Fredrik Wiklund

Summary

Country: Sweden

Publications

  1. ncbi Linkage analysis of prostate cancer susceptibility: confirmation of linkage at 8p22-23
    Fredrik Wiklund
    Department of Radiation Sciences, Oncology, University of Umea, 901 87 Umea, Sweden
    Hum Genet 112:414-8. 2003
  2. ncbi Genome-wide scan of Swedish families with hereditary prostate cancer: suggestive evidence of linkage at 5q11.2 and 19p13.3
    Fredrik Wiklund
    Department of Radiation Sciences, Oncology, University of Umea, Umea, Sweden
    Prostate 57:290-7. 2003
  3. ncbi Genetic analysis of the RNASEL gene in hereditary, familial, and sporadic prostate cancer
    Fredrik Wiklund
    Department of Radiation Sciences, Oncology, and Medical Biosciences, Pathology, University of Umea, Umea, Sweden
    Clin Cancer Res 10:7150-6. 2004
  4. ncbi Inherited variation in hormone-regulating genes and prostate cancer survival
    Sara Lindstrom
    Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden
    Clin Cancer Res 13:5156-61. 2007
  5. ncbi Comprehensive genetic evaluation of common E-cadherin sequence variants and prostate cancer risk: strong confirmation of functional promoter SNP
    Sara Lindstrom
    Department of Radiation Sciences, Oncology, University of Umea, 901 87, Umea, Sweden
    Hum Genet 118:339-47. 2005
  6. ncbi Comprehensive evaluation of genetic variation in the IGF1 gene and risk of prostate cancer
    Mattias Johansson
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University Hospital, Umea, Sweden
    Int J Cancer 120:539-42. 2007
  7. ncbi Estrogen receptor beta polymorphism is associated with prostate cancer risk
    Camilla Thellenberg-Karlsson
    Department of Radiation Sciences Oncology, University of Umea, Umea, Sweden
    Clin Cancer Res 12:1936-41. 2006
  8. pmc Genetic variation in the upstream region of ERG and prostate cancer
    Sara Lindstrom
    Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden
    Cancer Causes Control 20:1173-80. 2009
  9. ncbi Systematic replication study of reported genetic associations in prostate cancer: Strong support for genetic variation in the androgen pathway
    Sara Lindstrom
    Department of Radiation Sciences, Oncology, University of Umea, Umea, Sweden
    Prostate 66:1729-43. 2006
  10. doi Quality of life in patients with locally advanced prostate cancer given endocrine treatment with or without radiotherapy: 4-year follow-up of SPCG-7/SFUO-3, an open-label, randomised, phase III trial
    Per Fransson
    Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden
    Lancet Oncol 10:370-80. 2009

Detail Information

Publications47

  1. ncbi Linkage analysis of prostate cancer susceptibility: confirmation of linkage at 8p22-23
    Fredrik Wiklund
    Department of Radiation Sciences, Oncology, University of Umea, 901 87 Umea, Sweden
    Hum Genet 112:414-8. 2003
    ..Thus, we have confirmed evidence for prostate cancer linkage at 8p22-23. Follow-up studies to evaluate the possible association between prostate cancer and genes in this region, especially the MSR1 gene, are warranted...
  2. ncbi Genome-wide scan of Swedish families with hereditary prostate cancer: suggestive evidence of linkage at 5q11.2 and 19p13.3
    Fredrik Wiklund
    Department of Radiation Sciences, Oncology, University of Umea, Umea, Sweden
    Prostate 57:290-7. 2003
    ..Prostate cancer (CaP) is a common disorder with multiple genetic and environmental factors contributing to the disease. CaP susceptibility loci can be identified through genome-wide scans of high-risk families...
  3. ncbi Genetic analysis of the RNASEL gene in hereditary, familial, and sporadic prostate cancer
    Fredrik Wiklund
    Department of Radiation Sciences, Oncology, and Medical Biosciences, Pathology, University of Umea, Umea, Sweden
    Clin Cancer Res 10:7150-6. 2004
    ..To additionally evaluate the possible role of RNASEL in susceptibility to prostate cancer risk, we performed a comprehensive genetic analysis of sequence variants in RNASEL in the Swedish population...
  4. ncbi Inherited variation in hormone-regulating genes and prostate cancer survival
    Sara Lindstrom
    Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden
    Clin Cancer Res 13:5156-61. 2007
    ..However, little is known about genetic determinants of disease progression and prostate cancer-specific death...
  5. ncbi Comprehensive genetic evaluation of common E-cadherin sequence variants and prostate cancer risk: strong confirmation of functional promoter SNP
    Sara Lindstrom
    Department of Radiation Sciences, Oncology, University of Umea, 901 87, Umea, Sweden
    Hum Genet 118:339-47. 2005
    ..Due to the difficulties in replication of genetic association studies, this finding is unusual and novel...
  6. ncbi Comprehensive evaluation of genetic variation in the IGF1 gene and risk of prostate cancer
    Mattias Johansson
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University Hospital, Umea, Sweden
    Int J Cancer 120:539-42. 2007
    ..Further studies on genetic variations in the IGF1 gene in relation to prostate cancer risk as well as to circulating levels of IGF1 are needed to confirm this novel finding...
  7. ncbi Estrogen receptor beta polymorphism is associated with prostate cancer risk
    Camilla Thellenberg-Karlsson
    Department of Radiation Sciences Oncology, University of Umea, Umea, Sweden
    Clin Cancer Res 12:1936-41. 2006
    ..ERbeta is thought to exert an antiproliferative and proapoptotic effect. We examined whether sequence variants in the ERbeta gene are associated with prostate cancer risk...
  8. pmc Genetic variation in the upstream region of ERG and prostate cancer
    Sara Lindstrom
    Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden
    Cancer Causes Control 20:1173-80. 2009
    ..Here, we investigated if inherited genetic variation upstream of ERG alters prostate cancer risk and survival...
  9. ncbi Systematic replication study of reported genetic associations in prostate cancer: Strong support for genetic variation in the androgen pathway
    Sara Lindstrom
    Department of Radiation Sciences, Oncology, University of Umea, Umea, Sweden
    Prostate 66:1729-43. 2006
    ..Despite considerable efforts and initial promising findings, the field of prostate cancer genetics is characterized by inconclusive reports and no prostate cancer gene has yet been established...
  10. doi Quality of life in patients with locally advanced prostate cancer given endocrine treatment with or without radiotherapy: 4-year follow-up of SPCG-7/SFUO-3, an open-label, randomised, phase III trial
    Per Fransson
    Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden
    Lancet Oncol 10:370-80. 2009
    ..We aimed to assess quality of life in men with locally advanced prostate cancer in an open-label phase III randomised comparison between lifelong endocrine treatment with and without radiotherapy...
  11. ncbi -160C/A polymorphism in the E-cadherin gene promoter and risk of hereditary, familial and sporadic prostate cancer
    Björn Anders Jonsson
    Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden
    Int J Cancer 109:348-52. 2004
    ..6; 95% CI = 1.4-4.9). Our data indicate that the -160 single nucleotide polymorphism in CDH1 is a low-penetrant prostate cancer susceptibility gene that might explain a proportion of familial and notably hereditary prostate cancer...
  12. ncbi H6D polymorphism in macrophage-inhibitory cytokine-1 gene associated with prostate cancer
    Fredrik Lindmark
    Department of Radiation Sciences Oncology, Umea University, Umea, Sweden
    J Natl Cancer Inst 96:1248-54. 2004
    ..We examined whether sequence variants in the MIC-1 gene are associated with the risk of prostate cancer...
  13. ncbi Germ-line genetic variation in the key androgen-regulating genes androgen receptor, cytochrome P450, and steroid-5-alpha-reductase type 2 is important for prostate cancer development
    Sara Lindstrom
    Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden
    Cancer Res 66:11077-83. 2006
    ..Carriers of five high-risk alleles in the AR, CYP17, and SRD5A2 genes are at approximately 2-fold excess risk to develop prostate cancer...
  14. ncbi Breast cancer as a second primary in patients with prostate cancer--estrogen treatment or association with family history of cancer?
    Camilla Thellenberg Karlsson
    Department of Radiation Sciences, Oncology, University of Umea, Sweden
    J Urol 176:538-43. 2006
    ..In the current study we performed a comprehensive investigation of whether treatment for prostate cancer and/or family history is responsible for the excess risk...
  15. ncbi High risk of contralateral breast carcinoma in women with hereditary/familial non-BRCA1/BRCA2 breast carcinoma
    Katarina Shahedi
    Department of Radiation Sciences Oncology, University of Umea, Umea, Sweden
    Cancer 106:1237-42. 2006
    ....
  16. doi A comprehensive study of the association between the EGFR and ERBB2 genes and glioma risk
    Ulrika Andersson
    Department of Radiation Sciences, Oncology, Umea University Hospital, Umea, Sweden
    Acta Oncol 49:767-75. 2010
    ..Further studies are required to reinvestigate these findings and evaluate the functional significance...
  17. ncbi The MTHFR 677C --> T polymorphism and risk of prostate cancer: results from the CAPS study
    Mattias Johansson
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University Hospital, Umea 901 85, Sweden
    Cancer Causes Control 18:1169-74. 2007
    ..In conclusion, our results do not provide strong support for the hypothesis that the MTHFR 677C-->T polymorphism is related to prostate cancer risk...
  18. ncbi Implications for prostate cancer of insulin-like growth factor-I (IGF-I) genetic variation and circulating IGF-I levels
    Mattias Johansson
    Department of Surgical and Perioperative Sciences, Umea University Hospital, 901 85 Umea, Sweden
    J Clin Endocrinol Metab 92:4820-6. 2007
    ..We recently found a haplotype in the 3' region of the IGF-I gene associated with increased risk of prostate cancer, and we hypothesized that the observed association is mediated by circulating IGF-I...
  19. pmc A missense mutation in the aggrecan C-type lectin domain disrupts extracellular matrix interactions and causes dominant familial osteochondritis dissecans
    Eva Lena Stattin
    Department of Medical Biosciences, Medical and Clinical Genetics, Umea University Hospital, Umea, Sweden
    Am J Hum Genet 86:126-37. 2010
    ..Our results provide a molecular mechanism for the etiology of familial osteochondritis dissecans and show the importance of the aggrecan C-type lectin interactions for cartilage function in vivo...
  20. doi Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial
    Anders Widmark
    Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden
    Lancet 373:301-8. 2009
    ..To assess the effect of radiotherapy, we did an open phase III study comparing endocrine therapy with and without local radiotherapy, followed by castration on progression...
  21. pmc Risk of Prostate Cancer after Trans Urethral Resection of BPH: A Cohort and Nested Case-Control Study
    Camilla T Karlsson
    Department of Radiation Sciences, Oncology, Umea University, SE 901 87 Umea, Sweden
    Cancers (Basel) 3:4127-38. 2011
    ..Inflammation at the time of TURP is not associated with PCa risk in this material. The increased PCa risk may be attributed to increased surveillance and PSA screening. ..
  22. pmc Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12
    Jielin Sun
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Nat Genet 40:1153-5. 2008
    ..7 x 10(-9) for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP...
  23. ncbi Familial concordance in cancer survival: a Swedish population-based study
    Linda S Lindström
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Lancet Oncol 8:1001-6. 2007
    ..Nowadays, the fact that cancers can aggregate in families is generally accepted. The aim of this study was to complete a comprehensive analysis of cancer-survival concordance in parents and their children diagnosed with the same cancer...
  24. ncbi Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB2IP
    David Duggan
    Division of Genetic Basis of Human Disease, Translational Genomics Research Institute, Phoenix, AZ, USA
    J Natl Cancer Inst 99:1836-44. 2007
    ..The consistent finding of a genetic susceptibility to prostate cancer suggests that there are germline sequence variants predisposing individuals to this disease. These variants could be useful in screening and treatment...
  25. ncbi Combined genome-wide scan for prostate cancer susceptibility genes
    Elizabeth M Gillanders
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    J Natl Cancer Inst 96:1240-7. 2004
    ....
  26. pmc Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer
    Julius Gudmundsson
    deCODE Genetics, 101 Reykjavik, Iceland
    Nat Genet 40:281-3. 2008
    ..23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease...
  27. doi Cumulative association of five genetic variants with prostate cancer
    S Lilly Zheng
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    N Engl J Med 358:910-9. 2008
    ..3--have been associated with prostate cancer. Each SNP has only a moderate association, but when SNPs are combined, the association may be stronger...
  28. pmc Association of prostate cancer risk variants with clinicopathologic characteristics of the disease
    Jianfeng Xu
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Clin Cancer Res 14:5819-24. 2008
    ..Fifteen independent genetic variants have been implicated in prostate cancer risk by recent genome-wide association studies. However, their association with clinicopathologic features of prostate cancer is uncertain...
  29. pmc Cumulative effect of five genetic variants on prostate cancer risk in multiple study populations
    Jielin Sun
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Prostate 68:1257-62. 2008
    ..We carried out this study to confirm the finding in two U.S. study populations and perform a combined analysis to obtain a more stable estimate of the odds ratio (OR) for prostate cancer...
  30. pmc A multigenic approach to evaluating prostate cancer risk in a systematic replication study
    Fang Chi Hsu
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Cancer Genet Cytogenet 183:94-8. 2008
    ..99, P = 0.0014). A significant trend relationship was observed (P < 0.0001). In the present study, additive effects but not multiplicative effects among these six polymorphisms with significant main effects were observed...
  31. ncbi GLIOGENE an International Consortium to Understand Familial Glioma
    Beatrice Malmer
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 1340, P O Box 301439, Houston, TX 77230 1439, USA
    Cancer Epidemiol Biomarkers Prev 16:1730-4. 2007
    ..Here, we review the rationale for studying familial glioma and our proposed strategy for the GLIOGENE study...
  32. ncbi A comprehensive association study for genes in inflammation pathway provides support for their roles in prostate cancer risk in the CAPS study
    S Lilly Zheng
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Prostate 66:1556-64. 2006
    ..Considering inflammation is regulated by a complex system of gene products, we hypothesize sequence variants in many other genes of this pathway are associated with prostate cancer...
  33. ncbi Sequence variants in Toll-like receptor gene cluster (TLR6-TLR1-TLR10) and prostate cancer risk
    Jielin Sun
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Natl Cancer Inst 97:525-32. 2005
    ..In this study, we investigated whether sequence variants in the TLR6-TLR1-TLR10 gene cluster, residing within a 54-kb region on 4p14, were associated with prostate cancer risk...
  34. pmc A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer genetics
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Hum Genet 77:219-29. 2005
    ....
  35. ncbi Risk of invasive cervical cancer associated with polymorphic HLA DR/DQ haplotypes
    Mehran Ghaderi
    Department of Molecular Medicine, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden
    Int J Cancer 100:698-701. 2002
    ..4] and 4.33 (CI: 2.1-8.5), corresponding to population attributable proportions of 27.9% and 30.8%, respectively. A susceptibility locus in the HLA class II region is involved in a substantial fraction of the etiology of cervical cancer...
  36. ncbi The interaction of four genes in the inflammation pathway significantly predicts prostate cancer risk
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Epidemiol Biomarkers Prev 14:2563-8. 2005
    ....
  37. ncbi Two-locus genome-wide linkage scan for prostate cancer susceptibility genes with an interaction effect
    Bao Li Chang
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Hum Genet 118:716-24. 2006
    ....
  38. ncbi Interactions of sequence variants in interleukin-1 receptor-associated kinase4 and the toll-like receptor 6-1-10 gene cluster increase prostate cancer risk
    Jielin Sun
    Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Epidemiol Biomarkers Prev 15:480-5. 2006
    ..Although this study was based on a priori hypothesis and was designed to address many common issues facing this type of study, our results need confirmation in even larger studies...
  39. ncbi A common variant associated with prostate cancer in European and African populations
    Laufey T Amundadottir
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 38:652-8. 2006
    ..This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry...
  40. ncbi Dietary intake of phytoestrogens, estrogen receptor-beta polymorphisms and the risk of prostate cancer
    Maria Hedelin
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Prostate 66:1512-20. 2006
    ..Because phytoestrogens bind tightly to the estrogen receptor-beta, we conducted an epidemiologic investigation of synergistic effects between phytoestrogen intake and estrogen receptor-beta gene polymorphisms...
  41. ncbi Pooled genome linkage scan of aggressive prostate cancer: results from the International Consortium for Prostate Cancer Genetics
    Daniel J Schaid
    Harwick 7, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hum Genet 120:471-85. 2006
    ..This provides a basis for attempts to identify these genes, with potential clinical utility for men with aggressive prostate cancer and their relatives...
  42. ncbi Association of frequent consumption of fatty fish with prostate cancer risk is modified by COX-2 polymorphism
    Maria Hedelin
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
    Int J Cancer 120:398-405. 2007
    ..Frequent consumption of fatty fish and marine fatty acids appears to reduce the risk of prostate cancer, and this association is modified by genetic variation in the COX-2 gene...
  43. ncbi Genetic polymorphism of chemokine receptors CCR2 and CCR5 in Swedish cervical cancer patients
    Biying Zheng
    Department of Molecular Medicine and Surgery, Karolinska Institute, Center for Molecular Medicine and Karolinska University Hospital Solna, Stockholm, Sweden
    Anticancer Res 26:3669-74. 2006
    ..045) compare to HPV negative group. The delta-32 mutation on the CCR locus is imperceptibly associated with increased risk of HPV infection. In total, cervical neoplasia was not associated with genetic polymorphism of CCR2 and CCR5...
  44. pmc Compelling evidence for a prostate cancer gene at 22q12.3 by the International Consortium for Prostate Cancer Genetics
    Nicola J Camp
    University of Utah ICPCG Group and Division of Genetic Epidemiology, University of Utah School of Medicine, 391 Chipeta Way, Suite D, Salt Lake City, UT 84108, USA
    Hum Mol Genet 16:1271-8. 2007
    ..This collaborative study by the ICPCG illustrates the value of consortium efforts and the continued utility of linkage analysis using informative pedigrees to localize genes for complex diseases...
  45. ncbi Lactase persistence, dietary intake of milk, and the risk for prostate cancer in Sweden and Finland
    Suvi Torniainen
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Cancer Epidemiol Biomarkers Prev 16:956-61. 2007
    ..91-1.46; P = 0.23). In conclusion, lactase persistence/nonpersistence contains no risk for prostate cancer. Analysis of different milk products showed some evidence for low-fat milk as a potential risk factor for prostate cancer...
  46. doi The quality assurance process for the ARTSCAN head and neck study - a practical interactive approach for QA in 3DCRT and IMRT
    Karl Axel Johansson
    Sahlgrenska University Hospital, Goteborg, Sweden
    Radiother Oncol 87:290-9. 2008
    ....
  47. ncbi A population-based prospective study of Chlamydia trachomatis infection and cervical carcinoma
    Keng Ling Wallin
    Department of Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Int J Cancer 101:371-4. 2002
    ..trachomatis in both the prediagnostic smear and in the subsequent cervical cancer. In conclusion, a prior cervical C. trachomatis infection was associated with an increased risk for development of invasive cervical cancer...