Lisa M Sweeney

Summary

Publications

  1. doi request reprint Cancer mode of action, weight of evidence, and proposed cancer reference value for hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)
    Lisa M Sweeney
    Henry M Jackson Foundation for the Advancement of Military Medicine, Naval Medical Research Unit Dayton, Wright Patterson Air Force Base, Ohio, United States
    Regul Toxicol Pharmacol 64:205-24. 2012
  2. pmc Application of Markov chain Monte Carlo analysis to biomathematical modeling of respirable dust in US and UK coal miners
    Lisa M Sweeney
    Toxicology Excellence for Risk Assessment TERA, 2300 Montana Avenue, Suite 409, Cincinnati, OH 45211, USA
    Regul Toxicol Pharmacol 66:47-58. 2013
  3. doi request reprint Route-to-route extrapolation of 1,2-dichloroethane studies from the oral route to inhalation using physiologically based pharmacokinetic models
    Lisa M Sweeney
    Independent consultants, Dayton, OH, USA Electronic address
    Regul Toxicol Pharmacol 81:468-479. 2016
  4. doi request reprint Evaluation of submarine atmospheres: effects of carbon monoxide, carbon dioxide and oxygen on general toxicology, neurobehavioral performance, reproduction and development in rats. II. Ninety-day study
    Daniel J Hardt
    Naval Medical Research Unit Dayton NAMRU Dayton, Wright Patterson Air Force Base, OH, USA
    Inhal Toxicol 27:121-37. 2015
  5. doi request reprint Physiologically based pharmacokinetic model development and simulations for ethylene dichloride (1,2-dichloroethane) in rats
    Lisa M Sweeney
    The Sapphire Group, Dayton Office, 2661 Commons Boulevard, Suite 240, 2nd Floor, Dayton, OH 45431, USA
    Regul Toxicol Pharmacol 51:311-23. 2008
  6. doi request reprint Contribution of trichloroacetic acid to liver tumors observed in perchloroethylene (perc)-exposed mice
    Lisa M Sweeney
    The Sapphire Group, Inc, Dayton, OH, USA
    Toxicology 260:77-83. 2009
  7. doi request reprint Derivation of inhalation toxicity reference values for propylene oxide using mode of action analysis: example of a threshold carcinogen
    Lisa M Sweeney
    The Sapphire Group, Inc, 2661 Commons Blvd, Second Floor, Dayton, OH 45431, USA
    Crit Rev Toxicol 39:462-86. 2009
  8. doi request reprint Physiologically based pharmacokinetic modeling of chloroethane disposition in mice, rats, and women
    Michael L Gargas
    The Sapphire Group, Inc, Dayton, Ohio 45431, USA
    Toxicol Sci 104:54-66. 2008
  9. doi request reprint Development of a physiologically based pharmacokinetic (PBPK) model for methyl iodide in rats, rabbits, and humans
    Lisa M Sweeney
    The Sapphire Group, Inc, Dayton, Ohio 45431, USA
    Inhal Toxicol 21:552-82. 2009
  10. doi request reprint Assessing the non-cancer risk for RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) using physiologically based pharmacokinetic (PBPK) modeling
    Lisa M Sweeney
    Naval Medical Research Unit Dayton, Wright Patterson Air Force Base, OH, USA
    Regul Toxicol Pharmacol 62:107-14. 2012

Detail Information

Publications23

  1. doi request reprint Cancer mode of action, weight of evidence, and proposed cancer reference value for hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)
    Lisa M Sweeney
    Henry M Jackson Foundation for the Advancement of Military Medicine, Naval Medical Research Unit Dayton, Wright Patterson Air Force Base, Ohio, United States
    Regul Toxicol Pharmacol 64:205-24. 2012
    ..Thus, cleanup standards based on human health risk from RDX exposure could potentially depend on the willingness of risk managers to accept a nonlinear MOA and nonlinear toxicity risk value derivation...
  2. pmc Application of Markov chain Monte Carlo analysis to biomathematical modeling of respirable dust in US and UK coal miners
    Lisa M Sweeney
    Toxicology Excellence for Risk Assessment TERA, 2300 Montana Avenue, Suite 409, Cincinnati, OH 45211, USA
    Regul Toxicol Pharmacol 66:47-58. 2013
    ..These findings are relevant to the proposed update of the ICRP human respiratory tract model with revisions to the alveolar-interstitial region based on this long-term particle clearance and retention model...
  3. doi request reprint Route-to-route extrapolation of 1,2-dichloroethane studies from the oral route to inhalation using physiologically based pharmacokinetic models
    Lisa M Sweeney
    Independent consultants, Dayton, OH, USA Electronic address
    Regul Toxicol Pharmacol 81:468-479. 2016
    ....
  4. doi request reprint Evaluation of submarine atmospheres: effects of carbon monoxide, carbon dioxide and oxygen on general toxicology, neurobehavioral performance, reproduction and development in rats. II. Ninety-day study
    Daniel J Hardt
    Naval Medical Research Unit Dayton NAMRU Dayton, Wright Patterson Air Force Base, OH, USA
    Inhal Toxicol 27:121-37. 2015
    ..In summary, subchronic exposures to the submarine atmosphere gases did not affect the ability of the exposed rats or their offspring to reproduce and did not appear to have any significant adverse health effects...
  5. doi request reprint Physiologically based pharmacokinetic model development and simulations for ethylene dichloride (1,2-dichloroethane) in rats
    Lisa M Sweeney
    The Sapphire Group, Dayton Office, 2661 Commons Boulevard, Suite 240, 2nd Floor, Dayton, OH 45431, USA
    Regul Toxicol Pharmacol 51:311-23. 2008
    ....
  6. doi request reprint Contribution of trichloroacetic acid to liver tumors observed in perchloroethylene (perc)-exposed mice
    Lisa M Sweeney
    The Sapphire Group, Inc, Dayton, OH, USA
    Toxicology 260:77-83. 2009
    ..The analysis indicated that the levels of TCA observed in perchloroethylene-exposed mice are sufficient to explain the incidence of liver adenomas and carcinomas...
  7. doi request reprint Derivation of inhalation toxicity reference values for propylene oxide using mode of action analysis: example of a threshold carcinogen
    Lisa M Sweeney
    The Sapphire Group, Inc, 2661 Commons Blvd, Second Floor, Dayton, OH 45431, USA
    Crit Rev Toxicol 39:462-86. 2009
    ..The human reference values derived from the rat and mouse LED10 values were 0.7 and 0.5 ppm PO, respectively. A similar noncancer reference value, 0.4 ppm, was derived on the basis of non-neoplastic nasal effects in rats...
  8. doi request reprint Physiologically based pharmacokinetic modeling of chloroethane disposition in mice, rats, and women
    Michael L Gargas
    The Sapphire Group, Inc, Dayton, Ohio 45431, USA
    Toxicol Sci 104:54-66. 2008
    ..Choice of the most relevant dose metric for risk assessments involving uterine tumors in mice will require pharmacodynamic considerations in the mode of action in addition to the pharmacokinetic differences reported here...
  9. doi request reprint Development of a physiologically based pharmacokinetic (PBPK) model for methyl iodide in rats, rabbits, and humans
    Lisa M Sweeney
    The Sapphire Group, Inc, Dayton, Ohio 45431, USA
    Inhal Toxicol 21:552-82. 2009
    ..Variability analyses of the PBPK models support application of uncertainty factors (UF) of approximately 2 for intrahuman pharmacokinetic variability for the nasal effects and acute neurotoxicity...
  10. doi request reprint Assessing the non-cancer risk for RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) using physiologically based pharmacokinetic (PBPK) modeling
    Lisa M Sweeney
    Naval Medical Research Unit Dayton, Wright Patterson Air Force Base, OH, USA
    Regul Toxicol Pharmacol 62:107-14. 2012
    ..A proposed chronic RfD of 0.07 mg/kg/day, based on multiple effects observed in rats, was selected from among the cRfDs...
  11. doi request reprint Acute toxicity when concentration varies with time: A case study with carbon monoxide inhalation by rats
    Lisa M Sweeney
    Naval Medical Research Unit Dayton NAMRU D, 2728 Q Street, Area B, Building 837, Wright Patterson Air Force Base, OH 45433, USA Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA Electronic address
    Regul Toxicol Pharmacol 80:102-15. 2016
    ....
  12. doi request reprint Risk assessments for chronic exposure of children and prospective parents to ethylbenzene (CAS No. 100-41-4)
    Lisa M Sweeney
    a The Sapphire Group, Inc, Dayton, OH, USA
    Crit Rev Toxicol 45:662-726. 2015
    ..48 ppm was derived based on mouse lung tumors. The risk characterization for ethylbenzene indicated that even the most highly exposed children and prospective parents are not at risk for non-cancer or cancer effects of ethylbenzene. ..
  13. ncbi request reprint Ethyl acrylate risk assessment with a hybrid computational fluid dynamics and physiologically based nasal dosimetry model
    Lisa M Sweeney
    The Sapphire Group, Dayton, Ohio 45431, USA
    Toxicol Sci 79:394-403. 2004
    ..Thus, a chronic RfC based on maintaining GSH in the human nasal olfactory epithelium at levels equivalent to the rat NOEL would also provide an adequate margin of safety with respect to AA concentrations in nasal tissues...
  14. pmc Bayesian evaluation of a physiologically-based pharmacokinetic (PBPK) model of long-term kinetics of metal nanoparticles in rats
    Lisa M Sweeney
    Henry M Jackson Foundation for the Advancement of Military Medicine, Naval Medical Research Unit Dayton NAMRU Dayton, 2729 R Street, Building 837, Wright Patterson Air Force Base, OH 45433, USA Toxicology Excellence for Risk Assessment TERA, 2300 Montana Avenue, Cincinnati, OH 45211, USA Electronic address
    Regul Toxicol Pharmacol 73:151-63. 2015
    ..Additional toxicokinetic data are needed to further evaluate the model structure and performance and to reduce uncertainty in the kinetic processes governing in vivo disposition of metal nanoparticles...
  15. ncbi request reprint Physiologically based pharmacokinetic model parameter estimation and sensitivity and variability analyses for acrylonitrile disposition in humans
    Lisa M Sweeney
    The Sapphire Group, 4027 Colonel Glenn Highway, Fourth Floor, Dayton, Ohio 45431, USA
    Toxicol Sci 71:27-40. 2003
    ..8-times higher than an average individual...
  16. doi request reprint Disposition of styrene-acrylonitrile (SAN) trimer in female rats: single dose intravenous and gavage studies
    Michael L Gargas
    The Sapphire Group, Dayton, OH 45431, USA
    Toxicol Lett 178:1-8. 2008
    ..Total radioactivity and SAN Trimer blood concentrations in nonpregnant, pregnant, and lactating rats were both higher in lactating rats compared to nonpregnant and pregnant rats...
  17. ncbi request reprint Estimation of interindividual variation in oxidative metabolism of dichloromethane in human volunteers
    Lisa M Sweeney
    The Sapphire Group, 2661 Commons Boulevard, First Floor, Dayton, OH 45431, USA
    Toxicol Lett 154:201-16. 2004
    ..A comparison of the observed variation in V(maxC) values to other estimates of variability in the rate of oxidative metabolism and human CYP2E1 activity suggest a relatively narrow range in human hepatic activity toward DCM...
  18. ncbi request reprint Physiologically based pharmacokinetic modeling of 1,4-Dioxane in rats, mice, and humans
    Lisa M Sweeney
    The Sapphire Group, Dayton, Ohio 45431, USA
    Toxicol Sci 101:32-50. 2008
    ..Consistent with previous PBPK models, nasal tissues were not specifically included in the model. Use of these models will reduce the uncertainty in future 1,4-dioxane risk assessments...
  19. doi request reprint Evaluation of submarine atmospheres: effects of carbon monoxide, carbon dioxide and oxygen on general toxicology, neurobehavioral performance, reproduction and development in rats. I. Subacute exposures
    Daniel J Hardt
    Naval Medical Research Unit Dayton NAMRU D, Wright Patterson Air Force Base, OH, USA
    Inhal Toxicol 27:83-99. 2015
    ..In summary, subacute exposures to elevated concentrations of the submarine atmosphere gases did not affect the ability of rats to reproduce and did not appear to have any significant adverse health effects...
  20. doi request reprint Toxicokinetic Model Development for the Insensitive Munitions Component 2,4-Dinitroanisole
    Lisa M Sweeney
    Henry M Jackson Foundation for the Advancement of Military Medicine, Naval Medical Research Unit Dayton NAMRUD, Wright Patterson Air Force Base, OH, USA
    Int J Toxicol 34:417-32. 2015
    ....
  21. pmc Advances in Inhalation Dosimetry Models and Methods for Occupational Risk Assessment and Exposure Limit Derivation
    Eileen D Kuempel
    a National Institute for Occupational Safety and Health, Education and Information Division, Cincinnati, Ohio
    J Occup Environ Hyg 12:S18-40. 2015
    ..Inhalation dosimetry is the focus of this paper since it is a major route of exposure in the workplace. Practical examples of dose estimation and OEL derivation are provided for inhaled gases and particulates. ..
  22. doi request reprint Evaluating the validity and applicable domain of the toxic load model: impact of concentration vs. time profile on inhalation lethality of hydrogen cyanide
    Lisa M Sweeney
    Henry M Jackson Foundation for the Advancement of Military Medicine, Naval Medical Research Unit Dayton, Wright Patterson Air Force Base, OH 45433, United States Electronic address
    Regul Toxicol Pharmacol 71:571-84. 2015
    ..high then low) did not appear to have a meaningful impact on the toxic load required for median lethality...
  23. doi request reprint Subacute effects of inhaled Jet Fuel-A (Jet A) on airway and immune function in female rats
    Lisa M Sweeney
    Henry M Jackson Foundation for the Advancement of Military Medicine, Naval Medical Research Unit Dayton NAMRU D, Wright Patterson Air Force Base AFB, OH 45433 5707, USA
    Inhal Toxicol 25:257-71. 2013
    ..The lack of identified significant airway or immune effects was in contrast to previous examinations of jet fuel for pulmonary toxicity in mice and rats and for immunotoxicity in mice...