Lene Uhrbom

Summary

Affiliation: Uppsala University
Country: Sweden

Publications

  1. doi request reprint Forced expression of Sox21 inhibits Sox2 and induces apoptosis in human glioma cells
    Maria Ferletta
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, SE 751 85 Uppsala, Sweden
    Int J Cancer 129:45-60. 2011
  2. ncbi request reprint Cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesis
    Lene Uhrbom
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala, Sweden
    Cancer Res 65:2065-9. 2005
  3. ncbi request reprint Sox10 has a broad expression pattern in gliomas and enhances platelet-derived growth factor-B--induced gliomagenesis
    Maria Ferletta
    Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory C11, Dag Hammarskjoldsv 20, S 751 85 Uppsala, Sweden
    Mol Cancer Res 5:891-7. 2007
  4. pmc Identification of candidate cancer-causing genes in mouse brain tumors by retroviral tagging
    Fredrik K Johansson
    Department of Genetics and Pathology, The Rudbeck Laboratory, University Hospital, SE 751 85 Uppsala, Sweden
    Proc Natl Acad Sci U S A 101:11334-7. 2004
  5. pmc miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma
    Jelena Polajeva
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, SE 751 85 Uppsala, Sweden
    BMC Cancer 12:378. 2012
  6. doi request reprint Oncogenic signaling is dominant to cell of origin and dictates astrocytic or oligodendroglial tumor development from oligodendrocyte precursor cells
    Nanna Lindberg
    Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Rudbeck Laboratory, SE 75185 Uppsala, Sweden, Department of Cancer Biology and Genetics, and the Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, New York 10065, Human Biology Division and Solid Tumor Translational Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109
    J Neurosci 34:14644-51. 2014
  7. pmc Histidine-rich glycoprotein can prevent development of mouse experimental glioblastoma
    Maria Kärrlander
    Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
    PLoS ONE 4:e8536. 2009
  8. pmc Mast cell accumulation in glioblastoma with a potential role for stem cell factor and chemokine CXCL12
    Jelena Polajeva
    Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    PLoS ONE 6:e25222. 2011
  9. pmc Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates the recruitment of LRP1 positive mast cells
    Ananya Roy
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Oncotarget 6:23647-61. 2015
  10. pmc PDGF-B Can sustain self-renewal and tumorigenicity of experimental glioma-derived cancer-initiating cells by preventing oligodendrocyte differentiation
    Yiwen Jiang
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Neoplasia 13:492-503. 2011

Collaborators

Detail Information

Publications23

  1. doi request reprint Forced expression of Sox21 inhibits Sox2 and induces apoptosis in human glioma cells
    Maria Ferletta
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, SE 751 85 Uppsala, Sweden
    Int J Cancer 129:45-60. 2011
    ..We suggest that Sox21 can negatively regulate Sox2 in glioma. Our findings imply that Sox2 and Sox21 may be interesting targets for the development of novel glioma therapy...
  2. ncbi request reprint Cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesis
    Lene Uhrbom
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala, Sweden
    Cancer Res 65:2065-9. 2005
    ..Thus, Ink4a and Arf have independent and differential tumor suppressor functions in vivo in the glial cell compartment...
  3. ncbi request reprint Sox10 has a broad expression pattern in gliomas and enhances platelet-derived growth factor-B--induced gliomagenesis
    Maria Ferletta
    Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory C11, Dag Hammarskjoldsv 20, S 751 85 Uppsala, Sweden
    Mol Cancer Res 5:891-7. 2007
    ..The Sox10 expression was restricted to gliomas and melanomas. All glioma types expressed Sox10, and tumors of low-grade glioma had a much broader distribution of Sox10 compared with high-grade gliomas...
  4. pmc Identification of candidate cancer-causing genes in mouse brain tumors by retroviral tagging
    Fredrik K Johansson
    Department of Genetics and Pathology, The Rudbeck Laboratory, University Hospital, SE 751 85 Uppsala, Sweden
    Proc Natl Acad Sci U S A 101:11334-7. 2004
    ..Our findings indicate that retroviral tagging with a growth factor-encoding virus may be a powerful means of identifying candidate tumor-causing genes in nonhematopoietic tumors...
  5. pmc miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma
    Jelena Polajeva
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, SE 751 85 Uppsala, Sweden
    BMC Cancer 12:378. 2012
    ..We decided to investigate the expression of the oncogenic miR-21 during normal mouse development and glioma, focusing on PDGF signaling as a potential regulator of miR-21...
  6. doi request reprint Oncogenic signaling is dominant to cell of origin and dictates astrocytic or oligodendroglial tumor development from oligodendrocyte precursor cells
    Nanna Lindberg
    Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Rudbeck Laboratory, SE 75185 Uppsala, Sweden, Department of Cancer Biology and Genetics, and the Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, New York 10065, Human Biology Division and Solid Tumor Translational Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109
    J Neurosci 34:14644-51. 2014
    ..Our mouse data are supported by the fact that human astrocytoma and oligodendroglioma display a high degree of overlap in global gene expression with no clear distinctions between the two diagnoses. ..
  7. pmc Histidine-rich glycoprotein can prevent development of mouse experimental glioblastoma
    Maria Kärrlander
    Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
    PLoS ONE 4:e8536. 2009
    ..We found that HRG had little effect on tumor incidence but could significantly inhibit the development of malignant glioma and completely prevent the occurrence of grade IV tumors (glioblastoma)...
  8. pmc Mast cell accumulation in glioblastoma with a potential role for stem cell factor and chemokine CXCL12
    Jelena Polajeva
    Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    PLoS ONE 6:e25222. 2011
    ..Moreover, human GBMs were positive for CXCL12 and the infiltrating MCs were positive for CXCR4. In conclusion, we provide the first evidence for a role for MCs in glioma...
  9. pmc Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates the recruitment of LRP1 positive mast cells
    Ananya Roy
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Oncotarget 6:23647-61. 2015
    ..The connection between high-grade glioma and MC infiltration could contribute to patient tailored therapy and improve patient stratification in future therapeutic trials. ..
  10. pmc PDGF-B Can sustain self-renewal and tumorigenicity of experimental glioma-derived cancer-initiating cells by preventing oligodendrocyte differentiation
    Yiwen Jiang
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Neoplasia 13:492-503. 2011
    ..Our findings suggest that interfering with PDGF-controlled differentiation could be a therapeutic avenue for patients diagnosed with the PDGF-driven proneural subtype of human glioblastoma...
  11. doi request reprint Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin
    Yiwen Jiang
    Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University, 75185 Uppsala, Sweden
    Cell Rep 18:977-990. 2017
    ..Human GC lines that clustered with the mGC1GFAP cells were also significantly more self-renewing, tumorigenic, and sensitive to cancer drugs compared with those that clustered with mouse GCs of more differentiated origin...
  12. pmc On the origin of glioma
    Yiwen Jiang
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Ups J Med Sci 117:113-21. 2012
    ..Thus, it is essential to explore further the role of cellular origin in glioma...
  13. pmc CGGBP1 regulates cell cycle in cancer cells
    Umashankar Singh
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 751 85 Uppsala, Sweden
    BMC Mol Biol 12:28. 2011
    ..Recently we had found CGGBP1 to be a cell cycle regulatory midbody protein required for normal cytokinetic abscission in normal human fibroblasts, which have all the cell cycle regulatory mechanisms intact...
  14. doi request reprint Mouse Models of Pediatric Supratentorial High-grade Glioma Reveal How Cell-of-Origin Influences Tumor Development and Phenotype
    Smitha Sreedharan
    Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Rudbeck Laboratory, Uppsala, Sweden
    Cancer Res . 2016
    ..These two mouse models relevant to human pediatric supratentorial HGG propose an important role of the cell-of-origin for clinicopathologic features of this disease. Cancer Res; 77(3); 1-11. ©2016 AACR...
  15. ncbi request reprint Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model
    Lene Uhrbom
    Uppsala University, Department of Genetics and Pathology, Rudbeck Laboratory, SE 75185 Uppsala, Sweden
    Nat Med 10:1257-60. 2004
    ..In these platelet-derived growth factor (PDGF)-driven oligodendrogliomas, G1 cell-cycle arrest is generated by blockade of either the PDGF receptor or mTOR using small-molecule inhibitors...
  16. doi request reprint Pleiotrophin enhances PDGFB-induced gliomagenesis through increased proliferation of neural progenitor cells
    Lei Zhang
    Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, The Rudbeck Laboratory, Uppsala, Sweden
    Oncotarget . 2016
    ..Our data indicates that PTN expression is associated with chromosome 7 gain, and that PTN enhances PDGFB-induced gliomagenesis by stimulating proliferation of neural progenitor cells...
  17. pmc The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes
    Yuan Xie
    Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University, 751 85 Uppsala, Sweden
    EBioMedicine 2:1351-63. 2015
    ..The HGCC panel provides an open resource for in vitro and in vivo modeling of a large part of GBM diversity useful to both basic and translational GBM research. ..
  18. ncbi request reprint Complementary effects of platelet-derived growth factor autocrine stimulation and p53 or Ink4a-Arf deletion in a mouse glioma model
    Göran Hesselager
    Department of Genetics and Pathology, Rudbeck Laboratory, University Hospital, SE 75185 Uppsala, Sweden
    Cancer Res 63:4305-9. 2003
    ....
  19. doi request reprint Etomidate, propofol and diazepam potentiate GABA-evoked GABAA currents in a cell line derived from human glioblastoma
    Omar Babateen
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Eur J Pharmacol 748:101-7. 2015
    ..We propose that the U3047MG cell line may be used as a model system to study GABAA receptors function and pharmacology in glial cells...
  20. pmc Adenovirus serotype 5 vectors with Tat-PTD modified hexon and serotype 35 fiber show greatly enhanced transduction capacity of primary cell cultures
    Di Yu
    Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
    PLoS ONE 8:e54952. 2013
    ....
  21. doi request reprint Case-specific potentiation of glioblastoma drugs by pterostilbene
    Linnéa Schmidt
    Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala, Sweden
    Oncotarget . 2016
    ..Our results highlight a nontoxic stilbenoid compound as a modulator of anticancer drug response, and indicate that pterostilbene might be used to modulate two anticancer compounds in well-defined sets of GBM patients...
  22. pmc p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3
    Rebecca M Wolf
    Department of Cell Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 17:476-87. 2003
    ..This evidence strongly suggests that p190 regulates critical components of PDGF oncogenesis and can act as a tumor suppressor in PDGF-induced gliomas by down-regulating Rho activity...
  23. ncbi request reprint Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt
    Lene Uhrbom
    Department of Cell Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 62:5551-8. 2002
    ..Our data strongly supports the view that one role of loss of Ink4a-Arf in gliomagenesis could be to sensitize astrocytes to transformation through dedifferentiation in response to the appropriate oncogenic stimuli...