- AMPA receptor activation causes silencing of AMPA receptor-mediated synaptic transmission in the developing hippocampusPontus Wasling
Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
PLoS ONE 7:e34474. 2012..Our study shows that agonist binding to AMPARs is a sufficient triggering stimulus for the creation of AMPAR silent synapses at developing glutamate synapses...
- Long-term depression in the developing hippocampus: low induction threshold and synapse nonspecificityPontus Wasling
Institute of Physiology and Pharmacology, Goteborg University, SE 405 30 Goteborg, Sweden
J Neurosci 22:1823-30. 2002..They also support the notion that a brief rise in postsynaptic calcium can induce long-term potentiation (LTP) or LTD, a larger rise more likely to induce LTP, as well as that a prolonged modest increase produces selectively only LTD...
- Developmental changes in release properties of the CA3-CA1 glutamate synapse in rat hippocampusP Wasling
Institute of Physiology and Pharmacology, Department of Physiology, Goteborg University, Box 432, 405 30 Goteborg, Sweden
J Neurophysiol 92:2714-24. 2004....
- Creation of AMPA-silent synapses in the neonatal hippocampusMin Yi Xiao
Department of Physiology, Institute of Physiology and Pharmacology, Goteborg University, Box 432, 405 30 Goteborg, Sweden
Nat Neurosci 7:236-43. 2004..The AMPA silencing, possibly explained by a removal of postsynaptic AMPA receptors, could subsequently be reversed by paired presynaptic and postsynaptic activity...
- Modulation of low-frequency-induced synaptic depression in the developing CA3-CA1 hippocampal synapses by NMDA and metabotropic glutamate receptor activationJoakim Strandberg
Dept of Physiology, University of Gothenburg, Box 432, Medicinaregatan 11, 405 30 Gothenburg, Sweden
J Neurophysiol 101:2252-62. 2009..Our results seem in line with the notion that NMDARs and mGluRs may exert a bidirectional control on AMPA receptor recruitment to synapses...
- Altered cognitive performance and synaptic function in the hippocampus of mice lacking C3Marta Pérez-Alcázar
Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, The Sahlgrenska Academy at the University of Gothenburg, S 405 30 Gothenburg, Sweden Institute of Neuroscience and Physiology, Department of Physiology, The Sahlgrenska Academy at the University of Gothenburg, S 405 30 Gothenburg, Sweden
Exp Neurol 253:154-64. 2014..We conclude that C3 plays a role in the regulation of the number and function of glutamatergic synapses in the hippocampus and exerts negative effects on hippocampus-dependent cognitive performance. ..
- Human cerebrospinal fluid increases the excitability of pyramidal neurons in the in vitro brain sliceAndreas Björefeldt
Department of Physiology, Institute of Neuroscience and Physiology, University of Gothenburg, Medicinaregatan 11, Box 432, 405 30, Gothenburg, Sweden
J Physiol 593:231-43. 2015..Our findings highlight a previously unknown function of the CSF in promoting spontaneous excitatory activity, and may help to explain differences observed in the activity of pyramidal neurons recorded in vivo and in vitro...
- Synaptic retrogenesis and amyloid-beta in Alzheimer's diseasePontus Wasling
Department of Physiology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
J Alzheimers Dis 16:1-14. 2009..Here, we review the literature on the possible physiological roles of Abeta and its precursor protein AbetaPP during development with special focus on electrophysiological findings...
- Antisecretory factor modulates GABAergic transmission in the rat hippocampusMalin Kim
Institute of Physiology and Pharmacology, Goteborg University, Sweden
Regul Pept 129:109-18. 2005..Our results identify AF as a neuromodulator and further raise the possibility that the hippocampus and AF are involved in a gut-brain loop controlling intestinal secretion and inflammation...