L O Wahlund

Summary

Country: Sweden

Publications

  1. ncbi Inheritance of the ApoE epsilon4 allele increases the rate of brain atrophy in dementia patients
    L O Wahlund
    Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden
    Dement Geriatr Cogn Disord 10:262-8. 1999
  2. ncbi Visual assessment of medical temporal lobe atrophy in demented and healthy control subjects: correlation with volumetry
    L O Wahlund
    Department of Clinical Neuroscience and Family Medicine, Karolinska Institute B56, Huddinge University Hospital, Sweden
    Psychiatry Res 90:193-9. 1999
  3. ncbi A follow-up study of the family with the Swedish APP 670/671 Alzheimer's disease mutation
    L O Wahlund
    Department of Clinical Neuroscience and Family Medicine, Division of Geriatric Medicine, B 56, Huddinge University Hospital, Karolinska Institute, Huddinge, Sweden
    Dement Geriatr Cogn Disord 10:526-33. 1999
  4. ncbi Quantitative EEG abnormalities and cognitive dysfunctions in frontotemporal dementia and Alzheimer's disease
    M Lindau
    Karolinska Institutet, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Huddinge University Hospital, Stockholm, Sweden
    Dement Geriatr Cogn Disord 15:106-14. 2003
  5. doi Usefulness of computed tomography linear measurements in diagnosing Alzheimer's disease
    Yi Zhang
    Division of Clinical Geriatrics, Department of NVS, Karolinska Institute, Stockholm, Sweden
    Acta Radiol 49:91-7. 2008
  6. ncbi Quantitative electroencephalography in mild cognitive impairment: longitudinal changes and possible prediction of Alzheimer's disease
    V Jelic
    Karolinska Institutet, Neurotec, Division of Geriatric Medicine, B 84, Huddinge University Hospital, S 141 86, Huddinge, Sweden
    Neurobiol Aging 21:533-40. 2000
  7. ncbi Cerebrospinal fluid tau levels increase with age in healthy individuals
    M Blomberg
    Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research NEUROTEC, Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden
    Dement Geriatr Cogn Disord 12:127-32. 2001
  8. ncbi White matter lesions impair initiation of FAS flow
    S E Fernaeus
    Department of Clinical Neuroscience and Family Medicine, Division of Geriatric Medicine, Karolinska Institutet, Huddinge University Hospital, Huddinge, Sweden
    Dement Geriatr Cogn Disord 12:52-6. 2001
  9. ncbi Increased risk for frontotemporal dementia through interaction between tau polymorphisms and apolipoprotein E epsilon4
    M Ingelson
    Karolinska Institutet, Neurotec, Novum, KFC, Huddinge, Sweden
    Neuroreport 12:905-9. 2001
  10. ncbi Impaired cerebral glucose metabolism and cognitive functioning predict deterioration in mild cognitive impairment
    E Arnaiz
    Karolinska Institutet, Department of Clinical Neuroscience, Occupational Therapy, and Elderly Care Research NEUROTEC, Huddinge University Hospital, Sweden
    Neuroreport 12:851-5. 2001

Detail Information

Publications25

  1. ncbi Inheritance of the ApoE epsilon4 allele increases the rate of brain atrophy in dementia patients
    L O Wahlund
    Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden
    Dement Geriatr Cogn Disord 10:262-8. 1999
    ..The presence of ApoE epsilon4 allele did not influence the change in MMSE in any of the diagnostic groups...
  2. ncbi Visual assessment of medical temporal lobe atrophy in demented and healthy control subjects: correlation with volumetry
    L O Wahlund
    Department of Clinical Neuroscience and Family Medicine, Karolinska Institute B56, Huddinge University Hospital, Sweden
    Psychiatry Res 90:193-9. 1999
    ....
  3. ncbi A follow-up study of the family with the Swedish APP 670/671 Alzheimer's disease mutation
    L O Wahlund
    Department of Clinical Neuroscience and Family Medicine, Division of Geriatric Medicine, B 56, Huddinge University Hospital, Karolinska Institute, Huddinge, Sweden
    Dement Geriatr Cogn Disord 10:526-33. 1999
    ..To study the progression of Alzheimer's disease (AD) at a very early stage and to evaluate clinical markers of presymptomatic AD...
  4. ncbi Quantitative EEG abnormalities and cognitive dysfunctions in frontotemporal dementia and Alzheimer's disease
    M Lindau
    Karolinska Institutet, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Huddinge University Hospital, Stockholm, Sweden
    Dement Geriatr Cogn Disord 15:106-14. 2003
    ....
  5. doi Usefulness of computed tomography linear measurements in diagnosing Alzheimer's disease
    Yi Zhang
    Division of Clinical Geriatrics, Department of NVS, Karolinska Institute, Stockholm, Sweden
    Acta Radiol 49:91-7. 2008
    ..The current method of choice for measuring MTA is volumetric measurement based on 3D magnetic resonance imaging (MRI), but this complicated method has not been implemented clinically...
  6. ncbi Quantitative electroencephalography in mild cognitive impairment: longitudinal changes and possible prediction of Alzheimer's disease
    V Jelic
    Karolinska Institutet, Neurotec, Division of Geriatric Medicine, B 84, Huddinge University Hospital, S 141 86, Huddinge, Sweden
    Neurobiol Aging 21:533-40. 2000
    ....
  7. ncbi Cerebrospinal fluid tau levels increase with age in healthy individuals
    M Blomberg
    Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research NEUROTEC, Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden
    Dement Geriatr Cogn Disord 12:127-32. 2001
    ..In conclusion, we found an age-dependent increase in CSF tau in healthy individuals. We emphasise the importance of establishing an age-dependent interval of CSF tau in non-demented subjects...
  8. ncbi White matter lesions impair initiation of FAS flow
    S E Fernaeus
    Department of Clinical Neuroscience and Family Medicine, Division of Geriatric Medicine, Karolinska Institutet, Huddinge University Hospital, Huddinge, Sweden
    Dement Geriatr Cogn Disord 12:52-6. 2001
    ..The initial FAS performance was related to anterior WMH, in particular left frontal or lateral periventricular hyperintensities, whereas the late FAS performance was not related to any index of WMH...
  9. ncbi Increased risk for frontotemporal dementia through interaction between tau polymorphisms and apolipoprotein E epsilon4
    M Ingelson
    Karolinska Institutet, Neurotec, Novum, KFC, Huddinge, Sweden
    Neuroreport 12:905-9. 2001
    ..006). We thus propose that this extended tau haplotype in combination with apoE epsilon4 is a genetic risk factor for FTD...
  10. ncbi Impaired cerebral glucose metabolism and cognitive functioning predict deterioration in mild cognitive impairment
    E Arnaiz
    Karolinska Institutet, Department of Clinical Neuroscience, Occupational Therapy, and Elderly Care Research NEUROTEC, Huddinge University Hospital, Sweden
    Neuroreport 12:851-5. 2001
    ..Measures of temporoparietal cerebral metabolism and visuospatial function may aid in predicting the evolution to AD for patients with MCI...
  11. ncbi White matter lesions in Alzheimer patients are influenced by apolipoprotein E genotype
    L Bronge
    Radiology, Division of Geriatric Medicine, Huddinge University Hospital, Huddinge, Sweden
    Dement Geriatr Cogn Disord 10:89-96. 1999
    ..In patients carrying at least one sigma4 allele, the WMLs showed no age correlation. The results could imply that in APOE allele sigma4 carriers, the WMLs represent a pathological process related to the aetiology of the disease...
  12. ncbi Contrast-enhanced MRI of white matter lesions in patients with blood-brain barrier dysfunction
    L O Wahlund
    Department of Radiology, Huddinge University Hospital, Sweden
    Ann N Y Acad Sci 903:477-81. 2000
    ..We conclude that WMLs are not related to BBB damage to such a degree that is detectable with this method and that the elevated CSF albumin might have another origin...
  13. ncbi A new rating scale for age-related white matter changes applicable to MRI and CT
    L O Wahlund
    Department of Clinical Neuroscience, Neurotec, Karolinska Institutet at Huddinge University Hospital, Huddinge, Sweden
    Stroke 32:1318-22. 2001
    ..We have developed and evaluated a new scale and studied ARWMC in a large number of patients examined with both MRI and CT...
  14. ncbi Jargonagraphia in a case of frontotemporal dementia
    P Ostberg
    Division of Geriatric Medicine, Huddinge University Hospital, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Brain Lang 79:333-9. 2001
    ..The agraphia in this case is discussed with reference to both specific macroscopic and microscopic pathoanatomical lesions. We suggest that jargonagraphia can appear in frontotemporal dementia depending on the localization of lesions...
  15. doi Lack of accuracy for the proposed 'Dubois criteria' in Alzheimer's disease: a validation study from the Swedish brain power initiative
    A R Oksengard
    NVS Department, Karolinska Institute, Karolinska University Hospital, Huddinge, Sweden
    Dement Geriatr Cogn Disord 30:374-80. 2010
    ..Our purpose was to investigate whether the new research criteria for Alzheimer's disease proposed in 2007 by Dubois et al. are valid in a naturalistic memory clinic sample...
  16. ncbi Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment
    B Winblad
    Division of Geriatric Medicine, Neurotec Department, Karolinska Institutet, 11382 Stockholm, Sweden
    J Intern Med 256:240-6. 2004
    ....
  17. ncbi Reliability of interactive three-dimensional brain volumetry using MP-RAGE magnetic resonance imaging
    P Julin
    Karolinska Institute, Department of Clinical Neuroscience and Family Medicine, Huddinge University Hospital, Sweden
    Psychiatry Res 76:41-9. 1997
    ..The major advantages of the method are its simplicity and speed, which permits measurement and display of regional brain volumes and tissues in larger patient groups...
  18. pmc Mild cognitive impairment: a cross-national comparison
    E Arnaiz
    Karolinska Institutet, Neurotec Department, Huddinge University Hospital, Stockholm, Sweden
    J Neurol Neurosurg Psychiatry 75:1275-80. 2004
    ....
  19. doi Medial temporal lobe atrophy increases the specificity of cerebrospinal fluid biomarkers in Alzheimer disease with minor cerebrovascular changes
    Y Zhang
    Division of Radiology, Department of Clinical Science, Intervention, and Technology, Karolinska Institute, Stockholm, Sweden
    Acta Radiol 50:674-81. 2009
    ..Although cerebrospinal fluid (CSF) biomarkers and medial temporal lobe atrophy (MTA) contribute to the diagnosis of Alzheimer disease (AD), they may not be specific. Relatively little is known about how they correlate with each other...
  20. ncbi Conversion from preclinical to dinical stage of Alzheimer's disease as shown by decline of cognitive function in carriers of the Swedish APP-mutation
    O Almkvist
    Division of Geriatric Medicine, Karolinska Institutet, Department of Clinical Neuroscience, Occupational Therapy, and Elderly Care Research NEUROTEC, Huddinge University Hospital, Stockholm, Sweden
    J Neural Transm Suppl . 2002
    ..The findings question the generality of common MCI concepts and the commonly held beliefs about cognitive features in late preclinical stage of AD...
  21. doi A comparison between volumetric data generated by voxel-based morphometry and manual parcellation of multimodal regions of the frontal lobe
    O Lindberg
    Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden
    AJNR Am J Neuroradiol 33:1957-63. 2012
    ..The purpose of this study was to compare volumetric data generated by MM and VBM on 4 multimodal regions in the frontal lobe...
  22. doi Voxel-based correlation between coregistered single-photon emission computed tomography and dynamic susceptibility contrast magnetic resonance imaging in subjects with suspected Alzheimer disease
    L Cavallin
    Division of Radiology, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
    Acta Radiol 49:1154-61. 2008
    ..Neuroimaging techniques such as magnetic resonance imaging (MRI) and single-photon emission computed tomography (SPECT) could be valuable in the differential diagnosis of Alzheimer disease, as well as in assessing prognosis...
  23. ncbi Clinic-based cases with frontotemporal dementia show increased cerebrospinal fluid tau and high apolipoprotein E epsilon4 frequency, but no tau gene mutations
    S F Fabre
    Department of Neurotec, Karolinska Institutet, Huddinge, KFC, Novum, S 141 86, Sweden
    Exp Neurol 168:413-8. 2001
    ..Furthermore, we conclude that mutations in the tau gene are a rare cause of FTD. ...
  24. doi Cortical morphometric subclassification of frontotemporal lobar degeneration
    O Lindberg
    Department of Neurobiology, Care Science and Society, Section of Clinical Geriatrics, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden
    AJNR Am J Neuroradiol 30:1233-9. 2009
    ..We hypothesized that these symptoms would be correlated to characteristic patterns of brain atrophy, which could be indentified and used for subclassification of subjects with FTLD...
  25. ncbi White matter lesions in dementia: an MRI study on blood-brain barrier dysfunction
    L Bronge
    Department of Radiology, Huddinge University Hospital, Huddinge, Sweden
    Dement Geriatr Cogn Disord 11:263-7. 2000
    ..We conclude that WMLs are not connected to BBB damage to such a degree that is detectable with this method and that the elevated CSF albumin might have another origin...