
    Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fe de rale de Lausanne EPFL, 1015 Lausanne, Switzerland
    Sci Rep 1:134. 2011
    ..As such, these metabolites serve as biomarkers for aging and healthspan...
  3. pmc Mitonuclear protein imbalance as a conserved longevity mechanism
    Riekelt H Houtkooper
    Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Nature 497:451-7. 2013
    ....
  4. pmc Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics
    Hana Koutnikova
    Institut Clinique de la Souris, Illkirch, France
    PLoS Genet 5:e1000591. 2009
    ..We suggest that UBP1 and its functional partners are components of a network controlling blood pressure...
  5. pmc Ppargamma2 is a key driver of longevity in the mouse
    Carmen Argmann
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Illkirch, France
    PLoS Genet 5:e1000752. 2009
    ..These results establish Ppargamma2 as one of the determinants of longevity and suggest that lifespan may be rather determined by a purposeful genetic program than a random process...
  6. pmc Interference between PARPs and SIRT1: a novel approach to healthy ageing?
    Carles Canto
    Ecole Polytechnique Federale de Lausanne, Switzerland
    Aging (Albany NY) 3:543-7. 2011
    ..Recent findings identify PARPs as key modulators of metabolism through their influence on SIRT1 activity, hinting to a possible role of PARPs as longevity regulators...
  7. pmc Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?
    Carles Canto
    Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Pharmacol Rev 64:166-87. 2012
    ..We then analyze the pros and cons of the current strategies used to activate SIRT1 and explore the emerging evidence indicating that modulation of NAD(+) levels could provide an effective way to achieve such goals...
  8. pmc The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}
    Agnes Coste
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, 67404 Illkirch, France
    Proc Natl Acad Sci U S A 105:17187-92. 2008
    ..Collectively, these data suggest that SRC-3 is a critical link in a cofactor network that uses PGC-1alpha as an effector to control mitochondrial function and energy homeostasis...
  9. pmc Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice
    Lluis Fajas
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, Illkirch, France
    J Clin Invest 113:1288-95. 2004
    ..These data demonstrate that factors controlling cell proliferation, such as E2F1, determine pancreatic growth and function, subsequently affecting metabolic homeostasis...
  10. doi request reprint The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface
    Sami Heikkinen
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, 67404 Illkirch, France
    Cell Metab 9:88-98. 2009
    ..Altogether, our results establish the Pro12Ala variant of Ppargamma2 as an important modulator in metabolic control that strongly depends on the metabolic context...
  11. ncbi request reprint Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation
    Jerome N Feige
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, 67404, Illkirch, France
    Cell Metab 8:347-58. 2008
    ..Combined with our previous work on resveratrol, the current study further validates SIRT1 as a target for the treatment of metabolic disorders and characterizes the mechanisms underlying the therapeutic potential of SIRT1 activation...
  12. pmc The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling
    Laurent Mouchiroud
    Laboratory for Integrative and Systems Physiology, School of Life Sciences, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Cell 154:430-41. 2013
    ..Our data suggest that augmenting mitochondrial stress signaling through the modulation of NAD(+) levels may be a target to improve mitochondrial function and prevent or treat age-associated decline. ..
  13. pmc AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
    Carles Canto
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
    Nature 458:1056-60. 2009
    ..The AMPK-induced SIRT1-mediated deacetylation of these targets explains many of the convergent biological effects of AMPK and SIRT1 on energy metabolism...
  14. pmc The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity
    Carles Canto
    Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Cell Metab 15:838-47. 2012
    ..Consequently, our results indicate that the natural vitamin NR could be used as a nutritional supplement to ameliorate metabolic and age-related disorders characterized by defective mitochondrial function...
  15. pmc Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle
    Carles Canto
    Ecole Polytechnique Federale de Lausanne, Switzerland
    Cell Metab 11:213-9. 2010
    ....
  16. ncbi request reprint Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit
    Marie Bernard Debril
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP10142, 67404 Illkirch Cedex, France
    J Biol Chem 279:16677-86. 2004
    ..In conclusion, BAF60c represents a new coregulator that constitutes an important anchoring point by which the SWI/SNF complex is recruited to nuclear receptors and other transcription factors...
  17. pmc TGR5 potentiates GLP-1 secretion in response to anionic exchange resins
    Taoufiq Harach
    Laboratory of Integrative and Systems Physiology LISP, School of Life Sciences, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Sci Rep 2:430. 2012
    ..Thus, TGR5 represents an essential component in the pathway mediating the enhanced GLP-1 release in response to anionic exchange resins...
  18. ncbi request reprint Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation
    Oronza A Botrugno
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Universite Louis Pasteur, 67404 Illkirch, France
    Mol Cell 15:499-509. 2004
    ..The implication of LRH-1 in cell proliferation highlights an unanticipated crosstalk between LRH-1 and the beta-catenin/Tcf4 signaling pathway, which is relevant for the renewal of intestinal crypt cells...
  19. ncbi request reprint Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
    Marie Lagouge
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
    Cell 127:1109-22. 2006
    ..These pharmacological effects of RSV combined with the association of three Sirt1 SNPs and energy homeostasis in Finnish subjects implicates SIRT1 as a key regulator of energy and metabolic homeostasis...
  20. ncbi request reprint [SIRT1/PGC-1: a neuroprotective axis?]
    Soumya Rasouri
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1, rue Laurent Fries, 67404 Illkirch, France
    Med Sci (Paris) 23:840-4. 2007
    ....
  21. pmc Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
    Mitsuhiro Watanabe
    Institut de Génétique et Biologie Moléculaire et Cellulaire, CNRS INSERM ULP, Illkirch, France
    J Clin Invest 113:1408-18. 2004
    ..These results suggest that strategies aimed at increasing FXR activity and the repressive effects of SHP should be explored to correct hypertriglyceridemia...
  22. pmc Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells
    Bénédicte Mascrez
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Institut Clinique de la Souris, CNRS INSERM ULP, College de France, BP10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    EMBO Rep 5:285-90. 2004
    ..Our results also indicate that RXRbeta may be activated by a ligand distinct from 9-cis retinoic acid...
  23. doi request reprint Genetic background determines metabolic phenotypes in the mouse
    Marie France Champy
    Institut Clinique de la Souris, BP 10142, 67404, Illkirch Cedex, France
    Mamm Genome 19:318-31. 2008
    ....
  24. pmc The role of sirtuins in the control of metabolic homeostasis
    Jiujiu Yu
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Université Louis Pasteur and Institut Clinique de la Souris, Illkirch, France
    Ann N Y Acad Sci 1173:E10-9. 2009
    ..Here, we review the recent data related to the role of sirtuins in the control of metabolic homeostasis and possible underlying molecular mechanisms...
  25. doi request reprint Sirtuins as regulators of metabolism and healthspan
    Riekelt H Houtkooper
    Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Nat Rev Mol Cell Biol 13:225-38. 2012
    ..As a consequence, sirtuins regulate fat and glucose metabolism in response to physiological changes in energy levels, thereby acting as crucial regulators of the network that controls energy homeostasis and as such determines healthspan...
  26. pmc CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability
    Lilia G Noriega
    Ecole Polytechnique Federale de Lausanne, Laboratory of Integrative and Systems Physiology and Nestle Chair in Energy Metabolism, 1015 Lausanne, Switzerland
    EMBO Rep 12:1069-76. 2011
    ....
  27. ncbi request reprint Poly(ADP-ribose) polymerase-2 [corrected] controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the retinoid X receptor/peroxisome proliferator-activated receptor-gamma [corrected] heterodimer
    Peter Bai
    Département Intégrité du Génome, UMR 7175, CNRS, Ecole Superieure de Biotechnologie de Strasbourg, BP 10413, Illkirch, France
    J Biol Chem 282:37738-46. 2007
    ..In addition, we show a DNA-dependent interaction of PARP-2 and PPARgamma/RXR heterodimer by chromatin immunoprecipitation. In combination, our results suggest that PARP-2 is a novel cofactor of PPARgamma activity...
  28. pmc PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
    Peter Bai
    Biotechnologie et Signalisation Cellulaire, UMR7242 CNRS, Universite de Strasbourg, ESBS, Illkirch, France
    Cell Metab 13:461-8. 2011
    ..These data show how PARP-1 inhibition has strong metabolic implications through the modulation of SIRT1 activity, a property that could be useful in the management not only of metabolic diseases, but also of cancer...
  29. pmc Absence of the steroid receptor coactivator-3 induces B-cell lymphoma
    Agnes Coste
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Illkirch, France
    EMBO J 25:2453-64. 2006
    ....
  30. ncbi request reprint Histopathology in mouse metabolic investigations
    Manuel Mark
    Institut Clinique de la Souris and Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France
    Curr Protoc Mol Biol . 2007
    ....
  31. pmc Systems genetics of metabolism: the use of the BXD murine reference panel for multiscalar integration of traits
    Pénélope A Andreux
    Laboratory of Integrative and Systems Physiology, School of Life Sciences, École Polytechnique Fédérale de Lausanne 1015, Switzerland
    Cell 150:1287-99. 2012
    ..The assembled and curated phenotypes provide key resources and exemplars that can be used to dissect complex metabolic traits and disorders...
  32. pmc Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development
    Jean Sebastien Annicotte
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, ULP 67404, Illkirch, France
    Mol Cell Biol 23:6713-24. 2003
    ..Taken together, our data indicate that PDX-1 controls LRH-1 expression and identify LRH-1 as a novel downstream target in the PDX-1 regulatory cascade governing pancreatic development, differentiation, and function...
  33. pmc Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice
    Hana Koutnikova
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, 67404 Illkirch, France
    Proc Natl Acad Sci U S A 100:14457-62. 2003
    ....
  34. ncbi request reprint The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity
    Carole Brendel
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, BP 1042, 67404 Illkirch, France
    Mol Endocrinol 16:2065-76. 2002
    ..These results demonstrate that SHP is able to interact with LXR and to modulate its transcriptional activity...
  35. pmc Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1
    Chikage Mataki
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
    Mol Cell Biol 27:8330-9. 2007
    ..Our studies unequivocally demonstrate a pivotal role for LRH-1 in determining the composition of BAs, which, in turn has major consequences on whole-body lipid homeostasis...
  36. pmc Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation
    Kristina Schoonjans
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, 67404 Illkirch, France
    Proc Natl Acad Sci U S A 102:2058-62. 2005
    ..In combination, these data suggest a role of LRH-1 in the initiation of intestinal tumorigenesis both by affecting cell cycle control as well as through its impact on inflammatory pathways...
  37. ncbi request reprint In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue
    Sander M Houten
    Institut de Génétique et Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, Illkirch, France
    Mol Endocrinol 21:1312-23. 2007
    ..The use of this animal could facilitate the development of new therapeutic compounds that target FXRalpha in a tissue-specific manner...
  38. ncbi request reprint The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation
    Lluis Fajas
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
    Dev Cell 3:903-10. 2002
    ..These observations underscore an important function of both RB and HDAC3 in fine-tuning PPARgamma activity and adipocyte differentiation...
  39. pmc PPARgamma in human and mouse physiology
    Sami Heikkinen
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, 67404 Illkirch, France
    Biochim Biophys Acta 1771:999-1013. 2007
    ..Here we draw together and discuss these recent advances in the research into PPARgamma biology...
  40. pmc Transcriptional targets of sirtuins in the coordination of mammalian physiology
    Jerome N Feige
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, France
    Curr Opin Cell Biol 20:303-9. 2008
    ..This review will focus on recent advances that have started deciphering how mammalian Sirts regulate transcriptional networks and thereby control physiology...
  41. pmc Peroxisome proliferator-activated receptor-gamma: too much of a good thing causes harm
    Terrie Anne Cock
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, 67404 Illkirch, France
    EMBO Rep 5:142-7. 2004
    ....
  42. ncbi request reprint Sirtuins: the 'magnificent seven', function, metabolism and longevity
    Nassim Dali-Youcef
    Institut de Génétique et de Biologie Moléculaire et Cellulaire de Strasbourg IGBMC, INSERM CNRS ULP, Illkirch, France
    Ann Med 39:335-45. 2007
    ....
  43. ncbi request reprint Liver receptor homolog 1 controls the expression of carboxyl ester lipase
    Elisabeth Fayard
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, CNRS INSERM Universite Louis Pasteur, B P 10142, F 67404 Illkirch, C U de Strasbourg, France
    J Biol Chem 278:35725-31. 2003
    ..Our data, identifying CEL as the first pancreatic LRH-1 target gene, indicate that LRH-1 is an important player in enterohepatic cholesterol homeostasis...
  44. pmc LRH-1-dependent glucose sensing determines intermediary metabolism in liver
    Maaike H Oosterveer
    Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    J Clin Invest 122:2817-26. 2012
    ..Cumulatively, these data identify LRH-1 as a key regulatory component of the hepatic glucose-sensing system required for proper integration of postprandial glucose and lipid metabolism...
  45. pmc Liver receptor homolog 1 is essential for ovulation
    Rajesha Duggavathi
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
    Genes Dev 22:1871-6. 2008
    ..These results demonstrate that Lrh1 is a regulator of multiple mechanisms essential for maturation of ovarian follicles and for ovulation. Lrh1 is therefore a key modulator of female fertility and a potential target for contraception...
  46. ncbi request reprint LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis
    Elisabeth Fayard
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, Universite Louis Pasteur, 67404 Illkirch, France
    Trends Cell Biol 14:250-60. 2004
    ..These data highlight structural similarities between LRH-1 and other Ftz-F1 members but also underscore important functional differences, assigning to LRH-1 a unique position among nuclear receptors...
  47. doi request reprint Bile acids and the membrane bile acid receptor TGR5--connecting nutrition and metabolism
    Charles Thomas
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, CNRS INSERM ULP, Illkirch, France
    Thyroid 18:167-74. 2008
    ..These properties position TGR5 as an attractive and "drugable" target in our fight against the metabolic syndrome...
  48. ncbi request reprint Selective cyclo-oxygenase-2 inhibitors impair adipocyte differentiation through inhibition of the clonal expansion phase
    Lluis Fajas
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, B P 163, F 67404 Illkirch Cedex, C U de Strasbourg, France
    J Lipid Res 44:1652-9. 2003
    ..Modulation of the activity of the COX-2 enzyme via COX-2 selective inhibitors might open up new perspectives in the control of obesity and related metabolic diseases...
  49. pmc Clking on PGC-1alpha to inhibit gluconeogenesis
    Carles Canto
    Ecole Polytechnique Federale de Lausanne, Switzerland
    Cell Metab 11:6-7. 2010
    ..Rodgers and colleagues now introduce us to the Clk2 kinase, an Akt substrate that can directly phosphorylate and inhibit PGC-1alpha, blunting hepatic glucose production...
  50. doi request reprint Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies
    Hiroyuki Sato
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique INSERM ULP, Illkirch, France
    J Med Chem 51:1831-41. 2008
    ....
  51. pmc TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading
    Thijs W H Pols
    Laboratory of Integrative and Systems Physiology, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Cell Metab 14:747-57. 2011
    ..Taken together, these data attribute a significant immune modulating function to TGR5 activation in the prevention of atherosclerosis, an important facet of the metabolic syndrome...
  52. ncbi request reprint Suppression of allergen-induced airway inflammation and immune response by the peroxisome proliferator-activated receptor-alpha agonist fenofibrate
    Carine Delayre-Orthez
    EA3771 Inflammation et environnement dans l asthme, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, Illkirch, France
    Eur J Pharmacol 581:177-84. 2008
    ....
  53. ncbi request reprint SRC-1 and TIF2 control energy balance between white and brown adipose tissues
    Frederic Picard
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
    Cell 111:931-41. 2002
    ..Interestingly, a high-fat diet increases the TIF2/SRC-1 expression ratio, which may contribute to weight gain. These results reveal that the relative level of TIF2/SRC-1 can modulate energy metabolism...
  54. ncbi request reprint Transcriptional coregulators in the control of energy homeostasis
    Jerome N Feige
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Illkirch, France
    Trends Cell Biol 17:292-301. 2007
    ..The general picture that emerges indicates that these coregulators are metabolic switches, which convergently regulate metabolic pathways through their pleiotropic interactions with nuclear receptors and other transcription factors...
  55. pmc Metabolic characterization of a Sirt5 deficient mouse model
    Jiujiu Yu
    Laboratory of Integrative and Systems Physiology LISP NCEM, School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
    Sci Rep 3:2806. 2013
    ..These observations suggest that Sirt5 is likely to be dispensable for the metabolic homeostasis under the basal conditions...
  56. pmc Mitochondrial sirtuins and metabolic homeostasis
    Eija Pirinen
    Laboratory for Integrative and Systems Physiology, School of Life Sciences, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Best Pract Res Clin Endocrinol Metab 26:759-70. 2012
    ..Here we discuss current knowledge how mitochondrial sirtuins and SIRT1 govern mitochondrial processes involved in different metabolic pathways...
  57. pmc The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation
    Thijs W H Pols
    Laboratory of Integrative and Systems Physiology LISP, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    J Hepatol 54:1263-72. 2011
    ..Here we discuss the current knowledge on BA receptors, with a strong focus on the cell membrane receptor TGR5, which emerges as a valuable target for intervention in metabolic diseases...
  58. pmc Bioavailable copper modulates oxidative phosphorylation and growth of tumors
    Seiko Ishida
    Swiss Institute for Experimental Cancer Research and Laboratory for Integrative and Systems Physiology, Interfaculty Institute of Bioengineering, School of Life Sciences, and Biomedical Imaging Center, Institute of Physics of Biological Systems, Swiss Federal Institute of Technology Lausanne, CH 1015 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 110:19507-12. 2013
    ..Thus, activation of glycolysis in tumors may in part reflect insufficient copper bioavailability in the tumor microenvironment. ..
  59. pmc Protein deacetylation by SIRT1: an emerging key post-translational modification in metabolic regulation
    Jiujiu Yu
    Laboratory of Integrative and Systems Physiology LISP at the Ecole Polytechnique Fédérale de Lausanne, CH 1015 Lausanne, Switzerland
    Pharmacol Res 62:35-41. 2010
    ..This review surveys the evidence for the emerging role of SIRT1-mediated deacetylation in the control of metabolic homeostasis...
  60. ncbi request reprint Systematic gene expression mapping clusters nuclear receptors according to their function in the brain
    Francoise Gofflot
    Institut Clinique de la Souris, 67404 Illkirch, France
    Cell 131:405-18. 2007
    ..Mining the MousePat resource will improve the understanding of NR function in the brain and elucidate hierarchical networks that control behavior and whole body homeostasis...
  61. doi request reprint Dietary manipulation of mouse metabolism
    Jerome N Feige
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    Curr Protoc Mol Biol . 2008
    ....
  62. pmc LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease
    Agnes Coste
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, Universite Louis Pasteur, Illkirch, and Service des Maladies de l Appareil Digestif et de la Nutrition, Hopital Huriez, Lille, France
    Proc Natl Acad Sci U S A 104:13098-103. 2007
    ..These findings underscore the importance of LRH-1 in the control of intestinal inflammation and the pathogenesis of inflammatory bowel disease...
  63. ncbi request reprint Expression of the liver X receptor alpha and beta in embryonic and adult mice
    Jean Sebastien Annicotte
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Universite Louis Pasteur, Illkirch, France
    Anat Rec A Discov Mol Cell Evol Biol 277:312-6. 2004
    ..Later, LXRalpha expression remains high in organs involved in lipid homeostasis, such as liver, intestine, and brown adipose tissue, whereas LXRbeta is more ubiquitously expressed and enriched in tissues of neuronal and endocrine origin...
  64. pmc The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways
    Riekelt H Houtkooper
    Ecole Polytechnique Federale de Lausanne, Laboratory for Integrative and Systems Physiology, Building AI, Station 15, CH 1015 Lausanne, Switzerland
    Endocr Rev 31:194-223. 2010
    ....
  65. pmc AMP-activated protein kinase and its downstream transcriptional pathways
    Carles Canto
    Laboratory of Integrative and Systems Physiology, Ecole Polytechnique Federale de Lausanne EPFL, SV IBI, Building AI, Station 15, Lausanne, Switzerland
    Cell Mol Life Sci 67:3407-23. 2010
    ..In this review we will try to integrate our current knowledge on how AMPK regulates transcription in muscle and liver, which will serve as examples to illustrate the major advances in the field and the key challenges ahead...
  66. ncbi request reprint Key electrophysiological, molecular, and metabolic signatures of sleep and wakefulness revealed in primary cortical cultures
    Valérie Hinard
    Center for Integrative Genomics, University of Lausanne, CH 1015 Lausanne, Switzerland
    J Neurosci 32:12506-17. 2012
    ..With our in vitro model, the cellular and molecular consequences of sleep and wakefulness can now be investigated in a dish...